by linda self. regulation of water excretion regulation of electrolyte function regulation of...
TRANSCRIPT
![Page 1: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/1.jpg)
By Linda Self
![Page 2: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/2.jpg)
Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain
HCO3- and excrete acid in urine Regulation of blood pressure--RAAS Regulation of RBCs Vitamin D synthesis
![Page 3: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/3.jpg)
Secretion of prostaglandin E and prostacyclin which cause vasodilation, important in maintaining renal blood flow
Excretion of waste products-body’s main excretory organ. Urea, creatinine, phosphates, uric acid and sulfates. Drug metabolites.
![Page 4: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/4.jpg)
![Page 5: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/5.jpg)
Renin—raises BP Bradykinins—increase blood flow and
vascular permeability Erythropoietin ADH Aldosterone—promotes sodium
reabsorption and potassium excretion Natriuretic hormones—released from the
cardiac atria and brain.
![Page 6: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/6.jpg)
1. Hypertension2. Diabetes mellitus3. Immobilization4. Parkinson’s disease5. SLE6. Gout7. Sickle cell anemia, multiple myeloma8. BPH9. Pregnancy10. SCI
![Page 7: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/7.jpg)
GFR decreases following 40 years with a yearly decline of about 1 mL/min
Renal reserve declines Multiple medications can result in toxic
metabolites Diminished osmotic stimulation of thirst Incomplete emptying of bladder Urinary incontinence
![Page 8: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/8.jpg)
![Page 9: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/9.jpg)
Sp. Gravity—1.005-1.020 Microscopic examination for protein, RBCs,
ketones, glycosuria, presence of bacteria, general appearance and odor
Leukocyte esterase—enzyme found in WBCs
Nitrites –bacteria convert nitrates to nitrites Osmolality—accurate measurement of the
kidney’s ability to concentrate urine. Normal range is 500-1200 mOsm/kg.
Culture important in ‘Id’ing pathogen
![Page 10: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/10.jpg)
Albuminuria—albumin in urine not measurable by dipstick
Normal values in freshly voided sample should range between 2.0-20 for men and 2.8-28 for women. Higher levels indicate microalbuminuria.
Can also be determined by 24h specimen
![Page 11: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/11.jpg)
Urine osmolality—indication of concentrating ability, changes seen early in disease processes
Creatinine clearance—tests clearance of creatinine in one min. Reflects GFR.
Serum creatinine—measures effectiveness of renal function. 0.6 to 1.2 mg/dL
Urea nitrogen—also indicator of renal function. 7-18 mg/dL. Measures renal excretion of urea nitirogen, a byproduct of protein metabolism. Is not always elevated with kidney disease. Not best indicator of renal function.
![Page 12: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/12.jpg)
Liver must function properly to produce urea nitrogen. BUN levels indicate the extent of renal clearance of this nitrogenous waste product.
May see elevation of BUN with bleeding into tissues or from rapid cell destruction from infection/steroids
![Page 13: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/13.jpg)
Ratio of BUN to creatinine distinguishes between renal and non-renal factors causing elevations
Dehydration can affect the BUN When blood volume is down, or BP is low,
BUN level rises more rapidly than creatinine level.
![Page 14: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/14.jpg)
Volume of fluid filtered from renal glomerular capillaries into Bowman’s capsule per unit of time
Generally expressed in ml/minute Normal GFR generally is 125mL/minute
![Page 15: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/15.jpg)
Cockcraft-Gault formula Modification of Diet in Renal Disease
Study Group formula (MDRD) Schwartz formula Starling equation
![Page 16: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/16.jpg)
![Page 17: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/17.jpg)
No common pathologic condition, other than renal disease, increases the serum creatinine level
Serum creatinine does not increase until at least 50% of renal function is lost
![Page 18: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/18.jpg)
Is a calculated measure of glomerular filtration rate. Is best indicator of overall kidney function.
Based on 24 hour urine collection Midway will obtain serum creatinine.
