brian erickson, md clinical assistant professor, psychiatry, uvm fahc center for pain medicine...
TRANSCRIPT
![Page 1: Brian Erickson, MD Clinical Assistant Professor, Psychiatry, UVM FAHC Center for Pain Medicine Psychiatry Consultation Service Electroconvulsive Therapy](https://reader035.vdocuments.us/reader035/viewer/2022062300/56649de75503460f94ae0199/html5/thumbnails/1.jpg)
Brian Erickson, MD Clinical Assistant Professor,
Psychiatry, UVM FAHC Center for Pain
Medicine Psychiatry Consultation
Service Electroconvulsive Therapy UVM Program in Integrative
Health
Formulary Analgesic
Medications
![Page 2: Brian Erickson, MD Clinical Assistant Professor, Psychiatry, UVM FAHC Center for Pain Medicine Psychiatry Consultation Service Electroconvulsive Therapy](https://reader035.vdocuments.us/reader035/viewer/2022062300/56649de75503460f94ae0199/html5/thumbnails/2.jpg)
Acute Pain
![Page 3: Brian Erickson, MD Clinical Assistant Professor, Psychiatry, UVM FAHC Center for Pain Medicine Psychiatry Consultation Service Electroconvulsive Therapy](https://reader035.vdocuments.us/reader035/viewer/2022062300/56649de75503460f94ae0199/html5/thumbnails/3.jpg)
![Page 4: Brian Erickson, MD Clinical Assistant Professor, Psychiatry, UVM FAHC Center for Pain Medicine Psychiatry Consultation Service Electroconvulsive Therapy](https://reader035.vdocuments.us/reader035/viewer/2022062300/56649de75503460f94ae0199/html5/thumbnails/4.jpg)
![Page 5: Brian Erickson, MD Clinical Assistant Professor, Psychiatry, UVM FAHC Center for Pain Medicine Psychiatry Consultation Service Electroconvulsive Therapy](https://reader035.vdocuments.us/reader035/viewer/2022062300/56649de75503460f94ae0199/html5/thumbnails/5.jpg)
![Page 6: Brian Erickson, MD Clinical Assistant Professor, Psychiatry, UVM FAHC Center for Pain Medicine Psychiatry Consultation Service Electroconvulsive Therapy](https://reader035.vdocuments.us/reader035/viewer/2022062300/56649de75503460f94ae0199/html5/thumbnails/6.jpg)
![Page 7: Brian Erickson, MD Clinical Assistant Professor, Psychiatry, UVM FAHC Center for Pain Medicine Psychiatry Consultation Service Electroconvulsive Therapy](https://reader035.vdocuments.us/reader035/viewer/2022062300/56649de75503460f94ae0199/html5/thumbnails/7.jpg)
![Page 8: Brian Erickson, MD Clinical Assistant Professor, Psychiatry, UVM FAHC Center for Pain Medicine Psychiatry Consultation Service Electroconvulsive Therapy](https://reader035.vdocuments.us/reader035/viewer/2022062300/56649de75503460f94ae0199/html5/thumbnails/8.jpg)
![Page 9: Brian Erickson, MD Clinical Assistant Professor, Psychiatry, UVM FAHC Center for Pain Medicine Psychiatry Consultation Service Electroconvulsive Therapy](https://reader035.vdocuments.us/reader035/viewer/2022062300/56649de75503460f94ae0199/html5/thumbnails/9.jpg)
![Page 10: Brian Erickson, MD Clinical Assistant Professor, Psychiatry, UVM FAHC Center for Pain Medicine Psychiatry Consultation Service Electroconvulsive Therapy](https://reader035.vdocuments.us/reader035/viewer/2022062300/56649de75503460f94ae0199/html5/thumbnails/10.jpg)
Opioids
Codeine morphineHydrocodone hydromorphoneOxycodone oxymorphone Fentanyl patchMethadoneLevorphanolBuprenorphine
Freye, E. (2008). Opioids in Medicine: A comprehensive review on the mode of action and the use of analgesics in different clinical pain states. New York: Springer Publishing Co.
