Healing the Brain Applied Neurobiology 2008

Dr. Dietrich Klinghardt, M.D., PhD.February 22-24 2008

Kirkland, WA

Neurology Illness StatisticsWASHINGTON (Reuters) – Journal of Neurology:

Multiple sclerosis, Parkinson's disease and other neurological diseases may be far more common than most people had believed, according to new estimates published on Monday. Nearly one out of 1,000 Americans has multiple sclerosis or MS and one out of 100 elderly Americans has Parkinson's disease the survey found."Our estimate of MS prevalence is about 50 percent higher than a comprehensive review from 1982," said Dr. Deborah Hirtz of the National Institute of Neurological Disorders and Stroke, who led the survey.It is not clear whether the disease is actually more common or if it is being diagnosed more accurately, she said.

The new survey, published in the journal Neurology, also found the rate of Alzheimer’s Disease was up substantially from past estimates, with 67 out of 1,000 Americans over the age of 65 affected.Nearly 10 out of 1,000 older Americans have Parkinson's disease, and four out of every 100,000 has amyotrophic lateral sclerosis, also called ALS or Lou Gehrig's disease, the survey found.

The survey projects that the number of people with Parkinson's will double from about 4.3 million people now to 9 million people worldwide over the next 25 years.It corroborated other studies on childhood neurological disorders, finding that nearly six out of every 1,000 children has autism, and two out of every 1,000 children has cerebral palsy.

Hirtz and colleagues reviewed studies from nearly 500 medical papers published between 1990 and 2005 for their report.They found that 101 out of every 100,000 Americans has a traumatic brain injury each year, 50 percent fewer than previous estimates.More than 180 out of every 100,000 people suffer a stroke each year, and close to five out of every 100,000 have a new spinal cord injury each year.

Steven Albert of the Department of Behavioral and Community Health Sciences at the University of Pittsburgh said the impact of Alzheimer's will be substantial as the population ages."Current projections of AD (Alzheimer's disease) suggest that there will be about 10 million cases in the United States in 2050, of which 6 million are expected to have moderate or severe dementia," Albert wrote in a commentary in the journal.

There is currently no cure and treatments only delay the progression of Alzheimer's slightly. There is also no cure for MS or for Parkinson's, although drugs can also delay their progression.

Parkinson’s AbstractKidd PM. Parkinson's disease as multifactorial oxidative neurodegeneration: implications for integrative management. Altern Med Rev. 2000 Dec;5(6):502-29.

Parkinson's disease (PD) is the most common movement pathology, severely afflicting dopaminergic neurons within the substantia nigra (SN) along with non-dopaminergic, extra-nigral projection bundles that control circuits for sensory, associative, premotor, and motor pathways. Clinical, experimental, microanatomic, and biochemical evidence suggests PD involves multifactorial, oxidative neurodegeneration, and that levodopa therapy adds to the oxidative burden.

The SN is uniquely vulnerable to oxidative damage, having high content of oxidizable dopamine, neuromelanin, polyunsaturated fatty acids, and iron, and relatively low antioxidant complement with high metabolic rate. Oxidative phosphorylation abnormalities impair energetics in the SN mitochondria, also intensifying oxygen free radical generation.

These pro-oxidative factors combine within the SN dopaminergic neurons to create extreme vulnerability to oxidative challenge. Epidemiologic studies and long-term tracking of victims of MPTP (1-methyl-4-phenyl-1,2,3,6,-tetrahydropyridine) poisoning, suggest oxidative stress compounded by exogenous toxins may trigger the neurodegenerative progression of PD. Rational, integrative management of PD requires:

(1) dietary revision, especially to lower calories; (2) rebalancing of essential fatty acid intake away from pro-inflammatory and toward anti-inflammatory prostaglandins; (3) aggressive repletion of glutathione and other nutrient antioxidants and cofactors; (4) energy nutrients acetyl L-carnitine, coenzyme Q10, NADH, and the membrane phospholipid phosphatidylserine (PS), (5) chelation as necessary for heavy metals; and (6) liver P450 detoxification support.

Nutritional Support Protocols

2 North Rd. East Windsor, CT 06088 �� Phone (800) 847-8302 ��Fax (860) 627-0661 �� www.designsforhealth.com

Brain Injury Recovery ProtocolNutritional Support ProtocolLifestyle Recommendations:1. Practice good sleep habits and get between 8-9 hours of sleep a night.2. Engage in 30 minutes of intense aerobic exercise 4-5 times a week.3. Engage in mental exercise by consistently learning new skills and information.4. Avoid exposure to chemicals including skincare and hair care products such as Grecian Formula(contains lead), lipstick (contains aluminum), deodorant (aluminum), toxic cleaning products andartist’s paints.5. Build positive relationships in your life; practice clear communication, cooperation and forgiveness.6. Listen to a lot of great music.Dietary Recommendations:1. Choose lean, clean quality protein at each meal (chicken breast, turkey breast, lean beef, fish -especially salmon and tuna, lowfat cottage cheese, lowfat string cheese, eggs and whey protein).2. Emphasize omega 3 fatty acids (salmon, mackerel, herring, tuna) and omega 9 fats (olive oil,olives, almonds, hazelnuts, avocados, macadamia oil and coconut oil).3. Consume 10 servings of vegetables/fruits every day. In addition, substitute complex carbohydrates(non-starchy vegetables and whole grains) for refined and simple carbohydrates. Eliminate refinedcarbohydrates from the diet (this includes bread, cereal or pasta made with white flour, white rice,white potatoes, sugar, corn syrup, honey and candy).4. Limit or avoid trans fatty acids (hydrogenated vegetable oil, margarine and shortening). Cook witholive oil.5. Drink at least 64 ounces of filtered, bottled or non-chlorinated water every day. In addition, drink2-3 cups of green tea daily.6. Avoid or limit caffeine, alcohol and other potentially neurotoxic compounds like aspartame and MSG.Supplement Recommendations:The following supplements are in addition to Twice Daily Essential Packets to supply yourcore vitamins, minerals, antioxidants and essential fatty acids.Brain Vitale: 2 with breakfast and lunch, 4 per dayKrill Oil: 2 with each meal, 6 per dayThree-A-Day Antioxidant: 1 with each meal, 3 per dayPregnenolone: 1 dropper 3 times per dayInflammatone: 2 caps 3 times per day2 North Rd. East Windsor, CT 06088 �� Phone (800) 847-8302 �� Fax (860) 627-0661 �� www.designsforhealth.comTHIS INFORMATION IS PROVIDED FOR THE USE OF PHYSICIANS AND OTHER LICENSED HEALTH CARE PRACTITIONERS ONLY. THIS INFORMATIONIS INTENDED FOR PHYSICIANS AND OTHER LICENSED HEALTH CARE PROVIDERS TO USE AS A BASIS FOR DETERMINING WHETHER OR NOT TORECOMMEND THESE PRODUCTS TO THEIR PATIENTS. THIS MEDICAL AND SCIENTIFIC INFORMATION IS NOT FOR USE BY CONSUMERS. THE DIETARYSUPPLEMENT PRODUCTS OFFERED BY DESIGNS FOR HEALTH ARE NOT INTENDED FOR USE BY CONSUMERS AS A MEANS TO CURE, TREAT, PREVENT,DIAGNOSE, OR MITIGATE ANY DISEASE OR OTHER MEDICAL CONDITION. ®

ADD/ADHD Support ProtocolNutritional Support ProtocolLifestyle Recommendations:1. Avoid video and computer games, minimize tv viewing.2. Interactive metronome, biofeedback and neurofeedback, brain gym exercises3. Physical exercise involving coordination.Dietary Recommendations:1. Avoid candy and desserts. Xylitol is an excellent sweetener and helps to prevent cavities and earinfections.2. Avoid NutraSweet and other artificial sweeteners3. Avoid white flour and all refined carbohydrates including cereals and pasta especially those that aremade with yeast such as bread, bagels and English muffins. Replace these with brown rice, sweetor white potato and oatmeal.4. Increase consumption of omega 3's (salmon, mackerel, herring, tuna, or flax oil).5. Eat protein at every meal including eggs, fish, chicken and lean meat.6. Avoid hydrogenated vegetable oils.7. Healthy snacks would be vegetables, nuts, olives, avocado, celery with almond butter, PaleoBars,and Brain Power Sours.8. Eat 5-9 servings of fresh fruits and vegetables daily OR add one heaping tablespoon of PaleoGreensto your favorite drink.9. Replace sugar with the polyol sugar xylitol.10. Carry PaleoMeal Packets and/or PaleoBars with you throughout the day to prevent missing meals orsnacks.Supplement Recommendations:The following supplements are in addition to Twice Daily Essential Packets tosupply your core vitamins, minerals, antioxidants and essential fatty acids.Krill Oil: 1 with breakfast and 1 with dinner, 2 per dayNeurolink: 2 per mealCarnitine Synergy: 2 - 6 per dayPhosphatidyl Serine: 2 - 4 caps or 1/4 to 1/2 tsp. per dayNote: These are adult doses. For children, divide by weight difference. For example, assuming 120 lbadult, a 40 lb child would get 1/3 the dosage.THIS INFORMATION IS PROVIDED FOR THE USE OF PHYSICIANS AND OTHER LICENSED HEALTH CARE PRACTITIONERS ONLY. THIS INFORMATIONIS INTENDED FOR PHYSICIANS AND OTHER LICENSED HEALTH CARE PROVIDERS TO USE AS A BASIS FOR DETERMINING WHETHER OR NOT TORECOMMEND THESE PRODUCTS TO THEIR PATIENTS. THIS MEDICAL AND SCIENTIFIC INFORMATION IS NOT FOR USE BY CONSUMERS. THE DIETARYSUPPLEMENT PRODUCTS OFFERED BY DESIGNS FOR HEALTH ARE NOT INTENDED FOR USE BY CONSUMERS AS A MEANS TO CURE, TREAT, PREVENT,DIAGNOSE, OR MITIGATE ANY DISEASE OR OTHER MEDICAL CONDITION. ®

