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ICFAS2017

International Congress on Fundamental and Applied Sciences

21-25 August 2017 Sarajevo, Bosnia and Herzegovina

Book of Abstracts

icfas2017.intsa.org

Editors

Muhammet Kurulay Elif Segah Öztaş

ISBN 978-605-67052-1-2

International Congress on Fundamental and Applied Sciences 2017 (ICFAS2017)

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WELCOME NOTE “In the name of Allah, the Most Compassionate and the Most Merciful”. Thus first of all we are very grateful to Allah (s.w.t) that provided the life to meet all of us during this memorable occasion and all praise to be upon Muhammad (s.a.w) who is guidance for the entire universe. It is my great pleasure that I welcome you to the International Congress on Fundamental and Applied Sciences 2017 ( ICFAS2017). I feel truly honored to have the opportunity of addressing you for several reasons. As chairman of this international conference, one of the reasons that I am honored, International University of Sarajevo organizing this activity. ICFAS 2017 provides an ideal academic platform for researchers to present the latest research and emerging findings of Fundamental and Applied Sciences on Mathematics, Physics, Chemistry, Biology and Statistics and applications of these areas. The conference seeks to contribute to presenting novel research results in all aspects of Fundamental and Applied Sciences. The conference aims to bring together leading academic scientists, researchers and research scholars to exchange and share their experiences and research results about all aspects of Fundamental and Applied Sciences. It also provides the premier interdisciplinary forum for scientists, researchers, and practitioners to present their latest research results, ideas, developments, and applications in all areas of Fundamental and Applied Sciences. The conference brings together leading academic scientists, researchers and scholars in the domain of interest from around the world. This conference is an achievement of international cooperation we continuously strive to carry out and nourish. Therefore, on behalf of chairman of this conference and my own, I would particularly like to thank: Prof. Dr. Mehmet Can from International University of Sarajevo, Prof. Dr. Mehmet Seven Istanbul University I would also like to thank the persons who are involved in the scientific and organizational committee of the conference. Thank you, to each and every one of you, for taking the time to be part of this event and for honoring it with your presence. I would like to extend my best wishes to all of you with a hope that you go back with new and more powerful insights, and with new networks renewed or extended. Best wishes for an enjoyable and memorable conference! Muhammet Kurulay - Conference Chairman


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ICFAS2017 Committees Conference Chair Muhammet Kurulay, Yildiz Technical University Scientific Committee Ali Erdogmus, Yildiz Technical University Mehmet Can, International University of Sarajevo Masood Khalique, North-West University Khalid Jbilou, LMPA Abdelouahab Kadem, University of Setif M. Fatih Karaaslan, Yildiz Technical University Muhammet Kurulay, Yildiz Technical University Hari Mohan Srivastava, University of Victoria Elif Segah Oztas, Karamanoglu Mehmetbey University Fateh Ellaggoune, University of Guelma Hamid Boulares, University of Guelma Mustapha Hached, LMPA Shankar Lal Gargh Xiao Jun Yang, Dep. of Math. and Mechanics, China University of Mining and Technology Carlo Cattani, University of Tuscia, Mathematics, Italy Organizing Committee Yaprak Guldoğan, Yildiz Technical University M. Fatih Karaaslan, Yildiz Technical University Meltem Uzun, Yildiz Technical University Elif Segah Oztas, Karamanoglu Mehmetbey University Mirsad Yesiltepe, Yildiz Technical University


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Participants

Abdullah Yener [email protected]

Abdurrahman Akdag [email protected]

Ahmet Turgut Bı̇lgı̇çlı̇ [email protected]

Ahmet Yönetken [email protected]

Ahmet Yucekaya [email protected]

Ali Arslantas [email protected]

Anuar Ishak [email protected]

Armağan Günsel [email protected]

Ayla Doğan [email protected]

Ayse Sandikci [email protected]

Aysun Tok Onarcan [email protected]

Ayşe Yilmaz Demı̇r [email protected]

Barış Koçer [email protected]

Caner Deger [email protected]

Cemil Akkaş [email protected]

Ceyda Akbulut [email protected]

Elif Loğoğlu [email protected]

Elif Segah Öztaş [email protected]

Elif Tüzün [email protected]

Emel Ermiş [email protected]

Esra Karabal [email protected]

Fatih Temiz [email protected]

Fikriye Kurtoğlu [email protected]

Fuat Erkül [email protected]

Funda Çatan [email protected]

Göknur Yaşa Atmaca [email protected]

Hacer Dolas [email protected]

Hakan Ersoy [email protected]


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Hasan Kiliç [email protected]

Hasan Sadikoglu [email protected]

Hasan Yakan [email protected]

Hasan Yildirim [email protected]

Hasniye Yaşa [email protected]

Hidayet Çalişkan [email protected]

Hüseyin Adanır [email protected]

Hüseyin Çiçek [email protected]

Ibrahim Berkan Aydilek [email protected]

İbrahim Atmaca [email protected]

Levent Öztürk [email protected]

Mehmet Emin Koroglu [email protected]

Mehmet Fatih Karaaslan [email protected]

Mehmet Özen [email protected]

Mehmet Seven [email protected]

Meltem Uzun [email protected]

Merhmet Can [email protected]

Merve Cengiz Toklu [email protected]

Meryem Nilüfer Yaraşır [email protected]

Mesut Isik [email protected]

Mirsat Yeşiltepe [email protected]

Muhammet Arici [email protected]

Murat Bingül [email protected]

Murat Ibrahim Yazar [email protected]

Mustafa Akyol [email protected]

Nadir Ayrilmis [email protected]

Necla Bektaş [email protected]

Nevin Kanışkan [email protected]

Nihan Akin Sonmez [email protected]

Ozlem Ersoy Hepson [email protected]


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Özlem Kaştan [email protected]

Roslinda Nazar [email protected]

Sait Ali Uymaz [email protected]

Salih Paşa [email protected]

Semiha Kundakci [email protected]

Sena Kır [email protected]

Sibel Tatar Erkül [email protected]

Suleyman Ozcelik [email protected]

Şükriye Güveli [email protected]

Şükriye Ulubay Karabiberoğlu [email protected]

Şükrü Beydemir [email protected]

Taner Kalaycı [email protected]

Tuba Çayir [email protected]

Yaprak Dericioğlu [email protected]

Yasemin İşlek Coşkun [email protected]

Yasemin Süzen [email protected]

Yavuz Selim Aşçi [email protected]


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RECURRENT NEURAL NETWORKS FOR LINEAR B-EPITOPE PREDICTION

Mehmet Can, Betul Akcesme, Faruk Akcesme, Muhamed Adilovic

Faculty of Engineering and Natural Sciences, International University of Sarajevo [email protected], [email protected], [email protected], [email protected]

Abstract: B- and T- Cytotoxic T lymphocyte (CTL) epitopes are potential candidates for subunit vaccine design for various diseases which are caused by viral or bacterial antigens. Most of the existing T cell epitope prediction methods are indirect methods that predict MHC class I binders instead of identifying CTL epitopes directly. In this research work, a using recurrent neural networks, a systematic attempt has been made to develop a direct method for predicting b-epitopes from an antigenic sequence. 262.583 B epitopes are retrieved from iedb database (http://www.iedb.org/database_export_v3.php) 99.9% of these epitopes have lengths 6-25 amino acids. For each window size, 11 experts as recurrent neural networks are trained. To train these experts alongside epitopes, non epitopes re needed. Non epitopes are created as random sequences of amino acids of the same length after a filtering process. To distinguish epitopes and non epitopes, the votes of eleven experts are aggregated by majority vote. An overall accuracy of 97.23% is achieved. Then these experts are used to predict the linear b-epitopes of antigens, among them Meningitis, Plasmodium falciparum (malaria), Plasmodium vivax (Malaria), ESAT6 (Tuberculosis). Results obtained compare with the predictions by famous online tools, and it is seen that the success of our experts of recurrent neural networks over scores other online tools. Keywords: Linear b-epitopes, inslico drug design, neural networks


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EFFECTS OF ENVIRONMENTAL FACTORS ON HUMAN HEALTH AND EXPERT SUGGESTIONS

Mehmet Seven1, Mehmet Bugrahan Duz1, Selcuk Sozer Tokdemir1

1Deparment of Medical Genetics, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey

[email protected] Abstract: Research on anomalies formed by environmental, chemical, biological, and other agents and their developmental mechanisms is a topic of a different discipline in the science. Especially, during pregnancy period, environment may cause structural and/or functional defects in both pregnant women and her fetus. The most significant property of environmental factor caused diseases is that they are non-hereditary and can be prevented. Whereas, inherited diseases mostly cannot be prevented. In the earlier stages, people had been believed that death and diseases were related with some natural events such as lunar eclipse, solar eclipse, falling star in addition, up to middle of the last century, uterus was believed to be a protected area against environmental effects. People have accepted that congenital anomaly can be only genetic. Thalidomide, a medication used as sedative and an anti-emetic drug, have caused birth of armless and legless babies in Europe in 60's and that has ended up with birth of 12,000 disabled babies. In 1964-65, 20,000 babies with congenital rubella syndrome have been born during rubella epidemic, and 15,000 of them have died in abortus/postnatal period in U.S. Effect of radiation on developing fetus, which causes anomaly, has been experienced with Hiroshima/Nagasaki events. Studies have shown that radiation may cause to abortus, intrauterine death, mental retardation, intrauterine growth retardation, multiple congenital anomalies, and childhood cancer. "Thalidomide tragedy" in Europe, rubella epidemic in U.S, and radiation disaster in far east have been attracted attention to the environmental factors and lead to change opinions of scientists which were believed to congenital disorders are genetic originated. More than 20,000 pregnant women have been inquire about counseling to Clinic of Genetics and Teratology of Department of Medical Genetics in Cerrahpasa Medical Faculty of Istanbul University. Pregnancy reports of the patients have been analyzed. Expert suggestions and behavior of women exposed radiation during pregnancy period before and after counseling are evaluated. 98% of women have exposed at least one teratogen and 95% of them have not known their pregnancy during examination. Since in the first month "all-or-non" principle is valid, environmental factor caused anomies are not expected, even that, women in their first month of pregnancy have directed to our clinic from private practices (37%), private hospitals (33%), public hospitals (29%), and university hospitals (34%). Suggestions to terminate the pregnancy are 57.2% in private practices, 54.5% in private hospitals, 44.4% in public hospitals, and 43.1% in university hospitals. According to last studies, till 15 rad is accepted in safety range for radiation exposure and, although, fetus exposes 0.01-10.3 rad (0.75±1.59), termination of pregnancy is suggested 79% in private practices, 58% in private hospitals, 55% in public hospitals, and 27% in university hospitals.


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As a conclusion, 6.4% of pregnants terminated their pregnancy at own request although they were informed as that radiation exposure dosage does not increase risk of anomaly. 93.6% of pregnants have decided not to terminate the pregnancy. After that suggestion, approximately 11,000 babies have been born healthy. Keywords: Environmental factors, health


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STAGNATION POINT FLOW AND HEAT TRANSFER TOWARD A VERTICAL CYLINDER

Anuar Ishak

School of Mathematical Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia

[email protected] Abstract: In the present study, the mixed convection boundary layer flow past a vertical cylinder with prescribed surface heat flux is considered. The free stream velocity and the surface heat flux are assumed to vary linearly from the stagnation point. The governing partial differential equations are transformed into a system of ordinary differential equations, before being solved numerically using the Keller-box method. The solutions are obtained for various values of the mixed convection parameter, the curvature parameter and the Prandtl number. Dual solutions are found to exist for both buoyancy assisting and opposing flows. A stability analysis is performed to determine the stability of the solutions. The results are compared with those of the flat plate for a special case when the curvature parameter is absent. Keywords: Cylinder, dual solutions, heat transfer, stagnation flow ID 1002


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A NEW APPROACH TO WEIGHTED HARDY-TYPE INEQUALITIES ON THE HEISENBERG GROUP

Abdullah Yener

Istanbul Commerce University, Istanbul 34445, Turkey [email protected]

Abstract: In this study, we get a constructive method to derive Hardy-type inequalities on the Heisenberg Group H with general weights V and W. More precisely, in the setting of Heisenberg Group H , let W ∈ L H and V ∈ C H be nonnegative functions and Φ ∈ C H be a positive function such that

∙ V z, l | Φ| Φ W z, l Φ almost everywhere in H , then for every ϕ ∈ C H there holds

V z, l | ϕ| dzdl W z, l |ϕ| dzdl c V z, lϕΦ

Φ dzdl

where p 2 and c c p 0. A generic point in H , n 1, is defined by z, l x, y, l ∈H where z x, y ∈ , l ∈ and|z| |x| |y| / . Here dzdl denotes the Lebesgue measure on and X , X , … , X , Y , Y , … , Y is the subelliptic gradient

in H , where X 2y and Y 2x , i 1, … , n are left invariant vector fields.

It is important to point out that, a similar inequality with a different nonnegative remainder term also exists for the case1 p 2. The method we use here is practical in the sense that, by using convenient functions instead of V and Φ, it allows to get several weighted Hardy-type inequalities including previously known and also new results. Keywords: Heisenberg group, Hardy inequality, Hardy-Poincaré inequality ID 1010


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SYNTHESIS OF THE 4-(2-AMINOETHYL)- BENZENESULFONAMIDE DERIVATIVES AND INHIBITORY ACTIVITY AGAINST HUMAN

PON1

Yeliz Demira, Mesut Işikb, Mustafa Durgunc, Adem Necipb, Hatice Esra Aslana, Şükrü Beydemird

aAtatürk University, Faculty of Sciences, Department of Chemistry, Erzurum, 25240, Turkey

[email protected], [email protected] bHarran University, Health Services Vocational School, Department of Pharmacy Services, Şanlıurfa

63000, Turkey [email protected], [email protected]

cHarran University, Faculty of Arts and Sciences, Department of Chemistry, Sanliurfa 63190, Turkey [email protected]

cAnadolu University, Faculty of Pharmacy, Department of Biochemistry, Eskişehir, 26470, Turkey [email protected]

Abstract: Paraoxonase (PON) is a mammalian lactonase that especially exists in the liver and HDL-bound enzyme. PON1 is synthesized in the liver and released from here into the blood. Decrease of PON1 activities may related with some metabolic or genetic disorders such as diabetes mellitus, rheumatoid arthritis, cardiovascular diseases, chronic renal failure, age-related macular degeneration and hyperthyroidism. Sulfonamides known as powerful carbonic anydrase inhibitors have used in clinical medicine since 1954. Even today they are widely used for the treatment or prevention of a variety of diseases. The present study focuses on the in vitro inhibition role of 4-(2-aminoethyl)- benzenesulfonamide on human paraoxonase (hPON1). Therefore, PON1 was purified from human serum with a specific activity of 2603.57 EU/mg and 8.34% yield with using simple chromatographic methods. Molecular weight of the enzyme was determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) as 43 kDa. These derivatives were tested at various concentrations and reduced in vitro hPON1 activity. IC50 values were found in the range of 0.968–288 µM. Ki values of compounds were found in the range of 0.2594–290.8 µM. Compound H-10 had the highest inhibitory effect for hPON1, while compound S-8i showed lowest inhibition. Keywords: Paraoxonase, sulfonamides, inhibition, SDS-PAGE ID 1013


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THREE DIMENSIONAL FLOW OF A NANOFLUID OVER A PERMEABLE STRETCHING/SHRINKING SURFACE WITH

VELOCITY SLIP: A REVISED MODEL

Rahimah Jusoh, Roslinda Nazar, Ioan Pop

Faculty of Industrial Sciences & Technology, Universiti Malaysia Pahang,

26300 Gambang, Pahang, Malaysia. [email protected]

School of Mathematical Sciences, Faculty of Science & Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia.

[email protected] Department of Mathematics, Babeş-Bolyai University, R-400084 Cluj-Napoca, Romania.

[email protected] Abstract: A reformulation of three dimensional flow of a nanofluid over a permeable stretching/shrinking surface by employing the Buongiorno’s model is presented. A new boundary condition is implemented in this study with the assumption of nanoparticle mass flux at the surface is zero. This condition is practically more realistic since the nanoparticle fraction at the boundary is latently controlled. This study is devoted to investigate the impact of the velocity slip and suction to the flow and heat transfer of a nanofluid. The governing partial differential equations corresponding to the momentum, energy and concentration are reduced to the ordinary differential equations by utilizing the appropriate transformation. Numerical solutions of the ordinary differential equations are obtained by using the built-in bvp4c function in Matlab. Graphical illustrations displaying the physical influence of several nanofluid parameters on the flow velocity, temperature and nanoparticle volume fraction as well as the skin friction coefficient and the local Nusselt number are provided. The present study discovers the existence of dual solutions at a certain range of parameters. Surprisingly, both of the solutions merge at the stretching sheet indicating that the presence of the velocity slip affects the skin friction coefficients. Stability analysis is carried out to determine the stability of the solutions. It is found that the first solution is stable and physically realizable while the second solution is unstable. Keywords: Nanofluid, velocity slip, revised model, dual solutions, stability analysis ID 1014


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A NUMERICAL APPROXIMATION TO THE SOLUTIONS OF THE CAHN-HILLARD EQUATION

Aysun Tok Onarcan, Nihat Adar, Ozlem Ersoy Hepson, İdris Dağ

Eskişehir Osmangazi University, Dept. of Informatics, Eskişehir, 26480, Turkey [email protected]

Eskişehir Osmangazi University, Dept. of Computer Engineering, Eskişehir, 26480, Turkey [email protected]

Eskişehir Osmangazi University, Dept. of Mathematics & Computer, Eskişehir, 26480, Turkey [email protected]

Eskişehir Osmangazi University, Dept. of Computer Engineering, Eskişehir, 26480, Turkey [email protected]

Abstract: In this study, Trigonometric Quintic B-Splines(TQBS) are used to establish a collocation method for obtaining the numerical solutions of the Cahn-Hillard (C-H) equation. The fully-integration of the C-H equation is going to give a system of nonlinear algebraic equations. The time and space integrations have been managed by employing the Crack-Nicolson method and the quintic trigonometric B-spline approximation respectively. After getting solution of the algebraic system, some numerical solutions of the C-H equation will be presented in terms of combination of the TQBS. Implementation of easy and simple TQBS algorithm will be illustrated by studying some text problems of the C-H equation. Keywords: Trigonometric B-Spline, collocation method, Cahn-Hillard equation ID 1026


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THEORETİCAL STUDY OF MAGNETİC COUPLİNG İN FERROMAGNETİC LAYERS SEPERATED BY A METALLİC LAYER

Taner Kalaycı, Caner Değer, Fikret Yıldız

Marmara University, Department of Physics, Göztepe, İstanbul 34722, Turkey [email protected]


Gebze Technical University, Department of Physics, Gebze, Kocaeli 41440, Turkey [email protected]

Abstract: The development of numerical methods in the investigation of properties of inhomogeneous magnetic multilayer systems made it possible to study dynamic characteristics of a two-layer exchange-coupled ferromagnetic film of finite thickness. The thickness dependence of the ferromagnetic resonance (FMR) was theoretically investigated at different magnetic parameters and layers. Multilayer structure with different spacer thickness in nano-level is simulated based on Metropolis algorithm and Markov Chain Monte Carlo (MC-MC) method as realistic as possible. It is decided that 1000 MC steps/layer are appropriate to reach equilibrium state of the system after some smaller trials of step number. Herewith observables are obtained by using expectation values. All calculations are performed for room temperature to fit outputs of simulation with experimental data. It is concluded that FMR experiments are in good agreement with the reported values for Co/Pt multilayers. Keywords: Magnetic anisotropy, Monte-Carlo, spacer layer ID 1027


