bovine respiratory syncytial virus (brsv)
TRANSCRIPT
Bovine respiratory syncytial virus (BRSV).
Mirjam Laht
Introduction Problematic vaccination Procedures Diagnosis Treatment
Vaccination
Conclusions References
Outline
Formates syncytial cells Related to human BRSV High morbility rate (0-20) Many research about the effects of vaccination
Transmission via respiratory aerosols or direct contact
What BRSV is ?
Vaccine Lack of efficiency Apparent disease enhancementResearch Conducting Experimental challenge does not, unlike natural infection, result in respiratory tract disease
Problematic vaccination
Labile virus → isolation is rarely successful from the tissue of a post-mortem animal.
tracheal wash or lung lavage
Vaccinating
↓ Infecting
↓Searching clinical signs
→ cough, fever, depression, decreased feed intake, increased respiratory rate, nasal and
ocular discharge (subcutaneous emphysema)↓
Procedures
↓Killing calves
↓IFA, lungs examining and histochemical
research, sometimes also virus neutralising tests, enzyme
immunoassays (antigen, antibody detection), nucleid acid detection tests
and histopathology
Gross necropsy lesions: severe pulmonary edema interstitial emphysema
nasal swabs 3 samples of recently infected animals Reliable proof of virus can only be
provided in a period of 6 days after infection
IFA
Diagnosis
3 ways1)Supportive therapy• removing infected animals from the
group2) Antimicrobials 3)anti-inflammatory drugs (non – steroidal ones) → aspirin for food animals
Treatment
stressed cattle may not respond should be done after the maternal
antibodies have declined using inactivated or modified live vaccine
Short time protection have to revaccinate often
Vaccinating on branding or processing, weaning ,every following year
Vaccination
It is important to remember that: respiratory aerosols or direct contact Researches haven´t shown a
difference between vaccining one , two or three time
Most susceptible are housed calves aged 4 weeks to 4 months
Conclusion
http://homepage.usask.ca/~vim458/virology/studpages2009/VirusWebsite/brsv.html
http://www.animalhealth.bayerhealthcare.com/3372.0.html
https://animalhealth.pfizer.com/sites/pahweb/US/EN/Conditions/Pages/Bovine_Respiratory_Syncytial_Virus.aspx
http://www.addl.purdue.edu/newsletters/1997/spring/brsv.shtml
Used materials
Thank you !