Alzheimer’s ProtocolNutritional Support ProtocolLifestyle Recommendations:1. Avoid alcohol and any over the counter medications unless prescribed by your doctor.2. Exercise daily such as brisk walking to increase circulation.3. Avoid exposure to chemicals including skincare and hair care products such as Grecian Formula(contains lead), lipstick (contains aluminum), deodorant (aluminum), cleaning products andartists paints.4. Do mental exercises such as brain gym or crossword puzzles.Dietary Recommendations:1. Avoid or limit caffeine, alcohol and other potentially neurotoxic compounds like aspartame and MSG.2. Avoid pesticides, herbicides and chemicals by eating organic fruits and vegetables.3. Stabilize blood sugar by eating protein at every meal, 3 times per day. Hypoglycemia, lack ofglucose, can damage brain cells.4. Drink purified water, at least 8 glasses per day.5. Eat 5-9 servings of fresh fruits and vegetables daily OR add one heaping tablespoon of PaleoGreensto your favorite drink.6. Replace sugar with the polyol sugar xylitol.7. Carry PaleoMeal Packets and/or PaleoBars with you throughout the day to prevent missing meals orsnacks.Supplement Recommendations:The following supplements are in addition to Twice Daily Essential Packets tosupply your core vitamins, minerals, antioxidants and essential fatty acids.Brain Vitale: 1/2 tspn powder (in water or juice) with breakfast andlunch, 1 tspn per day OR 2 caps with breakfast and lunch,4 caps per dayGlutathione Power: 1/2 tspn (in water or juice) with breakfastLipoic Supreme: 1 capsule with breakfast, 300 mg per dayKrill Oil: 2 softgels per day with breakfast, 2 per day*Q-Avail 100mg orCoQ10 Synergy Powder: 1-2 softgels per day, or up to 1 tsp powder per day2 North Rd. East Windsor, CT 06088 �� Phone (800) 847-8302 �� Fax (860) 627-0661 �� www.designsforhealth.comTHIS INFORMATION IS PROVIDED FOR THE USE OF PHYSICIANS AND OTHER LICENSED HEALTH CARE PRACTITIONERS ONLY. THIS INFORMATIONIS INTENDED FOR PHYSICIANS AND OTHER LICENSED HEALTH CARE PROVIDERS TO USE AS A BASIS FOR DETERMINING WHETHER OR NOT TORECOMMEND THESE PRODUCTS TO THEIR PATIENTS. THIS MEDICAL AND SCIENTIFIC INFORMATION IS NOT FOR USE BY CONSUMERS. THE DIETARYSUPPLEMENT PRODUCTS OFFERED BY DESIGNS FOR HEALTH ARE NOT INTENDED FOR USE BY CONSUMERS AS A MEANS TO CURE, TREAT, PREVENT,DIAGNOSE, OR MITIGATE ANY DISEASE OR OTHER MEDICAL CONDITION. ®

Anxiety ProtocolNutritional Support ProtocolLifestyle Recommendations:1. Control stress and avoid extra obligations.2. Avoid smoking and alcohol consumption.3. Get regular exercise such as yoga, tai chi, walking.4. Avoid consumption of known or suspected food allergies.5. Check adrenal function and address sleep quality and quantity.Dietary Recommendations:1. Avoid all sugars including fruit and fruit juices.2. Avoid white flour and all refined carbohydrates including cereals and pasta especially those that aremade with yeast such as bread, bagels and English muffins.3. Get a balance of omega 3's (salmon, mackerel, herring, tuna) and omega 9 fats (olive oil, olives,almonds, hazelnuts, avocados).4. Stabilize blood sugar by eating protein at every meal including fish, chicken and lean meat.5. Avoid hydrogenated vegetable oils and fried foods.6. Cook with olive oil.7. Snack on vegetables and small amounts of nuts, olives or avocado.8. Excellent snacks are almonds, celery with almond butter, PaleoBars and Brain Power Sours.9. Do not skip meals.10. Eat 5-9 servings of fresh fruits and vegetables daily OR add one heaping tablespoon of PaleoGreensto your favorite drink.11. Replace sugar with the polyol sugar xylitol.12. Carry PaleoMeal Packets and/or PaleoBars with you throughout the day to prevent missing meals orsnacks.Supplement Recommendations:The following supplements are in addition to Twice Daily Essential Packets tosupply your core vitamins, minerals, antioxidants and essential fatty acids.StressArrest Capsules: 1-4 per dayInositol: 1-2 teaspoons at bedtimeTaurine Powder/Capsules: 2 grams (powder) or 1 capsule twice per day2 North Rd. East Windsor, CT 06088 �� Phone (800) 847-8302 �� Fax (860) 627-0661 �� www.designsforhealth.comTHIS INFORMATION IS PROVIDED FOR THE USE OF PHYSICIANS AND OTHER LICENSED HEALTH CARE PRACTITIONERS ONLY. THIS INFORMATIONIS INTENDED FOR PHYSICIANS AND OTHER LICENSED HEALTH CARE PROVIDERS TO USE AS A BASIS FOR DETERMINING WHETHER OR NOT TORECOMMEND THESE PRODUCTS TO THEIR PATIENTS. THIS MEDICAL AND SCIENTIFIC INFORMATION IS NOT FOR USE BY CONSUMERS. THE DIETARYSUPPLEMENT PRODUCTS OFFERED BY DESIGNS FOR HEALTH ARE NOT INTENDED FOR USE BY CONSUMERS AS A MEANS TO CURE, TREAT, PREVENT,DIAGNOSE, OR MITIGATE ANY DISEASE OR OTHER MEDICAL CONDITION. ®

Depression ProtocolNutritional Support ProtocolLifestyle Recommendations:1. Take long vacations and get adequate sleep.2. Avoid extra stress and obligations.3. Rule out heavy metal toxicity, overgrowth of candida albicans, and hormone imbalance.4. Rule out hypothyroidism, hypoglycemia, and weak adrenal function.5. Avoid smoking and alcohol consumption.6. Engage in regular aerobic exercise such as walking, yoga, or tai chi.Dietary Recommendations:1. Whey Protein or other Quality Protein is essential at every meal to stabilize blood sugar levels.2. Avoid sugar and sweetened products.3. Wheat and Dairy avoidance may prove extremely helpful for stabilizing moods.4. Avoid sugar and concentrate on fish and foods high in omega 3 fatty acids such as salmon,mackerel, and tuna.5. Avoid allergic foods.6. Eat 5-9 servings of fresh fruits and vegetables daily OR add one heaping tablespoon of PaleoGreensto your favorite drink.7. Replace sugar with the polyol sugar xylitol.8. Carry PaleoMeal Packets and/or PaleoBars with you throughout the day to prevent missing meals orsnacks.Supplement Recommendations:The following supplements are in addition to Twice Daily Essential Packets tosupply your core vitamins, minerals, antioxidants and essential fatty acids.Phosphatidyl Serine: 100-1,000 mgL-Carnitine: 500-2,000 mgFolic Acid/B12: 1 mg of eachOmega 3s/Krill: 2,000 mg, 2-4 daily5-HTP: 50-300 mgInositol: 1-2 grams2 North Rd. East Windsor, CT 06088 �� Phone (800) 847-8302 �� Fax (860) 627-0661 �� www.designsforhealth.comTHIS INFORMATION IS PROVIDED FOR THE USE OF PHYSICIANS AND OTHER LICENSED HEALTH CARE PRACTITIONERS ONLY. THIS INFORMATIONIS INTENDED FOR PHYSICIANS AND OTHER LICENSED HEALTH CARE PROVIDERS TO USE AS A BASIS FOR DETERMINING WHETHER OR NOT TORECOMMEND THESE PRODUCTS TO THEIR PATIENTS. THIS MEDICAL AND SCIENTIFIC INFORMATION IS NOT FOR USE BY CONSUMERS. THE DIETARYSUPPLEMENT PRODUCTS OFFERED BY DESIGNS FOR HEALTH ARE NOT INTENDED FOR USE BY CONSUMERS AS A MEANS TO CURE, TREAT, PREVENT,DIAGNOSE, OR MITIGATE ANY DISEASE OR OTHER MEDICAL CONDITION. ®

