brisbane cancer...

Thursday, 18 December – Friday 19 December 2014Brisbane Convention and Exhibition Centre

Co-ordinated by Professor Ken O’Byrne

Innovative healthcare through partnerships

brisbane diamantina health partners

Brisbane Cancer Conference

Supported by:

Brisbane Cancer Conference | December 18 – 19, 2014

Confirmed Sponsors

Montreux, 18 au 20 mars 2010 Fairmont Le Montreux Palace***** Grand-Rue 100, CH-1820 Montreux Tel: +41 21 962 12 12 Fax: +41 21 962 17 17 www.fairmont.com/montreux Email: [email protected]

Les extrémités - Orthopédie - Rhumatologie - Traumatologie - Les hanches du nouveau né / Cours

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Brisbane Convention and Exhibition Centre

18 December 2014

Dear Colleagues,

Welcome to the inaugural Brisbane Cancer Conference. With the establishment of the Brisbane Diamantina Health Partners, this meeting is an opportunity to draw together cancer researchers in Brisbane and Queensland to advance collaborative efforts in cancer research. The meeting comprises plenary lectures and workshops on recent scientific, technological, nursing, allied health and medical advances in the diagnosis and treatment of malignant disease.

On Thursday 18 December there will be plenary lectures from 2 – 4pm followed by workshops in these areas running from 4:30 – 6:30pm. This will be followed by a “Welcome Reception”, with food, drink and entertainment and a chance to socialise with colleagues particularly from other institutions in the city and from Queensland. The all-day meeting on 19 December will include plenary lectures followed by tumour-site specific workshops in the morning and afternoon. A key session will be lectures by Brisbane oncology researchers that have contributed to global advances in our understanding of the epidemiology, molecular biology and treatment of malignant disease.

In the region of 400 people have registered for the event demonstrating the need and potential value of an annual Brisbane Cancer Conference.

This conference would not have been possible without the support of the PA Research Foundation, Cancer Council Queensland, Brisbane Diamantina Health Partners, our sponsors, the time and effort of the chairs who put the workshops together and, finally, for special mention, Therese Rabbitt and Sally Smythe.

Best wishes and have an enjoyable and fulfilling 2 days. Yours sincerely,

Professor Ken O’Byrne

brisbane diamantina health partners


Conference Program

1.00pm Registration desk opens

2.00 – 3.00pm Plenary lectures (1) – Boulevard Auditorium Chairs: Lyn Griffiths; Brian Gabrielli

Genomics – Nic WaddellBioinformatics challenges in clinical sequencing – John PearsonMolecular Diagnostics in Solid Tumours – Sunil LakhaniMolecular Diagnostics in Haematological Malignancies – Andrew Perkins

3.00 – 4.00pm Plenary Lectures (2) – Boulevard Auditorium Chairs: Leanne Stone; Clive Eakin

Bedding research into front line therapy – experience with childhood cancers – Ross Pinkerton Research in Palliative and Supportive care – how have we changed practice? – Janet HardyNursing research – Alexandra McCarthy

4.00 – 4.30pm Break

4.30 – 6.30pm Workshops

Cellular Imaging Tools for Cancer Research – Room A1 Chairs: Anthony Davies & Rik Thompson

– High Content Imaging “Advanced Cellular Applications” – Anthony Davies – Live cell and confocal microscopy tools for research – Shaun Walters – FLIM life time imaging new approaches for cancer research – Washington Sanchez – Cellular screening for cancer targets – Brian Gabrielli – CTC isolation, culture and analysis – Arutha Kulasinghe

Q and A expert Panel: Chamindie Punyadeera; Elizabeth Williams; Shaun Walters; Rick Thomson

Genomics, Molecular Diagnostics and Bioinformatics – Room A2 Chair: John Pearson

– Copy number calling in cancer – Lachlan Coin – Crowd-sourced evaluation of mutation detection on realistic simulated tumours” – Adam Ewing – AML sequencing project – Paul Leo – Methylation detection in cancer using microarrays – Katia Nones – Detecting Structural Variants in Cancer – Ann-Marie Patch – Visualising very large datasets – Jim Hogan

Round table discussion: Where to from here?