Smith, H. (2009). Opioid metabolism. Mayo Clinic Proceedings, 84(7), 613-624
![Page 11: Brian Erickson, MD Clinical Assistant Professor, Psychiatry, UVM FAHC Center for Pain Medicine Psychiatry Consultation Service Electroconvulsive Therapy](https://reader035.vdocuments.us/reader035/viewer/2022062300/56649de75503460f94ae0199/html5/thumbnails/11.jpg)
Codeine
“mild opioid” 130 mg = morphine 30 mg
May be combined with Tylenol, Butalbital
Available in 15, 30, 60 mg
Max dose 60 mg q4hr (higher dose not more analgesia, more side effects
Half-life 2.9 hr
![Page 12: Brian Erickson, MD Clinical Assistant Professor, Psychiatry, UVM FAHC Center for Pain Medicine Psychiatry Consultation Service Electroconvulsive Therapy](https://reader035.vdocuments.us/reader035/viewer/2022062300/56649de75503460f94ae0199/html5/thumbnails/12.jpg)
Codeine
Metabolites: codeine-6-glucuronidate morphine (10%)
Renal excretion
Caution ultra-rapid metabolizers CYP2D6 convert to morphine more rapidly with increased effects
Caution alcohol, benzodiazepines,
![Page 13: Brian Erickson, MD Clinical Assistant Professor, Psychiatry, UVM FAHC Center for Pain Medicine Psychiatry Consultation Service Electroconvulsive Therapy](https://reader035.vdocuments.us/reader035/viewer/2022062300/56649de75503460f94ae0199/html5/thumbnails/13.jpg)
Codeine—Practice Agreement
“Universal Precautions” with opioids
Screen for history of substance abuse
Random drug screens
Lost/stolen scripts not refilled
One pharmacy
Involve family members
Document discussion of risks/benefits
![Page 14: Brian Erickson, MD Clinical Assistant Professor, Psychiatry, UVM FAHC Center for Pain Medicine Psychiatry Consultation Service Electroconvulsive Therapy](https://reader035.vdocuments.us/reader035/viewer/2022062300/56649de75503460f94ae0199/html5/thumbnails/14.jpg)
Cautions with Opioids
May cause depression/maniaConstipation, sedation, nausea, myoclonusDecrease testosterone levelsMethadone – metabolite long half-life; QRSOpioid-Induced HyperalgesiaDeath – patient, others
Krantz, M., Martin, J., Stimmel, B., Mehta, D. & Haigney, M. (2009). QTc interval screening in methadone treatment. Annals of Internal Medicine, 150(6), 387-395.
Tenant, F. (2009, Nov/Dec). Testosterone replacement in female chronic pain patients. Practical Pain Management.
Webster, L. & Dove, B. (2007). Avoiding opioid abuse while managing pain. North Branch, MN: Sunrise River Press.