Epilepsy ProtocolNutritional Support ProtocolLifestyle Recommendations:1. Avoid steroids such as dehydroepiandrosterone.2. Check for hormonal imbalances, low progesterone can be trigger for seizures.3. Practice good sleep habits and get between 8-9 hours of sleep a night.4. Engage in 30 minutes of intense aerobic exercise 4-5 times a week.5. Engage in mental exercise by consistently learning new skills and information.4. Try therapeutic body-based methods such as: chiropractic and message which are examples ofthis type of therapy.Dietary Recommendations:1. Consider a ketogenic diet; it has been shown to be successful in children with chronic seizures.2. Emphasize omega 3 fatty acids (salmon, mackerel, herring, tuna) and omega 9 fats (olive oil,olives, almonds, hazelnuts, avocados, macadamia oil and coconut oil).3. Choose lean, clean quality protein at each meal (chicken breast, turkey breast, lean beef, fish -especially salmon and tuna, lowfat cottage cheese, lowfat string cheese, eggs and whey protein).3. Limit or avoid trans fatty acids (hydrogenated vegetable oil, margarine and shortening). Cook witholive oil.4. Drink at least 64 ounces of filtered, bottled or non-chlorinated water every day. In addition, drink2-3 cups of green tea daily.5. Avoid or limit caffeine, alcohol and other potentially neurotoxic compounds like aspartame and MSG.Supplement Recommendations:The following supplements are in addition to Twice Daily Essential Packets tosupply your core vitamins, minerals, antioxidants and essential fatty acids.Water Ease: 1 capsule with breakfast & 1 packet with lunchKrill Oil: 1 softgel per dayCarniClear (L-Carnitine): 1 tsp. before breakfast daily2 North Rd. East Windsor, CT 06088 �� Phone (800) 847-8302 �� Fax (860) 627-0661 ��www.designsforhealth.comTHIS INFORMATION IS PROVIDED FOR THE USE OF PHYSICIANS AND OTHER LICENSED HEALTH CARE PRACTITIONERS ONLY. THIS INFORMATIONIS INTENDED FOR PHYSICIANS AND OTHER LICENSED HEALTH CARE PROVIDERS TO USE AS A BASIS FOR DETERMINING WHETHER OR NOT TORECOMMEND THESE PRODUCTS TO THEIR PATIENTS. THIS MEDICAL AND SCIENTIFIC INFORMATION IS NOT FOR USE BY CONSUMERS. THE DIETARYSUPPLEMENT PRODUCTS OFFERED BY DESIGNS FOR HEALTH ARE NOT INTENDED FOR USE BY CONSUMERS AS A MEANS TO CURE, TREAT, PREVENT,DIAGNOSE, OR MITIGATE ANY DISEASE OR OTHER MEDICAL CONDITION. ®

Herpes ProtocolNutritional Support ProtocolLifestyle Recommendations:1. Avoid stress and extra obligations.2. Get regular exercise such as walking, yoga, tai chi.3. Avoid corticosteroids and NSAIDS (if possible).4. Always balance arginine supplementation with the amino acid lysine.Dietary Recommendations:1. Avoid wheat flour and dairy products.2. Avoid sugar and hydrogenated oils.3. Avoid alcohol consumption and caffeine.4. Avoid refined and processed foods.5. Avoid omega 6 oils such as safflower, sunflower, corn and soybean oil.6. Nuts contain arginine which depletes the anti-viral nutrient lysine. Frequent consumption of nutscan cause a viral outbreak.7. Eat omega 3 anti-inflammatory foods such as salmon, mackerel and tuna.8. Consume green drinks (PaleoGreens) or fresh vegetable juices.9. Helpful teas: chamomile, green tea, echinacea or slippery elm.Supplement Recommendations:The following supplements are in addition to Twice Daily Essential Packets tosupply your core vitamins, minerals, antioxidants and essential fatty acids.Allicidin: 1 capsule with each meal, 3 per dayImmunitone Plus: 2 capsules with breakfast and lunch, 4 per dayLysine: 2 capsules with breakfast and lunch, 4 per dayOlive Leaf Extract: 1 capsule with breakfast and lunch, 2 per dayStellar C: 1 capsule with breakfast and lunch, 2 per day2 North Rd. East Windsor, CT 06088 �� Phone (800) 847-8302 �� Fax (860) 627-0661 ��www.designsforhealth.comTHIS INFORMATION IS PROVIDED FOR THE USE OF PHYSICIANS AND OTHER LICENSED HEALTH CARE PRACTITIONERS ONLY. THIS INFORMATIONIS INTENDED FOR PHYSICIANS AND OTHER LICENSED HEALTH CARE PROVIDERS TO USE AS A BASIS FOR DETERMINING WHETHER OR NOT TORECOMMEND THESE PRODUCTS TO THEIR PATIENTS. THIS MEDICAL AND SCIENTIFIC INFORMATION IS NOT FOR USE BY CONSUMERS. THE DIETARYSUPPLEMENT PRODUCTS OFFERED BY DESIGNS FOR HEALTH ARE NOT INTENDED FOR USE BY CONSUMERS AS A MEANS TO CURE, TREAT, PREVENT,DIAGNOSE, OR MITIGATE ANY DISEASE OR OTHER MEDICAL CONDITION. ®

Insomnia ProtocolINSOMNIANutritional Support ProtocolLifestyle Recommendations:1. Engage in regular aerobic exercise such as walking, swimming, yoga, or tai chi.2. Avoid extra stress and obligations.3. Rule out hormone imbalance/deficiencies.4. Rule out hypothyroidism, hypoglycemia, and weak adrenal function.5. Avoid smoking and alcohol consumption.6. Avoid caffeine containing products, stimulant-containing herbs, and hypoglycemic conditions7. Exercise late in the day.8. Check prescription drugs for side effects. Many contain caffeine.Dietary Recommendations:1. Eat turkey or drink warm milk before bed as they contain tryptophan. Calcium and magnesium atbedtime have a relaxing effect on the body and can aid sleep.2. Whey Protein or other quality protein is essential at every meal to stabilize blood sugar levels.3. Avoid sugar and sweetened products.4. Avoid allergic foods.Supplement Recommendations:The following supplements are in addition to Twice Daily Essential Packets tosupply your core vitamins, minerals, antioxidants and essential fatty acids.Inositol: ¼ to 1 tsp. or more before bedStressArrest: 1 or more capsules before bed5-HTP: 1 or more capsules before bedIf needed:Melatonin: 1 tablet before bed2 North Rd. East Windsor, CT 06088 �� Phone (800) 847-8302 �� Fax (860) 627-0661 ��www.designsforhealth.comTHIS INFORMATION IS PROVIDED FOR THE USE OF PHYSICIANS AND OTHER LICENSED HEALTH CARE PRACTITIONERS ONLY. THIS INFORMATIONIS INTENDED FOR PHYSICIANS AND OTHER LICENSED HEALTH CARE PROVIDERS TO USE AS A BASIS FOR DETERMINING WHETHER OR NOT TORECOMMEND THESE PRODUCTS TO THEIR PATIENTS. THIS MEDICAL AND SCIENTIFIC INFORMATION IS NOT FOR USE BY CONSUMERS. THE DIETARYSUPPLEMENT PRODUCTS OFFERED BY DESIGNS FOR HEALTH ARE NOT INTENDED FOR USE BY CONSUMERS AS A MEANS TO CURE, TREAT, PREVENT,DIAGNOSE, OR MITIGATE ANY DISEASE OR OTHER MEDICAL CONDITION. ®

Migraine ProtocolNutritional Support ProtocolLifestyle Recommendations:1. Control stress and avoid extra obligations.2. Avoid smoking and alcohol consumption.3. Avoid use of toxic cleaning chemicals and recreational drugs.Dietary Recommendations:1. Avoid Tyramine containing foods such as aged cheeses; brewers yeast and yeast containingfoods such as bread and soups; pickled, aged, smoked and fermented meats includingfrankfurters, pepperoni, salami, bacon, bologna, and ham; chocolate, citrus fruits, red wine,and beer.2. Avoiding Tannin containing foods may be helpful such as black teas, many herb teas, applejuice, dates, kiwi, peaches, berries, coffee, carob, alfalfa, walnuts and pecans.3. Dairy products often aggravate sinus congestion which can contribute to migraines.4. Avoid known food allergens.5. Eat a diet high in omega 3 fats including fish such as salmon, mackerel and tuna.Supplement Recommendations:The following supplements are in addition to Twice Daily Essential Packets tosupply your core vitamins, minerals, antioxidants and essential fatty acids.Feverfew Synergy: 2 with breakfast and 2 with lunch, 4 per dayB-Supreme: 1 with breakfast and 1 with lunch, 2 per dayAmino-D-Tox: 2 capsules with breakfast, lunch and dinner, 6 per dayProbiotic Synergy: 1/2 teaspoon with breakfast and lunch or 2 capsules daily*In cases of premenstrual migraines, check hormone levels. Progesterone levels may need to beincreased by direct supplementation or indirectly by giving Pregnenolone and/or DHEA.2 North Rd. East Windsor, CT 06088 �� Phone (800) 847-8302 �� Fax (860) 627-0661 ��www.designsforhealth.comTHIS INFORMATION IS PROVIDED FOR THE USE OF PHYSICIANS AND OTHER LICENSED HEALTH CARE PRACTITIONERS ONLY. THIS INFORMATIONIS INTENDED FOR PHYSICIANS AND OTHER LICENSED HEALTH CARE PROVIDERS TO USE AS A BASIS FOR DETERMINING WHETHER OR NOT TORECOMMEND THESE PRODUCTS TO THEIR PATIENTS. THIS MEDICAL AND SCIENTIFIC INFORMATION IS NOT FOR USE BY CONSUMERS. THE DIETARYSUPPLEMENT PRODUCTS OFFERED BY DESIGNS FOR HEALTH ARE NOT INTENDED FOR USE BY CONSUMERS AS A MEANS TO CURE, TREAT, PREVENT,DIAGNOSE, OR MITIGATE ANY DISEASE OR OTHER MEDICAL CONDITION. ®

