by diaa ahmed elsaied lecturer omfs minia university3)sem 8... · 2020. 3. 24. · it is the second...
TRANSCRIPT
![Page 1: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/1.jpg)
By
Diaa Ahmed Elsaied
Lecturer OMFS Minia University
![Page 2: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/2.jpg)
ILO’S
![Page 3: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/3.jpg)
1. Memorize phases of hemostasis
2. Classify hemostasis abnormalities
3. Management of bleeding disorders
4. Describe homeostasis screening tests
5. Learn management of postoperative bleeding
![Page 4: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/4.jpg)
It is the abnormalities of hemostasis and / or coagulation,
characterized by local or extensive skin or mucocutaneous
hemorrhage derived from capillary.
The bleeding is usually spontaneous or from slight
trauma
![Page 5: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/5.jpg)
Blood vessel injury triggers the
following sequence:
1. Vessel constricts.
2. Circulating platelets adhere to the vessel.
3. Complex series of enzymatic reactions involving
coagulation proteins, produces fibrin to form a stable
hemostatic plug .
![Page 6: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/6.jpg)
Primary hemostasis
-- Platelet plug formation at sites of injury
![Page 7: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/7.jpg)
Secondary hemostasis
--Plasma coagulation system
reaction resulting in fibrin
formation
Primary and secondary
hemostasis are closely linked
![Page 8: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/8.jpg)
HEMOSTASIS
1. VASCULAR PHASE
2. PLATELET PHASE
3. COAGULATION PHASE
4. FIBRINOLYTIC PHASE
Hemostasis or normal blood
clotting is essential for
survival
![Page 9: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/9.jpg)
WHEN A BLOOD VESSEL
IS DAMAGED,
VASOCONSTRICTION
RESULTS. 15:60sec
Contracting Vessel diameter Blood flow
This also promotes the accumulation of platelets & other
clotting factors.
![Page 10: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/10.jpg)
Platelets Adhere To The
Damaged Surface And Form
A Temporary Plug (White
Thrombus).
< 60sec
![Page 11: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/11.jpg)
Through Two
Separate Pathways
The Conversion Of
Fibrinogen To
Fibrin Is Complete. 3:6 Min
![Page 12: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/12.jpg)
INTRINSIC EXTRINSIC
PROTHROMBIN
(II)
FIBRINOGEN
FIBRIN
(I) V
X
Tissue Thromboplastin Collagen
VII
XII
XI
IX
VIII
Coagulation Phase
THROMBIN
(III)
![Page 13: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/13.jpg)
![Page 14: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/14.jpg)
Factor I - fibrinogen
Factor II - prothrombin
Factor III - tissue thromboplastin (tissue factor)
Factor IV - ionized calcium ( Ca++ )
Factor V - labile factor or proaccelerin
Factor VI - unassigned
Factor VII - stable factor or proconvertin
Factor VIII - antihemophilic factor
Factor IX - plasma thromboplastin component, Christmas
Factor X - Stuart-Prower factor
Factor XI - plasma thromboplastin antecedent
Factor XII - Hageman factor
Factor XIII - fibrin-stabilizing factor
![Page 15: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/15.jpg)
It is a process that prevents blood clots from growing and
becoming problematic. The primary type is a normal body
process.
![Page 16: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/16.jpg)
![Page 17: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/17.jpg)
Vessel wall disorders
Abnormalities of blood platelets
1) Quantitative platelets defects:
Thrombocytopenia
2) Qualitative platelets defects:
Thrombasthenia
![Page 18: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/18.jpg)
Disturbance of coagulation in circulation
Deficiency of coagulation factors
Increase of anti-coagulation substances
Hyper function of fibrinolysis
![Page 19: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/19.jpg)
I. VESSEL DEFECTS
II. PLATELET DISORDERS
III. FACTOR DEFICIENCIES
IV. OTHER DISORDERS
![Page 20: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/20.jpg)
1) VITAMIN C DEFICIENCY
Scurvy cause haemorhagic features as defect in collagen
synthesis)
2) Cushing Syndrome:
resulting from excessive Corticosteroid intake or production,
leads to general protein wasting & atrophy of supporting CT.