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FERROMAGNETISM IN METAL ION DOPED DNA: A MONTE-CARLO STUDY

Caner Deger, Taner Kalayci, Izzet Parug Duru, Vahap Eldem and Ilhan Yavuz




Istanbul University, Department of Biology, Vezneciler, İstanbul 34134, Turkey [email protected]


Abstract: As a natural nanobiomaterial, DNA is an interesting structure for potential applications in a wide range of fields such as biosensors, optoelectronics, spintronics, nanophotonics and nanoelectronics. Magnetic properties of ion-modified DNA (M-DNA) nanowire at room temperature under a uniform magnetic field (~100 Oe) are investigated for different doping concentrations by Monte Carlo simulation. Studying thermodynamic quantities of nanowire formed by Cr M-DNA is followed by analysing the dependency of the ferromagnetic behaviour of the M-DNA to dopant concentration. It is proposed that the source of ferromagnetism is the exchange interaction between Cr and DNA helical atoms expressed in the Heisenberg Hamiltonian rather than long range interactions. Keywords: Nanobiotechnology, Monte-Carlo, magnetic DNA ID 1028


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FIRST PRINCIPLES STUDY OF REGIOSELECTIVITY OF METAL ION DOPING TO DNA BASE PAIRS

Caner Deger, Taner Kalayci, Izzet Parug Duru, Vahap Eldem and Ilhan Yavuz

Marmara University, Department of Physics, Göztepe, Istanbul 34722, Turkey [email protected]



Istanbul University, Department of Biology, Fatih, Istanbul 34452, Turkey [email protected]


Abstract: Efficient and robust DNA sequencing methods are one of the major innovations in medical technologies such as diagnostics and personalized treatment. Fine-tuning of DNA base pairs by metal ion doping (m-DNA) could be a promising material for DNA applications. However, atomic-scale understanding of the interaction between the metal-ion and DNA is still challenging. Here we report our density-functional theory (DFT) calculations to understand the structural and electronic properties and regioselectivity of m-DNA. Keywords: DNA sequencing, density functional theory, metal doping ID 1029


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THE EFFECT OF APPLIED VOLTAGES AND COATING THICKNESS ON THE CAPACITANCE OF ELECTRODE COATED WITH

POLY(POTASYUM TETRAKIS-2-THIENYL BORATE)

Necla Bektaş, Hacer Dolaş, A.Sezai Saraç

Istanbul University, Faculty of Engineering,Department of Chemistry 34320, Istanbul, Turkey [email protected]

Department of Chemistry and Vocational School of Hilvan, Harran University, 63300, Sanliurfa, Turkey

[email protected] Department of Chemistry, Polymer Science and Technology, Istanbul Technical University, Maslak,

34469, Istanbul, Turkey [email protected]

Abstract: To obtain super capacitors having high power density and to develop the mechanic and the electrochemical properties of conducting polymer, the researchers modified the electrodes with conducting polymers electrochemically [1-2]. Electrochemical impedance spectroscopy (EIS) was applied investigating the charge transfer, ion diffusion and capacitive property of electrodes coated with conducting polymer [2-3]. Potassium tetrakis-2-thienyl borate (PT2TB) is a monomer having thienyl and Boron (B) and exists in form tetrakis-2-borate anion in solution. When it was polymerized electrochemically, polythiophene including B is obtained at chain [4]. In this study, PT2TB was polymerized electrochemically in 0.1M tetrabutylhexafluorophosphate (Bu4PF6)-Polycarbonate (PC) at range of 0-1.7V and scan rate of 50 mV/s and obtained electrode coated with poly(PT2TB) was investigated in the way of impedance and capacitance. As a result, it was found that impedance values changed and its capacitive property decreased with increasing of coating thickness. So, specific capacitances (Cspe)were 0.31mF/cm2 and 0.064 mF/cm2 at 2 cycle and 8 cycle, respectively. On the other way, as applied voltage was increased, capacitive feature of polymer was decreased, due to that the structure of polymer was damaged. It was determined that the voltage must be 0V or 0.2V. Keywords: Potassium tetrakis-2-thienyl borate, electrochemical impedance spectroscopy, capacitance ID 1032 References [1] As. Sarac, S. Sezgin, M. Ates, CM. Turhan. “Electrochemical impedance Spectroscopy

and morphological analyses of pyrrole, phenylpyrrole and methoxyphenylpyrrole on carbon fiber microelectrodes” Surface&CoatingsTechnology 202 (2008) 3997-4005.

[2] Hacer Dolas, A.SezaiSarac, “An impedance-morphology study on poly(3-methylthiophene) coated electrode obtained in boron trifuoride diethyl Etherate-acetonitrile” Synthetic Metals, 195(2014), 44-53.


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[3] Hacer Dolas, Digdem Giray And A.Sezai Sarac, “Effect of the Sizing Compound on the Electropolymerization of Pyrrole and the Impedance of Carbon Fiber Coated with Polypyrrole” JOTCSA. 2016; 3(3): 281-298.

[4] B. Fabre, “Anodic electropolymerization of tetrakis(2-thienyl) borate: is the boron retained in the polythiophene film?” Electrochemistry Communications 3 (2001) 421-424.


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INVESTIGATION OF DNA-BINDING ACTIVITIES OF PERIPHERALLY 2, 10,16,24-TETRAKIS DIMETHYL 5-(PHENOXY)-

ISOPHTHALATE-SUBSTITUTED NI(II) PHTHALOCYANINE COMPOUND

Ali Arslantas, M. Salih Agirtas

Biomedical Engineering Department, School of Engineering, Karabuk University,78050, Karabuk, Turkey

[email protected] Department of Chemistry, Faculty of Science, Yüzüncü Yıl University, 65080,

Van, Turkey [email protected]

Abstract: In this study, peripherally 2, 10, 16, 24-tetrakis dimethyl 5-(phenoxy)-isophthalate-substituted Ni(II) phthalocyanine compound was previously synthesized and characterized. Calf thymus- DNA was used to investigate DNA-binding activities of Ni (II) phthalocyanine compound (PcNi). DNA-binding activities of the pthalocyanine compound were investigated using absorption spectra, fluorescense titration, thermal denaturation studies, cyclic voltametry. The results showed that PcNi binds to CT-DNA through intercation binding mode. In addition to above methods, gel electrophoresis and viscosity measurements were also performed to determine DNA-binding activities of PcNi in a Tris-HCl buffer solution. The findings of these technique indicated that Ni (II) phthalocyanine compound interacts with CT-DNA. All these results demonstrate that Ni (II) phthalocyanine compound could have drug agent potential for cancer thearpy because of its biological features. Keywords: DNA-binding, phthalocyanine, uv/vis spectroscopy, cyclic voltametry, gel electrophoresis ID 1036 Acknowledgments This study was supported by the Commission of Scientific Research Projects of Karabuk University.


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SEPARATION OF MALIC ACID FROM THEIR AQUEOUS SOLUTION BY REACTIVE EXTRACTION AND MODELING WITH RESPONSE

SURFACE METHOD

Tais Evlik, Süheyla Çehreli, Yavuz Selim Aşçı Istanbul University, Engineering Faculty, Chemical Engineering Department, İstanbul 34320, Turkey

[email protected] Istanbul University, Engineering Faculty, Chemical Engineering Department, İstanbul 34320, Turkey

[email protected] Istanbul University, Engineering Faculty, Chemical Engineering Department, İstanbul 34320, Turkey

[email protected]

Abstract: Malic acid is a 4-carbon containing carboxylic acid and an intermediate of the tricarboxylic acid cycle. It is a valuable product which has a wide range of usage in pharmaceuticals, polymer and food industries. Two of the main uses of malic acid in the food industry are as a flavoring and an aging agent of wine. One of the most important production methods is the fermentation in industry application. However, using this method, 10% malic acid aqueous solutions can be obtained. As a result, separation of the product in the production environment constitutes is one of the most important steps of the process. In this study, separation of malic acid by using reactive extraction from aqueous solutions was examined and using the obtained experimental data, this process was modeled by the response surface method (RSM). In the experiments, tributyl amine was used as the reactant and octyl acetate was used as the diluent. Experiments were conducted in initial concentrations of the different amines and different initial acid concentrations. Amine was used as the starting concentration 0.2, 0.4, 0.6, 0.8, 1.0, 1.2 mol / L. The starting acid concentration for malic acid 5%, 10%, 15% was examined. Additionally, organic- aqueus phase rate of 1:5, 3:5, 5:5 effect on the results of the organic phase was investigated. Distribution coefficient for each of the investigated system and the extraction efficiency of loading factor values were calculated. Modeling with the RSM was performed using the Design Expert 10.0 program. Keywords: Malic acid, reactive extraction, response surface method ID 1037


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A LITERATURE REVIEW OF THE DECISION MAKING PROBLEMS STUDIED IN THE THEORIES OF INTUITIONISTIC FUZZY SETS

Murat Ibrahim Yazar, Serhat Aydin

Karamanoglu Mehmetbey University, Karaman 70100, Turkey [email protected]

Karamanoglu Mehmetbey University, Karaman 70100, Turkey [email protected]

Abstract: In this study, we survey the latest studies about decision making problems handled with the intuitionistic fuzzy set (IF) theory. We also include intuitionistic fuzzy soft set and some other combinations of set theories dealing with uncertainties such as intuitionistic fuzzy parameterized soft set, Interval-valued intuitionistic fuzzy parameterized soft sets, etc. Firstly, we make a list of hybrid models combining intuitionistic fuzzy sets with other mathematical structures describing uncertainty. Then, we compile the developed algorithms and methods about decision making problems and present our observations in detail. Keywords: Intuitionistic fuzzy set, decision making problems ID 1038 Acknowledgments This study is supported by Karamanoglu Mehmetbey University BAP, Project no: 26-M-16.


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NUMERICAL STUDY BASED ON TRIGONOMETRIC B-SPLINES FOR BOUSSINESQ SYSTEM OF THE BONA-SMITH FAMILY

Ozlem Ersoy Hepson Eskişehir Osmangazi University, Department of Mathematics and Computer, Eskişehir, 26480, Turkey

[email protected] Abstract: Finite element methods are commonly used to construct approximate solutions to partial differential equations. In this study, collocation method, one of finite elements technique, based on higher degree trigonometric B-spline functions is proposed to solve one-dimensional nonlinear Boussinesq system of Bona-Smith family numerically. The system is discretized in space variable by higher degree trigonometric B-splines while the time integration of the system is performed by Crank-Nicolson method. Several initial boundary value problems are studied by the proposed technique. Keywords: Boussinesq system, trigonometric B-splines, finite element method, collocation method ID 1039


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ANALYTICAL SOLUTION TO COUNTERCURRENT DIFFUSION PROBLEM WITH DYNAMIC BOUNDARY CONDITIONS

Hasan Sadikoglu, Ebubekir Siddik Aydin, Ozgun Yucel Yildiz Technical University, Department of Chemical Engineering, Esenler, İstanbul, 34210, Turkey

[email protected] Gebze Technical University, Department of Chemical Engineering, Gebze, Kocaeli, 41400, Turkey

[email protected] İzmir Katip Celebi University, Department of Environmental Engineering, Cigli, İzmir, 35620, Turkey

[email protected]

Abstract: Unsteady state countercurrent diffusion problem with variable boundary conditions can be modeled using Fick’s second law. In this study, a mathematical model was constructed and solved analytically to quantitatively describe the dynamic behavior of solute diffusion through homogeneous materials that submerge into solvent where concentration of solute changes with time. The model results were compared with the experimental data of the potassium sorbate diffusion through whey protein films, and excellent agreements between the experimental data and the model results are observed. The experimental data for potassium sorbate diffusion through whey protein films were utilized in mathematical model to determine both potassium sorbate and solvent diffusion coefficients. Also, analysis of the diffusion mechanism of the potassium sorbate showed non-Fickian or anomalous diffusion behavior. Keywords: Mathematical modeling; countercurrent diffusion; analytical solution; diffusion coefficient ID 1043


24

NUMERICAL SOLUTION OF THE FREEZE DRYING OF BLACK TEA EXTRACT WITH ORTHOGONAL COLLOCATION METHOD

Ebubekir Siddik Aydin, Ozgun Yucel, Hasan Sadikoglu

Gebze Technical University, Department of Chemical Engineering, Gebze, Kocaeli, 41400, Turkey [email protected]

İzmir Katip Celebi University, Department of Environmental Engineering, Cigli, İzmir, 35620, Turkey [email protected]

Yildiz Technical University, Department of Chemical Engineering, Esenler, İstanbul, 34210, Turkey [email protected]

Abstract: Conservation of mass, energy and momentum can be used to obtain mathematical modeling of freeze drying of solutions placed in trays of a freeze dryer. The physical representation of the freeze-drying process requires two different phase zones, dried and frozen, and a moving interface between these phases. Obtained equations are partial differential equations and they are nonlinear due to their nature. As a result of nonlinearity these multi-dimensional dynamic equations can’t be solved analytically. In this work, the dynamic mathematical models were solved numerically by the method of orthogonal collocation based on polynomial approximation. The solution complexity of the numerical results obtained in the model was reduced by transforming the system of partial differential equations to a system of ordinary differential equations. The multi-dimensional mathematical validated with experimental data obtained by freeze drying of black tea extract. Furthermore, transport parameters and physical properties describing the freeze drying of black tea extract were determined by fitting the experimental data using Levenberg–Marquardt algorithm. Experimental results showed good agreement with the theoretical predictions. Keywords: Freeze drying; moving interface; transport parameters; orthogonal collocation; black tea extract ID 1044


25

TRAVELING WAVES IN RATIONAL EXPRESSIONS OF EXPONENTIAL FUNCTIONS TO THE CONFORMABLE TIME FRACTIONAL JIMBO-MIWA AND ZAKHAROV-KUZNETSOV

EQUATIONS

Alper Korkmaz, Ozlem Ersoy Hepson

Çankırı Karatekin University, Dept. of Mathematics, Çankırı, 18200, Turkey. [email protected]

Eskişehir Osmangazi University, Dept. of Mathematics & Computer, Eskişehir, 26480,Turkey [email protected]

Abstract: The conformable time fractional Jimbo-Miwa and Zakharov-Kuznetsov equations are solved by the generalized form of the Kudryashov method. A simple compatible wave transformation is employed to reduce the dimension of the equations to one. The predicted solution is of the form of a rational expression of two finite series at both the numerator and the denominator. The terms of both series are of the powers of some functions having exponential expressions satisfying a particular ODE. The exact solutions are expressed explicitly in terms of powers of some exponential functions in form of rational expressions. Keywords: Conformable time fractional jimbo-miwa equation, conformable time fractional zahharov-kuznetsov equation, exact solution, solitary wave ID 1045


26

SYNTHESIS OF SOME IMINES FROM 5-SUBSTITUTED ALDEHYDES UNDER MICROWAVE IRRADIATION

Hasan Yakan, Fatma Yalınyiğit, Halil Kütük Ondokuz Mayis University, Department of Chemistry, Faculty of Education, Samsun, 55139, Turkey

[email protected] Ondokuz Mayis University, Faculty of Arts and Sciences, Chemistry Department, 55139, Samsun,

Turkey Ondokuz Mayis University, Faculty of Arts and Sciences, Chemistry Department, 55139, Samsun,

Turkey [email protected]

Abstract: Imine compounds are most widely used as fine chemicals, medical substrates, ligands for metal complexes in coordination chemistry and they are also used as starting materials in the synthesis of important drugs such as antibiotics, antiallergic, antiphologistic, and antitumor substances [B.J. Gangani, P.H. Parsani, Spectrosc Lett. 40, 1, 2007, 97-112. A.S. Munde, A.N. Jagdale, S.M. Jadhav, T.K. Chondhekar, J. Serb. Chem. Soc. 75, 3, 2010, 349–359]. Schiff bases [Waldo H. Correa, Stavroula Papadopoulos, Peta Radnidge, Brett A. Roberts, Janet L. Scott, Green Chem. 4, 2002, 245–251. Cahit Demetgül , Didem Deletioğlu , Filiz Karaca , Süleyman Yalçinkaya , Mahir Timur & Selahattin Serin. J. Coord. Chem. 63, 12, 2010, 2181-2191] have been synthesized by condensation of 5-substituted salicylic aldehyde derivatives with 2-aminobenzylamine by two different methods as by conventional method and microwave accelerated synthesis. It is clear that the synthesized compounds were obtained in a much shorter time and at higher yields under microwave irradiation than by classical heating.

Figure 1. They have been characterized by IR, 1H-NMR, and 13C-NMR spectroscopic methods and element analysis. Keywords: Schiff bases; 2-aminobenzylamine; microwave irradiation; spectroscopy methods ID 1046


27

THE SYNTHESIS AND INVESTIGATION OF THE ANTI-CANCER ACTIVITY OF 5,6-DISUBSTITUTED INDOLE-3-CARBALDIMINES

Murat Bingul, Belamy B. Cheung, Glenn M. Marshall, Salih Pasa, Naresh Kumar, David StC. Black

School of Pharmacy, Dicle University, Diyarbakır, 21280, Turkey

[email protected] Children’s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, The

University of New South Wales, Sydney, NSW 2052, Australia [email protected]

Centre for Children’s Cancer and Blood Disorders, Sydney Children’s Hospital, Randwick, NSW 2031, Australia

[email protected] School of Chemistry, The University of New South Wales, Sydney, NSW 2052, Australia

[email protected] School of Chemistry, The University of New South Wales, Sydney, NSW 2052, Australia

[email protected]

Abstract: Chemotherapy is one of the most common treatments for high-risk cancer patients. [1,2] A range of well-known agents have been used to combat to various cancers in modern chemotherapeutic approaches. [3,4] However, a major problem faced in chemotherapy is the resistance to commonly-used anti-cancer drugs. [5] Therefore, exploration of novel chemotherapeutic agents is in urgent demand in the area of drug discovery and development. The key objective of this research is to synthesize a range of novel indole-based heterocyclic molecules that can potentially be used for multi-targeted cancer therapies in combination with clinical doses of Histone deacetylase (HDAC) inhibitors. The work therefore consists of the design and synthesis of novel indole scaffolds as well as their systematic pre-clinical in vitro evaluation against human cancer cell lines in combination with HDAC inhibitors. New structures derived from 3-formyl-5,6-disubstituted-indoles and primary amines have been prepared by Schiff base chemistry. The cytotoxic profile of the novel compound was determined against a range of neuroblastoma (SH-SY5Y and Kelly) and breast cancer (MCF-7 and MBA-231) cells. The toxicity study for the healthy human cells was evaluated against the MRC-5 and WI-38 human fibroblast cells. Keywords: Indole, schiff base, neuroblastoma, breast cancer, HDAC inhibitors ID 1047


28

APPLICATION OF ASSEMBLY LINE BALANCING IN A TRACTOR FACTORY

Sena Kır, Harun Reşit Yazgan, Furkan Yener, Serap Ercan Cömert, Gizem Turgut

Sakarya University, Engineering Faculty, Department of Industrial Engineering, Sakarya, Turkey [email protected], [email protected], [email protected], [email protected],

[email protected]

Abstract: This study is a line balancing project, in which the body assembly line of a tractor factory producing single-model tractors was balanced. The aim of the work is to minimize the difference in total processing time between workstations and to make production more efficient, considering the priority diagrams of the works of the existing assembly line. In this direction, first of all the current flow of the line was observed and analyzed. As a result of the observations, the stations were regulated according to the cycle time to improve the current situation. Then, line balancing was performed using a heuristic method named Computer Method for Sequencing Operations for Assembly Lines (COMSOAL) and Positional Weighted Method. Consequently statistical analyzes show that all work was assigned to work stations in a balanced manner and assembly line efficiency was increased. Keywords: Assembly line balancing, COMSOAL, Positional weighted method ID 1048


29

MIXED NORM LORENTZ TYPE SOBOLEV SHUBIN SPACES

Ayşe Sandıkçı

Ondokuz Mayıs University, Faculty of Arts and Sciences, Department of Mathematics, Samsun, 55139, Turkey

[email protected] Abstract: We introduce as counterimage of mixed-norm Lorentz type modulation spaces through Toeplitz operators with any appropriate weight function w . We investigate when this spaces which are modelled Lorentz spaces with mixed norm modulation spaces will be Sobolev-Shubin spaces. Moreover we study Lorentz mixed normed modulation space continuity (shortly

, dM P Q continuity) for Toeplitz operators.