Multiple Sclerosis (MS) ProtocolNutritional Support ProtocolSupplement Recommendations:The following supplements are in addition to Twice Daily Essential Packets tosupply your core vitamins, minerals, antioxidants and essential fatty acids.Ultra B12- Folate: 2-4 capsulesKrill Oil: 2-4 softgelsBrain Vitale: ½ teaspoonN-Acetyl Cysteine: 1 capsule per dayUltimate Antiox-LS: 3 per dayThe goal is to remove all foods that may be triggering the body to attack its owntissues. Researchers believe that one of the possible causes of autoimmune ailments,such as MS, is certain foods that are new to humanity (grain products, dairy products,lentils and beans, and yeasted foods) which have only appeared in the past 40,000years. Meats, nuts, vegetables and fruits have been eaten for over 2 million years.Therefore, returning to a diet that is made of meat, nuts, and produce may removeone of the main offending causes behind autoimmune problems. It can take 3-6months to assess whether this dietary elimination of mimetic proteins in allergenicfoods is effective. Check for candida albicans infection. Mercury is also considered tobe possible contributing cause of MS.Diet: Dairy, grain, yeast and legume free, high in EFAs2 North Rd. East Windsor, CT 06088 �� Phone (800) 847-8302 �� Fax (860) 627-0661 ��www.designsforhealth.comTHIS INFORMATION IS PROVIDED FOR THE USE OF PHYSICIANS AND OTHER LICENSED HEALTH CARE PRACTITIONERS ONLY. THIS INFORMATIONIS INTENDED FOR PHYSICIANS AND OTHER LICENSED HEALTH CARE PROVIDERS TO USE AS A BASIS FOR DETERMINING WHETHER OR NOT TORECOMMEND THESE PRODUCTS TO THEIR PATIENTS. THIS MEDICAL AND SCIENTIFIC INFORMATION IS NOT FOR USE BY CONSUMERS. THE DIETARYSUPPLEMENT PRODUCTS OFFERED BY DESIGNS FOR HEALTH ARE NOT INTENDED FOR USE BY CONSUMERS AS A MEANS TO CURE, TREAT, PREVENT,DIAGNOSE, OR MITIGATE ANY DISEASE OR OTHER MEDICAL CONDITION. ®

MS and FatigueTherapy Found To Relieve Fatigue Of Multiple Sclerosis Patients

Science Daily — COLUMBUS, Ohio - For the first time, researchers here have found an effective therapy that can alleviate the fatigue often accompanying multiple sclerosis. Many therapies have been developed to treat symptoms of multiple sclerosis, but few have helped, to any degree, the excessive, debilitating fatigue that accompanies other disease symptoms in some patients. Their study appears today in the Journal of Neurology, Neurosurgery and Psychiatry.

Dr. Kottil W. Rammohan, neurologist at The Ohio State University Medical Center, and his colleagues wondered whether the drug modafinil might be effective in relieving this fatigue. Modafinil is used currently in the treatment of narcolepsy, a disease in which patients experience uncontrolled daytime sleepiness. "We were very pleased to find that a medication that was effective against narcolepsy was able to treat the fatigue associated with multiple sclerosis." Two doses of modafinil (200 and 400 mg) were compared against a placebo in 72 patients with multiple sclerosis ranging in age from 18 to 65. It was observed that the 200 mg dose of the drug administered once daily showed highly significant improvement in patients. Three separate instruments of rating fatigue were used, and all three showed concordant response to this drug. No previous drug has been able to show this degree of improvement in treating multiple sclerosis-related fatigue in any previous clinical trial.

Fatigue is one of the most common and disabling symptoms of multiple sclerosis. It affects 75 to 90 percent of patients with the disease. As many as 46 to 66 percent of multiple sclerosis patients experience fatigue on a daily basis. Rammohan said that more studies are needed to better understand the dosage and length of therapy necessary for patients, but he hopes more neurologists will start using modafinil for the treatment of severe fatigue that often accompanies multiple sclerosis.

Also participating in this study were researchers at Kaiser Permanente in San Diego. Multiple sclerosis is an unpredictable, progressive disease in which scattered patches of nerve fibers in the brain and spinal cord lose "myelin," their protective covering. Resultant loss of neurological function can manifest with a multitude of symptoms.

In addition to fatigue, patients experience a combination of a number of symptoms that include visual loss, loss of motor function, sensory impairment, imbalance, bowel and bladder dysfunction, and sometimes problems related to cognition, memory and personality. Multiple sclerosis is a common disorder and affects about 350,000 people in the United States, mostly women.

Note: This story has been adapted from a news release issued by Ohio State University

MS & Hyperbaric Oxygen TreatmentK. Paul Stoller, MDAssitant Clinical Professor Pediatrics, UNM School of MedicinePresident, International Hyperbaric Medical Association

MS is a demyelinating disease of the central nervous system (CNS). It is characterized by exacerbations, remissions, and stability The long awaited drug that was to give hope to thousands of sufferers of Multiple Sclerosis (MS) was voluntarily pulled from the market the last weekend in February due to the death of one patient and the CNS injury of another. Biogen and Elan shares fell 40% and 60% respectively, but belying this tragedy is the fact that two decades ago another drug showing tremendous promise for treating MS - one with virtually no serious side effects, but it never had a chance to come to the fore because market driven forces didn’t want it to be recognized.

B.H. Fischer, a tenured professor at New York University became the principal investigator of a study funded by the Multiple Sclerosis (MS) Society, which receives substantial financial support from the pharmaceutical industry. The MS Society in the USA had a very difficult time accepting the results of the work Dr. Fischer had completed and made their objections known. The study required multiple revisions to tone down the results so they would be bland and noncontroversal enough for New England Journal of Medicine editors to print, on January 27th 1983 the results of Fischer’s study were published: “Hyperbaric-oxygen treatment of Multiple Sclerosis: Arandomized placebo-controlled, double blind study.”

What Fischer found was that there were significant improvement in objective measurements and treatment effect persisted at 1-year follow-up (Fischer BH, et al NEJM 1983; 308:181-186). Despite the positive results, and the treatment languished for lack of financial support and sponsorship. Fischer himself faired less well and was expunged from the NYU faculty and his chamber chopped up and sent to the city dump. Two years later, M.P. Barnes published another double-blind, placebo controlled study showing statistically significant improvement in bladder and bowel control (Barnes MP, Bates D, Cartlidge NEF, et al. Hyperbaric oxygen and multiple sclerosis: Short-term results of a placebo-controlled, double-blind trial. Lancet 1985;i:297-300). Associated Press sent out an article saying the study showed hyperbaric oxygen ineffective and that the Barnes study contradicted the Fischer study.

In 1987, a follow-up study was published in the Journal of Neurology, Neurosurgery, and Psychiatry, which not only confirmed theresults of the Fischer study, but revealed significant preservation of cerebellar function (coordination) with hyperbaric oxygen (Barnes, MP et al: Hyperbaric oxygen therapy in the treatment of multiple sclerosis. J Neurol Neurosurg Psychiatry 50(11):1402-6, 1987). But now no one was even listening.

In the United Kingdom, the Fischer article had prompted an eight year longitudinal study of hyperbaric oxygen and MS that showed a significant difference in the relapse rates of patients being treated with oxygen under pressure and those that were not so treated. A Trust was created which went onto open over 60 hyperbaric charity clinics, and today using oxygen under pressure has become the mainstay of MS therapy in the UK with well over 1.5 million treatments completed to date. Hyperbaric oxygen stabilizes the network of capillaries in the brain called the Blood-Brain-Barrier which is exactly the same mechanism behind the effectiveness of the drug Tysabri –neither treatment is a cure for the disease, but both alter the natural history of the disease in a favorable fashion. One had apharmaceutical company behind it and one didn’t because oxygen is not patentable – end of story?

MS & NADCan A Vitamin Alleviate Chronic, Progressive Multiple Sclerosis?

Science Daily — Researchers have found a possible way to protect people with multiple sclerosis (MS) from severe long-term disability: increase nervous-system levels of a vital compound, called nicotinamide adenine dinucleotide (NAD), by giving its chemical precursor -- nicotinamide, a form of vitamin B3.