Serum creatinine levels vary with age, gender and body muscle mass
Calculate: (Volume of urine X urine creatinine)
Divided by serume creatinine
![Page 19: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/19.jpg)
KUB Ultrasonography CT MRI Nuclear scans IV urography—IVP. NPO before. Bowel
prep. Nephrotoxic agent. Metformin. VCUG
![Page 20: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/20.jpg)
Cystoscopy Ureteral brush biopsy Kidney biopsy Urodynamic tests—cystometrogram.
Measures detrusor muscle function.
![Page 21: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/21.jpg)
Antigen-antibody complexes form in blood and become trapped in glomerular capillaries
Induce an inflammatory response Manifested by proteinuria, hematuria,
decreased GFR and alteration in excretion of sodium
Acute and chronic glomerulonephritis Nephrotic syndrome
![Page 22: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/22.jpg)
![Page 23: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/23.jpg)
Staph, klebsiella, CMV, mono, hep B, mycoplasma, group A beta-hemolytic strep
![Page 24: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/24.jpg)
Hematuria Edema Azotemia-accumulation of nitrogenous
wastes Urine appearance may be cola colored Hypertension Hypoalbuminemia Hyperlipidemia Rising BUN and creatinine
![Page 25: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/25.jpg)
Hypertensive encephalopathy Heart failure Rapid decline in renal function can occur
to ESRD
![Page 26: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/26.jpg)
Treat s/s such as elevated BP Check GFR by 24h urine for creatinine
clearance ANA Treat streptococcal infection with antibiotics,
preferably PCN Corticosteroids Immunosuppressants Limit dietary protein, increase CHO Restrict sodium May progress to chronic glomerulonephritis,
will treat as in CKD
![Page 27: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/27.jpg)
Is not a specific glomerular disease Is a syndrome with a cluster of findings
that include: Marked increase in protein in urine
(especially albumin) Hypoalbuminemia Edema High serum cholesterol and LDL
![Page 28: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/28.jpg)
A condition of increased glomerular permeability
Results in massive protein loss Often linked genetically or r/t
immune/inflammatory process Caused by chronic glomerulonephritis,
diabetes mellitus with glomerulosclerosis, amyloidosis, lupus, multiple myeloma and renal vein thrombosis
Major manifestation is edema Hallmark is albuminuria exceeding 3.5g/day
![Page 29: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/29.jpg)
![Page 30: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/30.jpg)
![Page 31: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/31.jpg)
Massive proteinuria Hypoalbuminemia Edema Lipiduria Hyperlipidemia Increased coagulation Renal insufficiency
![Page 32: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/32.jpg)
Renal biopsy to determine specific cause Steroids Immunosuppressive agents ACEIs can decrease proteinuria Cholesterol lowering agents Heparin to reduce coagulability Limit sodium intake
![Page 33: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/33.jpg)
Reversible clinical syndrome whereby there is sudden and pronounced loss of kidney function
Occurs over hours to days Results in kidneys failure to excrete
nitrogenous wastes
![Page 34: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/34.jpg)
Intrarenal actual parenchymal damage Prolonged renal ischemia from
myoglobinuria (rhabdo, trauma, burns), hemoglobinuria (transfusion reaction, hemolytic anemia)
Nephrotoxic agents like aminoglycosides, radiopaque contrast, heavy metals, solvents, NSAIDs, ACEIs, acute glomerulonephritis
![Page 35: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/35.jpg)
Prerenal 60-70% of cases Volume depletion as seen in hemorrhage,
renal losses from diuretics, GI losses from vomiting, diarrhea
Impaired cardiac output 2ndary to MI, heart failure, dysrhythmias, cardiogenic shock
Vasodilation from sepsis, anaphylaxis, antihypertensive meds
![Page 36: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/36.jpg)
Postrenal
Urinary tract obstruction by calculi, tumors, BPH, blood clots
![Page 37: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/37.jpg)
1. Initiation occurs with the insult2. Oliguria with urinary output less than
400ml/24h . rising potassium, BUN, Cr. Not responsive to fluid challenges.