Keywords: Lorentz mixed normed modulation spaces, toeplitz operator, sobolev - shubin spaces. ID 1049


30

SPECTROSCOPIC, DFT AND XRD STUDIES OF (2-AMINO-5-CHLOROPHENYL) (MORPHOLINO) METHANONE

Nevin Kanışkan

Anadolu University, Science Faculty, Dept. of Chemistry, Eskişehir, 26470, Turkey

Email: [email protected] Abstract: 2-Aminobenzamide derivatives have attracted special research interest because of their remarkable applications as a starting compound or an intermediate in the synthesis of biologically important compounds.1 In addition, they also possess different kinds of pharmacological activities such as antimicrobial activity,2 antithrombotic activity,3 glycogen phosphorylase inhibition,4 and thyroid-stimulating hormone receptor (TSHR) antagonistic activity.5 Due to these biologically significances, scientists are interested in developing various new benzamide derivatives. There is still need to improve the already used benzamide derivatives and search for the new and more effective benzamide derivatives. In the present work, a combined experimental and computational study on molecular structure and spectroscopic characterization on the title compound has been reported. The compound crystallizes in the triclinic system with the space group P ̅1 with a = 6.7286(4) Å, b = 8.4746(5) Å, c = 10.8779(7) Å, α = 71.392(3)°, β = 76.467(3)°, γ = 71.727(3)°, V = 551.99(6) Å3, Z = 2. In the crystal structure, the morpholine ring of the compound adopts a chair conformation. Moreover, intermolecular N–H…...O hydrogen bonds stabilize the crystal structure and play a crucial role in crystal packing. The molecular geometry which was obtained from the X-ray structure determination was optimized using the density functional theory (DFT/B3LYP) method with the 6-311++g(d,p) basis set in ground state. From the optimized geometry of the molecule, geometric parameters are in agreement with the XRD data. The harmonic vibrational frequencies were calculated and the scaled values were compared with experimental FTIR spectrum. The observed and the calculated frequencies are in good agreement. The 1H and 13C NMR chemical shifts of the molecule were calculated using the GIAO method and compared with those of experimental data. The electronic properties, such as HOMO and LUMO energies, were performed by time-dependent DFT (TD-DFT) approach. Keywords: 2-Aminobenzamide derivatives, XRD, IR spectra, NMR spectra, DFT calculation ID 1050 References

[1] Huang P.-Q., Huang Y.-H., Xiao K.-J., Wang Y., Xia X.-E. J. Org. Chem. 80, 2015, 2861 − 2868.

[2] Huang, F.-Q.; Dong, X.; Qi, L.-W.; Zhang, B. Tetrahedron Lett., 57, 2016, 1600−1604.

[3] Verma A., Giridhar R., Kanhed A., Sinha A., Modh P., Yadav M. R. ACS Med. Chem. Lett., 4, 2013, 32−36.

[4] Krimm, I. Lancelin J. M., Praly J. P. J. Med. Chem., 55, 2012, 1287−1295. [5] Englund E. E., Neumann S., Eliseeva E.; McCoy J. G.,Titus, S., Zheng, W., Southall,

N., Shinn P., Thomas C. J., Inglese J., Austin C. P., Gershengorn M. C., Huang W. MedChemComm, 2, 2011, 1016−1020.


31

NOVEL PHOTOSENSITIZER AXIALLY 2-MERCAPTOQUINOLINE SUBSTITUTED SILICON PHTHALOCYANINE; SYNTHESIS, CHARACTERIZATION AND PHOTOPHYSICOCHEMICAL

PROPERTIES

Göknur Yaşa Atmaca, Ali Erdoğmuş

Department of Chemistry, Yildiz Technical University, 34210 Esenler, Istanbul-Turkey [email protected]

Department of Chemistry, Yildiz Technical University, 34210 Esenler, Istanbul-Turkey [email protected]

Abstract: Phthalocyanines have attracted attention for many decades because of their comprehensive applications, is increasing rapidly as a result of the synthesis of new compounds. We need to develop photophysical properties for a photodynamic reagent and the photophysical properties of MPc dyes are strongly influenced by nature of the central metal ion. Closed shell and diamagnetic ions, for example Zn2+, Ga3+ and Si4+, give phthalocyanine complexes excellent properties such as high triplet yields and long triplet lifetimes [1-2].

Figure 1. Synthetic route of the new silicon phthalocyanine In this work, we want to combine the above-mentioned properties for more effective photodynamic agent. Thus, axially 2-mercaptoquinoline substituted silicon phthalocyanine (SiPc) will be prepared. The new compound will be analyzed and characterized by using the ways of UV–Vis, IR, 1H NMR, and MS spectral data. Photophysical (fluorescence quantum yield and lifetime) and photochemical (singlet oxygen and photodegradation quantum yield) properties of complex were reported . The results of spectral measurements were showed that the new complex is a potential photosensitizer to use for photodynamic therapy (PDT). Keywords: Type your keywords here, separated by colons ID 1052 References [1] G.Y. Atmaca, C. Dizman, T. Eren, A. Erdoğmuş, Spectrochimica Acta Part A: Molecular and

Biomolecular Spectroscopy 137 (2015) 244–249 [2] A, Ogunsipe.; D, Maree.; T, Nyokong., Journal of Molecular Structure ,650 (2003) 131–140


32

DIET CONTROL SYSTEM

Ayla Sayli, Ceyda Akbulut

Department of Mathematical Engineering, Yildiz Technical University, Istanbul 34220, Turkey Correspondence: [email protected]

Department of Mathematical Engineering, Yildiz Technical University, Istanbul 34220, Turkey [email protected]

Abstract: The diet control system is a package to establish the best communication between dietitian, dieter and admin. This work can give flexible opportunity for the people who do not want to worry about time and costs. The research is started to get in touch with various dietitians to learn their works. This consultation is used during the system analysis and design stages to determine deficiencies and redundancies. Things have become even more complicated when we deal with a dietitian that many consultants refer to. Because diet programs, analysis results are given irregularly only with papers. We have seen this for a long time and have seen various complains. Moreover the dieter has difficulty reaching the previous measurement results and dietary lists. Within the scope of our study, we considered these kinds of problems and our system can solve them easily. After analysis and design stages, the system is implemented using C# based on SQL. The counselor has been provided better services by offering various possibilities; one of which, when a dieter asks for a measure, he or she is given the opportunity to access the desired measurement and diet information from anywhere. The dietician has also been able to display past diet lists, analysis results on the same screen, and to write the new diet list more efficiently. The most important feature is that the dieters do not waste of time and money. Keywords: Diet control system, SQL, C#, software analysis and design ID 1053


33

ANTICORROSIVE BEHAVİOUR OF POLY(O-PHENILENEDIAMINE) AND POLY (O-PHENILENEDIAMINE -co-PYRROLE) COATINGS ON

ALLOY PLATED ELECTRODE

Abdurrahman Akdag, Ali Tuncay Ozyilmaz

Department of Medical Laboratory Techniques, Vocational School of Health Services, Harran University, 63300, Sanliurfa, Turkey

[email protected] Department of Chemistry, Faculty of Arts and Sciences, Mustafa Kemal University,

31040, Hatay, Turkey [email protected]

Abstract: Steel is one of the most important commodity metal from technological point of view; however, it must be protected against corrosion under normal environmental conditions [1]. Application of zinc alloy electrodeposited coatings in various industrial sectors has significantly increased. This may be mostly due to their excellent corrosion resistance, paintability and good formability [2]. Morphological and electrical propeties of conducting polymers like polyaniline, polypyrrole and polythiophene have opened a large field for specific applications such as batteries, sensors and corrosion [3]. In this study, Zinc-iron (ZnFe) alloy was deposited on carbon steel (CS) by chronopotentiometry technique, in acidic medium. Then, poly(o-phenilenediamine) film was synthesized from 0.05 M o-phenilenediamine containing 0.30 M sodium oxalate solution. Poly(o-phenilenediamine-co-pyrrole) film was synthesized from 0.05 M o-phenilenediamine + 0.05 M pyrrole containing 0.30 M sodium oxalate solution. The syntheses were achieved on ZnFe alloy plated carbon steel (CS/ZnFe) by using cyclic voltammetry technique. poly(o-phenilenediamine) and Poly(o-phenilenediamine-co-pyrrole) films characterized by linear sweep voltametry and scanning electron microscopy techniques. Anticorrosive properties of ZnFe deposited CS electrodes with and without polymer films in 3.5% NaCl solution were investigated with AC impedance spectroscopy technique and anodic polarization curves. Corrosion test results showed that Poly(o-phenilenediamine-co-pyrrole) coating provided a remarkable anodic protection against the attack of corrosive environment to CS/ZnFe electrode. At the same time, corrosion resistance of Poly(o-phenilenediamine-co-pyrrole) top coated CS/ZnFe electrode was rather better than CS/ZnFe and poly(o-phenilenediamine) coated CS/ZnFe electrodes in different exposure times. Keywords: Poly (o-phenilenediamine), Poly (o-phenilenediamine-co-pyrrole), corrosion ID 1054 References [1] Su W., Iroh J. O., Synthetic metals, 114 (2000) 225-234. [2] Karahan, I. H., Karabulut, O., Alver, U., Physica scripta, 79 (2009) 055801. [3] Bazzaoui, M, Bazzoui, E. A., Martins, L., Martins, J. I., Synthetic metals, 130 (2002) 73-

83.


34

IMPROVING THE CORROSION RESISTANCE OF ZINC-IRON PLATED ELECTRODES BY POLY(O-ANISIDINE) AND POLY(O-

ANISIDINE-co-ANILINE) COATINGS

Abdurrahman Akdag, Ali Tuncay Ozyılmaz

Department of Medical Laboratory Techniques, Vocational School of Health Services, Harran University, 63300, Sanliurfa, Turkey

[email protected] Department of Chemistry, Faculty of Arts and Sciences, Mustafa Kemal University,

31040, Hatay, Turkey [email protected]

Abstract: Iron based metals such as mild and stainless steel have been widely used in numerous applications for many years. Protective coatings such as organics, silicones, inorganic compounds and metallic coatings have been used widely for metal corrosion control [1]. Conducting polymers have aroused considerable interest in recent years because of their importance in industry. Especially, there are the most studies that report anticorrosive applications of electrochemically synthesized conducting polymers [2]. In this study, Zinc-iron (ZnFe) alloy was deposited on carbon steel (CS) by galvanostatic technique, in acidic solution medium. Then, poly(o-anisidine) film was synthesized from 0.06 M o-anisidine containing 0.30 M oxalic acid solution. Poly(o-anisidine-co-aniline) film was synthesized from 0.03 M o-anisidine + 0.03 M aniline containing 0.30 M oxalic acid solution. The syntheses were achieved on ZnFe alloy plated carbon steel (CS/ZnFe) by using cyclic voltammetry technique. Poly(o-anisidine) and poly(o-anisidine-co-aniline) films characterized by scanning electron microscopy and linear sweep voltametry techniques. The corrosion behaviour of ZnFe deposited CS electrodes with and without polymer films in 3.5% NaCl solution were investigated with AC impedance spectroscopy technique and anodic polarization curves. The results showed that poly(o-anisidine) and poly(o-anisidine-co-aniline) coatings provided an increase in corrosion resistance of CS/ZnFe electrode, in longer exposure time. Keywords: Poly(o-anisidine), Poly(o-anisidine-co-anilin), ZnFe: corrosion ID 1055 References

[1] Sazou D., 2000. Synthetic metals, 118 (2001) 33-147. [2] Ozyilmaz, A. T, Polymer-Plastics Techn.and Eng. 2006, 45, 285-291.


35

WATER AND DYE SORPTION CHARACTERIZATION OF NOVEL BIOSORBENT ACRYLAMIDE / SODIUM METHACRYLATE /

GELATIN / POLY (ETHYLENE GLYCOL) HYDROGELS

Semiha Kundakci, Erdener Karadağ

Adnan Menderes University, Department of Chemistry, Aydın, 09010, Turkey [email protected]

Adnan Menderes University, Department of Chemistry, Aydın, 09010, Turkey [email protected]

Abstract: Polymeric hydrogels are very functional materials and have found widespread application in many technological areas such as biotechnology, agriculture, pharmaceutical and water treatment by sensor and sorbent materials. There are many studies on the use of the hydrogels as sorbent materials in the removal of dyes, heavy metals and other some hazardous materials from waste water 1-3. Properties of hydrogels such as swelling rate and mechanical strength could be modulated by preparing interpenetrating polymer network hydrogels. In this study, it was aimed that produce a new polymeric biosorbent hydrogels and that investigate the equilibrium swelling and methyl violet sorption. Novel biosorbent hydrogels, composed of acrylamide with sodium methacrylate as co-monomer, with natural polymer gelatin and synthetic polymer such as poly(ethylene glycol) and multifunctional crosslinker such as poly(ethylene glycol)diacrylate was prepared by free radical solution polymerization by using ammonium persulfate/N,N,N’,N’-tetramethylethylenediamine as redox initiating pair1-3. FTIR analysis was used for structural characterization. Surface morphology was characterized by SEM studies. For swelling characterization, some parameters such as equilibrium percentage swelling (687-5877%), diffusional exponent (0.5627-0.8502), diffusion coefficient (5.93 x 10-5-55.51 x 10-5) and equilibrium water content (0.8729-0.9833) were investigated. The polymeric systems were used in experiments on sorption of water-soluble cationic dye such as methyl violet and some sorption parameters such as dye removal capacity (5.30 x 10-6-6.87 x 10-6 mol g-1), removal efficiency (76.05-94.07%) and partition coefficient (3.17-15.85) of the polymeric systems were investigated. Water uptake and dye sorption properties of the crosslinked polymeric systems were investigated as a function of chemical composition of the hydrogels. The utilization of these types of materials, in pharmaceuticals, agriculture, biotechnology, environment, separation, purification and immobilization makes hydrogels more popular. Keywords: Acrylamide, hydrogels, swelling, sorption, PEG ID 1056 Acknowledgement: The work was supported by Adnan Menderes University Research Fund, under project number FEF 11 008.


36

References: [1] Karadağ E., Kasim Z.D., Kundakcı S. Üzüm, Ö.B., Fibers and Polymers, 2017, 18, 9-21. [2] Dragan E.S., Loghin D.F.A., Cocarta A.I., Doroftei M., Reactive and Functional Polymers, 2016,

105, 66-77. [3] Karadağ E., Kundakcı S., Fibers and Polymers, 2015, 16, 2165-2176.


37

PARTIALLY PURIFICATION AND CHARACTERIZATION OF PROTEASE ENZYME FROM Clostridium botulinum TYPE A

Şeyma Dadı, Eda Çınar Avar, Elif Loğoğlu

Department of Materials Science and Nanotechnology Engineering, Engineering Faculty, Abdullah [email protected]

Department of Chemistry, Faculty of Science, Gazi University, Ankara 06500, Turkey [email protected]

Department of Chemistry, Faculty of Science, Gazi University, Ankara 06500, Turkey [email protected]

Abstract: Proteases are enzymes that catalyze the hydrolytic cleavage of peptide bonds in the structure of proteins. The hydrolysis of peptide bonds by proteases in the presence of H2O is termed proteolysis. Proteolysis products are peptide fragments, proteins and free amino acids. Annual sales of proteases constitute 60% of the total world enzyme market [1]. Due to the high production capacity and catalytic activity of bacterial proteases as compared to animal and fungal proteases, there are more commercial applications in the food, leather, detergent, etc. industries. High-activity proteases at high temperatures and at different pH values have new applications in the drug, treatment, contact-lens cleaning agent, skin, amino acid production, detergent industries [2,3]. In this study, partial purification and characterization of protease enzyme from Clostridium Botulinum Type A ATCC 7948 was investigated. To produce protease, Clostridium botulinum Type A ATCC 7948 was cultured for 20 hours at 37 ° C in a specific compound solution. Protease enzyme with 85% ammonium sulfate precipitation and DEAE-cellulose anion exchange chromatography, the crude extract was purified with a yield of 6.12% to 3.67 times. Specific activity of enzyme was found to be 650 U/mg. The optimum pH and temperature of the enzyme are 8 and 50 °C respectively. While enzyme activity increased in the presence of Zn2+, Ca2+, Co2+, Mg2+ and Ni2+ ions, the enzyme inhibited Cd2+ and Sn2+ ions. The enzyme showed the highest activity against casein versus natural substrates such as casein, gelatin, soy flour, and BSA. The detergent additives Triton X-100 and Tween 80 increased the enzyme activity. The enzyme is inhibited by the metalloprotease inhibitor EDTA. In the presence of the PMSF, a decrease in activity was observed. This inhibition profile has shown that the enzyme is metalloprotease and that there are serine residues near the active center. Keywords: Clostridium botulinum, purification, metalloprotease, characterization ID 1057 References [1] Turk, B., “Targeting proteases: successes, failures and future prospect.”, Nature Reviews

Drug Discovery, 5: 785-798 (2006). [2] Kumar, C.G., Takagi, H., “Microbial alkaline proteases: from a bioindustrial viewpoint”,

Biotechnol Adv, 17: 561–594 (1999). [3] Rao, S., Sathish, T., Ravichandra, P., Prakasham, R.S., “Characterization of thermo- and

detergent stable serine protease from isolated Bacillus circulans and evaluation of eco-friendly applications”, Process Biochemistry, 44: 262-268 (2009).