Paediatric Malignancies – Room B1 Chair: Ross Pinkerton

– Molecular profile guided therapy in medulloblastoma – Tim Hassall – Selective T cell manipulation in allogeneic BMT in children – Richard Mitchell – Laparoscopic surgery in childhood tumours – Peter Borsi – Psychosocial impact of ceasing first line therapy – Cherie Lowe – Anti GD2 antibody therapy in advanced neuroblastoma – Helen Irving – Timing of antibiotic therapy in febrile neutropaenia – shared care experience – Rachel Edwards

Discussion on Pediatric Research in Brisbane

Thursday 18 December 2014


Conference Program

4.30 – 6.30pm Workshops continued

Palliative care – Room B2 Chair: Janet Hardy

– Non pharmacological management of dyspnoea – Patsy Yates (QUT) – Care for carers – Geoff Mitchell (UQ) – Individualised opioid therapy – Phillip Good (Mater-UQ) – Improving nutrition outcomes in patients with head and neck cancer – Teresa Brown (RBWH) – When is it time to refer patients with melanoma to palliative care – Jenny Fox (QUT)

Discussion on where to go from here for research in Brisbane

Nursing and supportive care research – Room B3 Chair: Ray Chan

4.40 – 6.30pm Overview of Cancer Nursing Research (approximately 3 slides each topic) – Symptom Management Research – Patsy Yates – Advanced practice nursing roles in cancer care – Patsy Yates – Nurse led clinics in Cancer Care – Leanne Stone – Management of anti-cancer treatment toxicities – Sandie McCarthy – Geriatric Assessment in Cancer Care – Sandie McCarthy – Survivorship Cancer Care Provision – Ray Chan – Venous Access Devices Management in Cancer Care – Ray Chan – Translational research in venous access devices – Nicole Gavin – Genetics and outcomes in cancer care – Kimberley Alexander

Discussion – Patsy YatesArticulating themes: Discuss ways forward on how to strengthen the collaboration and recognition of cancer nursing and supportive care research within Brisbane Diamantina Health Partners

6.30pm Welcome reception

Thursday 18 December 2014


Conference Program

7.30am Registration desk opens

8.00 – 10.00am Plenary lectures – Boulevard Auditorium Chairs: David Theile; Roger Allison

Advances in Surgery – Michael WagelsHigh throughput screening for anti-cancer therapies – Ron QuinnPersonalised, oncogene driven, therapy – David GrimesRecent Advances in Immunotherapy

– Checkpoint inhibitors & Novel approaches – Mark Smyth – Cell Based Therapies & Vaccines – Rajiv Khanna

Novel chemotherapy approaches – Vikram JainImaging – Stanley NgaiRadiation Oncology – Liz Kenny

10.00 – 10.30am Break

10.30am – 12.00pm Workshops

Hepato-biliary/pancreas – Room A1 Chairs: Warren Joubert; Thomas O’Rourke

– Modern management of resectable liver metastases – Thomas O’Rourke – The tumorigenic liver fluke Opisthorchis viverrini –multiple pathways to cholangiocarcinoma – Jason Mulvenna – Immunotherapy in hepato-cellular carcinoma – Jason Steel – Overview of clinical trials and opportunities – Warren Joubert

Gynae-oncology – Room A2 Chairs: Donal Brennan; John Hooper

10.30am Introductory comments – A/Prof Lewis Perrin

10.35am Workshop overview and goals – Dr Donal Brennan; A/Prof John Hooper

10.40am Three Parallel Discussion Groups to develop a list of:Key strengths; possible joint projects; possible funding sources (short, medium and long term aspirations); Other/out of the box possibilities; logistical issues/barriers