3. Diuresis period— gradual increase in urinary output. Beginning recovery. Renal function gradually improves
4. Recovery—may take 3-12 months. May have permanent reduction in functioning of 1%-3%.
![Page 38: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/38.jpg)
Prerenal-hypotension, tachycardia, decreased CO, decreased urinary output, lethargy
intrarenal and postrenal—oliguria or anuria, hypertension, tachycardia, SOB, orthopnea, n/v, generalized edema and weight gain, lethargy, confusion
![Page 39: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/39.jpg)
Nonoliguric form also exists. Phases are similar.
![Page 40: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/40.jpg)
Elevated BUN and creatinine Sodium retention but may be deceptive
due to water retention Potassium increased Phosphorus increased Calcium decreased H&H decreased Sp. Gravity decreased and fixed
![Page 41: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/41.jpg)
Objectives : Restore normal chemical balance and prevent
complications until restoration of renal function Identify and treat underlying cause Maintain fluid balance—wts, serial CVP
readings, BP, strict I&O May give Mannitol, Lasix or Edecrin May need temporary dialysis
![Page 42: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/42.jpg)
If prerenal, fluid challenges and diuretics to enhance renal blood flow
Oliguric renal failure, low dose dopamine. Calcium channel blockers may be used to prevent influx of calcium into kidney cells, maintains cell integrity and increase GFR
![Page 43: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/43.jpg)
Hyperkalemia—closely monitor electrolytes
Kayexalate/Sorbitol—may need Flexiseal IV dextrose, insulin and calcium may help
shift K+ Cautious administration of any
medication that can be nephrotoxic Monitor ABGs and acid-base balance Monitor phosphate levels
![Page 44: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/44.jpg)
Azotemia and uremia are directly related to the rate of protein breakdown
Dietary proteins are individualized to each patient. Is a catabolic state and if insufficient intake, patient may lose up to 0.5-1 pounds daily. Encourage high CHO. Protein needs for non-dialysis patients need 0.6g/kg of body weight
Dialysis patients will need 1-1.5g/kg Fluid restriction=urine volume plus 500ml
![Page 45: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/45.jpg)
Monitor fluid and electrolyte balance Reduce metabolic demands Promote pulmonary function Prevent infection Provide skin care Provide support
![Page 46: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/46.jpg)
Progressive, irreversibe deterioration in renal function
Causation: #1 diabetes mellitus, hypertension, glomerulonephritis, pyelonephritis, polycystic kidney disease, vascular disorders, others
Uremia---collection of nitrogenous wastes normally excreted by the kidneys. S/S include: HA, seizures, coma, dry skin, rapid pulse, elevated BP, scanty urine, labored breathing
![Page 47: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/47.jpg)
Nephrons hypertrophy and work harder until 70-80% of renal function is lost
Nephrons could only compensate by decreasing water reabsorption thus:
Hyposthenuria—loss of urine concentrating ability occurs
Polyuria—increased urine output Then isosthenuria—fixed osmolality Gradual decline in urinary output
![Page 48: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/48.jpg)
1. GFR greater than or equal to 90mL/min/1.73 m2. Kidney damage w/normal or increased GFR
2. GFR = 60-89, mild decrease in GFR3. GFR = 30-59, moderate decrease in GFR4. GFR = 15-29. severe decrease in GFR5. GFR < 15. Kidney failure
![Page 49: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/49.jpg)
Every body system is affected CV—hypertension (RAAS), heart failure,
pulmonary edema, pericarditis, MI Pulm.—crackles, Kussmaul, pleuritic pain Derm—severe pruritus, uremic frost (urea
crystals) GI—n/v, anorexia, uremic fetor (ammonia
odor to breath), constipation or diarrhea Neurologic—LOC changes, confusion,
seizures, agitation, neuropathies, RLS
![Page 50: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/50.jpg)
Hematologic—anemia, thrombocytopenia Musculoskeletal—muscle cramps, renal
osteodystrophy, bone pain, bone fractures
Metabolic changes—urea and creatinine, sodium, potassium, acid-base, calcium and phosphorus
![Page 51: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/51.jpg)
Calcium and phosphorus binders—Calcium carbonate, calcium acetate
Antihypertensives Antiseizure—valium or dilantin Erythropoietin Iron supplements Diet—CHO and fat, vitamins, restrict
protein
![Page 52: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/52.jpg)
Indications:1. Uremia2. Persistent hyperkalemia3. Uncompensated metabolic acidosis4. Fluid volume excess5. Uremic encephalopathy6. Remove toxic substances
![Page 53: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/53.jpg)
Based on principles of diffusion, osmosis and ultrafiltration
Diffusion—removal of toxins and wastes. Move from blood to dialysate.