Current therapies for MS mainly address the relapsing-remitting phase of the disease, but some of these have severe side effects, and most patients eventually enter a chronic progressive phase for which there is no good treatment. Using a mouse model of MS, researchers in the Neurobiology Program at Children's Hospital Boston found strong evidence that nicotinamide may protect against nerve damage in the chronic progressive phase, when the most serious disabilities occur. Their findings appear in a cover article in the September 20 Journal of Neuroscience.

MS is a neurologic disorder in which nerve fibers, or axons, are damaged through inflammation, loss of their insulating myelin coating, and degeneration. This damage disrupts nerves' ability to conduct electrical impulses to and from the brain, causing such symptoms as fatigue, difficulty walking, pain, spasticity, and emotional and cognitive changes. Current treatments mainly protect against inflammation and myelin loss, but do not completely prevent long-term axon damage. A team led by Shinjiro Kaneko, MD, a research fellow at Children's, and senior investigator Zhigang He, PhD, also from Children's, worked with mice that had an MS-like disease called experimental autoimmune encephalitis (EAE). Through careful experiments, they showed that nicotinamide protected the animals' axons from degeneration -- not only preventing axon inflammation and myelin loss, but also protecting axons that had already lost their myelin from further degradation.

Intriguingly, mice with EAE who received daily nicotinamide injections under their skin had a delayed onset of neurologic disability, and the severity of their deficits was reduced for at least eight weeks after treatment. The greater the dose of nicotinamide, the greater the protective effect. [See accompanying figure.]On a scale of 1 to 5 (1 indicating mild weakness only in the tail, 4 indicating paralysis involving all four limbs, and 5, death from the disease), mice receiving the highest doses of nicotinamide had neurologic scores between 1 and 2, while control mice had scores between 3 and 4. All differences between treated groups and controls were statistically significant.

Mice with the greatest neurologic deficits had the lowest levels of NAD in their spinal cord, and those with the mildest deficits had the highest NAD levels. Mice that had higher levels of an enzyme that converts nicotinamide to NAD (known as Wlds mice) responded best to treatment.Moreover, nicotinamide significantly reduced neurologic deficits even when treatment was delayed until 10 days after the induction of EAE, raising hope that it will also be effective in the later stages of MS. "The earlier therapy was started, the better the effect, but we hope nicotinamide can help patients who are already in the chronic stage," says Kaneko.In other experiments, the researchers demonstrated that nicotinamide works by increasing levels of NAD in the spinal cord and that NAD levels decrease when axons degenerate. Finally, they showed that giving NAD directly also prevented axon degeneration.

NAD is used extensively by cells to produce energy through the breakdown of carbohydrates. Its chemical precursor, nicotinamide, has several characteristics that make it a promising therapeutic agent: it readily crosses the blood-brain barrier, is inexpensive and available in any drugstore, and its close relative, vitamin B3, is already used clinically to treat pellagra (vitamin B3 deficiency), high cholesterol, and other disorders. Although nicotinamide is thought to have few side effects, the doses used in mice would translate to much higher human doses than are normally used clinically, so would need to be tested for safety.

"We hope that our work will initiate a clinical trial, and that nicotinamide could be used in real patients," Kaneko says. "In the early phase of MS, anti-inflammatory drugs may work, but long-term you need to protect against axonal damage."The research was funded by the National Multiple Sclerosis Society and the National Institute of Neurological Disorders and Stroke.Note: This story has been adapted from a news release issued by Children's Hospital Boston.

MS & SoyNatural, Soy-based Substance Might Help Fight Multiple Sclerosis, Neuroscientists Find

Science Daily — A natural substance made from soy appears to have amazing restorative powers when given to animals with a multiple sclerosis (MS)-like disease.

Using an animal model of MS, neurologists at Jefferson Medical College found that giving doses of a substance called Bowmann-Birk Inhibitor Concentrate (BBIC) dramatically improved the animals' ability to move and walk. The scientists, led by A. M. Rostami, M.D., Ph.D., professor and chair of the Department of Neurology at Jefferson Medical College of Thomas Jefferson University and the Jefferson Hospital for Neuroscience in Philadelphia, say the treatment's effects may be useful in conjunction with more mainstream therapies such as beta-interferon in helping patients with MS. They report their findings December 12, 2006 in the journal Multiple Sclerosis.MS, one of the most common neurological diseases affecting young adults, is thought to be an autoimmune disease (in which the body attacks its own tissue) affecting the central nervous system (CNS). In MS, the myelin coating of nerve fibers becomes inflamed and scarred. As a result, "messages" cannot be sent through the nervous system.

Dr. Rostami, who is also director of the Neuroimmunology Laboratory in the Department of Neurology at Jefferson Medical College, and his group used an animal model of experimental autoimmune encephalomyelitis (EAE), which mimics MS, to investigate BBIC's potential immune system-suppressing properties. BBIC inhibits proteases, enzymes that play important roles in the inflammation and demyelination processes that are at the heart of MS. It has been used for other conditions, notably precancerous conditions in the mouth. He and his co-workers compared two groups of animals with EAE. One group received BBIC, while the other received only aninert substance. "Animals that received BBIC were able to walk while those that didn't get the drug were not," he says. He notes that the animals aren't cured but can walk with some limp or weakness. "The results are promising because this is a safe, natural compound from soybean and is given orally."

Further analysis revealed that the central nervous systems of animals that received BBIC showed "significantly less inflammation and demyelination" than those that didn't receive the therapy. "It's the first time that BBIC has been used in an EAE model and has shown significant disease suppression, and we hope it can eventually be used in humans," says Dr. Rostami. His group's next step is to design clinical trials in humans. The scientists are not sure how BBIC works in multiple sclerosis, but they theorize that it suppresses the immune response to some extent, in addition to inhibiting proteases. Dr. Rostami sees BBIC as being used as a single therapy or in conjunction with other drugs in treating MS. He notes that because current therapies for MS involve injecting drugs such as interferon and copaxane, one goal is to develop an oral agent. BBIC could be given by pill daily.

Over 400,000 Americans acknowledge having MS, though nearly one million Americans may be living with the disease. Symptoms can include fatigue, loss of coordination, muscle weakness, numbness, inability to walk or use hands and arms, pain, vision problems, slurred speech and bladder/bowel dysfunction.

Note: This story has been adapted from a news release issued by Thomas Jefferson University.

MS Tips

Hypericum gespritzt 2 ml plus Aloe D 2 (Frima Schumacher Deutschland)gespritzt 2 ml, je nach Stresssituation bzw. auch als Kur zwei Mal die Woche, in Italien hat meine beste Freundin ein Alternativkurzentrum, die beste Erfahrungen damit haben - ich aber auch.

Weiters sehr gut ist Inositol mit Cholin gemischt eins zu eins (ab besten gewonnen von der Brennessel), wobei zusätzlich Vitamin B zu nehmen ist. Natürlich kann man einwenden, da nehm ich gleich Lecithin, aber oft, wie ich auch bei mir bemerkt habe, ist das Pulver Inositol mit Cholin gemischt ein Teelöffel über den Tag gemischt mit einen halben Liter Wasser weitaus besser und man fühlt sich wirklich viel stärker.

MS Workbook Reference

The MS WorkbookBy authors: Kurt Johnson, Dawn Ehde, George Kraft, Robert FraserYour Essential Guide to Living Well with MS

You can live a fuller and more rewarding life with multiple sclerosis. In this book you'll find clear, practical tips for taking care of your health, your livelihood, and your relationships-step-by-step advice for creating real change in your life.

Recommended by leaders in the nation's top MS organizations, this book offers you more than just strategies for dealing with physical challenges. The authors, a team of experienced doctors and psychologists, offer tips to help you manage the emotional aspects of MS, too. Put these clear and straightforward techniques to use in your life today for greater physical comfort and mobility, financial security, and a more positive state of mind.

Learn how to:- Manage your physical and mental health care- Negotiate accommodation and comfort issues in the workplace - Stay on top of financial matters, including health insurance- Foster a strong sense of spirituality and community- Enjoy more intimate relationships and a better sex life- Utilize government and private resources and other sources of support

Bartonella & Vitamin DJAMA. 1998 Feb 18;279(7):532-4. Related Articles, Links Hypercalcemia due to endogenous overproduction of active vitamin D in identical twins with cat-scratch disease. Bosch X. Internal Medicine Unit, Hospital Casa Maternitat, Corporacio Sanitaria Clinic, Barcelona, Spain.

CONTEXT: The extrarenal synthesis of active vitamin D sterols has a central causative role in the hypercalcemia associated with various granulomatous diseases.

OBJECTIVE: To study the calcium metabolism in patients with cat- scratch disease who have hypercalcemia. DESIGN: Case report. SETTING: University hospital in Barcelona, Spain.

PATIENTS: Two identical twins who developed asymptomatic hypercalcemia during the acute phase of cat-scratch disease.

MAIN OUTCOME MEASURES: Serial measures of calcium homeostasis and metabolism over a 2-month period.