Group 1 – At risk patients and survivorship Facilitator: Penny Webb, QIMR Participants: Monika Janda, Debra Anderson, Maree Colosimo, Amanda Spurdle, Jyotsna Batra, Donal Brennan,

Group 2 – Trials and Therapeutics Facilitator: Jim CowardParticipants: Maree Smith, David Fairlie, Lewis Perrin, Steve Ogbourne, John Pearson, Nic Waddell, Adam Ewing, Louise Hutley (Mater Governance), Brian Gabrielli

Group 3 – In vitro and in vivo models of disease Facilitator: Pam PollockParticipants: John Hooper, Rohan Lourie, Glen Boyle, Ying Dong, Daniela Loessner, Dietmar Hutmacher, Kristen Radford

11.25am Development of an action plan for a Trans-Brisbane Gynaecological Cancer Initiative – Donal Brennan & John Hooper

Friday 19 December 2014


Conference Program

10.30am – 12.00pm Workshops continued

Thoracic malignancies – Room B1 Chairs: Brett Hughes; Michelle Murphy; Rishendran Naidoo

Platinum resistance – Ken O’Byrne

NHMRC genomic study in mesothelioma – Nic Waddell

Overview of current clinical trials in Brisbane – Brett Hughes

Mesothelioma – Keith Horwood

Radiation Oncology trials – Margot Lehman

Tissue the issue – Respiratory perspective (6mins) – Farzad Bashirzadeh – Radiology perspective (6mins) – Karin Steinke

General discussion: Where to from here in Brisbane?

Brain tumours – Room B2 Chairs: Matthew Foote; Sarah Olsen

– Surgical Perspective of Brain tumour Research and development of biobanking – Sarah Olsen – An overview of the search of specific markers in brain tumours and clinical implications (eg the Medullo

hedgehog story) or similar – Brandon Wainright – Moving towards personalised approaches in brain tumours eg the EPhA3 story or similar – Bryan Day – A prospective study of language function following surgical resection of left hemisphere primary brain tumours

– Greig de Zubicaray

GU malignancies – Room B3 Chairs: Ian Vela; Kristen Radford

10.30am Molecular expression profiles of different types of renal cell carcinomas – Glenda Gobe

10.38am Targeting bladder cancer progression – Elizabeth Williams

Prostate Basic/Translational

10.46am New vaccines for prostate cancer – Kristen Radford

10.54am Use of an imaging theranostic for prostate cancer – Pam Russell

Prostate Clinical/Trials

11.02am Multidisciplinary research into quality of life and health after prostate cancer treatment – Sandie McCarthy

11.10am Split course radiation treatment for locally advanced castrate resistant prostate cancer – a Phase II trial – Tanya Holt

11.18am Implementing a translational research programme: Metabolic syndrome and prostate cancer – Handoo Rhee

11.34am A Randomised Double-Blind Controlled Trial of Metformin and Atorvastatin – with treatment commenced following prostatic biopsy and ceasing just before radical prostatectomy- Frank Gardiner

Wrap up and overview

12.00 – 12.30pm Lunch



Conference Program

12.30 – 2pm Plenary Lectures: Lectures celebrating cancer research success in Brisbane – Boulevard Auditorium Chairs: John Prins; Ross Young

Genomics – Brandon WainwrightRole of the Queensland Childrens Cancer Biobank in International studies – Andrew MooreSerrated polyps and colorectal cancer – Barbara Leggett Circulating tumour cells – Ian VelaProstate cancer – Paul MainwaringMelanoma

– Epidemiology – David Whiteman – Therapy – Victoria Atkinson

Breast cancer sentinel node biopsy – Owen Ung

2.00 – 2.30pm Break

2.30 – 4.00pm Workshops

Hematology – Room A1 Chairs: Maher Gandhi; Steve Lane; Andrew Perkins

Introduction and welcome – Steve Lane, 5 mins – Overview Mater/PAH/TRI research – Andrew Perkins – Immune responses and immunotherapies in blood cancers utilizing mouse models – Steve Mattorolo – Disrupting stem cell niches: new approaches to improved clinical care – Ingrid Winkler – Overview QIMR/RBWH research – Steve Lane – The role of IL6 in allogeneic haematopoietic stem cell transplantation – Antiopi Varelias