![Page 21: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/21.jpg)
Diagnosis is facilitated by a detailed case history and a
thorough clinical examination.
The underlying cause should be managed, if reversible.
Blood replacement and iron therapy may be necessary
following dental procedures (surgical) in involved areas
![Page 22: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/22.jpg)
I. VESSEL DEFECTS
II. PLATELET DISORDERS
III. FACTOR DEFICIENCIES
IV. OTHER DISORDERS
![Page 23: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/23.jpg)
Thrombocytopenia:
The number of platelets is reduced. Could be due to:
i) Decreased production in bone marrow
ii) Increased sequestration in the spleen
iii) Accelerated destruction
Thrombasthenia :
Qualitative platelet disorders. May result from defects in
any of the platelet reactions.
![Page 24: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/24.jpg)
NORMAL 100,000 - 400,000 CELLS/MM3
,
< 100,000 Thrombocytopenia
50,000 - 100,000 Mild Thrombocytopenia
< 50,000 Sever Thrombocytopenia
![Page 25: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/25.jpg)
•DRUG INDUCED
•thiazide diuretics
•BONE MARROW FAILURE
Viral Infections
Nutritional Deficiencies
Chemotherapy & Radiation Therapy
Infiltration of Abnormal Cells
Aplastic Anemia Leukemia Metastatic Cancer
•HYPERSPLENISM
Increase in Size Leads to Destruction of Platelets Associated with Portal Hypertension Seen in Patients with Cirrhosis
![Page 26: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/26.jpg)
• THROMBOCYTOPATHY (adequate No but abnormal
function)
Uremia
Inherited Disorders
Myeloproliferative Disorders
Drug Induced
![Page 27: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/27.jpg)
DRUG INDUCED
ASPIRIN IRREVERSIBLY BINDS TO THE
PLATELET FOR ITS ENTIRE LIFESPAN
(7-10 DAYS)
![Page 28: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/28.jpg)
NSAIDS REVERSIBLY BINDS TO THE PLATELET
FOR A LIMITED TIME PERIOD
(APPROX 6 HOURS)
![Page 29: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/29.jpg)
It is aimed at identification and correction of the
reversible defects at the earliest.
Prevention of hemorrhagic episodes.
Prompt control of bleeding when it occurs.
The management of sequelae of the disease.
Thrombocytopenias are managed with transfusions of
platelets.
![Page 30: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/30.jpg)
I. VESSEL DEFECTS
II. PLATELET DISORDERS
III. FACTOR DEFICIENCIES
IV. OTHER DISORDERS
![Page 31: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/31.jpg)
Hemophilia A
Hemophilia B
VON WILLEBRAND’S DISEASE
![Page 32: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/32.jpg)
I) Secondary to drugs: -
Heparin
Coumarin
II) Disease related: -
Liver Disease
Vitamin K deficiency
Fibrinolytic Disorders
![Page 33: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/33.jpg)
A deficiency of factor VIII, (Antihemophilic factor), is
inherited as an X-Iinked recessive trait that affects males
(hemizygous), females being the carriers (heterozygous).
SIGNS AND SYMPTOMS: -
Hemtomas – Gastrointestinal bleeding - Bleeding from
Lacerations
Hemarthroses
Hematuria
Lab Results - Prolonged PTT
![Page 34: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/34.jpg)
It is the second most common inherited bleeding disorder,
after von Willebrand disease (vWD), with a worldwide
incidence of approximately 1 case per 5000 males.
In its severe form, this condition can cause significant
morbidity from recurrent spontaneous bleeding into
joints, muscles, and the brain.
In its more mild form, hemophilia A can lead to prolonged
oozing of blood after injuries, tooth extractions, or surgery.
![Page 35: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/35.jpg)
It is a blood clotting disorder caused by a mutation of the
factor IX gene, leading to a deficiency of factor IX. It is
rarer than haemophilia A.