38

THE EFFECTS OF WATER-SOLUBLE PHTHALOCYANINE ON THE GROWTH AND SOME ANTIOXIDANT ENZYMES IN ARTHROSPIRA

PLATENSIS-M2 STRAIN

Armağan Günsel

Department of Chemistry, Sakarya University, Serdivan, Sakarya, 5418, Turkey [email protected]

Abstract: Phthalocyanines (Pcs) have attracted enormous attention in many fields ranging from dyes, metal sensors, non-linear optical devices, artificial light harvesting antenna, chemical sensors, photosensitizer for photodynamic therapy (PDT) and organic solar cells, photochemical catalysts because of their unique physical, chemical, biological, and spectral properties (Cheng et al., 2010; Sorokin, 2013; Margulis et al., 2013; Venkatramaiah et al., 2015). Although evaluating phthalocyanine as potential algicidal agents, they have never been tested in a natural ecosystem (Jančula and Maršálek, 2011). Chemicals released into the environment from agricultural and industrial activities may cause destructive ecological effects if the concentrations are higher than a threshold of environmental self-purification and organism tolerance (Chen and Jiang, 2011). In this study, we have synthesized water-soluble phthalocyanine and analyzed superoxide dismutase (SOD), ascorbate peroxidase (APX) and Glutathione reductase (GR) activities and biomass accumulation in the Arthrospira platensis-M2 strain grown at different concentrations of water-soluble phthalocyanine. Keywords: Phthalocyanine, water-soluble, ascorbate peroxidase, glutathione reductase, superoxide dismutase ID 1058


39

TETRA SUBSTITUTED PHTHALOCYANINES: SYNTHESIS, CHARACTERIZATION, AGGREGATION, FLUORESCENCE AND

ANTIOXIDANT PROPERTIES

Meryem Nilüfer Yaraşır, Armağan Günsel, Ahmet Turgut Bilgiçli

Department of Chemistry, Sakarya University, Serdivan, Sakarya, 5418, Turkey [email protected], [email protected],

[email protected]

Abstract: Functional phthalocyanines bearing metal binding donors are of particular chemical interest because of their tendency to specific analytes, and capable of binding multiple metal ions for the development of new sensor molecules/macrocycles. Optochemical sensor was prepared based on fluorescence quenching depends on metal ion concentration. Electronic spectra of the modified phthalocyanines exhibited distinct changes in the UV/vis region, both absorbance and fluorescence, in response to treatment with metal ions in solution. Fuctional ligands able to recognize transition and lanthanide metal ions will make them valuable for the development of high-tech applications [1-3]. In this study, we have prepared soft or hard metal ion sensor alkyl chain gruoup substitue phthlocyanines (The new synthesized compounds have been characterized by elemental analysis, FTIR, 1H- and 13C-NMR, UV-Vis and MS (Maldi-TOF) spectral data. It was also investigated their metal sensor properties with by UV-Vis. Additionally, the antioxidant properties of newly synthesized metallophthalocyanines were also investigated by using three different antioxidant methods: free radical scavenging ability of 1,1-diphenyl-2-picrylhydrazyl (DPPH), ferrous ion chelating ability and reducing power activity. The highest DPPH activity was found from cobalt phthalocyanines (4) compound respectively. Keywords: Phthalocyanine, aggregation, fluorescence, antioxidant ID 1059 References [1] C.S. de Paula, A. C. Tedesco, F. L. Primo, J.M.C. Vilela, M.S. Andrade, V.C.F. Mosqueira,

Eur. J. Pharm Sci. 49 (2013) 371–381. [2] F.B. do Nascimento, T.M. Manieri, G. Cerchiaro, A.O. Ribeiro, Dyes Pigments 99 (2013)

316-322. [3] M.R. Detty, S.L. Gibson, S.J. Wagner, J. Med. Chem. 47 (2004) 3897–3915.


40

THE SYNTHESIS OF NOVEL TYPE METAL-FREE AND METALLOPHTHALOCYANINES, AGGREGATION, FLUORESCENCE

AND ANTIOXIDANT PROPERTIES

Ahmet Turgut Bilgiçli, Armağan Günsel, Meryem Nilüfer Yaraşır

Department of Chemistry, Sakarya University, Serdivan, Sakarya, 5418, Turkey [email protected], [email protected], [email protected]

Abstract: Metal phthalocyanine (MPc) is a kind of promising complex which has high technological application fields with various metal ions in its central cavity. In recent years, some of the many efforts to be devoted the construction of well-defined molecular materials are chemical sensors, semiconductors, electrochromic display devices, liquid crystals, solar cells, photovoltaics various catalytic processe and photosensitizers. Also, phthalocyanines well known to possess the photosensitizer activity are commonly used in PDT (photodynamic cancer therapy) due to their intense absorption in the red region of the visible light [1-3]. In this study, The synthesis and characterization of peripherally tetra substituted metal-free(2), Zn(II) (3) and Co(II) (4) phthalocyanine derivatives were reported. These newly synthesized phthalocyanine derivatives showed the enhanced solubility in organic solvents and they were characterized by a combination of elemental analysis, FTIR, 1H-NMR, 13C-NMR, UV-vis and MALDI-TOF/MS spectral data. Their aggregation properties were investigated in THF by UV-vis and fluorescence. These metal-free and metallophthalocyanine compounds were also evaluated for their total antioxidant abilities by using three different antioxidant methods such as 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging, ferrous ion chelating and reducing power activity. Keywords: Phthalocyanine, aggregation, fluorescence, antioxidant ID 1060 References [1] Lu H, Xue Z.L., Mack J. Shen Z, You XZ, Kobayashi N. Chem, Communn. 46 (2010) 3565-

3567. [2] Liu X.J., Qi C, Bing T., Cheng XH, Shangguan D.H. Anal, Chem. 81 (2009) 3699-3704. [3] [Trivedi E.R, Lee S., Zong H., Blumenfeld C.M, Barrett A.G.M., Hoffman B.M. J. Org.

Chem. 75 (2010) 1799-1802.


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EVALUATING THE ELECTRICITY SUPPLY IN TURKEY UNDER ECONOMIC GROWTH AND INCREASING ELECTRICITY DEMAND

Ahmet Yücekaya

Department of Industrial Engineering, Kadir Has Universitesity, Istanbul, Turkey [email protected]

Abstract: The growing economy and residential consumption cause and increasing trend in the demand for electricity in Turkey. The country imports a quite ratio of its energy resources and heavily depend on the fossil fuels. On the other hand, the demand for electricity that needs to be provided using resources that have minimum cost, sustainable supply and long-term cycle is increasing parallel to the economic growth in the country. The long-term investments renewable energy resources and hydroelectric plants affects the electricity supply. The country is planning to have a nuclear power plant in near future. Turkey stills provides the large part of its electricity from coal and natural gas. The natural gas based power generation is still expensive and that affect the power prices. In this research, the Turkish electricity market is analysed first, then the relationship between economic growth and electricity demand are analysed. The annual electricity demand and supply their classifications are also discussed. Keywords: Electricity, natural gas, planning, Turkey, economic growth ID 1061


42

NEW CARRIER SYNTHESIS FOR PROPOLIS EXTRACT AND THEIR ANTIMICROBIAL ACTIVITY DETECTION

Hatice Karakus, Ozgur Ceylan, Huseyin Cicek

Department of Biology, Faculty of Science, Mugla Sitki Kocman University, Mugla, 48000, Turkey [email protected]

Food Quality Control and Analysis Program, Ula Ali Kocman Vocational School, Mugla Sitki Kocman University, Ula-Mugla, 48147, Turkey

[email protected] Department of Chemistry, Faculty of Science, Mugla Sitki Kocman University, Mugla, 48000, Turkey

[email protected]

Abstract: Propolis samples were collected from the districts of Koycegiz(KZ), Bodrum (BM), Marmaris (MS), Milas (MIS), Fethiye (FE) and Kavaklıdere (KE) in Muğla province and ethanol extracts were obtained. Synthesis of new appropriate alginate/ gelatin / chitosan loaded pH sensitive carriers were carried out using these extracts. The release kinetics of the propolis extracts added to this carrier construct were determined in the digestive system media carrying different pH values. The antimicrobial activities of propolis quantities released in the different pH environments adapted to the mouth and digestive system and the obtained propolis extracts were detected by broth dilution method against to Candida albicans ATCC 10239, Bacillus subtilis ATCC 6633, Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, Salmonella typhimurium ATCC 14028 and Enterococcus faecalis ATCC 19433. Propolis release from newly synthesized carriers in a controlled manner. Propolis extracts showed the highest antimicrobial activity against Bacillus subtilis ATCC 6633 strain. At the same time, the Minimum Inhibition Concentration (MIC) values of all propolis extracts against Pseudomonas aeruginosa ATCC 27853 were found to be 50 mg / mL and ≥50 mg / mL. The highest antimicrobial activity values were determined in the obtained carriers, KZ-5 (Koycegiz propolis extract without chitosan), BM-1 (Bodrum propolis extract with chitosan) and KE-2 (Kavaklıdere propolis extract without chitosan). Propolis extracts loaded onto carrier molecules were found to be more effective against Gram negative bacteria than crude extracts. The carrier molecule BM-1 (Bodrum propolis extract with chitosan) showed a 97.1% inhibition against Salmonella typhimurium ATCC 14028. In this study, carrier molecules were produced in stable structures for propolis extracts. These molecules may be used in the treatment of digestive system diseases, including colon cancer. Keywords: Propolis: Carrier molecule, antimicrobial activity, ethanol extract, MIC ID 1063 Acknowledgements: We would like to thank the financial support from The Mugla Sitki Kocman University, with BAP 2015/081 project number.


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SPRAY-PREPARED COATING FOR USE IN THERMAL INSULATION

Huseyin Cicek and Burak Ozcelik

Department of Chemistry, Faculty of Science, Muğla Sıtkı Koçman University, Kötekli, 48000, Muğla, Turkey,

[email protected], [email protected]

Abstract: Buildings with steel construction skeletons under fire and the metal surfaces exposed to aerodynamic heating in case of flying at high speed are required to be protected from the effect of high surface temperature. For this reason, metal surfaces must be protected by coating with an insulating material of the desired thickness. Among the methods used, surface coating with a sprayable coating is the foreground because it is an easy method to apply. In this study, coatings up to 5 mm thickness containing epoxy based resin, phenolic and glass microballoons, mushroom dusts and vermuculite were obtained with successive coatings made by spraying the mixture with a suitable solvent. Two types of epoxy resins, conventional and epoxy novolac have been tested. In addition, the glass microballoons and fumed silica have been modified with glycidyl functionalized silanes (GPS) used in formulations. The coatings were also prepared with vermiculite carrying layers intercalated with cethyl triammonium bromide (CTAB). The modifications were confirmed by FTIR, TGA, XRD and SEM. The breaking strength of the coatings were determined by measuring the shear strength in a mechanical tension meter. The coating densities were measured by Archimedes' law and thermal diffusivity coefficients by flash method. GPS and CTAB modifications have been found to improve the shear strength and the coatings using epoxy-novolac resin have been obtained to have high ash yield as well as low thermal diffusivities. The front face of 5 mm thick plates prepared with this coating was flame applied for 5 seconds by oxyacetylene test and the back face temperature increased slightly to 67oC. It has been found that the ash layer remaining after partial ablation on the surface is smooth and porous and retains its integrity. It has been assessed that the high thermal insulation performance obtained is mainly due to the removal of the energy from the surface by combustion products in the form of gas. Keywords: Ablative coating, sprayable coating, heat insulation, thermal insulation, heat shielding, composite coating, vermiculite, epoxy coating ID 1064 Acknowledgement: We would like to thank the financial support from Turkish Republic Science, Industry and Technology Ministry with project number 0069.STZ-2013-1.


44

CALCIUM CHANNEL BLOCKERS INHIBIT HUMAN PARAOXONASE-I

Cüneyt Türkeş, Yeliz Demir, Şükrü Beydemir

Erzincan University, Faculty of Pharmacy, Department of Biochemistry, Erzincan, 24100, Turkey [email protected]

Atatürk University, Faculty of Sciences, Department of Chemistry, Erzurum, 25240, Turkey [email protected],

Anadolu University, Faculty of Pharmacy, Department of Biochemistry, Eskişehir, 26470, Turkey [email protected]

Abstract: Serum paraoxonase-I (E.C.3.1.8.1, PON1) is an arylesterase which is associated with high-density lipoproteins (HDL) in blood. PON1 is also present protection opposed to coronary artery disease by eradicating inflammatory oxidized lipids existing in oxidized low-density lipoproteins (LDL). Calcium channel blockers are meds which comfort blood vessels and rise the supply of blood and oxygen to the heart whereas also lessen the burden on the heart's, therefore drop blood pressure. The present study focuses on the in vitro inhibition role of calcium channel blockers on human paraoxonase-I (hPON1). Thus, PON1 was purified from human serum with a specific activity of 2603.57 EU/mg and 8.34% yield with using chromatographic methods. Enzyme molecular weight was determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and found approximately 43 kDa. These drugs were tested various concentrations and reduced in vitro hPON1 activity. IC50 values of nilvadipine and cinnarizine were determined 0.18 and 0.048 mM respectively. Ki constants of compounds were calculated 0.174±0.020 and 0.022±0.010 mM respectively. The inhibition mechanism cinnarizine was competitive, and for nilvadipine was non-competitive. The inhibition mechanisms of cetuximab, etoposide, docetaxel, and ifosfamide were non-competitive, and for paclitaxel was competitive. The inhibition mechanisms of cetuximab, etoposide, docetaxel, and ifosfamide were non-competitive, and for paclitaxel was competitive. Keywords: Paraoxonase, PON, HDL, calcium channel blockers, inhibition ID 1065


45

INHIBITION EFFECTS OF CHEMOTHERAPY DRUGS ON HUMAN PON1

Yeliz Demir, Cüneyt Türkeş, Şükrü Beydemir

Atatürk University, Faculty of Sciences, Department of Chemistry, Erzurum, 25240, Turkey [email protected]

Erzincan University, Faculty of Pharmacy, Department of Biochemistry, Erzincan, 24100, Turkey [email protected]

Anadolu University, Faculty of Pharmacy, Department of Biochemistry, Eskişehir, 26470, Turkey [email protected]

Abstract: Paraoxonase-I (PON1) is an enzyme located on high-density lipoprotein (HDL) particles possessing anti-inflammatory and antioxidative properties. It prevents the development of atherosclerosis and protects low-density lipoproteins (LDL) against oxidative stress. Chemotherapy is a method applied to the treatment of cancer, which aims to kill tumor cells with substances called antineoplastics. The present study focuses on the in vitro inhibition role of chemotherapy drug on human paraoxonase (hPON1). Therefore, PON1 was purified from human serum with a specific activity of 2603.57 EU/mg and 8.34% yield with using chromatographic methods. Enzyme molecular weight was determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and found approximately 43 kDa. IC50 values were found for pemetrexed, trastuzumab, irinotecan, dacarbazine and azacitidine

as 9.63, 0.03, 30.13, 53,31 and 2100 µM respectively. Ki constants were calculated as 8.29±1.47, 0.031±0.015, 43.94±7.66, 120.86±55.68 and 1936.13±271.00 µM respectively. The inhibition mechanism of pemetrexed, trastuzumab and irinotecan were competitive, and for dacarbazine and azacitidine were non-competitive. The inhibition mechanisms of cetuximab, etoposide, docetaxel, and ifosfamide were non-compe-titive, and for paclitaxel was competitive. The inhibition mechanisms of cetuximab, etoposide, docetaxel, and ifosfamide were non-competitive, and for paclitaxel was competitive. Keywords: Paraoxonase, PON, HDL, chemotherapy drug, inhibition ID 1066


46

FABRICATION OF OVER-OXIDIZED POLY(PYRROLE) FILM- MODIFIED GLASSY CARBON ELECTRODE FOR VANILLIN

DETERMINATION IN COMMERCIAL FOOD PRODUCTS

Şükriye Ulubay Karabiberoğlu, Çağrı Ceylan Koçak

Department of Chemistry, Science Faculty, Ege University, 35100 Bornova, Izmir, Turkey [email protected]

Occupational Health and Safety Department, Bergama Vocational School, Dokuz Eylul University, İzmir, Turkey

[email protected] Abstract: The main chemical component of natural vanilla is vanillin (4-hydroxy-3-methoxybenzaldehyde), which is extensively used as a flavouring in confectionary, tobaccos, beverages, foods, pharmaceuticals and perfumes. The excessive consumption of synthetic vanillin (VAN) can cause some side effects such as headache, nausea, vomiting, and allergic reactions, and it can also cause damage to the liver and kidneys. Hence, for the sake of food safety and quality, it is crucial to develop an approach for simple, sensitive and low-cost determination of VAN concentrations in foodstuff [1-3]. In this work, a very simple, rapid, cheap, sensitive and selective polymer film modified electrode for vanillin determination in commercial food products was developed via electrochemical polymerization and over-oxidation of pyrrole. The formation of both poly(pyrrole) and over-oxidized poly(pyrrole) films on a glassy carbon electrode surface was characterized by electrochemical impedance spectroscopy, scanning electron microscopy and X-ray photoelectron spectroscopy. Under optimized conditions, the calibration graph comprises two linear segments of 0.032–1.500 µmol L−1 and 3.00–150.00 µmol L−1 with a detection limit of 0.012 µmol L−1. The selectivity of the modified electrode was examined in the presence of metals, inorganic ions and organic substances. Moreover, the proposed method was successfully used for the assessment of vanillin contents in commercial food products with satisfactory results. Keywords: Over-oxidize polymer, vanillin, voltammetry ID 1069 References [1] Bettazzi F., Palchetti I., Sisalli S., Mascini M. A., Anal. Chim. Acta. 55 (2006): 134-138. [2] Shang, L.; Zhao, F.; Zeng, B. Food Chem151 (2014): 53-57. [3] Xinying, M. A. Int. J. Electrochem. Sci. 9 (2014): 3181-3189.


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STRUCTURAL AND OPTICAL PROPERTIES OF CU-DOPED NIO FILMS PREPARED BY SILAR METHOD

Tuba Çayır, Yunus Akaltun

Department of Biomedical Engineering Kocaeli University, Kocaeli, 41000, Turkey [email protected]

Department of Electrical and Electronic Engineering, Erzincan University, Erzincan, 24000, Turkey [email protected]

Abstract: In this study, Cu doped NiO films were prepared by SILAR method. The crystal morphology, structure and optical properties of the films were characterized by scanning electron microscopy, atomic force microscopy, X-ray diffraction and UV–visible spectroscopy, respectively. From the SEM analysis it is seen that Cu-doping concentration affects the shapes of the nanostructures. XRD analysis showed that the films have poly-crystalline structures. The room temperature UV–vis analysis showed that the optical band gap of the NiO films was changed with the increasing cupper doping concentration.