Sum up and discussion of Future vision

Breast Cancer – Room A2 Chairs: Owen Ung; Kate Cuff; Rik Thompson

2.30pm Welcome and Introduction – Owen Ung

2.35 – 3.30pm Overview of Ongoing Research, Opportunities for Collaboration – 4 minutes each presentation (3 slides maximum) plus 2 minutes for questions

2.35pm Surgery – Chris Pike

2.41pm Breast Pathology – Sunil Lakhani

2.47pm Radiology – Thomas Lloyd

2.53pm Molecular Imaging Carolyn Mountford

2.59pm Breast Care Nursing Janine Porter-Steele

3.05pm Medical Oncology – Nicole McCarthy

3.11pm Palliative care & women’s wellness after cancer – Patsy Yates

3.17pm Consumer’s perspectives – Patricia Hancock/Leonie Young

3.24pm Translational Research – Kum Kum Khanna

3.30pm Mammary tissue engineering – Dietmar Hutmacher

3.30pm General discussion (Chaired by Kate Cuff, Owen Ung, Rik Thompson)

3.50pm Wrap up. Actions going forward – Rik Thompson



Conference Program

2.30 – 4.00pm Workshops continued

Melanoma and skin cancer – Room B1 Chairs: Euan Walpole

– Melanoma mortality: recent trends show more people die from thin melanoma than thick melanoma in Queensland – David Whiteman

– UV and DNA repair in melanoma – Sandra Pavey – GWAS meta-analysis identifies three novel risk loci for melanoma at 6p22, 7q21 and 9q31 – Matthew Law – miR-514a regulation of NF1and resistance to PLX4032 targeted therapy of melanoma – Mitchell Stark – Investigating the role of Interferon Regulatory Factor-4 in melanocyte function and nevogenesis – Aaron Smith – Dynamic tumour heterogeneity and its implications in melanoma therapy – Nikolas Haass

Discussion: Integrating melanoma research across Brisbane

Head and Neck cancer – Room B2 Chairs: Ben Panizza; Sam Dowthwaite

– Overview of head and neck cancer translational research – Ben Panizza – Learning from past mistakes in research translation to give future health improvement – Fiona Simpson – Optimizing therapeutic response to chemoradiotherapy in head and neck cancer – Sandro Porceddu – Modern surgical approaches – Sam Dowthwaite

Discussion on integrating head and neck research

Colorectal cancer – Room B3 Chairs: Vikram Jain; Nick Lutton; Mike McGuckin

2.30pm The serrated pathway to colorectal cancer – Vikki Whitehall

2.42pm Surgery for colorectal cancer – Nick Lutton, Carina Chow and Joanne Dale

3.06pm Challenges for defining the molecular pathology of colon cancer – Christophe Rosti

3.18pm Colorectal cancer treatment and research opportunities: A Medical Oncologist Perspective – Vikram Jain

3.30pm Panel discussion: How could more Brisbane wide collaborative activity in research and treatment address the challenges of managing colorectal cancers

4.00pm Plenary Lectures – Boulevard Auditorium Chairs: David Siddle; Carolyn Mountford

Placing Brisbane at the Forefront of Cancer Translational Research – Frank Gannon

