building blocks and beyond u.s. based manufacturing since 1928
DESCRIPTION
Building Blocks and Beyond U.S. Based Manufacturing Since 1928. GFS Chemicals. Specialty chemical manufacturing Volumes from research to bulk Focused on Core Competencies. Acetylene chemistry Propargylic amines Grignard chemistry Specialty halides. Si blocked compounds - PowerPoint PPT PresentationTRANSCRIPT
Building Blocks and BeyondBuilding Blocks and Beyond
U.S. Based Manufacturing U.S. Based Manufacturing Since 1928Since 1928
GFS ChemicalsGFS Chemicals
• Specialty chemical Specialty chemical manufacturingmanufacturing
• Volumes from Volumes from research toresearch to bulk bulk
• Focused on Core Focused on Core CompetenciesCompetencies
Core CompetenciesCore Competencies
• Acetylene Acetylene chemistrychemistry
• Propargylic aminesPropargylic amines
• Grignard chemistryGrignard chemistry
• Specialty halidesSpecialty halides
• Si blocked Si blocked compoundscompounds
• Birch reductionsBirch reductions
• Alpha/omega Alpha/omega functionalizationfunctionalization
Acetylene ChemistryAcetylene Chemistry
HC CH R1C CR2
O
O
(CH2)9CH3
Propargylic AminesPropargylic Amines
H2N
NH
N
NH
NH
Recently Manufactured Recently Manufactured GrignardsGrignards
O
MgBr
CH3(CH2)nMgX
n = 0 - 7; X = Cl, BrMgBr
MgBr
RC CMgX
R = H
Scale: 10's - 1000's LT
10's of LT
1000's of LT
10's - 1000's of LT
100's of LT
Specialty HalidesSpecialty Halides
I
Br
Si(CH3)3
X
X = Cl, Br, I
Br
Br
X
ClX = F, Cl
Si Blocked CompoundsSi Blocked Compounds
Br
Si(CH3)3X
Si(CH3)3
X = OH, Br
Si CH2MgCl (H3C)3Si Si(CH3)3
Si
(H3C)3Si Si(CH3)3
Birch ReductionsBirch Reductions
Y
Z H3COOH
O
H3CO CH3
Y,Z = H, R, OR, COOH
αα,,ωω Functionalized Functionalized MoleculesMolecules
Br
Cl NH2
OH
ICl
BrBr
New TechnologiesNew Technologies
• ThiophenesThiophenes
• Bridged orthoestersBridged orthoesters
Specialty ThiophenesSpecialty Thiophenes
• OLED/Conductive Polymer ApplicationsOLED/Conductive Polymer Applications
• Pharmaceutical and Biotechnology ApplicationsPharmaceutical and Biotechnology Applications
SS
S
Br
R
S
O
H
O
H
S
O O
Bridged OrthoestersBridged Orthoesters• Protected Carboxylic acidsProtected Carboxylic acids
OCH2OH
CH3
O
O
O
Br
O
O
O
R
R OR'
O
R = alkyl, aryl, vinyl, alkynyl
Protecting Group Reagent:
Contact GFS ChemicalsContact GFS ChemicalsDavid K. Baust – General Manager –Specialty Organic ManufacturingDavid K. Baust – General Manager –Specialty Organic Manufacturing
[email protected]@gfschemicals.com
Office: 614-224-5013 extension 103Office: 614-224-5013 extension 103
Cell: 614-975-6304Cell: 614-975-6304 visit us at www.gfschemicals.com
oror
www.gfsorganics.comwww.gfsorganics.com