Keywords: Cupper, NiO, SILAR, XRD, SEM, AFM ID 1071


48

REMOVAL OF CATIONIC DYES ON NICKEL/NICKEL BORIDE NANOPARTICLES COATED RESIN

Merve Çınar, Yasemin İşlek Coşkun, Tülin Deniz Çiftçi

Department of Chemistry, Faculty of Science, University of Ege, 35100 Bornova, Izmir, Turkey [email protected], [email protected], [email protected]

Abstract: Nickel/nickel boride nanoparticles coated resin was used to remove methyl violet and methylene blue from waters. The effects of pH, adsorbent dose, contact time and initial dye concentration on the adsorption efficiencies were investigated. Isotherm studies were carried out by Langmuir, Freundlich, and Dubinin-Radushkevich models and also thermodynamic studies were executed. The adsorption of dyes was found to obey Langmuir isotherm and endothermic by thermodynamically. The maximum adsorption capacities calculated from the Langmuir isotherm were 66.67 and 144.9 mg/g for methylene blue and methyl violet, respectively. E values obtained from Dubinin-Radushkevich isotherm showed that the adsorption mechanism was chemical in nature. In addition, three kinetic models (pseudo first order, pseudo second order and intraparticle model) were investigated. The pseudo second order kinetic model fitted best for these cationic dyes. Keywords: Nanoparticles, removal, dye, spectrophotometry General area of research: Chemistry ID 1072


49

ASSESSING BREAST CANCER RISK ESTIMATES BASED ON THE GAIL MODEL AND ITS PREDICTORS IN QATARI WOMEN

Abdulbari Bener, Funda Çatan, Hanadi R. El Ayoubi, Ahmet Acar, Wanis H. Ibrahim

Dept. of Biostatistics & Medical Informatics, Cerrahpaşa Faculty of Medicine, Istanbul University, Istanbul, 34098, Turkey

School of Epidemiology and Health Sciences, University of Manchester, Manchester, UK [email protected]

Dept. of Biostatistics & Medical Informatics, Cerrahpaşa Faculty of Medicine, Istanbul University, Istanbul, 34098, Turkey

Dept. of Computer Education and Instructional Technologies, Faculty of Education, University of Kastamonu, Kastamonu, 37200, Turkey

[email protected] Al Amal Hospital, Hamad Medical Corparation, Doha, 3050, Qatar

Dept.Clinical Hematologist and stem cell transplantation, Hospital Saint Louis-Porte 5, 75475 Paris 10, France

[email protected] Dept. of Biostatistics & Medical Informatics, Cerrahpaşa Faculty of Medicine, Istanbul University,

Istanbul, 34098, Turkey [email protected]

Dept. Clinical Medicine & Pulmonology, Hamad General Hospital, Weill-Cornell Medical College, Doha, 3050, Qatar

[email protected]

Abstract: Background: The Gail model is the most widely used breast cancer risk assessment tool. An accurate assessment of individual’s breast cancer risk is very important for prevention of the disease and for the health care providers to make decision on taking chemoprevention for high-risk women in clinical practice in Qatar. Aim: To assess the breast cancer risk among Arab women population in Qatar using the Gail model and provide a global comparison of risk assessment. Subjects and Methods: In this cross-sectional study of 1488 women (aged 35 years and older), we used the Gail Risk Assessment Tool to assess the risk of developing breast cancer. Sociodemographic features such as age, lifestyle habits, body mass index, breast-feeding duration, consanguinity among parents, and family history of breast cancer were considered as possible risks. Results: The mean age of the study population was 47.8 ± 10.8 years. Qatari women and Arab women constituted 64.7% and 35.3% of the study population, respectively. The mean 5-year and lifetime breast cancer risks were 1.12 ± 0.52 and 10.57 ± 3.1, respectively. Consanguineous marriage among parents was seen in 30.6% of participants. We found a relationship between the 5-year and lifetime risks of breast cancer and variables such as age, age at menarche, gravidity, parity, body mass index, family history of cancer, menopause age, occupation, and level of education. The linear regression analysis identified the predictors for breast cancer in women such as age, age at menarche, age of first birth, family history and age of menopausal


50

were considered the strong predictors and significant contributing risk factors for breast cancer after adjusting for ethnicity, parity and other variables. Conclusion: The current study is the first to evaluate the performance of the Gail model for Arab women population in the Gulf Cooperation Council. Gail model is an appropriate breast cancer risk assessment tool for female population in Qatar. Keywords: breast cancer, Gail model risk assessment, lifestyle, predictor, risk factors, consanguinity, Arab women ID 1074


51

CHEMOSENSOR PROPERTIES OF 2-HYDROXYACETOPHENONE-N4- CYCLOHEXYL-THIOSEMICARBAZONE AND ITS NICKEL(II)-

PPh3 COMPLEX

Şükriye Güveli, Tülay Bal-Demirci, Hale İşlek, Bahri Ülküseven

Istanbul University, Faculty of Engineering, Department of Chemistry, 34320 Avcılar, Istanbul, Turkey

[email protected], [email protected], [email protected] [email protected]

Abstract: Thiosemicarbazones undertake a major significance as ligand because of biological, medicinal, pharmacological and analytical properties. Thiosemicarbazones possess different coordination modes, can be in neutral or anionic form because of thione–thiol tautomerism and give generally neutral or rarely cationic metal complexes [1-3]. Researches on sensors are a constantly evolving field. The synthesis of chemosensors for sensing of anions, especially the anions involved in enzymatic reactions have an important place. Therefore, studies on chemosensor development are one of the areas of interest of chemistry, and the efforts in this area are steadily increasing [4, 5]. In this study, 2-hydroxyacetophenone-N4-cyclohexyl-thiosemicarbazone and its nickel(II) complex in compositon [Ni(L)PPh3] were synthesized, and these compounds were characterized using spectroscopic and single crystal X-ray diffraction methods. For the purpose of examine the chemosensor properties of both compounds, the interactions between the compounds and some anions (F-, Cl-, Br-, I-) were investigated by means of spectrophotometric methods. Keywords: Thiosemicarbazone, triphenlyphosphine, nickel(II) complex, colorimetric sensor ID 1075 Acknowledgement: This work was supported by the Scientific Research Projects Coordination Unit of Istanbul University and TUBITAK under 2209-A Program, Project 1919B011600091. References: [1] Zhang H., Thomas R., Oupicky DPeng., F., J. Biol. Inorg. Chem 13 (2008): 47-55. [2] Lobana T.S., Kumari P., Butcher R.J., Jasinski J.P., Golen J.A., Z. Anorg. Allg. Chem. 638

(2012): 1861-1867. [3] Güveli, Ş., Özdemir, N., Koca A. Bal-Demirci, T., Ülküseven, B., Inorganica Chimica

Acta 443 (2016): 7–14. [4] Singh A. , Singh A., Singh N., Doo Ok Jang D. O., Tetrahedron 72 (2016): 3535-3541. [5] Mathan Kumar S., Dhahagani K., Rajesh J., Nehru K., Annaraj J., Chakkaravarthi G.,

Rajagopal G., Polyhedron 59 (2013): 58-68.


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3-((2,6-DIMETHOXY PHENYLIMINO)METHYL)PHENYL BORONIC ACID: SYNTHESIS AND PROSTATE CANCER EXAMINATION

Salih Paşa, Ömer Erdoğan, Burçin İrem Abbas, Murat Bingül

Department of Science, Faculty of Education, Afyon Kocatepe University, 03200, Afyonkarahisar, Turkey

[email protected] Department of Biochemistry, Faculty of Medicine, Adnan Menderes University, 09100, Aydın,

Turkey Department of Biochemistry, Faculty of Medicine, Adnan Menderes University, 09100, Aydın,

Turkey School of Pharmacy, Dicle University, Diyarbakır, 21280, Turkey

Abstract: Boron has increasing importance in many scientific researches such agriculture, industry and health due to its significant features. For example, boronated structures of porphyrins have been investigated as transient agents for binary anticancer treatment by Valentina A. Ol'shevskaya and et. al. However, polyhedral boron hydrides have been also examined for cancer treatment which is traditionally connected with boron neutron capture therapy (BNCT) by V.I. Bregadze et. al.

Figure 1. In the present study, 3-((2,6-dimethoxyphenylimino)methyl)phenylboronic acid was synthesized and its structure was identified. Then it was applied PC-3 human prostate cancer cell lines (ATCC). Cells were grown in a RPMI-1640 medium supplemented with 10% heat-inactivated fetal bovine serum (FBS) and 100 U/ml penicillin–streptomycin. Cells were cultured at 37 °C in an atmosphere of 95% air and 5% of CO2. 3-((2,6-dimethoxyphenylimino)methyl)phenylboronic acid compounds has decreased the cancer cells when compared to the control group. The free boronic acid and methoxy groups may have an efficiency onto cancer cells. Keywords: Boronic structure; prostate cancer; synthesis ID 1077


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SYNTHESIS AND ANTICANCER APPLICATION OF BORONIC STRUCTURED SCHIFF BASE LIGAND

Salih Paşa, Ömer Erdoğan, Çiğdem Yenisey

Department of Science, Faculty of Education, Afyon Kocatepe University, 03200, Afyonkarahisar, Turkey

[email protected] Department of Biochemistry, Faculty of Medicine, Adnan Menderes University, 09100, Aydın,

Turkey Department of Biochemistry, Faculty of Medicine, Adnan Menderes University, 09100, Aydın,

Turkey

Abstract: Schiff base ligands and its various derivatives have still valuable position in research fields. It is really versatile group to bind or to interact with any other substituents. They readily coordinate with a wide range of transition metals, yielding stable and intensely colored metal complexes, which exhibit interesting physical, chemical, biological and catalytic properties. In the last decades, many antimicrobial activities such antifungal, antibacterial have been detected with fascinating results. This research topic includes the interaction of formyl phenyl boronic acid with primary amine groups by Schiff base condensation to give a novel boronic bearing ligand. Its detailed characterization has been conducted by various spectral methods. Anticancer properties was carried out by injection of several boronic compound solutions (25 µM, 50 µM, 75 µM, 100 µM) to human cancer cells in partial time periods. The boronic bearing Schiff base compound has demonstrated meaningful activity onto cancer cells. Keywords: Schiff base, anticancer activity, synthesis, boronic compound ID 1078


54

A NEW APPROACH TO VEHICLE ROUTING PROBLEM BASED ON MODIFYING THE CLARKE AND WRIGHT ALGORITHM

Merve Cengiz Toklu

Sakarya University, Industrial Engineering Department M5 Block, Sakarya, 54050, Turkey [email protected]

Abstract: Logistics management involves activities such as inbound and outbound transport management, warehousing, materials handling, production planning and scheduling, customer services and etc. Vehicle routing problem is also included in logistics management. The classical vehicle routing problem aims to determine best routes at a minimal cost beginning and ending the route at the depot. The Clarke and Wright (CW) savings algorithm is the most widely applied heuristic for solving capacitated vehicle routing problem. While the saving matrix is being created, distance criterion is taken into account in CW savings algorithm. However, in real world problems, the distance criterion may not be sufficient to decide. The decision stage may need to be evaluated on other criteria, such as traffic density, the physical condition of the road or suitability of orders to be transported in the same vehicle. In this study, a new approach is proposed to solve the capacitated vehicle routing problem based on modifying the Clarke and Wright algorithm. The proposed method involves evaluating different criteria simultaneously. In accordance with this purpose, an importance coefficient has been determined for combine the routes by using Analytic Hierarchy Process which is one of the multi-criteria decision-making technique. The objective is to find the feasible solutions to minimize travelling distances and number of routes while at the same time reaching the optimal solution in the light of the other criteria. Keywords: Heuristics, optimization, vehicle routing problem, clarke and wright algorithm, analytic hierarchy process ID 1079


55

ANTI-CANCER EFFECT OF 4-(3,5-DIKLORO-2-HIDROKSI-BENZILAMINO) BENZENSULFONAMIT ON HT-29 (COLON

ADENOCARCINOMA CELLS)

Ismail Koyuncu1, Ataman Gonel1, Mustafa Durgun2, Mesut Isik3, Abdurrahman Akdag4, Mahmut Padak5, Adem Necip6, Resat Dikme6, İbrahim Bektaş6, Omer Goç6

1Department of Medical Biochemistry, Harran University, 63190, Sanlıurfa-Turkey

2Department of Chemistry, Harran University, 63190, Sanliurfa-Turkey 3Department of Pharmacy Services, Harran University, 63300, Sanlıurfa-Turkey

[email protected] 4Department of Medical Laboratory Techniques, Harran University, 63300, Sanlıurfa-Turkey

5Department of Perfusion Techniques, Harran University, 63300, Sanlıurfa-Turkey 6Department of Pharmacy Services, Harran University, 63300, Sanlıurfa-Turkey

Abstract: Sulfonamides posses many types of biological activities and have recently been reported to show substantial antitumor activity in vitro and/or in vivo. There are a variety of mechanisms for the anticancer activity and the most prominent of these is through the inhibition of carbonic anhydrase isozymes. The aim of this study will be to evaluated the effects of CA IX inhibitor, namely 4-(3,5-Dikloro-2-Hidroksi-benzilamino) benzensülfonamit sulfonamide derivatives newly synthesized aromatic sulfonamides with high affinity for CA IX, on cell proliferation and apoptosis in CA IX-positive cell lines. For this purpose, CA IX positive HELA (human serviks adenocarsinom cell line), HT-29 (human colon adenocarsinom cell line) and as a control PNT1 (normal human prostad cell line), HEK-293 (normal human embriyonic kidney cell lines) were used. Effect of sulfonamides on cell viability was determined by WST-1 assay and then IC50 value of component was determined. Apoptosis or necrosis induction was determine by flow cytometric annexin V analyse, intracellular free radical induction was determined by ROS analyse by flourence prob analyses. DNA damage effect was analysed by apodirect DNA damage kit (BD) flow cytometric analyse. The in vitro cytotoxicity was compound, dose, and cell line dependent. 4-(3,5-Dikloro-2-Hidroksi-benzilamino) benzensülfonamit was the potent inducer of apoptosis and the most effective inhibitor of cell growth and proliferation, with half maximal inhibitory concentration values for HT-29 and HELA cell lines in the range of 38,1 to 75,6 µmol/L. 4-(3,5-Dikloro-2-Hidroksi-benzilamino) benzensülfonamit has also shown citotoxic, genotoxic, apoptotic and ROS generating effects in a dose-dependent manner.

Figure 1. 4-(3,5-Dikloro-2-Hidroksi-benzilamino) benzensülfonamit (S-1i)


56

Keywords: Colon, cancer, apoptosis, sulfonamides ID 1080 Acknowledgement: This study supported by TUBITAK ( Project no: 115Z681)


57

ZILLA SPINOSA IN THE RED SEA GREENFINCH AND THE MEDICAL USAGE ACCORDING TO SOME EXPERIMENTAL

STUDIES

Levent Öztürk

Sakarya University, Theology Faculty, Department of Islamic History, Sakarya, Turkey [email protected]

Abstract “Zilla Spinosa” which grows in Saudi Arabia that has coast in Red Sea Greenfinch and in the coastal strip and interior of Egypt is recorded as “Shubrum” in Arabic resources. Zilla Spinosa which is known starting from Dioscorides (A.D. 40-90) and used as purgative, is analyzed in laboratories in the scope of botanical studies in the last century. In this study, after showing the historical background of the medical usage of extracts gained from “Zilla Spinosa” and its usage will be covered. Keywords: Zilla Spinosa, Red Sea Greenfinch, Saudi Ariba, Egypt, botany ID 1081


58

LIVER ANATOMY AND HEPATIC ARTERY VARIATIONS

Özlem Kaştan

Akdeniz University Vocational School of Health Services, Antalya, 07050, Turkey [email protected]

Abstract: The liver is located on the upper right side of the abdominal cavity under the diaphragm. Regio fills the entire hypochondriaca dextra. The upper part of Regio epigastrican and the upper right half of Regio hypochondriaca sinistran. The liver has two sides and two faces; The liver has two sides called margo inferior and margo posterior. On the front side is the margo inferior, which is found below. The margin at the back of the liver, which is blunt compared to margo inferior, is also called margo posterior. This edge is a sharp line. The liver has two facies called diaphragmatica and facies visceralis. Facies diaphragmatica is the name given to the upper face that contacts the diaphragm. Facies visceralis; This face is the face facing the hollow of the abdomen and organs. The facies visceralis, with traces of internal organs, are carved with H-shaped slits and grooves. H's arch is formed by a transversal groove called portage hepatis. Porta hepatis contains vena (v) potae hepatis, arteria (a) hepatica propria, ductus hepaticus dexter, and sinister, which enter and exit the liver. The liver has four lobes. The diaphragmatic face can see two of these lobes. The visceral percentage is four lobes. The diapragmatic face is divided into two lobes by lig. Falciforme hepatis. The remaining left lobe is called hepatis dexter, and the left lobe is called lobus hepatis sinister. Facies visceraliste porta hepatitis in front of the loba lobus quadratus, porta hepatisin lobe behind the lobus caudatus are given names. The liver is divided into 8 segments. The liver takes arterial blood from a.hepatata propria. This artery comes from a.hepatica communis, a branch of the truncus coeliacus. The venous blood from the liver to the heart is the vena hepatica. The variations of the liver arteries should be well known. Most of the surgical errors stem from not knowing these variations. dexter hepatic artery, which is separated from hepatica propria, passes 64% of people after the ductus hepaticus communis, 24% before and 12% after ductus cyticus. Hepatica artery is sinistra and sinister hepaticus ductus is always in front of it. According to the portal vena, a.hepatica dextra and v.porta pass in 91% of the people.9% of people pass behind the vena porta. Keywords: Liver, hepatic artery, variations ID 1082


59

ENERGY ANALYSIS OF SIMULTANEOUS SPACE COOLING AND HOT WATER SUPPLY USING HEAT PUMP

İbrahim Atmaca, Cemil Şaşmaz

Akdeniz University, Engineering Faculty, Mechanical Engineering Department, Antalya [email protected], [email protected]

Abstract: The heat pump systems have become more common because of several reasons such as; the depletion of fossil fuels, environmental harm caused by the fossil fuelled air-conditioning systems and an increased environmental awareness. Heat pumps can be air source, waterborne, ground source due to the environment that they transfer or reject heat. Water is the most efficient way to transfer heat in comparison to other resources. Considering cooling systems, waterborne systems are more efficient and smaller than air source systems. It is seen that the air temperature values are very high in the Mediterranean region and it decreases COP (coefficient of performance) of air source heat pumps. This study carries out the energy analysis of a heat pump which transfers the heat between cooled space and hot water tank. The waterborne air pump is installed in the Thermodynamics Laboratory of Engineering Faculty and the energy analysis of both cooling system and hot water supply is performed based on various parameters for a sample day. Mean water heating, space cooling and overall COP are calculated as 2.61, 2.08 and 4.69, respectively. Keywords: Heat pump, hot water, space cooling, energy analysis ID 1084


60

EXPERIMENTAL INVESTIGATION OF THE EFFECT OF THE METAL FOAM MATERIAL ON CPU COOLING

Ayla Dogan, Oguzhan Ozbalci

Akdeniz University, Engineering Faculty, Antalya, Turkey [email protected]

Abstract: One of the most important components of computers are processors (CPU). Because of the reasons like running too many programs simultaneously and playing games may cause the processor to overheat. This situation may cause unwanted computer malfunction. The CPU capacity and heat quantities increase with increasing the CPU speed and its performance. In order to run the system effectively, this heat must be removed and the critical surface temperature of the CPU must be kept below approximately 85 °C. In this present study, aluminum open cell metal foam (Al-6101) heat sink having pore density of 10 and 40 PPI (pore per inch) was used instead of the conventional plate type aluminum heat sink. 10 and 40 PPI aluminum metal foam materials are compared with each other and the results are presented in graphics at different fan speeds. (1140, 1742, 2439, 2944, 3308 and 4187 rpm) According to the results, in %0-10 CPU usage, lower surface temperatures were reached while using 10 PPI aluminum metal foam material and in %100 CPU usage, lower surface temperatures were reached while using 40 PPI aluminum metal foam material. Keywords: Aluminum foam material, CPU cooling, electronic cooling, heat transfer ID 1085


61

GROWTH OF Cu2ZnSnS4 THIN FILM ABSORBERS BY SPUTTERING: CHARACTERIZATION AND PHOTOVOLTAIC

PERFORMANCE

Neslihan Akçay1, Yunus Ozen1, Nihan Akin Sonmez1 , Ellen Zaretskaya2 and Suleyman Ozcelik1

1Physics Department of Science Faculty, Gazi University, 06500 Ankara-Turkey

[email protected], [email protected], [email protected], [email protected] 2Scientific-Practical Materials Research Centre of the National Academy of Sciences of Belarus, P.