Clinical symptoms are similar to hemophilia A.
Factor IX deficiency leads to an increased propensity for
hemorrhage. This is in response to mild trauma or even
spontaneously, such as in joints or muscles.
Lab Test - Prolonged PTT
![Page 36: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/36.jpg)
It is dependent upon the severity of disease, type and site
of hemorrhage.
Factor Replacement Therapy is considered the primary
mode of management.
Cryoprecipitate & Fresh Frozen Plasma are rarely used
because of their disadvantages of potential viral
transmission.
![Page 37: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/37.jpg)
It is the most common hereditary coagulation abnormality
described in humans.
It arises from a qualitative or quantitative deficiency of
von Willebrand factor (vWF) & Factor VIII, a protein that
is required for platelet adhesion.
Lab Results - Prolonged BT, PTT
![Page 38: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/38.jpg)
![Page 39: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/39.jpg)
Signs and symptoms:
The various types of vWD present with varying degrees
of bleeding tendency, usually in the form of easy
bruising, nosebleeds and bleeding gums.
Women may experience heavy menstrual flow and blood
loss during childbirth.
Severe internal or joint bleeding is uncommon.
![Page 40: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/40.jpg)
Desmopressin is recommended for use in cases of minor
trauma, or in preparation for dental procedures. It
stimulates the release of von Willebrand factor (vWF).
Platelet concentrate infusions may be used to control
bleeding.
Local Hemostatic agents are to be used.
![Page 41: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/41.jpg)
ORAL ANTICOAGULANTS
COUMADIN (WARFARIN) (dose dependant, 3-5dys, onset
12-24 hrs, PT 24 hrs prior to surgery, reversed by vit K,
resist further anticoag, harmeful if stopprd suddenly)
HEPARIN (affects intrinsic & common pathway, duration
2-4 hrs, inhibit action of thrombin on fibrinogen, PTT)
![Page 42: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/42.jpg)
ORAL ANTICOAGULANTS
Coumarin Prevents Thromboembolic Events &
is a Vit K Antagonist. Monitored by PT times.
Heparin Therapy is Monitored by PTT times.
![Page 43: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/43.jpg)
MALABSORPTION
Various Intestinal Diseases Will Interfere w/ Bile Acid
Metabolism.
Bile Acids are Required for Vit K Absorption so You
Will See a Deficiency in Vit K Dependent Coagulation
Factors (II,VII,IX,X).
![Page 44: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/44.jpg)
LIVER DISEASE
Jaundice Results in Malabsorption of Vit K.
Liver Disease can Result in Reduced Production of
Coagulation Factors (I,II,V,VII,IX,X).
![Page 45: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/45.jpg)
I. VESSEL DEFECTS
II. PLATELET DISORDERS
III. FACTOR DEFICIENCIES
IV. OTHER DISORDERS
![Page 46: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/46.jpg)
BROAD-SPECTRUM ANTIBIOTICS
Change in Intestinal Flora which Might Decrease
Vitamin K Production.
Vitamin K is Necessary for the Liver to Produce
Coagulation Factors II,VII,IX,X.
![Page 47: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/47.jpg)
![Page 48: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/48.jpg)
![Page 49: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/49.jpg)
Leukopenia :
Deficient WBC , Decrease of neutrophils is most common etiology .
![Page 50: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/50.jpg)
Physical finding are increased risk microbial infection.
Increased risk of fungal infection.
Management include :
-- Prophylactic Antibiotic.
![Page 51: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/51.jpg)
Elevated percentage of immature WBC in peripheral circulation.
It is cancer of the WBCs that affects the bone marrow and circulating blood. It involves exponential proliferation of a clonal myeloid or lymphoid cell.