RESULTS: On admission and 6 and 7 days later, both patients were found to have increased levels of serum and urinary calcium, serum phosphate, and serum 1,25-dihydroxyvitamin D [1,25(OH)2D], whereas they had normal values of serum 25-hydroxyvitamin D and urinary cyclic adenosine monophosphate and decreased serum concentrations of intact parathyroid hormone. Sixteen and 20 days after admission, these abnormalities had resolved without treatment. A direct correlation was observed between the serum 1,25(OH)2D levels and both the serum and 24-hour urinary calcium concentrations. Also, the concentrations of calcium and1,25(OH)2D paralleled the clinical activity of the infectious disease over the period these parameters were measured.

CONCLUSIONS: Our cases provide evidence that cat-scratch disease can produce hypercalcemia through the unregulated production of the metabolite 1,25(OH)2D. Cat-scratch disease should be added to the list of granuloma-forming diseases that are responsible for 1,25(OH)2D-mediated hypercalcemia.

Bartonella & TeethResearchers conclude Napoleon's troops felled by liceBy Thomas H. Maugh II

Los Angeles Times: Louse-borne diseases such as typhus and trench fever devastated Napoleon's army during his ill-fated invasion of Russia in 1812, killing nearly one-third of his army, according to a study by French researchers.Napoleon invaded Russia with half a million men that summer, but escaped with only a few thousand. Twenty-five thousand French soldiers escaped to Vilnius, Lithuania during the retreat, but only 3,000 survived to continue the retreat. The rest were buried in mass graves.

Historians have long stressed the role of disease in the deaths, but now Dr. Didier Raoult and his colleagues at the Universite de la Mediterranee in Marseille, France, have provided the first firm evidence confirming this supposition. The team worked with remains found during construction at a former Soviet Army barracks in the northern suburbs of Vilnius.

Napoleon's soldiers were known to be plagued with body lice, Raoult said.The team found body segments of five lice among clothing remnants from the soldiers. Three of the five lice contained DNA from "Bartonella quintana," which causes the disease known as trench fever, they reported this week in the online version of the Journal of Infectious Diseases.

They also studied dental pulp from the unerupted teeth of 35 soldiers. Teeth from seven of the soldiers carried DNA from "B. quintana" and those from three others contained DNA from "Rickettsia prowazakii," which causes epidemic typhus.When the DNA of such a deadly agent is present in teeth, the team wrote, "It is very likely that the organism was the cause of death."

BabesiaPIROPLASMOSIS (Babesiosis)

Piroplasms are not bacteria, they are protozoans. Therefore, they will not be eradicated by any of the currently used Lyme treatment regimens. Therein lies the significance of co-infections — if a Lyme patient has been extensively treated yet is still ill, suspect a co-infection.

Babesia infection is becoming more commonly recognized, especially in patients who already have Lyme Disease. It has been published that as many as 66% of Lyme patients show evidence of co-infection with Babesia. It has also been reported that Babesial infections can range in severity from mild, subclinical infection, to fulminant, potentially life-threatening illness. The more severe presentations are more likely to be seen in immunocompromised and elderly patients. Milder infections are often missed because the symptoms are incorrectly ascribed to Lyme. Babesial infections, even mild ones, may recrudesce and cause severe illness. This phenomenon has been reported to occur at any time, even up to several years after the initial infection. Furthermore, asymptomatic carriers pose risks: to the blood supply as this infection has been reported to be passed on by blood transfusion, and to the unborn child from an infected mother as it can be transmitted in utero. Some quotes from the literature: Krause, PJ. Spielman, A, Telford, SR et.al. Persistent parasitemia after acute Babesiosis N Engl J Med 1998. 339:160

“The clinical spectrum of human Babesiosis ranges from an apparently silent infection to a fulminant malaria-like disease.” “When left untreated, silent Babesial infection may persist for months to years." “Silent infections, which occur in about a third of infected people, may recrudesce." “Babesial infection may recrudesce after many months of asymptomatic parasitemia.” “Although parasites were initially detected microscopically in the blood of two of the untreated subjects, and all of the treated subjects, none could be found a week after the onset of illness.” “Persistent symptoms of Babesiosis accompanied persistent blood-borne Babesial DNA.” “The persistence of seroreactivity increasingly correlated with the persistence of Babesial DNA.” “In those with only subtle symptoms, Babesiosis often remains undiagnosed.”

“Furthermore, physicians tend not to recognize Babesial infection in those who are co-infected with the agent of Lyme Disease, because Babesial symptoms tend to be ascribed to Lyme Disease.” “Physicians caring for patients with moderate to severe Lyme disease should consider obtaining diagnostic tests for Babesiosis and possibly other tick-borne pathogens... especially in patients experiencing "atypical Lyme disease” or patients in whom the response to antibiotic treatment is delayed or absent.”

Krause, PJ, Telford, SR, Spielman, A, et.al. Concurrent Lyme disease and Babesiosis. JAMA 1996. 275 (21):1657

Brain and HerpesHerpes Virus May Play Role In Central Nervous System Diseases

ScienceDaily (Dec. 25, 2007) — Scientists have discovered evidence suggesting a herpesvirus may be responsible for some cases of meningitis and encephalitis.Human herpesvirus 6 (HHV-6) is one of the most prevalent in humans. There are two variants of HHV-6, HHV-6A and HHV-6B which is attributed to a common childhood disease characterized by a high fever and rash. Studies indicate that by age 3 the majority of children have been infected by HHV-6, after which the virus persists in the salivary glands into adulthood. The virus may remain dormant or reactivate in immunocompetent or immunocompromised individuals.Over a span of four years, researchers from the New York State Department of Public Health, Albany and SUNY, Albany collected specimens from patients hospitalized with symptoms of encephalitis and meningitis, and tested them for the presence of HHV-6. The majority of the specimens were taken from cerebrospinal fluid and some of the symptoms exhibited by the patients include fever, altered mental status, and abnormal CSF profile, as well as seizures in those ages 3 and under.Adapted from materials provided by American Society for Microbiology.Need to cite this story in your essay, paper, or report? Use one of the following formats: American Society for Microbiology (2007, December 25). Herpes Virus May Play Role In Central Nervous System Diseases. ScienceDaily. Retrieved December 26, 2007, from http://www.sciencedaily.com- /releases/2007/12/071221094901.htm

Human Herpes Virus 6B Is Associated With Mesial Temporal Lobe Epilepsy

ScienceDaily (May 30, 2007) — There is strong evidence that one particular type of epilepsy is associated with a viral infection, according to new research. The international group of researchers, led by Steve Jacobson from National Institute of Neurological Disorders and Stroke, USA, found DNA from the virus, Human Herpes Virus 6B (HHV-6B) in specific regions of the brains in 11 of 16 patients with mesial temporal lobe epilepsy (MTLE) referred for investigation compared with zero of seven (0%) patients without MTLE. Citation: Fotheringham J, Donati D, Akhyani N, Fogdell-Hahn A, Vortmeyer A, et al. (2007) Association of human herpesvirus- 6B with mesial temporal lobe epilepsy. PLoS Med 4(5): e180.(http://medicine.plosjournals.org/perlserv/"request=get-document&doi=10.1371/journal.pmed.0040180)Adapted from materials provided by Public Library of Science.

Lyme and MycoplasmaWhat If It's Not Lyme Disease? - Groundbreaking Research May Provide Answers To Why Many Chronic Sufferers Don't Respond To TreatmentMain Category: University of New Haven Article Date: 13 Jun 2007 - 1:00 PDT

It is common knowledge that Lyme disease can be difficult to diagnose and treat, but, according to Eva Sapi, Ph.D., assistant professor of cellular and molecular biology at the University of New Haven-and unbeknownst to the public and even many physicians-the deer ticks so notorious for carrying Lyme disease may often carry other crippling bacteria.

Sapi, an assistant professor of biology and environmental science at the University of New Haven, and several graduate students recently presented research demonstrating that over 84 percent of the ticks they tested were infected by Mycoplasma pathogens, bacteria which can wreak havoc reminiscent of the Borrelia bacterium responsible for Lyme disease. "Doctors are starting to realize that some of the patients who exhibit symptoms of Lyme disease but don't respond to treatment may be infected with a Mycoplasma pathogen," Sapi says. "We now have evidence of the presence of human pathogenic Mycoplasma species in deer ticks."

Sapi presented the research, "Recent Discoveries of Novel Pathogens in Ixodes Ticks in Southern Connecticut," during the national Lyme disease conference at UNH in May, and will submit it for publishing later this month. She notes that other studies have shown that some patients not responding to treatment for Lyme disease have responded to treatment for Mycoplasma. Determined to find the "missing link," Sapi and her cohorts tested 150 deer ticks for Mycoplasm bacteria, with over 84 percent of the ticks exhibiting infection with a single Mycoplasma pathogen. Co-infection rates were also very significant, at 27 percent, and three percent of the ticks were infected with all three Mycoplasma pathogens.

"More comprehensive studies on the transmission of Mycoplasma from ticks to humans need to be carried out to prove whether they are, in fact, transmitted from the ticks to humans," Says Sapi. "But, in the meantime, more doctors should consider testing suspected Lyme disease patients who are not responding well to treatment for Mycoplasma."