Provka 19, 220072 Minsk, Belarus [email protected]

Abstract: Cu2ZnSnS4 (CZTS) is a quaternary semiconductor material which is formed earth abundant and environmentally friendly elements like Zn and Sn. It has a direct bandgap in the range of 1.4-1.5 eV and a large absorption coefficient of about 104 cm-1. Due to its suitable optical and electrical properties and these advantages, it is a promising alternative material to CdTe and CIGS based thin film solar cells technologies. In this work, the CZT precursor layer was sequentially formed on Mo-coated SLG substrate by depositing Zn, Sn and Cu metallic layers at room temperature. Zn and Sn layers were deposited by RF magnetron sputtering with 50 W power for 14 and 23 min, respectively. Cu was sputtered for 25 min at a DC power of 40 W. The depositions were carried out in a sputtering chamber with a basic pressure of 7.44x10-6 Torr and the Ar gas pressure was maintained at 20 mTorr during the deposition. The sulphurization of the precursor films was performed in a two-zoned diffusion furnace at atmospheric pressure by heating 0.5 g powder Sulphur to 300 °C in one zone and the precursor film to 550 °C in another zone of the furnace. Then the solar cell device was completed by deposition of RF sputtering 66 nm thick CdS buffer layer and 658 nm thick i-ZnO/ZnO window layer on CZTS absorber layer, respectively. The structural and morphological properties of CZTS absorber layers were studied by X-ray diffraction (XRD) technique, Raman Spectroscopy and Atomic Force Microscopy (AFM). Electrical properties of the films were determined by Hall Effect measurement system. The optical transmittance of the CZTS films were measured using UV-Vis Spectroscopy and the optical band gap was calculated as ~1.4 eV by extrapolating the linear region of the graph of (αhγ)2 to photon energy. Secondary ion mass spectroscopy (SIMS) depth profile measurements of the CZTS absorber films were carried out to reveal the compositions of the relative elements through the layer. The solar cell was characterized by current-voltage measurements under simulated Am1.5 G spectrum at 0.1 W/cm2 illumination. It was obtained the solar cells with 1.64% efficiency with an active area of 1.28 cm2. The open-circuit voltage (VOC), the short circuit current (ISC) and the fill factor (FF) of the solar cells were 0.55 V, 9.95 mA and 0.37 respectively. Keywords: CZTS, thin films, solar cells, sputtering ID 1086 Acknowledgement: This work was supported by TÜBİTAK (project number is 115F280)


62

DISPERSION ANALYSIS OVER BOAT GEOMETRY

Tarık Türkmen, Hakan Ersoy, Kayra Kurşun

Istanbul Technical University, İTÜ Ayazağa, Istanbul 34469, Turkey [email protected]

Akdeniz University, Kampüs, Antalya 07058, Turkey [email protected]

Akdeniz University, Kampüs, Antalya 07058, Turkey [email protected]

Abstract: The purpose of this study is, carrying out a dispersion analysis over a mid - scale boat geometry by using computational fluid dynamics tools and getting a connection between analysis results and different engineering branches. By the help of computational fluid dynamics analysis; results which are so hard to be taken experimentally is taken in shorter periods and a cost effective way. All of the analysis steps consisting of creating geometry, meshing, defining boundary conditions, solution and results carried out via a finite element software. Dispersion analysis studies are generally used in the design and modernization processes of marine vehicles. Analysis results taken in the design and modernization processes of marine vehicles are mostly used for determining manoeuvre capabilities, forces over marine hulls and optimization details about hull aerodynamics. The velocity profile around the vessel geometry was investigated in addition to the surface forces, manoeuvrability, friction coefficient and drag force minimization which are frequently examined in the design and modernization of watercrafts. The difference of this study is; instead of interpreting results on boat structures, creating some ideas about the regime and transportation distances of bilge which have the possibility to be created by boat geometry. Keywords: Computational Fluid Dynamics (CFD), Dispersion, Hull geometry ID 1087


63

NATURAL RADIOACTIVITY LEVELS OF MODERN BUILDING MATERIALS: TURKISH INDUSTRIAL GRANITOIDS

Sibel Tatar Erkül, Süleyman Fatih Özmen, Fuat Erkül

Akdeniz University, Department of Geological Engineering, Antalya, 07058, Turkey [email protected]

Akdeniz University, Nuclear Research and Application Center, Antalya, 07058, Turkey cAkdeniz University, Department of Physics, Antalya, 07058, Turkey

[email protected] dkdeniz University, Technical Sciences of Vocational School, Antalya, 07058, Turkey

[email protected]

Abstract: Industrial granitoids are commonly used for many commercial purposes and are of economic value in construction. They are widely considered as eco-friendly owing to their natural appearance. Granitoid rocks are formed by various minerals and contain naturally radioactive elements of potassium (K), uranium (U) and thorium (Th). These elements are more enriched in felsic granitoids with respect to mafic equivalents. Therefore, the radioactivity of these rocks may be correlated with the abundance of the mineralogical composition. In this study, natural radioactivity values of commercially used granitoids in Turkey have been measured in order to investigate the safety for use as construction materials. Various commercial granites have been sampled in Turkey and the following questions have been answered: (1) Are there any correlation between natural radioactivity and colour indexes of granitoid samples? (2) Do all granitoid samples have almost similar natural radioactivity values? (3) Do natural activity values in granitoids change from region to region? and (3) Are natural radioactivity values of studied granitoids below safety dosage limits specified in international standards? Natural radioactivity levels of granitoid samples have been measured using gamma-ray spectrometry with high-resolution Germanium detector (HPGe). Investigated granitoids have 226Ra, 228Ac and 40K values of 6.7-139.7 Bq/kg, 4.7-108.1 Bq/kg, 99.1-1366.4 Bq/kg, respectively. On the basis of calculated dose rate (D), radium equivalent activity(Raeq), annual effective dose equivalent (AED) and external hazard index (Hex), industrial granitoids in Turkey were found to be within normal limits compared to the world averages given in the UNSCEAR 2000 report and hence did not pose any health risks. Keywords: Natural radioactivity, granitoids, HPGe gamma spectrometry, UNSCEAR 2000 ID 1091


64

MICROSTRUCTURAL CHARACTERISTICS OF GRANITE ULTRAMYLONITES ASSOCIATED WITH STRIKE-SLIP SHEAR

ZONES: AN SEM-EBSD STUDY

Fuat Erkül, Sibel Tatar Erkül

Akdeniz University, Technical Sciences of Vocational School, Antalya, 07058, Turkey [email protected]

Akdeniz University, Department of Geological Engineering, Antalya, 07058, Turkey [email protected]

Abstract: Microstructural studies on mylonitic rocks provide insights into the development of ductile shear zones. Mylonites associated with granitic plutons contain abundant quartz crystals that bear important information to resolve many geological problems related to ductile deformation. Electron Backscattered Diffraction (EBSD) method has been proven as a powerful tool to acquire fast and reliable data of crystallographic orientation. Lattice preferred orientation (LPO) textures in quartz crystals are commonly used in order to estimate deformation temperatures, strain state and deformation. In this study, we investigated microstructural characteristics of quartz and feldspar crystals in granite ultramylonites that developed within the Gerni shear zone located in the northern Menderes Core Complex in western Turkey, representing the exposures of upper crustal levels. Phase maps show that ultramylonites have a polymineralic matrix consisting of an alternation of dynamically recrystallized quartz and feldspar ribbons together with minor interstitial mica flakes. Feldspars consist of plagioclase and orthoclase aggregated between quartz ribbons. Plagioclase ribbons are a major constituent of feldspars, locally occur as porphyroclasts and are dominantly replaced by orthoclase crystals. Microstructural studies of petrography and SEM-BSE and EBSD indicate that dynamically recrystallized quartz grains in ultramylonites have common bulging grain boundaries (BLG) and relatively minor subgrain rotation (SGR) and grain boundary migration (GBM) intergrain relationships, suggesting deformation temperatures ranging between 400 and 500C under lower amphibolite facies conditions. Well-developed quartz c-axis crossed girdle patterns in ultramylonites are commonly defined by bipolar maxima around the centre, indicative for middle to high-temperature deformation with a dominant combined prismatic and rhomb slip. LPO patterns appear consistent with grain boundary relations. In contrast, feldspars do not show any significant preferred crystallographic orientation with respect to quartz crystals in ribbons. Conventional petrographic methods suggest low-grade, greenschist deformation temperatures. In contrast, LPO patterns revealed relatively higher temperature estimates and the analysis of LPO using EBSD is a way to understand deformation conditions using geological samples. Replacement of plagioclase by orthoclase can be explained by fluid involved deformation conditions during the development of ultramylonites. Keywords: Oligo-Miocene, Alaçamdağ, Eğrigöz, structural geology, kinematic analysis, ductile deformation, SEM-EBSD analysis ID 1092


65

EFFECT OF COARSE FIBER IN THE CORE LAYER ON DIMENSIONAL STABILITY OF THREE-LAYERED MDF PANELS

Nadir Ayrılmış, Turgay Akbulut

Department of Wood Mechanics and Technology, Forestry Faculty, Istanbul University, Istanbul, Turkey

[email protected] Department of Wood Mechanics and Technology, Forestry Faculty, Istanbul University, Istanbul,

Turkey

Abstract: The main objective of the present study was to investigate dimensional stability of three-layered MDF panels containing coarse fibers in the core layer. In the experimental design of the present study, the gap distance between the defibrator discs was gradually increased from 0.4 to 1.2 mm, to obtain five different sizes of coarse wood fibers. The coarse fibers were used in the core layer while fine fibers were used in the surface layer. The optimum coarse fiber size were determined based on the technological properties of the MDF panel produced with five different coarse fibers. In the second phase of the study, the MDF density was decreased from 730 to 650 kg/m3 and the surface/core layer ratio (50/50) was kept constant in all the formulations. The results showed that the thickness swelling (24 h) and linear expansion/contraction of the MDF panels were significantly affected by the coarse fibers and panel density. Keywords: Fiberboard, coarse fiber, wood fiber, furniture, wood ID 1096 Acknowledgements: This work was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) under Grant 114O263.


66

INVESTIGATION OF CERAMIC-METAL COMPOSITE FROM Ni-AlN AND Al POWDERS

Ahmet Yönetken

Afyon Kocatepe University, Faculty of Engineering, ANS Campus 03200 Afyonkarahisar, Turkey [email protected]

Abstract: Al metal matrix composites reinforced with AlN have been fabricated by Tube furnace sintering at various temperatures. A uniform nickel layer on Al(%1AlN)%19Ni, Al(%2AlN)%18Ni, Al(%3AlN)%17Ni, Al(%4AlN)%16Ni, Al(%5AlN)%15Ni powders were deposited prior to sintering using electroless plating technique, allowing closer surface contact than can be achieved using conventional methods such as mechanical alloying. A composite consisting of quaternary additions, a ceramic phase, AlN, within a matrix of Al, AlN, Ni has been prepared at the temperature range at 600°C under Ar shroud. X-Ray diffraction, SEM (Scanning Electron Microscope) density, and hardness measurements were employed to characterize the properties of the specimens. Experimental results carried out for 600°C suggest that the best properties as comprehension strength σmax and hardness 604.86(HV) were obtained at 600°C and the tube furnace sintering of electroless Al plated (%2AlN)%18Ni powders is a promising technique to produce ceramic reinforced Al (%2AlN)%18Ni composites. Keywords: Electroless Nickel plating, ceramic - metal composites, powder metallurgy, sintering ID 1099 Acknowledgments: This research was supported by the University of Afyon Kocatepe project no: 16.KARİYER.90 We would like to extend our gratitude to the Scientific Research Coordination Unit.


67

NUMERICAL SOLUTIONS TO LARGE-SCALE SINGULARLY PERTURBED SYSTEMS USING KRYLOV SUBSPACE METHOD

Yaprak Dericioglu, Muhammet Kurulay, Mustapha Hached, Khalide Jbilou

Department of Mathematics, Yildiz Technical University, 34220 Istanbul, Turkey [email protected]

Department of Mathematical Engineering, Yildiz Technical University, 34220 Istanbul, Turkey. [email protected]

Université des Sciences et Technologies de Lille, Villeneuve dAscq, France [email protected]

L.M.P.A, Université du Littoral Côte d'Opale, 50 rue F. Buisson BP. 699, F-62228 Calais Cedex, France

[email protected]

Abstract: In this work we study the finite time optimal control problem for large-scale singularly perturbed systems. These equations have many applications in mathematics and conrol systems engineering. The proposed method is based on Extended block Krylov subspace method. The solution is obtained using corresponding solution of algebraic Riccati equation and low-dimensional differential Lyapunov equation that is solved by BDF method. We give some theoretical results and present some numerical experiments to show the effectiveness of our method. Keywords: Extended Block Krylov, BDF, Low rank, Lyapunov equation, Singularly perturbed systems ID 1101


68

GENERALIZED LIFTED POLYNOMIALS AND THEIR APPLICATIONS

Elif Segah Öztaş

Karamanoglu Mehmetbey University, Turkey [email protected]

Abstract: In this study, lifted polynomials are generalized over commutative rings and new form of lifted polynomials are used to obtain new codes over extended commutative rings. Reversible DNA codes are given as an applications of the polynomials. Keywords: Generalized lifted polynomials ID 1102


69

PHYTASE ACTIVE OF LACTIC ACID BACTERIA FROM TURKISH SOURDOUGH

Rusen Metin Yildirim, Muhammet Arici, Gorkem Ozulku, M. Zeki Durak

Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Yildiz Technical University, 34210 Esenler, Istanbul, Turkey

[email protected], [email protected], [email protected], [email protected]

Abstract: Whole grain food is highly recommended in terms of its nutritional benefits. It is rich in fiber, minerals, vitamins and many phytochemicals such as phenolic compounds, sterols and tocopherols. Besides all this nutrients, it contains considerable amounts of phytic acid. Which reduces the nutritional quality of food by chelating divalent minerals such as iron and zinc. Efficient reduction of the phytate content can be achieved by adding exogenous phytic acid-degrading enzymes, either by enzymatic degradation during food processing or by addition of phytase-active yeast, lactic acid bacteria, or other microorganisms. Although pyhytase is found in wheat and rye, their activities are insufficient to significantly improve the mineral bioavailability in whole grain bread. The aim of this study was to isolate and identify phytase active lactic acid bacteria from Turkish sourdough. For this purpose thirty four yeast were isolated from sourdoughs collected different region of Turkey. All of isolates identified by PCR and partial sequencing of 16S rDNA gene analysis. To detect phytase activity of lactic acid bacteria, growth test was done by using media with dipotassium salt as only phosphorus source. According to the DNA sequencing and the BLAST search analyses, Lactobacillus paracasei (8 isolates), Lactobacillus plantarum (7 isolates), Lactobacillus crustorum (5 isolates), Lactobacillus namurensis (5 isolates), Lactobacillus koreensis (2 isolates), Lactobacillus paralimentarius (2 isolates), Weissella cibaria (2 isolates), Lactobacillus rossiae (1 isolate), Lactobacillus parabuchneri (1 isolate), Lactobacillus brevis (1 isolate) were found in sourdough samples. Generally phytase activitiy of Lactobacillus plantarum and Lactobacillus paracasei strains are higher than other isolates. The study showed that Lactobacillus plantarum and Lactobacillus paracasei isolates with highest phytase activities may be ideal candidate for improving mineral bioavailability in whole grain bread. Keywords: Lactic acid bacteria, phytase activity, sourdough ID 1104 Acknowledgement: This work supported by TUBITAK-TEYDEB (Project number: 5150003).


70

DETERMINATION OF ECONOMIC METHOD FOR OBTAINING QUARTZ AND BIOTITE FROM GÖKÇEADA ANDESITES

H.H.Cengiz, Ş.E. Yersela, Hidayet Çalışkan Çanakkale Onsekiz Mart University, Engineering Faculty, Mining Engineering Department, 171000,

Çanakkale, Turkey [email protected]

Çanakkale Onsekiz Mart University, Engineering Faculty, Mining Engineering Department, 171000, Çanakkale, Turkey

[email protected] Çanakkale Onsekiz Mart University, Engineering Faculty, Mining Engineering Department, 171000,

Çanakkale, Turkey [email protected]

Abstract: The quartz and biotite amounts were found to be high in the sample taken from andesitic rocks formed in the Tepeköy village of Gökçeada, Çanakkale. In this study, economical availability of quartz and biotite minerals were investigated by milling the relevant rock and experimentally using dry magnetic separator and flotation method. As a result, it has been determined that we cannot reach an economic value from andesite rock by working with the biotite and quartz ore dressing methods (dry magnetic separation and flotation technique). In this study, it was observed that the ferric magnesium hornblende in the andesite rocks variates 10-20% in the grain size. Keywords: Hornblende, Flotation, collector, Biotite, Andesite ID 1110


71

HIGH TEMPERATUREEFFECT ON THESTRENGTH OF SAND-CEMENT PLASTER

M. Ünal, F.Latifov, Hidayet Çalışkan Çanakkale Onsekiz Mart University, Engineering Faculty, Mining Engineering Department, 171000,

Çanakkale - Turkey [email protected]

Çanakkale Onsekiz Mart University, Engineering Faculty, Mining Engineering Department, 171000, Çanakkale - Turkey

[email protected] Çanakkale Onsekiz Mart University, Engineering Faculty, Mining Engineering Department, 171000,

Çanakkale - Turkey [email protected]

Abstract: One of the main physical effects leading to durability problems in buildings is high temperature. This effect can cause permanent damage to structures, resulting in loss of service, life and property. Sand-cement plaster is used extensively in building work as a decorative or protective coating for concrete and. Masonry walls. One of the important tasks of the sand-cement plaster is to protect the building elements against the high temperature which is the result of the fire. The determination of the degree of the influence of high temperatures on the sand-cement plaster is important in this respect. In this study, commonly used sand cement plaster material is used. The impact ratings of the plaster samples exposed to different temperatures were tried to be determined by measuring ultrasonic sound transmission value sand bending strengths. Keywords: Cement, building, durability, temperature, decorative ID 1111


72

ELECTROCHEMICAL BEHAVIOR OF ACID BLUE 127 ON CARBON PASTE ELECTRODE MODIFIED WITH DIFFERENT GEOLOGICAL

MATERIALS

Elif Tüzün, Gülten Atun

İstanbul Üniversity Engineering Faculty Department of Chemistry, Avcılar, İstanbul, 34320, Turkey [email protected]

İstanbul Üniversity Engineering Faculty Department of Chemistry, Avcılar, İstanbul, 34320, Turkey [email protected]

Abstract: Acid Blue 127 (AB 127) is an anionic dye used in textile industry especially for nylon dying process. It is an anthraquinone dye containing hazardous –NH2 groups. It must be present below legislatory limits in drinking water and its trace amounts must be sensitively determined. Electrochemical methods are more sensitive other analytical techniques for dye determination. In this work cyclic (CV) and square wave voltammetry (SWV) techniques were used to study electrochemical properties of AB 127 using carbon paste electrode (CPE) modified with magnezit (MAG-CPE), fullers earth (FE-CPE) and Ca-montmorrillonite (CaM-CPE). The bare CPE is insensitive for AB 127 and no peak was observed on the CV in acetate buffer. One irreversible anodic peak appeared nearly the same potential on the CVs of MAG-CPE and FE-CPE while an anodic response was obtained at more positive potential and a cathodic peak also obtained at the reverse scan for CaM-CPE. A linear concentration dependence was obtained with FE-CPE working electrode in 0.1-10 µM range in SWV measurements whereas a well defined peak appeared even 1 nM dye concentration on the SWV of MAG-CPE. Keywords: Acid blue 127, square wave voltammetry, cyclic voltammetry, electrochemistry ID 1116


73

PERFORMANCE OF ARTIFICIAL ALGAE ALGORITHM ON CONSTRAINED SINGLE OBJECTIVE REAL-PARAMETER

OPTIMIZATION

Sait Ali Uymaz, Barış Köçer, İbrahim Berkan Aydilek

Dept. of Computer Eng., Selcuk University, Konya, Turkey [email protected]

Dept. of Computer Eng., Selcuk University, Konya, Turkey [email protected]

Dept. of Computer Eng., Harran University, Şanlıurfa, Turkey [email protected]

Abstract: Artificial algae algorithm (AAA) is one of the population based bio-inspired optimization algorithms. AAA has been developed from inspiration of living behaviours of microalgae. The original version of AAA needs additional mechanism to deal with the constraints of a numerical optimization problem. This paper presents self-adaptive technique that has been adopted with AAA. To indicate the performance of AAA with self-adaptive constraint handling technique, experiments were performed on six constraint problems. Keywords: Artificial algae algorithm, bio-inspired algorithms, self-adaptive penalty, constraint-Handling techniques. ID 1128 Acknowledgment: This work was financially supported by the Coordinator ship of Scientific Research Projects of Selçuk University.