Osmosis—excess water is removed. Goes from area of higher solute concentration (blood) to lower concentration (dialysate)
Ultrafiltration—water moves from high pressure area to lower pressure. Applied by negative pressure, more efficient than just by osmosis
![Page 54: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/54.jpg)
ASHD Disturbances of lipids worsened by dialysis Anemia and fatigue Gastric ulcers Renal osteodystrophy Sleep problems Hypotension Muscle cramps Dysrhythmias Dialysis equilibrium from cerebral fluid shifts
![Page 55: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/55.jpg)
Caused by rapid decrease in fluid volume and blood urea nitrogen levels during HD
Change in urea levels can cause cerebral edema and increased ICP
Neurologic complications include: HA, vomiting, restlessness, decreased LOC, seizures, coma or death
Can be prevented by starting HD for short periods and low blood flows
![Page 56: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/56.jpg)
Hemodialysis In ICUs where patient is too unstable to
have hemodialysis, can have CRRT Peritoneal dialysis
![Page 57: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/57.jpg)
More successful if done before dialysis HLA and ABO compatibility Donor kidney placed in iliac fossa Patient must be free from infection Similar care for patient post-op as any
surgery
![Page 58: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/58.jpg)
Post-op—assess for s/s of rejection such as oliguria, edema, fever, increasing blood pressure, weight gain and swelling or tenderness over transplanted area
Monitor creatinine level, in those on cyclosporine, may be the only s/s
Monitor WBCs Monitor urinary output, may need
hemodialysis temporarily (2-3 weeks may initially have ATN)
![Page 59: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/59.jpg)
Occurs in types 1 and 2 Severity of diabetic renal disease is
related to extent, duration and effects of atherosclerosis, htn and neuropathy.
![Page 60: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/60.jpg)
Microvascular complication of diabetes First manifestation is persistent
albuminuria Diabetic patients are always considered
to be at risk for renal failure Avoid nephrotoxic agents and
dehydration
![Page 61: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/61.jpg)
Stage 1—at time of diagnosis of diabetes. Kidney size and GFR are increased. Blood sugar control can reverse the changes.
Stage 2, 2-3 years after diagnosis. Basement membrane changes result in loss of filtration surface area and scar formation. These changes are called glomerulosclerosis.
![Page 62: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/62.jpg)
Stage 3, 7-15 years after diagnosis. Microalbuminuria is present. GRF may be normal or increased.
Stage 4, albuminuria is detectable by dipstick. GRF decreased. BP is increased. Retinopathy is present.
Stage V, GFR decreases at an average rate of 10ml/min./year
![Page 63: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/63.jpg)
Cystitis Ureterovesical reflux
![Page 64: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/64.jpg)
If bacteriuria, following should have cultures done:
All men All children Patients with diabetics Those with recent instrumentation Those hospitalized or who live in long term care Pregnant women Sexually active Postmenopausal
![Page 65: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/65.jpg)
Obstruction Stones Diabetes mellitus Gender Age—anticholinergics, neuromuscular
conditions, hypoestrogenism Sexual activity Alkalotic urine Vesicoureteral reflux
![Page 66: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/66.jpg)
Most common organism is E. coli Other causative organisms are: S.