![Page 15: Brian Erickson, MD Clinical Assistant Professor, Psychiatry, UVM FAHC Center for Pain Medicine Psychiatry Consultation Service Electroconvulsive Therapy](https://reader035.vdocuments.us/reader035/viewer/2022062300/56649de75503460f94ae0199/html5/thumbnails/15.jpg)
Ultram (tramadol)
Non-opioid– affinity for mu-receptor 10x less than codeine
Metabolite o-desmethyltramadol 200x greater affinity that tramadol
Inhibits serotonin and norepinephrine re-uptake (similar but less than SNRI)
Lower abuse potential than opioids
![Page 16: Brian Erickson, MD Clinical Assistant Professor, Psychiatry, UVM FAHC Center for Pain Medicine Psychiatry Consultation Service Electroconvulsive Therapy](https://reader035.vdocuments.us/reader035/viewer/2022062300/56649de75503460f94ae0199/html5/thumbnails/16.jpg)
Tramadol
•Available 50 mg tabs•Sustained Release 100mg,200mg,300mg•Dosage: 50 mg q 6hr prn•May use 50 mg qid•Max dose 100mg qid•Studied in osteoarthitis, back pain, others•Side effects: dizziness, nausea, constipation
![Page 17: Brian Erickson, MD Clinical Assistant Professor, Psychiatry, UVM FAHC Center for Pain Medicine Psychiatry Consultation Service Electroconvulsive Therapy](https://reader035.vdocuments.us/reader035/viewer/2022062300/56649de75503460f94ae0199/html5/thumbnails/17.jpg)
Tramadol--warnings
Seizure risk: reported in recommended dosage range, increased risk combined with TCA, SSRI, SNRI, opioids, MAO-I
Serotonin Syndrome: other serotonergic drugs– triptans, neuromuscular activity,autonomic activity, altered mental status
![Page 18: Brian Erickson, MD Clinical Assistant Professor, Psychiatry, UVM FAHC Center for Pain Medicine Psychiatry Consultation Service Electroconvulsive Therapy](https://reader035.vdocuments.us/reader035/viewer/2022062300/56649de75503460f94ae0199/html5/thumbnails/18.jpg)
Tramadol—warnings (cont)
Serotonin Syndrome management:
--stop agents, iv hydration, consider cyproheptadine
Suicide warning—class warning with antidepressants
Caution with alcohol, CNS depressants
Pregnancy cat C
![Page 19: Brian Erickson, MD Clinical Assistant Professor, Psychiatry, UVM FAHC Center for Pain Medicine Psychiatry Consultation Service Electroconvulsive Therapy](https://reader035.vdocuments.us/reader035/viewer/2022062300/56649de75503460f94ae0199/html5/thumbnails/19.jpg)
Neurontin (gabapentin)
Structure similar to GABA, no known direct activity on GABA receptor
Acts on alpha-2 sub-unit Calcium Channel receptor in spinal cord
Approved for Partial-Complex Seizure,Post-Herpetic Neuralgia,
Used for neuropathic pain, migraine, Fibromyalgia (similar to Lyrica), CRPS
![Page 20: Brian Erickson, MD Clinical Assistant Professor, Psychiatry, UVM FAHC Center for Pain Medicine Psychiatry Consultation Service Electroconvulsive Therapy](https://reader035.vdocuments.us/reader035/viewer/2022062300/56649de75503460f94ae0199/html5/thumbnails/20.jpg)
Gabapentin
May help anxiety
Sleep: enhance slow-wave, help Fibro
Not helpful in Bipolar D/O
Half-life 5.9 hours
Renal excretion, caution renal impairment
Side effects: somnolence, peripheral edema, weight gain, cognitive effects
![Page 21: Brian Erickson, MD Clinical Assistant Professor, Psychiatry, UVM FAHC Center for Pain Medicine Psychiatry Consultation Service Electroconvulsive Therapy](https://reader035.vdocuments.us/reader035/viewer/2022062300/56649de75503460f94ae0199/html5/thumbnails/21.jpg)
Gabapentin
•Available 100mg, 300mg,600mg,800mg•Dosage 100mg hs• 100mg tid, increase by 100mg tid q 3days•Max 800mg two qid
• Pregnancy cat C
![Page 22: Brian Erickson, MD Clinical Assistant Professor, Psychiatry, UVM FAHC Center for Pain Medicine Psychiatry Consultation Service Electroconvulsive Therapy](https://reader035.vdocuments.us/reader035/viewer/2022062300/56649de75503460f94ae0199/html5/thumbnails/22.jpg)
Flexeril (cyclobenzaprine)
Relieves muscle spasm of local origin without interfering with muscle function