A leader in experiential learning, the University of New Haven provides its students with a unique combination of solid liberal arts and real-world, hands-on professional training. A private University founded in 1920, UNH has a full-time undergraduate enrollment of more than 2,400 students-with 70 percent residing on its 80-acre main campus-and a graduate school enrollment that exceeds 1,700. The University offers more than 80 undergraduate degrees and more than 25 graduate degrees through its four colleges, in fields such as sports management, nutrition and dietetics, forensic science, music and sound recording, engineering, computer science, fire science and criminal justice. University of New Haven students study abroad through a variety of distinctive programs.

Brain and MercuryStudies Link Other Ills to Mercury, Too By MARIAN BURROS Published: January 23, 2008In the past few years, several studies have concluded that elevated mercury levels may be associated not only with neurological problems but with cardiovascular disease among adults as well.One of the studies, reported by Dr. Eliseo Guallar, an associate professor of epidemiology at the Johns Hopkins School of Public Health, in 2002 in The New England Journal of Medicine, looked at men in European countries and Israel. The mercury levels among men who had had a heart attack were 15 percent higher than those who had not. In 2006, a National Academy of Sciences’ Institute of Medicine report titled “Seafood Choices: Balancing Benefits and Risks” acknowledged some of these findings, saying that “increased methylmercury exposure might be a risk factor for adult cardiovascular toxicity.” The report added, “For child neurodevelopment and adult cardiovascular health, emerging evidence suggests that the health benefits of seafood consumption are greater among individuals whose body burden of methylmercury is lower.”Other studies have concluded that the benefits of consuming fish, because it contains omega-3 fatty acids that may help prevent heart disease, may outweigh the risks of mercury contamination. Dr. Dariush Mozaffarian, a cardiologist and assistant professor of medicine and epidemiology at Harvard Medical School, said that “the evidence is inconsistent that high mercury level has any effect” on the risk of cardiovascular death among adults. More research had to be done, Dr. Mozaffarian said.But some researchers who have examined thelinks between mercury and cardiovascular disease agree with Dr. Ellen Silbergeld, professor of environmental health sciences andepidemiology at Johns Hopkins School of Public Health, who said “the existing evidence is strong and striking,” even though morestudies were needed“It is very unwise to wait until we have complete scientific truth,” said Dr. Philippe Grandjean, adjunct professor of environmental health at the Harvard School of Public Health and chairman of the department of environmental medicine at the University of SouthernDenmark. “The prudent judgment is to protect human health.” There is also recent epidemiological evidence on the relationship between mercury and neurological problems. One study, published in Environmental Health in 2003, linked low-level methylmercury exposurewith impaired dexterity and concentration. The greater the mercury level, the greater the effect, the researchers found. The study also suggested that adults exposed to methylmercury might be at risk for vision loss and numbness of fingers and toes as well as blood pressure and fertility problems. Increasing numbers of physicians are reporting on signs of mercury poisoning among patients who eat large quantities of fish.Dr. Jane Hightower, a clinician and diagnostician in San Francisco, evaluated more than 100 patients who had vague, unexplained symptoms. Of them, 89 percent had mercury in their blood that exceeded the level considered acceptable by the Environmental Protection Agency. The symptoms included memory lapses, hair loss, fatigue, sleeplessness, tremors, headaches, muscle and joint pain, trouble thinking, gastrointestinal disturbances and an inability to do complex tasks.Dr. Hightower tracked 67 of the patients, directing them to stop eating all fish. After 41 weeks, all but two had blood mercury levels lower than the level considered acceptable. Her clinical observations, published in 2003 in Environmental Health Perspectives, indicate that such neurological problems in otherwise healthy adults recede when blood mercury levels go down. No one is recommending that people stop eating fish, unless their blood mercury levels are dangerously high. In fact, health professionals and researchers encourage eating seafood selectively, choosing species, like salmon and sardines, that have high omega-3 fatty acids and low levels of mercury. Fish in the diet “is not an all-or-nothing story,” Dr. Silbergeld said. “The trick is to figure out which ones to eat.”

Brain and Folate

Key vitamin deficiency linked to tripled risk of dementia study:Tue Feb 5, 9:25 AM ET

PARIS (AFP) - Lack of folate, also called vitamin B-9, may triple the risk of developing dementia in old age, according to a study published Tuesday. Researchers in South Korea measured naturally occurring folate levels in 518 elderly persons, none of whom showed any signs of dementia, and then tracked their development over 2.4 years.

At the end of the period, 45 of the patients had developed dementia, including 34 diagnosed with Alzheimer's disease, said the study, published by the British Medical Association's Journal of Neurology, Neurosurgery and Psychiatry.When the researchers, led by Jin-Sang Yoon of Chonnam National University in Kwangju, South Korea, remeasured folate levels, they uncovered a strong link with the dementia.Even after other factors were taken into account -- including age, disability, alcohol consumption, weight change -- "the onset of dementia was significantly associated with an exaggerated decline in folate," the researchers concluded.

Folate and folic acid, another form of the compound, are essential for the creation of new cells in the body.The compound occurs naturally in leafy vegetables such as spinach, turnip greens, lettuces, dried beans and peas and in certain fruits.An study published last year in The Lancet showed an improvement in short-term memory, mental agility and verbal fluency among persons over 50 who took a daily dose of 800 micrograms (mcg) of folic acid. The US recommended daily dose is 400 mcg.

Taking folic acid before conception and throughout the first trimester helps a mother ensure that her child will not develop certain brain and spinal cord defects, including spina bifida, according to previous research

Brain – Magnetic FieldsTranscranial Magnetic Stimulation Reduces Auditory Hallucinations in SchizophreniaNEW YORK (Reuters Health) medscape- Apr 20 - Slow repetitive transcranial magnetic stimulation appears to be an effective treatment for resistant auditory hallucinations in schizophrenic patients, according to results of a meta-analysis published in the March issue of the Journal of Clinical Psychiatry.

"Slow repetitive transcranial magnetic stimulation (rTMS), at a frequency of 1 Hz, has been proposed as a treatment for auditory hallucinations," Dr. Andre Aleman, of the University of Groningen, the Netherlands, and colleagues write. "Several studies have now been reported regarding the efficacy of TMS treatment, but results were inconsistent.“

They therefore applied meta-analytic techniques integrate data from 10 trials of rTMS that were sham-controlled and met inclusion criteria. All of the studies targeted the left temporoparietal cortex using 1 Hz rTMS. A total of 212 subjects were included in the studies.

A significant mean weighted effect size was observed for rTMS versus sham across the 10 studies (d = 0.76, p = 0.0001). Significant heterogeneity was observed among individual effect sizes. When only the nine studies that used continuous stimulation were included, the mean effect size increased to 0.88 (p < 0.0001), and heterogeneity disappeared.

The team found no significant effect of rTMS on a composite index of general psychotic symptoms.On a clinical level, the investigators note, rTMS may be a promising method for reducing the frequency and intensity of auditory hallucinations in treatment-resistant schizophrenic patients.

"On a more fundamental note, the evidence of reduction of hallucinations after magnetic stimulation over the left temporoparietal cortex may yield clues to the pathophysiology of auditory hallucinations," Dr. Aleman's team points out. "That is, the finding that reducing cortical excitability in speech perception areas may interfere with hallucinations suggests aberrant activation of language perception areas as a cause of auditory hallucinations.

Options for Elimination of Neurotoxins

Injections for Detox

DMPS: 3 mg/kg once per month i.m or slow i.v.IV Vitamin C: 37-50 grams in 500 ml distilled water with 10 ml Ca gluconateGlutathione: 1200 mg 1-3x weekly, IV pushAlpha-lipoic acid: 600 mg in normal saline (250 cc) over 1 hrPhospholipids (Lipostabil – German product): 2 ampoules diluted with client’s blood (50:50) given slow IV over 3 minutesCalcium EDTA: 4-10 ml slow IV push once weeklyZinc DTPA (not available in the US)Desferal: 500 mg in 4 divided doses over 4 days, 500 mg/week or up to 1x monthly (Kruck protocol for Alzheimer’s disease)DMPS and glutathione: very effective in neural therapy and ganglion blocks (9 part procaine, 1 part glutathione or DMPS)

Oral Detox AgentsChlorella: 4-16 grams/dayCilantro: 10-15 drops in hot water at night, or topical as segmental therapy treatment“Matrix Metals” 2-8 sprays twice dailyNDF and NDF Plus (nanonized cilantro and chlorella): 1-10 drops twice dailyMalic acid (aluminum)Intestinal binding: beta sitosterol, charcoal, chlorella, apple pectinDMSA: 10 mg/kg/day in divided doses q3-4 h (3 days on, 11 days off)D-Penicillamine (Russell Jaffe protocol)D-Alpha Lipoic: 100 mg q 3-4 hours (600 mg/day)- helps glutathione bound toxins to make it through the cell wall Organic freeze dried garlic (energetically enhanced from BioPure) : 2-3 caps after each meal 3-4 times/dayPhospholipid Exchange (from BioPure: energized phospholipids, alpha-Lipoic acid, magnesium and Na-EDTA)-enhances acetylcholine in the braincold processed whey (branched chain amino acids)Forceful electrolyte supplementation (Matrix Electrolyte from BioPure is the most balanced and best tolerated formula for metal detox)Forceful trace mineral supplementation, including copper (only Albion chelated minerals are absorbed in sufficient quantity, from Design for Health)Carnosine: 1000 mg 3x daily (prevents collagen breakdown)Branched chain amino acids: valine, leucine and iso-leucine (high in all whey products) Correct neurotransmitter imbalances (use Braverman test from “The Edge Effect”)Dopamine is most depleted when chronic infections are present. Use Mucuna powder as precursor