Symptoms includes:
Nausea – Fever – Weight Loss
Fatigue – Malaise - Epistaxix
Liver or spleen enlargment Bone pain & tenderness
Oral manifestation includes:
Gingival Enlargement & ulceration
Pain Erythema & oral infection
![Page 52: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/52.jpg)
The cause of leukemia is unknown
Increased risk is associated with large doses of ionizing
radiation, certain chemicals(benzene), and infection with
specific viruses [EPV] and human lymphotropic virus
[HTLV]-1
Smoking & exposure to electromagnetic
Genetic factors may cause cytogenetic abnormalities that
affect transcriptional cascades of myeloid precursor cells.
![Page 53: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/53.jpg)
Acute leukemia
Result from accumulation of immature , functionless WBCs in the marrow & blood
1. Acute myeloid leukemia (AML)
2. Acute lymphocytic leukemia (ALL)
Chronic leukemia
Have slower onset which allows production of larger numbers of more mature, functional cells
1. Chronic myeloid leukemia (CML)
2. Chronic lymphocytic leukemia (CLL)
![Page 54: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/54.jpg)
Bone marrow test
1. Bone marrow aspiration :
Remove a liquid marrow sample
2. Bone marrow biopsy
Lumbar puncture:
Removes a small amount of
cerebrospinal fluid (CSF) from the space around the spine
![Page 55: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/55.jpg)
Chemotherapy
The main treatment for many kinds of leukemia
It has 3 phases:
1- Induction
2- Consolidation
3- Maintenance
Radiation therapy
To prevent leukemia from spreading to, or treat leukemia that has spread to, the central nervous system (CNS)
Bone marrow transplant
![Page 56: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/56.jpg)
![Page 57: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/57.jpg)
LEUKEMIA
![Page 58: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/58.jpg)
Anemia is a decrease in the total amount of red blood cells (RBCs) or hemoglobin in the blood, or a lowered ability of the blood to carry oxygen.
Laboratory definition:
Reduction in haemoglobin concentration
below normal
WHO criteria:
Males Hgb <13 gm/dl,
Females Hgb <12gm/dl
![Page 59: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/59.jpg)
![Page 60: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/60.jpg)
Symptoms:
Fatigue Weakness Dyspnea Palpitation
Headache Dizziness Angina Tinnitus
Signs:
Pallor Tachycardia Cardiac Failure
![Page 61: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/61.jpg)
Medical & family history & perform a physical exam.
Complete blood count (CBC):- A CBC is used to count the number of blood cells in a sample of your blood. For anemia the levels of the red blood cells contained in the blood (hematocrit) and the hemoglobin in the blood is interested.
Tests for internal bleeding:- To ensure that internal bleeding is causing anemia, may also perform an endoscopy. These test can help identify sources of gastrointestinal bleeding.
![Page 62: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/62.jpg)
Treatments for anemia depend on cause and severity. Vitamin supplements given orally (folic acid or vitamin B12) or intramuscularly (vitamin B12) will replace specific deficiencies.
Anemia treatment depends on the cause.
a) Iron deficiency anemia
b) Vitamin deficiency anemia
c) Anemia of chronic disease
d) Aplastic anemia
e) Anemia associated with bone marrow disease
f) Hemolytic anemia
g) Sickle cell anemia
![Page 63: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/63.jpg)
Iron deficiency anemia:- Treatment for this form of anemia usually involves taking iron supplements & making changes to your diet.
• Diet as red meat, dark green leafy vegetables, dried fruits, nuts, iron-fortified cereals.
Vitamin deficiency anemia:- Treatment for folic acid & B-12 deficiency involves dietary supplements & increasing these nutrients in diet.
•If your digestive system has trouble absorbing vitamin B-12 from the food you eat, you may need vitamin B-12 shots.