Not act at neuromuscular junction
Mechanism of action unknown, thought to act at brainstem rather than spinal level
Similar in structure and effect to tricyclic anti-depressants
Half-life 3.2 hrs
![Page 23: Brian Erickson, MD Clinical Assistant Professor, Psychiatry, UVM FAHC Center for Pain Medicine Psychiatry Consultation Service Electroconvulsive Therapy](https://reader035.vdocuments.us/reader035/viewer/2022062300/56649de75503460f94ae0199/html5/thumbnails/23.jpg)
Cyclobenzaprine
Primarily renal excretion
Some hepatic metabolism –caution p450 metabilism, CYP2D rapid metabolizers
Caution with TCA, MAO-I
Side effects anticholinergic: dry mouth, constipation, urinary retention, vision, cognitive, sedation
Caution alcohol, CNS depressants
![Page 24: Brian Erickson, MD Clinical Assistant Professor, Psychiatry, UVM FAHC Center for Pain Medicine Psychiatry Consultation Service Electroconvulsive Therapy](https://reader035.vdocuments.us/reader035/viewer/2022062300/56649de75503460f94ae0199/html5/thumbnails/24.jpg)
Cyclobenzaprine
Available 5mg, 10mg
Amrix(cyclobenzaprine extended release),15mg,30mg
Dosage 5mg tid to 10mg tid
Amrix 15mg to 30mg qd
![Page 25: Brian Erickson, MD Clinical Assistant Professor, Psychiatry, UVM FAHC Center for Pain Medicine Psychiatry Consultation Service Electroconvulsive Therapy](https://reader035.vdocuments.us/reader035/viewer/2022062300/56649de75503460f94ae0199/html5/thumbnails/25.jpg)
Soma (carisoprodol)
Muscle spams, low back pain
Mechanism of action unknown
Metabolized to meprobamate (carbamate, resembles barbituate)
Side effects drowsiness, dizziness, headache,
Caution porphyria
Caution of CNS agent
![Page 26: Brian Erickson, MD Clinical Assistant Professor, Psychiatry, UVM FAHC Center for Pain Medicine Psychiatry Consultation Service Electroconvulsive Therapy](https://reader035.vdocuments.us/reader035/viewer/2022062300/56649de75503460f94ae0199/html5/thumbnails/26.jpg)
Carisoprodol
Available 250mg, 350mg
Dosage 250mg hs
May use 250qid up to 350 qid
Concern for misuse, street value
![Page 27: Brian Erickson, MD Clinical Assistant Professor, Psychiatry, UVM FAHC Center for Pain Medicine Psychiatry Consultation Service Electroconvulsive Therapy](https://reader035.vdocuments.us/reader035/viewer/2022062300/56649de75503460f94ae0199/html5/thumbnails/27.jpg)
Compounded Formulations
Topical, sublingual, rectal, nasal delivery avoid systemic side effects, metabolism problems
NSAID—ketoprofen
Neuropathic agents—amitriptyline, gabapentin
Muscle relaxants—MgCl, baclofen
Topical anesthetics—bupivicaine
![Page 28: Brian Erickson, MD Clinical Assistant Professor, Psychiatry, UVM FAHC Center for Pain Medicine Psychiatry Consultation Service Electroconvulsive Therapy](https://reader035.vdocuments.us/reader035/viewer/2022062300/56649de75503460f94ae0199/html5/thumbnails/28.jpg)
Compounded formulations (cont)
Intranal Lidocaine—migraines
Rectal baclofen—spasms
Naturopaths can’t use Schedule II presently
Some insurances will pay for compounds
![Page 29: Brian Erickson, MD Clinical Assistant Professor, Psychiatry, UVM FAHC Center for Pain Medicine Psychiatry Consultation Service Electroconvulsive Therapy](https://reader035.vdocuments.us/reader035/viewer/2022062300/56649de75503460f94ae0199/html5/thumbnails/29.jpg)
![Page 30: Brian Erickson, MD Clinical Assistant Professor, Psychiatry, UVM FAHC Center for Pain Medicine Psychiatry Consultation Service Electroconvulsive Therapy](https://reader035.vdocuments.us/reader035/viewer/2022062300/56649de75503460f94ae0199/html5/thumbnails/30.jpg)
Adjuvants to Opioids(Nitric Oxide activity)
Oxytocin 10 units q3-6 hr Helps mood, anxiety, sexual interest Side effects – fluid retention, vasopressin
(Kovacs, 1993)
L-Arginine 1000 mg bid
Kovacs (1993). Role of oxytocin in neuroadaptation to drugs of abuse. Psychoneuroendocrinology, 19(1), 85-117.