Adjunctive Modalities

SaunaElectro-mobilization (Toxaway foot bath, KMT 24, KMT 300)Mercury vapor lampPhoto-mobilization (IR- light shield, Photon Wave, Dinshah color therapy, Mandel color puncture, BioPure eye glasses)Colon hydrotherapyLymphatic drainage (KMT or Vodder technique)Foot pads (Segiun, Kinotakara)Applied Psychoneurobiology / MFTAlpha tocopherol: 1200-2400 IU/day during acute reverse toxicityMethylcobalamin: IV with procaine (McGuff: (800) 854-7220)Selenium: locks Hg into inert complex, which can be removed via sauna txHyaluronic acid: enhances IV therapy

Blood Brain Barrier Visual

Diagram of a cerebral capillary enclosed in astrocyte end-feet. Characteristics of the blood-brain barrier are indicated: (1) tight junctions that seal the pathway between the capillary (endothelial) cells; (2) the lipid nature of the cell membranes of the capillary wall which makes it a barrier towater-soluble molecules; (3), (4), and (5) represent some of the carriers and ion channels; (6) the 'enzymatic barrier'that removes molecules from the blood; (7) the efflux pumps which extrude fat-soluble molecules that have crossed into the cells

Blood Brain Barrier HistoryThe blood-brain barrier (BBB) is a membranic structure that acts primarily to protect the brain from chemicals in the blood, while still allowing essential metabolic function. It is composed of endothelial cells, which are packed very tightly in brain capillaries. This higher density restricts passage of substances from the bloodstream much more than endothelial cells in capillaries elsewhere in the body. Astrocyte cell projections called astrocytic feet (also known as "glial limitans") surround the endothelial cells of the BBB, providing biochemical support to those cells. The BBB is distinct from the similar blood-cerebrospinal fluid barrier, a function of the choroidal cells of the choroid plexus.

The existence of such a barrier was first noticed in experiments by Paul Ehrlich in the late-19th century. Ehrlich was a bacteriologist who was studying staining, used for many studies to make fine structures visible. When injected, some of these dyes (notably the aniline dyes that were then popular) would stain all of the organs of an animal except the brain. At the time, Ehrlich attributed this to the brain simply not picking up as much of the dye.

However, in a later experiment in 1913, Edwin Goldmann (one of Ehrlich's students) injected the dye into the spinal fluid of the brain directly. He found that in this case the brain would become dyed, but the rest of the body would not. This clearly demonstrated the existence of some sort of barrier between the two. At the time, it was thought that the blood vessels themselves were responsible for the barrier, as no obvious membrane could be found. The concept of the blood-brain barrier (then termed hematoencephalic barrier) was proposed by Lina Stern in 1921.[1] It was not until the introduction of the scanning electron microscope to the medical research fields in the 1960s that the actual membrane could be demonstrated.

It was once believed that astrocytes rather than epithelial cells were the basis of the blood-brain barrier because of the densely packed astrocyte processes that surround the epithelial cells of the BBB.

Blood Brain Barrier PhysiologyIn the rest of the body outside the brain, the walls of the capillaries (the smallest of the blood vessels) are made up of endothelial cells which are fenestrated, meaning they have small gaps called fenestrations. Soluble chemicals can pass through these gaps, from blood to tissues or from tissues into blood. However in the brain endothelial cells are packed together more tightly with what are called tight junctions. This makes the blood-brain barrier block the movement of all molecules except those that cross cell membranes by means of lipid solubility (such as oxygen, carbon dioxide, ethanol, and steroid hormones) and those that are allowed in by specific transport systems (such as sugars and some amino acids). Substances with a molecular weight higher than 500 daltons (500 u) generally cannot cross the blood-brain barrier, while smaller molecules often can. In addition, the endothelial cells metabolize certain molecules to prevent their entry into the central nervous system. For example, L-DOPA, the precursor to dopamine, can cross the BBB, whereas dopamine itself cannot. (As a result, L-DOPA is administered for dopamine deficiences (e.g., Parkinson's disease) rather than dopamine).

In addition to tight junctions acting to prevent transport in between endothelial cells, there are two mechanisms to prevent passive diffusion through the cell membranes. Glial cells surrounding capillaries in the brain pose a secondary hindrance to hydrophilic molecules, and the low concentration of interstitial proteins in the brain prevent access by hydrophilic molecules.[2]

The blood-brain barrier protects the brain from the many chemicals flowing within the blood. However, many bodily functions are controlled by hormones in the blood, and while the secretion of many hormones is controlled by the brain, these hormones generally do not penetrate the brain from the blood. This would prevent the brain from directly monitoring hormone levels. In order to control the rate of hormone secretion effectively, there exist specialised sites where neurons can "sample" the composition of the circulating blood. At these sites, the blood-brain barrier is 'leaky'; these sites include three important 'circumventricular organs', the subfornical organ, the area postrema and the organum vasculosum of the lamina terminalis (OVLT).

The blood-brain barrier acts very effectively to protect the brain from many common infections. Thus, infections of the brain are very rare. However, since antibodies are too large to cross the blood-brain barrier, infections of the brain which do occur are often very serious and difficult to treat.

Blood Brain Barrier PapersNew Method For Crossing Blood-Brain Barrier PatentedScienceDaily (May 26, 2007) — The blood-brain barrier is a group of cells that line the brain’s blood vessels, protecting vital brain structures from foreign substances. The barrier has posed enormous difficulties for researchers who want to deliver therapeutic drugs to the brain to treat tumors, infections and degenerative brain diseases such as Alzheimer’s and Parkinson’s. Researchers are hopeful that this will some day be helpful to patients, according to Daniel Alkon, M.D., scientific director of BRNI. “This may lead to a powerful new tool that clinicians can use to treat brain diseases,” U.S. patent number 7,220,833, “Artificial Low-Density Lipoprotein Carriers for Transport of Substances Across the Blood-Brain Barrier,” was issued to BRNI for this development May 22. Adapted from materials provided by West Virginia University.Transport System Smuggles Medicines Into BrainScienceDaily (Feb. 16, 2005) — Dutch researcher Corine Visser investigated a new way of transporting medicines into the brain. Her approach made use of an iron transport system located on the blood-brain barrier. The smaller the medicine, the more easily it penetrates the brain. A special barrier between the blood and the brain, the so-called blood-brain barrier (BBB), protects the brain from toxic substances. It only lets through important nutrients for the brain such as iron, glucose and oxygen. Visser allowed largermolecules, such as medicines, to pass through the blood-brain barrier by attaching these to the iron-containing The research was funded by the Netherlands Organisation for Scientific Research.Adapted from materials provided by Netherlands Organization For Scientific Research.Blood-brain Barrier: A Misunderstood Key To Finding Life-saving Cures To Brain DiseaseScienceDaily (Dec. 18, 2007) — An international team of scientists that includes a Saint Louis University researcher suggest several strategies to propel research for treatments of brain diseases that include multiple sclerosis, Alzheimer's disease, obesity and stroke in the January issue of the Lancet Neurology.The blood-brain barrier is a gate-keeping system of cells that protects the brain from toxins and lets in nutrients. Because it passes no judgment on which foreign substances are there to treat diseases and which are penetrating the brain to do harm, it locks all of them out. That makes getting drugs into the brain where they can do their work in treating brain diseases difficult.Sometimes the blood-brain barrier lets in things that it shouldn't and doesn't let out things that it should. Learning more about the secrets of the blood-brain barrier system is critical in understanding Alzheimer's disease, for instance, because the BBB makes it difficult to target medication where it's needed in the brain and won't allow toxic amyloid beta proteins, believed to cause Alzheimer's, to drain out of the brain.(BBB), is available in an early online edition on Dec. 17.

University Of Maryland Researchers Discover "Key" To Blood-Brain BarrierScienceDaily (Jan. 4, 2000) — Findings Could Lead to New Treatments for Brain DisordersResearchers at the University of Maryland School of Medicine in Baltimore have identified a receptor in the human brain that regulates the interface between the bloodstream and the brain, which is known as the blood-brain barrier. This breakthrough could lead to a better understanding of this nearly impenetrable barrier and to treatment of diseases that affect the brain, such as Multiple Sclerosis, brain tumors, meningitis, Alzheimer's disease, and HIV infection. The findings are published in the January issue of the Journal of Neurochemistry. Adapted from materials provided by University Of Maryland Medical Center.University Of Maryland Medical Center (2000, January 4). University Of Maryland Researchers Discover "Key" To Blood-Brain Barrier. ScienceDaily. Retrieved December 18, 2007, from http://www.sciencedaily.com- /releases/2000/01/000104065455.htm