74

APPLICATION OF DEEP STACKED AUTO ENCODERS WITH BIOMEDICAL DATA

İbrahim Berkan Aydilek, Sait Ali Uymaz, Barış Koçer

Harran University, Engineering Faculty, Dept. of Computer Engineering, Şanlıurfa, Turkey [email protected]

Selçuk University, Engineering Faculty, Dept. of Computer Engineering, Konya, Turkey [email protected]

Selçuk University, Engineering Faculty, Dept. of Computer Engineering, Konya, Turkey [email protected]

Abstract: Diagnostic, treatment and decision making can be done in computer-aided health systems with biomedical data by deep learning. Biomedical datasets contain valuable information about diseases and patients. Also biomedical datasets may provide info about reason or result of treatment processes. Deep learning is a sub-section and popularly use in machine learning recently. Deep Neural Networks (DNN) are used successfully on image and speech etc. classification tasks in deep learning. One of the deep neural network architecture type is Stacked Auto Encoders (SAE) that use a couple of separated neural networks to classify commonly on big dimensional data. In this paper, Stacked Auto Encoders that have different architectures are used and compared on biomedical data. Experimental results showed that using of the proper SAE type in deep neural network on biomedical data provides successful and reliable classification accuracy results. Keywords: Deep Neural Networks (DNN), Stacked Auto Encoders (SAE), Biomedical data ID 1129


75

EFFECT OF SECONDARY PARAMETER UPDATE ON ARTIFICIAL BEE BASED ALGORITHMS

Barış Koçer, İbrahim Berkan Aydilek, Sat Ali Uymaz

Selçuk Universtiy Department of the Computer Engineering, Konya, Turkey [email protected]

Harran University, Engineering Faculty, Department of the Computer Engineering, Şanlıurfa, Turkey [email protected]

Selçuk Universtiy Department of the Computer Engineering, Konya, Turkey [email protected]

Abstract: In this work a secondary parameter update method is proposed to improve performance of ABC based algorithms. According to method, after original parameter update, another update is applied to employed bees using best food source found so far and best parameter according to statistical calculations. Performance comparison is performed using 15 benchmark functions in different dimensions. Proposed method finds better result than original method for most of the benchmark problems with the same fitness evaluations. Keywords: Artificial bee colony algorithm, Initialization methods, swarm intelligence ID 1130


76

AN HDG METHOD FOR NUMERICAL SOLUTION OF NONLOCAL FRACTIONAL BOUNDARY VALUE PROBLEM

Mehmet Fatih Karaaslan

Yıldız Technical University, Department of Statistics, 34220, İstanbul, Turkey [email protected]

Abstract: We investigate the approximate solution of the fractional differential equation with nonlocal boundary condition using a hybridizable discontinuous Galerkin method (HDG). These methods are efficiently implementable since we can eliminate all internal degrees of freedom and construct a linear system that involves unknowns at the element interfaces. The stability parameter has a key point to convergence of the HDG method on nonlocal FBVPs. We test the performance of the HDG method on some numerical experiments involving Caputo fractional derivative. Keywords: Hybridizable discontinuous Galerkin methods, nonlocal fractional boundary value problem, Caputo derivative. ID 1133


77

HYDRATION KINETICS AND THERMODYNAMICS FOR SOME NOVEL PYRIMIDINES CONTAINING SEMI AND

THIOSEMICARBAZONE MOIETY: EXPERIMENTAL EVIDENCE OF ENERGETICALLY FAVORABLE HYDRATION

Hasan Kılıç Department of Chemistry, Faculty ofArts and Sciences, Marmara University, Ziverbey 34722 Istanbul,

Turkey hkilic©marmara.edu.tr

Abstract: The time‐dependent effect on the hydration properties of recently synthesized 5‐ benzoyl‐1‐(methylphenylmethyleneamino)‐4‐phenyl‐1H‐pyrimidine‐2‐one (I) and 5‐benzoyl‐l‐ (methylphenylmethyleneamino)‐4‐phenyl‐1H‐pyrimidine‐2‐thione (II) were investigated in the

range 1.013.0 using UV‐Vis spectroscopy at a temperature of 25 0.1 oC. Pseudo‐first‐ order hydration kinetics and thermodynamics data, including rate constants, hydration‐ dehydration equilibrium constants, and the corresponding Gibbs energy values, were calculated at all levels. Hydration was found to occur energetically favorably for II at a of ca. 12. The preferred hydration mechanisms were suggested for the compounds based on the experimental UV‐Vis data obtained.

Figure 1. Keywords: Hydration kinetics and thermodynamics, favorable hydration, pyrimidines, semicarbazone, thiosemicarbazone, uv/vis, spectroscopy ID 1135


78

A NOTE ON THE EXACT SOLUTION METHODS FOR NONLINEAR PDES

Ozgur Yildirim, Meltem Uzun

Department of Mathematics,Yildiz Technical University, İstanbul 34220, Turkey [email protected]


Abstract: This work presents several powerful techniques for solving nonlinear partial differential equations. These techniques are used to obtain soliton solutions and travelling wave solutions of well known equations occurs in physical phenomena such as fluid mechanics, plasma waves, solid physics, etc. Some examples of symbolic computation is given in order to obtain the required analytical solutions. Keywords: Nonlinear boundary value problems, traveling wave solutions ID 1136 References [1] L. Debnath, “Nonlinear Partial Differential Equations for Scientists and Engineers”, Third

Edition, Birkhäuser, Boston,(2012).. [2] A.C. Scott, American Journal of Physics, (1969): 37, 52. Acknowledgement: This study is supported by the Research Fund of the Yildiz Technical University (Project number: 2016-01-03-DOP02).


79

UNIQUE SOLVABILITY RESULTS ON BOUNDARY VALUE PROBLEMS FOR SEMILINEAR HYPERBOLIC EQUATIONS

Ozgur Yildirim, Meltem Uzun



Abstract: In this work we investigate the unique solvability of semilinear hyperbolic equations using fixed point theorems. In order to find the approximate solution of boundary value problem, we use combined iterative methods. To verify our results, we use numerical experiments. Keywords: Picard-Lindelöf Theorem, k-contractivity ID 1137 References [1] E. Zeidler, “Nonlinear Functional Analysis and Its Applications 1: Fixed point Theorems”,

Springer- Verlag, Leipzig, Germany, (1986). [2] N. Aggez , G. Yucel , “On the NBVP for Semilinear Hyperbolic Equations, Filomat,” 31:4 (2017),

999–1007. Acknowledgement: This study is supported by the Research Fund of the Yildiz Technical University (Project number: 2016-01-03-DOP02).


80

UNFRIENDING IN SOCIAL NETWORKS: A RESEARCH ON FACEBOOK

Cemil Akkaş, Hülya Bakırtaş,

Aksaray University, Adana highway 7.km., Aksaray, 68100, Turkey [email protected]


Abstract: Nowadays, individuals spend more time in the virtual environment expressed as social media, meet their different needs here and see this virtual world as a part of their daily life. Because of these features, young people view social media as an element of socialization and in this virtual environment they develop friendship relationships. Facebook, which is one of the most popular social networks, has been determined as the social network where the research has been implemented. The purpose of this study is to reveal the factors that affect the unfriending in social networks. The web-based questionnaire prepared for the research was carried out the students of the Department of Management Information Systems of Aksaray University. Analysis was made on 285 students as a result of cleaning up the data which was erroneous and incomplete. As a result of the research, factors that affect Facebook users' decision to unfriending can be grouped under two headings: online and offline. Online factors; unnecessary and frequent sharing, sharing polarizers, sharing inappropriate content, and sharing about daily works. Offline factors are the end of the real life relationship and dislike behavior. Unfriending behaviour in social networks could also be examined in terms of the sides of the relationship such as student- teacher, employer- worker, parent-child. Keywords: Unfriending behavior, social networks, Facebook ID 1138 Acknowledgement: This research was prepared by supporting Aksaray University Scientific Research Projects Coordinatorship under Project No: 2017-001 and 68003-Master's Projects titled "An Experimental Design on the Acceptance of Friendship in Social Media and the Determinants of Unfriending ".


81

A RESEARCH ON THE RELATIONSHIPS OF FRIENDSHIP IN YOUTH’S SOCIAL NETWORKS

Cemil Akkaş, Hülya Bakırtaş,



Abstract: Technological developments that fully influence the lives of people affect people's social lives through social networks. Individuals can also establish social relationships as in real life through social networks. Young people use social networks to build new friendships, to communicate with each other more and to share with each other. The purpose of this study is to reveal the general Facebook usage habits and behaviors of individuals. The web-based questionnaire prepared for the research was conducted to the students of the Department of Management Information Systems of Aksaray University. Analysis was made on 285 students as a result of cleaning up the data which was erroneous and incomplete. According to the results of the analysis, the users who are both friends and their parents in social networks share more carefully. Men are more eager to share post than women. Almost a third of the individuals have more than one Facebook account. Moreover, male users are more likely to accept friendship requests from people they never know in real life according to female user. Research has some limitations. The first of these studies is to be conducted only to Aksaray university students. Implementation on Facebook, which is one of the social network sites, is another limitation of research. Keywords: Friendship, social network, Facebook behaviours ID 1139 Acknowledgement: This research was prepared by supporting Aksaray University Scientific Research Projects Coordinatorship under Project No: 2017-001 and 68003-Master's Projects titled "An Experimental Design on the Acceptance of Friendship in Social Media and the Determinants of Unfriending ".


82

SOME RIDGE PARAMETER ESTIMATORS FOR THE RESTRICTED RIDGE ESTIMATION IN GENERALIZED LINEAR MODELS

Fikriye Kurtoğlu Çukurova University, Faculty of Science and Letters, Department of Statistics, Adana, 01330 Turkey

[email protected]

Abstract: This study generalizes some different methods for estimating the ridge parameter for the first-order approximated restricted ridge estimation in generalized linear models. By conducting an extensive Monte-Carlo simulation study, the performances of the first-order approximated restricted ridge and maximum likelihood estimators are investigated in the presence of multicollinearity and under the different conditions. The results from the simulation study show that the estimated approximated mean squared error is lower for the first-order approximated restricted ridge estimators than those of the first-order approximated maximum likelihood estimator for all the different evaluated situations. Keywords: Ridge parameter estimator, restricted ridge estimation, generalized linear models, simulation study, gamma response ID 1140


83

ON IDEALS OF THE RING s sp pu

Fatih Temiz, E. Mehmet Özkan

Yıldız Technical University, Esenler, 34220 Istanbul, Turkey [email protected]

Yıldız Technical University, Esenler, 34220 Istanbul, Turkey [email protected]

Abstract: In this study, we first determine all the ideals of the ring q qu where sq p , p is any

prime and s is any positive integer with 2 0u . Next, we give a formula that enumerates the number of the ideals of this ring. In this way, we investigate the cyclic codes of length n where gcd( , ) 1p n and number of them by considering the ideal structure of the ring

( )[ ] 1nq qu x x is an ongoing search.

Keywords: Cyclic codes, codes over ring, non-chain rings ID 1141 Acknowledgement: The research is supported by Yıldız Technical University Scientific Research. Projects Coordination Department (Project Number: FDK-2017-3037).


84

STIGMAEID (ACARI: STIGMAEIDAE) MITES IN DILEK PENINSULA AND BUYUK MENDERES DELTA NATIONAL PARK, TURKEY

Mustafa Akyol, Melis Pınar Gül

Department of Biology, Faculty of Arts and Sciences, Manisa Celal Bayar University, Şehit Prof Dr İlhan Varank Campus, Yunusemre/ Manisa 45140, Turkey

[email protected] Department of Biology, Institute of Science, Manisa Celal Bayar University, Şehit Prof Dr İlhan

Varank Campus, Yunusemre/ Manisa 45140, Turkey [email protected]

Abstract: Stigmaeidae family is one of 11 families belonging to the Raphignathoidea supperfamily. Members of this family live in or on soil, grass, leaf, lichen, bark, crevices in rock and leaf cavities and are predators and feed on arthropods, ectoparasites of dipterans and polen feeders. This family inculudes 33 valid genera and more than 560 described species. By now, 11 genera and 103 species in this family were found in Turkey: Agistemus Summers (3 species), Cheylostigmaeus Willmann (5 species), Eryngiopus Summers (4 species), Eustigmaeus Berlese (25 species), Ledermuelleriopsis Willmann (11 species), Mediolata Canestrini (8 species), Prostigmaeus Kuznetsov (1 species), Stigmaeus Koch (38 species), Storchia Oudemans (4 species), Villersia Oudemans (1 species) and Zetzellia Oudemans (3 species). In order to determine the stigmaeid fauna of the Dilek Peninsula and the Büyük Menderes Delta National Park and to contribute to biodiversity, for a period of per month in year, the stigmaeid specimens extracted from the litter and soil samples collected from the study area Eustigmaeus Berlese (4 species: Eustigmaeus anauniensis (Canestrini, 1889), E. ioanninensis Kapaxidi & Papadoulis, 1999, E. segnis Koch (1836), E. sculptus Doğan, Ayyıldız & Fan, 2003 ), Ledermuelleriopsis Willmann (1 species: Ledermuelleriopsis plumosa Willmann, 1951), Stigmaeus Koch (1 species: Stigmaeus dazkiriensis Akyol & Koç, 2007), Storchia Oudemans (1 species: Storchia robustus (Berlese, 1885) species in the Stigmaidae family, have been identified as a new record for the study area and description of male of E. ioanninensis Kapaxidi & Papadoulis in this study. This work was supported by the Project 2016-024 by Manisa Celal Bayar University, Scientific Research Projects Coordination Unit. Keywords: Acari, Raphignathoidea, Stigmaeidae, National park, Turkey. ID 1142 Acknowledgement: This work was supported by the Project 2016-024 by Manisa Celal Bayar University, Scientific Research Projects Coordination Unit.


85

HEALING PRESSURE ULCERS WITH TOPICAL N-ACETYLCYSTEINE (NAC): A CASE REPORT

Karabal Esra1, Akçakaya Adem1, Albez Fadime Sultan2, Ayşe Yilmaz Demir1, Gümüş Asli1, Kiziltan Huriye Şenay1, Çakir Fatma Betül1, Aydoğdu İbrahim1,

Başibüyük Meryem1, Şimşek Muharrem1

1Bezmialem Vakif University Hospital, Palliative Care Unit, İstanbul, Turkey

[email protected] 2Erzurum Atatürk University Medical Faculty, Department of Chest Diseases, Erzurum, Turkey

Abstract: N-acetylcysteine (NAC), coming from aminoacid L-cysteine, leads to formation of glutathione in the body and prevents oxidative stress and inflammation. Besides anti-oxidative properties, it is also shown to be enhancing angiogenesis. It has roles in repair processes, including cell proliferation and migration, and it promotes healing also in diabetic wounds. 20 year old male patient, after being exposed to high frequency electric shock, was internalized to Intensive Care Unit of our hospital with multiple organ insufficiency. The patient was in dorsal decubitus position with total contractures of upper and lower limbs. After being detached from mechanical ventilator, the patient was taken to palliative care unit of Bezmialem Vakif University Hospital. Glascow Coma Score of the patient was less than 8, and huge pressure ulcers were formed in the locations of pelvic, sacral, lumbar and humeral regions of the patient. Two of the stage IV*** pelvic ulcers were 11 cm in diameter, two of the stage III pelvic ulcers were 6 cm in diameter, stage III sacral ulcer was 7 cm in diameter, and stage III humeral ulcer was 3 cm in diameter when the patient was internalized to our Palliative Care Unit. With the properties of enhancing angiogenesis and decreasing oxidative stress, we performed daily topical application of 300 mg NAC on each pressure ulcer and observed the epithelization process on the pressure ulcers. After 120 days of treatment with topical NAC, the ulcers decreased to 3 cm, to 3 cm, and to 4 cm in diameter, respectively. Stage III humeral ulcer has completely regressed to stage I with topical NAC application for 90 days. In conclusion, we aim to show the efficacy and efficiency of daily topical NAC application on the healing process of pressure ulcers. ***EPUAP Pressure Ulcer Classification System (updated in Oct 2014) was used in the report. Keywords: Palliative care, pressure ulcers, N-acetylcystein, coma. ID 1143


86

SUPERIORITY OF THE FIRST-ORDER APPROXIMATED r-d CLASS ESTIMATOR OVER SOME ESTIMATORS BY THE MEAN SQUARE

ERROR MATRIX CRITERION IN GENERALIZED LINEAR MODELS

Fikriye Kurtoğlu Çukurova University, Faculty of Science and Letters, Department of Statistics, Adana, 01330 Turkey

[email protected]

Abstract: In order to combat multicollinearity, Kurtoğlu and Özkale (2017) introduced the iterative and first-order approximated r-d class estimator by the combining principle components regression estimator and the Liu estimator in generalized linear models. In this study, we derive conditions for the superiority of the r-d class estimator over the ordinary least squares, the principal components regression and the Liu estimators by the matrix mean square error criterion in generalized linear models. We also illustrate our findings with a numerical example. Keywords: r-d class estimator, multicollinearity, mean square error, generalized linear models ID 1144


87

JOINING OF ALUMINIUM (6061-7075) ALLOYS BY FRICTION STIR WELDING

Hüseyin Adanır

Department of Mechanical Enginnering, Marmara University, Istanbul, Turkey [email protected]

Abstract: In the study, friction stir welding (FSW) behaviour of aluminium alloys (6061 and 7075) is investigated. Surface roughness (0.6 and 6 micron) and rotational speed (1100 and 1800 rpm) are used as effective variables. The investigation of joint strength selected as the response variable. The highest joint strength is measured as 96 MPa for the joining of 6061-7075 Al alloys combination at 1100 rpm with rough surfaces (6 µm). At the same time, precipitation hardening method is applied for the welded samples. After precipitation hardening application, homogeneous hardness distribution is observed and hardness on the joining samples are increased (119 HB). In metallographical studies, microstructure of the joint area is examined by optical microscope. Voids are observed on the joint area. Brittle fracture surfaces of the samples are observed in SEM studies. In EDS studies, the elemental amount of aluminium, magnesium, silicon and oxygen are identified on the joint area. Keywords: Aluminium, magnesium, sample. ID 1146