saprophyticus, K. pneumoniae, Proteus and Enterobacter
![Page 67: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/67.jpg)
Bactrim, Macrodantin, Cipro,Levaquin Fluids, avoid urinary irritants Hygiene Prevention
![Page 68: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/68.jpg)
Acute pyelonephritis Will have fever, chills, leukocytosis,
bacteriuria and pyuria CVA tenderness US or CT to r/o any obstruction Urine C&S
![Page 69: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/69.jpg)
Tx: Hydration Antiemetics Two week course of antibiotics such as
Bactrim, Cipro, gentamycin w/or w/o ampicillin, 3rd generation cephalosporin
Pregnant women hospitalized for 2-3 days
f/u culture in two weeks
![Page 70: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/70.jpg)
Stress incontinence—invol. loss of urine w/ activities that increase intraabdominal pressure
Urge incontinence—unable to suppress signal from bladder to brain
Overflow incontinence-when bladder is distended, will have small amount of incont.
Functional incontinence as seen in Alzheimer’s Reflex incontinence as seen in SCI patients Mixed-stress and urge Neurogenic bladder—lesion of ns leads to
urinary incontinence
![Page 71: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/71.jpg)
May be caused by MS, SCI, HNP, spinal tumor, spina bifida, diabetes
Spastic—upper motor neuron lesion Flaccid—lower motor neuron lesion. Fills
then have overflow incontinence Assess by checking residuals, I&O, UA,
assessing sensory awareness Tx-urecholine, surgery, intermittent
caths, S/P caths
![Page 72: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/72.jpg)
Diuretics CNS depressants which affect LOC CVAs Parkinson’s Depression and altered self-esteem Inability to ambulate safely Assistance products cost prohibitive for
patient UTI
![Page 73: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/73.jpg)
TCAs Anticholinergics—Sudafed, Detrol,
Ditropan Estrogen in women
![Page 74: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/74.jpg)
Weight loss in obese Fluid management Transvaginal or transrectal electrical
stimulation Inflatable cuff Vaginal cone retention exercises Urinary catheterization Scheduled toileting Pelvic muscle exercises
![Page 75: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/75.jpg)
Presence of calculi in urinary tract Cause pain as they pass Nephrolithiasis is formation of stones in
the kidney
![Page 76: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/76.jpg)
Involves three conditions:1. Slow urine flow resulting in
supersaturation of the urine with the particular element
2. Damage to the lining of the urinary tract3. Decreased inhibitor substances in the
urine that would otherwise prevent supersaturation and crystal aggregation
![Page 77: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/77.jpg)
Metabolic risk factors such as hyperuricemia, hyperoxaluria or hypercalcemia
High dietary calcium not contributive unless metabolic or renal tubular defect exists
Immobilization Urinary stasis, dehydration and urinary
retention mamy be causative
![Page 78: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/78.jpg)
Evaluate for bladder obstruction UA will reveal RBCs, odor, turbidity, WBCs MRI, KUB, CT Noncontrast helical CT has highest
sensitivity IV urography will show obstruction
![Page 79: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/79.jpg)
Analgesia Avoid NSAIDs if to have lithotripsy (affect
platelets) Hydration Urine straining Lithotripsy (monitor ECG and sedate
patient) Minimally invasive surgical procedures
(MIS) such as stenting, nephrolithotomy
![Page 80: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/80.jpg)
Antibiotics Thiazide diuretics for hypercalciuria Allopurinol and vitamin B6 for oxalate
containing stones Uric acid stone—allopurinol and
alkalinizing the urine. Sodium bicarbonate or potassium citrate helpful.
Cystine –captopril and alphamercaptopropionylglycine w/ hydration and alkalinazation of urine
![Page 81: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/81.jpg)
Urothelial Tx with BCG Radiation chemotherapy
![Page 82: By Linda Self. Regulation of water excretion Regulation of electrolyte function Regulation of acid-base balance—retain HCO3- and excrete acid in](https://reader030.vdocuments.us/reader030/viewer/2022032703/56649d0b5503460f949ddec0/html5/thumbnails/82.jpg)
Ureterostomy Conduits—to intestine and stoma Sigmoidostomies-divert urine to large
intestine so no stoma Ileal reservoir—surgically created pouch