![Page 64: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/64.jpg)
Platelets Phase:
Platelet Count
Bleeding Time (BT)
Platelets Funtion Analyzer (PFA)
Coagulation Phase:
Prothrombin Time (PT)
Partial Thromboplastin Time (PTT)
Thrombin Time (TT)
![Page 65: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/65.jpg)
NORMAL 100,000 - 400,000 CELLS/MM3
,
< 100,000 Thrombocytopenia
50,000 - 100,000 Mild Thrombocytopenia
< 50,000 Sever Thrombocytopenia
![Page 66: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/66.jpg)
Provides Assessment Of Platelet Count & function (Quantitative & Qualitative)
NORMAL VALUE
2-8 Min
![Page 67: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/67.jpg)
Quntative lab test for platelets function & avoid variability of BT
Normal < 193 s
![Page 68: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/68.jpg)
Measures Effectiveness of the Extrinsic Pathway
Mnemonic - PET
NORMAL VALUE
11- 14 SECS
![Page 69: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/69.jpg)
Measures Effectiveness of the Intrinsic
Pathway
Mnemonic - PITT
NORMAL VALUE
27 – 38 SECS
![Page 70: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/70.jpg)
Time for Thrombin To Convert
Fibrinogen Fibrin
A Measure of Fibrinolytic Pathway
NORMAL VALUE
9-13 SECS
![Page 71: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/71.jpg)
Dental management of the medically compromised patient
PT, aPTT, TT, BT History bleeding problem
BT, aPTT Aspirin therapy
PT Coumarin therapy
aPTT Renal dialysis (heparin)
BT – PT Possible liver disease
BT Chronic leukemia
PT Long term antibiotic therapy
BT Vascular wall alteration
TT Cancer (fibrinogenolysis)
![Page 72: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/72.jpg)
TT PT PTT BT Platelet count Condition
- + + + + Aspirin therapy
- ++ ++ - - Coumarin therapy
- - ++ + + Heparin therapy
++ ++ ++ + + Liver disease
- - - + + Leukemia
++ ++ ++ - - Long term antibiotic
- - - + - Vascular wall defect
- - - ++ ++ Thrombocytopenia
- - ++ - - Hemophilia
++ + + - - Fibrinogenolysis
- normal, + may be abnormal, ++ abnormal
![Page 73: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/73.jpg)
GOOD THOROUGH MEDICAL HISTORY
A PHYSICAL EXAMINATION
SCREENING CLINICAL LAB TESTS
EXCESSIVE BLEEDING FOLLOWING SURGICAL
PROCEDURE
![Page 74: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/74.jpg)
Family HX
Personal HX
Medications
Past & Present Illness
Spontaneous Bleeding
![Page 75: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/75.jpg)
FIVE DRUGS THAT INTERFERE WITH HEMOSTASIS
ASPIRIN
ANTICOAGULANTS
ANTIBIOTICS
ALCOHOL
ANTICANCER
![Page 76: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/76.jpg)
Petechiae & Ecchymosis
Gingival Hyperplasia
Spontaneous Gingival Bleeding
Ulceration of Oral Mucosa
Lymphadenopathy
![Page 77: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/77.jpg)
LOW RISK
Patients with No Hx of Bleeding Disorders
Normal Laboratory Results
MODERATE RISK
Patients on Chronic Oral Anticoagulant
Therapy. PT is 1.5 - 2 Times Control Range
Patients on Chronic Aspirin Therapy
![Page 78: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/78.jpg)
DENTAL PATIENTS
HIGH RISK
Patients with Known Bleeding Disorders
Patients without Known Bleeding Disorders
Who Have Abnormal Laboratory Results
![Page 79: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/79.jpg)
LOW RISK PATIENTS
Normal Protocol
MODERATE RISK PATIENTS
Anticoagulants - Consult Physician
Aspirin Therapy - BT, Consult Physician
![Page 80: By Diaa Ahmed Elsaied Lecturer OMFS Minia University3)Sem 8... · 2020. 3. 24. · It is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with](https://reader036.vdocuments.us/reader036/viewer/2022081623/61449a18b5d1170afb43fb0e/html5/thumbnails/80.jpg)
DENTAL MANAGEMENT
HIGH RISK PATIENTS
Close Coordination with Physician
Hospitalization (Platelet Transfusion)
(Factor Replacement)
(Vit K Therapy)
(Dialysis)