Close: Ken O’Byrne



Venue Floor Plans

Arbour LevelBCEC on Grey Street

Lower Level of BoulevardAuditorium

Speakers Presentation Centre

Lift

Backstage

ChangeRoom

GreenRoom

ArbourSpeakers Lounge

Lobby

Arbour Boardroom

Lift

Lift

Arbour Foyer

Lift

BarArbour LoungeA2

Lift

Retail Mezzanine A1

Arbour Level Rooms Theatre Classroom Banquet Cocktail Metres2

Arbour Lounge - - - 150 190

Meeting Room A1 50 30 20 60 70

Meeting Room A2 120 70 80 120 120

Arbour Speakers Presentation Centre - - - - 70

Arbour Boardroom - - 16 - 38

Grey StMerivale St

Glenelg St

Melbourne StMezzanine Level

Foyer Level Ground Level

Arbour Level

Boulevard Level

Plaza Level(Grey Street)

(Grey Street)

(Grey Street)

(Grey Street)

(Grey Street)

Sky Level(Grey Street)

Plaza Level(Merivale Street)

(Merivale Street)

(Merivale Street)

Concord Level

Important notes• Theatre and classroom capacities include staging, for speaker appropriate to the size of the room.• Banquet and cocktail capacities are the comfortable maximums for each room. Staging and/or dance floors have not been incorporated and will reduce these capacities.• Information accurate at time of printing.

more personal - more choice

31.7.2012 www.bcec.com.au

Boulevard LevelBCEC on Grey Street

BoulevardAuditorium

Boulevard Auditorium Foyer

BoulevardRoom

B1B2B3Lobby

Lift

Lift

Lift

Boulevard Room Foyer

Boulevard North Terrace

Boulevard Central TerraceRegistration

Bar

LoadingGreen Room

Bar

Boulevard Level Rooms Theatre Classroom Banquet Cocktail Metres2

Boulevard Auditorium 430 - - - -

Meeting Room B1 130 75 80 110 113

Meeting Room B2 130 75 80 110 113

Meeting Room B3 130 75 80 110 113

Meeting Room B1 & B2 270 160 180 240 231

Meeting Room B2 & B3 270 160 180 240 231

Meeting Rooms B1, B2 & B3 450 260 280 350 345

Boulevard Room 600 350 390 600 530

Grey StMerivale St

Glenelg St



Arbour Level

Boulevard Level


(Grey Street)

(Grey Street)

(Grey Street)

(Grey Street)



(Merivale Street)

(Merivale Street)

Concord Level




Boulevard Level

Arbour LevelBCEC on Grey Street

Lower Level of BoulevardAuditorium

Speakers Presentation Centre

Lift

Backstage

ChangeRoom

GreenRoom

ArbourSpeakers Lounge

Lobby

Arbour Boardroom

Lift

Lift

Arbour Foyer

Lift

BarArbour LoungeA2

Lift

Retail Mezzanine A1

Arbour Level Rooms Theatre Classroom Banquet Cocktail Metres2

Arbour Lounge - - - 150 190

Meeting Room A1 50 30 20 60 70

Meeting Room A2 120 70 80 120 120

Arbour Speakers Presentation Centre - - - - 70

Arbour Boardroom - - 16 - 38

Grey StMerivale St

Glenelg St



Arbour Level

Boulevard Level


(Grey Street)

(Grey Street)

(Grey Street)

(Grey Street)



(Merivale Street)

(Merivale Street)

Concord Level




Arbour Level


UP

UP

810 9

4 35

5

3

5

3

5

3

4 4

3

6

3 7 6

4 4

3

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MSD

RocheCancer Council

Queensland

Boehringer Ingelheim

Merck SeronoAmgen

Lilly Oncology

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BRISBANE CANCER CONFERENCE18-19 DECEMBER 2014

4AUDITORIUM FOYER - BOULEVARDE LEVEL BCEC

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Thermofisher

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Sponsor Floor Plan

Astrazeneca 8

Lilly Oncology 5

Boehringer-Ingelheim 3

MSD 4

Roche 7

Amgen 10

Merck Serono 9

Thermofisher 13

HCP Biosciences 14

Cancer Council Queensland 6

Thursday, 18 December – Friday 19 December 2014Brisbane Convention and Exhibition Centre

Brisbane Cancer Conference

brisbane cancer...

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