88

INVESTIGATION OF THE EFFECTS OF VARIOUS FIRE RETARDANTS ON THE THERMAL PROPERTIES OF FLAT-

PRESSED WPCS

Ferhat Özdemir, Ertuğrul Altuntaş, Nadir Ayrilmiş

Kahramanmaras Sütcü İmam Üniversitesi, Orman Fakültesi, Orman Endüstri Mühendisliği Bölümü, Kahramanmaras, Türkiye. [email protected]

Kahramanmaras Sütcü İmam Üniversitesi, Orman Fakültesi, Orman Endüstri Mühendisliği Bölümü, Kahramanmaras, Türkiye

[email protected] Istanbul University, Forestry Faculty, Department of Wood Mechanics and Technology. Bahcekoy,

Sariyer, 34473, Istanbul, Turkey [email protected]

Abstract: The thermal properties of flat-pressed wood plastic composites (WPCs) produced from a mixture of polypropylene; MAPP, some flame retardants and wood flour at different ratios were investigated. In the production of the WPC panels, wood flour was used in different proportions (40%, 50% and 60%) whereas the fire retardants such as Ammonium polyphosphate (AP), Decabromodiphenyl oxide (BR), Magnesium hydroxide (MH) and Zinc borate (ZB) at the 10% ratio were used. Differential Scanning Calorimetry (DSC) and Thermogravimetric Analysis (TGA) tests of the WPC panels were performed to determine thermal properties. According to the obtained DSC and TGA results, it was determined that the amount of weight loss was increased due to the increase of the amount of wood flour, while the degree of crystallization was found to decrease. Among the WPC panel groups, the highest crystallization degree was detected in panels with 58% PP- 48% WF and 2% MAPP. On weight loss, zinc borate was found to be the most effective flame retarder. Keywords: Thermal properties, fire retardant, composite, crystallization ID 1147


89

ON THE EXAMINATION OF PISA 2015 SCORES VIA HIERARCHICAL AND NON-HIERARCHICAL CLUSTERING

METHODS

Hasan Yildirim

Çukurova University, Science and Letters Faculty, Statistics Department, Adana, 01330, Turkey [email protected]

Abstract: Education is a primary concern of any developed country. It has been key feature while assessing and comparing countries. The Programme for International Student Assessment (PISA) is a triennial international survey which aims to evaluate education systems worldwide by testing the skills and knowledge of 15-year-old students (OECD). Since 2000, it has been carried out by accompanying a large number of countries. The contribution of statistical researches to this programme’s results has received little attention within this process. The principal objective of this study was to investigate the similarities/dissimilarities between countries and to cluster them according to their PISA 2015 scores. The research consisted of some popular approaches that included hierarchical (such as centroid, average and six more) and non-hierarchical clustering methods (such as k-means and PAM). While utilizing these methods, some indices like CH (Calinski and Harabasz, 1974), Duda (Duda and Hart, 1973), DB (Davies and Bouldin, 1967), Hartigan (Hartigan, 1975), Marriot (Marriot, 1971), Friedman (Friedman and Rubin, 1967), KL (Krzanowski and Lai, 1988), Silhouette (Rousseeuw, 1987), GAP (Tibshirani et al., 2001) and 17 more are used to choose the ideal number of clusters. Cophenetic correlation coefficient was used to validate hierarchical clustering methods. In non-hierarchical clustering methods, change of within sum of squares was examined to validate the ideal number of clusters. The findings indicated that average linkage method in hierarchical clustering methods was the best and it created three distinct clusters. On the other hand, k-means generated two clusters according to all indices values. PAM method was applied using same number of clusters in k-means methods. PAM’s results were similar to previous ones. It is evidently clear from the findings that mostly OECD members formed a clusters and the rest of countries were belong to second clusters. With a little exception, some countries - such as Kosovo, Lebanon, Tunisia and three more - created a third cluster in hierarchical clustering. Although Turkey, Chile and Mexico are members of OECD, they joined the cluster including mostly non-OECD members. All of these results can provide a better insight about the lacks on education systems and can be useful to advance education systems. Keywords: Pisa, Education, K-Means, Hierarchical Clustering, PAM, Clustering Validity ID 1150


90

ON LCD CODES FROM GROUP RINGS

Mehmet E. Koroglu, Bayram Ali Ersoy

Department of Mathematics, Yildiz Technical University, Esenler, Istanbul 34220, Turkey [email protected]

Department of Mathematics, Yildiz Technical University, Esenler, Istanbul 34220, Turkey [email protected]

Abstract: A linear code with complementary dual (abbreviated LCD) is a linear code C such that

0C C [1]. LCD codes are of great importance due to their wide range of applications

in consumer electronics, data storage and cryptography. In this work, we derive two class of LCD codes from group rings. Keywords: Linear codes, LCD codes, group rings ID 1151 Acknowledgement: This research is supported by Yıldız Technical University Scientific Research Projects Coordination Department. Project Number: 2016-01-03-DOP01. References: [1] Massey, James L. "Linear codes with complementary duals."Discrete Mathematics 106

(1992): 337-342.


91

ON THE EXISTENCE OF PERFECT LINEAR CODES OVER THE RING WITH RESPECT TO HOMOGENOUS METRIC

Ömer Kara, Hüseyin Kocaman, Mehmet Özen

Department of Mathematic,Sakarya University, Sakarya, Turkey Department of Mathematic,Sakarya University, Sakarya, Turkey Department of Mathematic,Sakarya University, Sakarya, Turkey

[email protected]

Abstract: In this study, the existence problem of perfect linear codes over the ring kp

of integer modulo

lp with respect to homogenous metric is investigated. In the cases that the existence of perfect codes are possible, a computer program is written to test the existence. Keywords: Homogenous weight, perfect codes ID 1152


92

ENCRYPTION MECHANISM IN QUANTUM COMPUTERS

Mirsat Yeşiltepe, Muhammet Kurulay

Yildiz Technical University, Department of Mathematical Engineering, 34220 Esenler - İstanbul, Turkey

[email protected] Yildiz Technical University, Department of Mathematical Engineering, 34220 Esenler - İstanbul,

Turkey [email protected]

Abstract: Quantum computers are based on quantum physics and can operate faster and faster than modern computers [1]. Quantum cryptography draws its strength from the weirdness of reality at small scales [2]. In this paper, the logic of quantum computers, quantum algorithms, quantum encryption issues will be explained. In this different encryption environment, it will explain the protocols that can be used in key exchange. Keywords: E91 protocol, BB84 protocol, Grover algorithm, key exchange, man in the middle attack ID 1154 References: [1] Hüseyin Bodur, Java Diliyle Kriptoloji Uygulamaları (Abaküs, 2016), 290. [2] Devin Powel, “What Is Quantum Cryptography? And can it make codes truly

unbreakable?”, Popular Science, 2016.


93

SYNTHESIS OF β-AMINO KETONES: A THREE-COMPONENT MANNICH-TYPE REACTION OF AROMATIC ALDEHYDE, ANILINE,

AND KETONES

Hasniye Yaşa, Belma Hasdemir, Özge Erken

Istanbul University, Engineering Faculty, Chemistry Department, Organic Chemistry Division, Avcilar, Istanbul-Turkey [email protected]

Istanbul University, Engineering Faculty, Chemistry Department, Organic Chemistry Division, Avcilar, Istanbul-Turkey

Istanbul University, Science Institute, Chemistry Department, Organic Chemistry Division, Fatih, Istanbul-Turkey

Abstract: The Mannich reaction is an organic reaction commonly used in the amino alkylation of the acidic proton of a carbonyl group with an aldehyde and an amine compounds. The product obtained by this reaction is the aminocarbonyl compounds known as the Mannich base. The Mannich reaction plays an important role in the synthesis of natural compounds, especially peptides, nucleotides and alkaloids. In addition, it has a wide range of uses of catalyst, plant protection in agriculture and chemistry of dye and polymer. The aim of this work is to synthesize the original amino ketones which can exhibit biological activity in a different structure by the mannich reaction. Synthesized new amino ketones are identified by GC-MS, LC-MS, 1 H-NMR, 13 C-NMR and mass methods.

Figure 1. R= Furyl-, cyclohexyl-, 4-metoxybenzyl- Keywords: Mannich reaction, amino ketones ID 2025


94

THE EFFECT OF DIFFERENT CONDITIONS ON THE IMPEDANCE OF ELECTRODE COATED WITH CONDUCTING POLYMER

Hacer Dolas, A. Sezai Sarac

Department of Chemistry and Vocational School of Hilvan Harran University, 63300 Sanliurfa, Turkey [email protected]

Department of Chemistry, Polymer Science and Technology, Istanbul Technical University, Maslak, 34469 Istanbul, Turkey

[email protected]

Abstract: To obtain super capacitors having high power density and to develop the mechanic and the electrochemical properties of conducting polymer, the researchers modified the electrodes with conducting polymers, electrochemically [1-2]. Electrochemical impedance spectroscopy (EIS) was applied for investigating the charge transfer, ion diffusion and capacitive property of electrodes coated with conducting polymer. Carried out studies showed that impedance values were affected by both electrolyte composition and electrode surface at electrolyte/electrode system [2-4]. The aim of this study was to investigate the effect of monomer type, monomer concentration, the dielectric constant of electrolyte media and coating thickness on impedance and capacitance values of conducting polymer coated electrode. In this study, ethylenedioxythiophene (EDOT) or pyrrole (Py) was selected to form conducting polymer (PPy or PEDOT) as monomer. 10, 5, 2.5 and 1.25 mM monomer were used to investigate the effect of monomer concentration. The dielectric constant of electrolyte media was changed by being used acetonitrile (ACN) and pure water (H2O) at various ratios. According to obtained data, it was found that increasing of the dielectric constant of media increased total charge and capacitance values in sample of PPy, conversely in that of PEDOT. Also, the thickness of coating affected the capacitance values of coating. It was thought that EIS may be used to monitor the coating thickness. Keywords: Conducting polymer, dielectric constant, coating thickness, impedance ID 2031 References [1] Sarac, A. Sezai, "Electrochemical impedance spectroscopy and morphological analyses

of pyrrole, phenylpyrrole and methoxyphenylpyrrole on carbon fiber microelectrodes." Surface and Coatings Technology 202.16 (2008): 3997-4005.

[2] Dolas, Hacer, A. Sezai Sarac, "An impedance-morphology study on poly (3-methylthiophene) coated electrode obtained in boron trifluoride diethyl etherate–acetonitrile." Synthetic Metals 195 (2014): 44-53.

[3] Dolas, Hacer, Digdem Giray, A. Sezai Sarac. "The Effect Of Sizing Compound On The Electropolymerization Of Pyrrole And The Impedance Of Carbon Fiber Coated With Poly (Pyrrole)." Journal Of The Turkish Chemical Society, Section A: Chemistry 3.3 (2016): 281-298.

[4] Dolas, Hacer, Burcu Sayinli, A. Sezai Sarac. "A Determination Method of Dopamine or Epinephrine by Conducting Polymers: The Electrochemical Impedance Spectroscopy." (2016): 89-106.


95

SYNTHESIS OF SALICYLALDIMINE MODIFIED NANOSCALED MESOPOROUS SILICA CUBES AND ADSORPTION BEHAVIOUR

TOWARDS DYES

Emel Ermiş

Anadolu University, Faculty of Science, Department of Chemistry, Eskişehir and 26470, Türkiye [email protected]

Abstract: In this study, nanoscaled mesoporous silica cubes (MS-NC) were synthesized via a modified Stöber process using cetyltrimethylammonium bromide (CTAB) as the template and n-hexane as the pore expanding agent and tetraethyl orthosilicate (TEOS) as the silicon source1,2. The morphology of mesoporous silica nanocubes was determined by scanning electron microscopy (SEM).

Figure 1. SEM images of MS-NC. Condensation of aminopropyltriethoxysilane (APTES) with 3,5-dichlorosalicylaldehyde produced 3,5-dichlorosalicylaldimine propyl triethoxysilane (L). Characterization of the ligand (L) was perfomed by FTIR , 1H-13C NMR spectroscopic methods and elemental analysis. The surface of MS-NC was modified using 3,5-dichlorosalicylaldimine propyl triethoxysilane. The structure of modified MS-NC was elucidated with FTIR spectroscopy and elemental analysis. The specific surface area was calculated by Brunauer−Emmett−Teller (BET) method. The adsorption performance of modified MS-NC for dyes from aqueous solutions was investigated.

SiOO

O O(TEOS)

OHOHOH

N(CH2)11

CH3

H3C

H3C CH3

BrCTAB

OO

O

Si N

HO

OOO

Si N

HO

+

LMS-NC Modified MS-NC

Hexane (35 C)°

+NH4OH

Cl

Cl Cl

Cl

Scheme 1. Synthesis of 3,5-dichlorosalicylaldimine propyl triethoxysilane modified MS-NC. Keywords: Mesoporous silica nanocubes, Modified silica nanocubes, cationic dye adsorption ID 2040


96

References [1] Wang Xiqing, Zhang Yu, Luo Wei, Elzatahry A. Ahmed, Cheng Xiaowei, Alghamdi,

Abdulaziz, Abdullah M. Aboubakr, Den Yonghui, Zhao Dongyuan. “Synthesis of Ordered Mesoporous Silica with Tunable Morphologies and Pore Sizes via a Nonpolar Solvent-Assisted Stöber Method” Chemistry of Materials 28 (2016): 2356-2362.

[2] Zhao Dongyuan, Yang Peidong, Margolese I. David, Chmelkab F. Bradley, Stucky D. Galen. “Synthesis of continuous mesoporous silica thin films with three-dimensional accessible pore structures” Chem. Commun. (1998): 2499–2500.


97

ADSORPTION OF HEAVY METAL IONS BY USING NOVEL IMINE FUNCTIONALISED MESOPOROUS SILICA NANOSPHERES AS AN

ADSORBENT

Yasemin Süzen

Anadolu University, Faculty of Science, Department of Chemistry, Eskişehir and 26470, Türkiye [email protected]

Abstract: In this study, mesoporous silica nanospheres (MS-NS) were synthesized by using cetyltrimethylammonium bromide (CTAB) as the template and tetraethyl orthosilicate (TEOS) as silica precursor in a nonpolar solvent-assisted Stöber method1-3. Surface morphology of the nanospheres was investigated by scanning electron microscopy (SEM). Imine based ligand, 5-chlorosalicylaldimine propyl triethoxysilane (L), was synthesized by condensation of aminopropyltriethoxysilane (APTES) and 5-chlorosalicylaldehyde. Characterization of the ligand was elucidated by elemental analysis, 1H-13C NMR and FTIR spectroscopic methods. Imine functionalized nanosphere silica particles were prepared by using silica template and 5-chlorosalicylaldimine propyl triethoxysilane, structure was supported by elemental analysis and FTIR. The Brunauer−Emmett−Teller (BET) method was utilized to calculate the specific surface area. The adsorption ability of heavy metal ions onto imine functionalized MS-NS from aqueous solutions was also examined.

Scheme 1. Synthesis of imine functionalized MS-NS.

Figure 1. SEM images of MS-NS. Keywords: Mesoporous silica, imine functionalized silica nanospheres, heavy metal adsorption ID 2041


98

References [1] Stöber Werner, Fink Arthur, Bohn Ernst “Controlled growth of monodisperse silica

spheres in the micron size range” J. Colloid Interface Sci. 26 (1968): 62−69. [2] Shimura Naoki, Ogawa Makoto “Preparation of surfactant templated nanoporous silica

spherical particles by the Stöber method. Effect of solvent composition on the particle size” J. Mater. Sci. 42 (2007):5299–5306.

[3] Wang Xiqing, Zhang Yu, Luo Wei, Elzatahry A. Ahmed, Cheng Xiaowei, Alghamdi Abdulaziz, Abdullah M. Aboubakr, Deng Yonghui, Zhao, Dongyuan “Synthesis of Ordered Mesoporous Silica with Tunable Morphologies and Pore Sizes via a Nonpolar Solvent-Assisted Stöber Method” Chemistry of Materials 28 (2016): 2356-2362.


99

INFLUENCE OF DEPOSITION TEMPERATURE ON STRUCTURAL AND OPTICAL PROPERTIES OF SPUTTERED CUBIC MgZnO THIN

FILMS

Nihan Akın Sönmez, Süleyman Özçelik

Photonics Application and Research Center, Gazi University, Ankara, 06500, Turkey Department of Physics, Gazi University, Ankara, 06500, Turkey

[email protected], [email protected]

Abstract: In this work, cubic-phase MgxZn1-xO thin films, having 100 nm thick, were deposited on (0001) oriented c-plane sapphire substrate by RF magnetron sputtering method at RT, 500 and 800 °C substrate temperatures. Both XRD and AFM results showed that crystallinity of the films was destroyed at 800 °C due to oxygen defects caused by the thermal effect on the substrate surface during the high deposition temperature. However, deposition at 500 °C was the most optimal condition for obtain uniform atomic distribution in the film, seen from the results of SIMS depth profile. The films have a very sharp absorption edge at around 240 nm and their transmission in visible and near infrared regions is around 85%. In addition, the Mg content in the cubic-phase MgxZn1-xO ternary alloy calculated as around 60% using Vegard’s quadratic approximation. It can be concluded that obtained structure which has 5.1 eV band gap energy can be used for fabrication of solar blind UV photodetectors. Keywords: c-MgZnO, sputtering, deposition temperature, depth profile ID 2051


100

INVESTIGATION EFFECTS OF SOME SULFONAMIDE DERIVATIVES ON AChE ENZYME

Mesut Işık, Şükrü Beydemir, Yeliz Demir, Mustafa Durgun, Adem Necip

Department of Pharmacy Services, Health Services Vocational School, Harran University, 63000, Şanlıurfa, Turkey

[email protected], Department of Biochemistry, Faculty of Pharmacy, Anadolu University, 26470, Eskişehir, Turkey

[email protected] Department of Chemistry, Faculty of Sciences, Atatürk University, 25240, Erzurum, Turkey

[email protected] Department of Chemistry, Faculty of Education, Harran University, 63190, Sanliurfa, Turkey

[email protected] Department of Pharmacy Services, Health Services Vocational School, Harran University, 63000,

Şanlıurfa, Turkey [email protected]

Abstract: Alzheimer’s disease (AD) is the most common form of neurodegenerative disorder with dementia. Alzheimer disease occurs as result of a combination of genetic factors with different epigenetic events. Besides, oxidative stress, which is defined as the disruption of the physiological balance between oxidant and antioxidant systems is caused to occur various diseases such as coronary artery and Alzheimer disease. Because, oxidative metabolic reactions and their by-products have played a role in coronary artery and Alzheimer disease pathogenesis. In addition, Alzheimer’s disease is related with alterations and degeneration in the metabolism of cholinesterase. Acetylcholinesterase (AChE) inhibitors are used in symptomatic theraphy of the disease. There are evidence that AChE inhibitors used in the the symptomatic theraphy of Alzheimer’s disease protect cells from oxidative damage and increase production of antioxidants. This study, AChE was partially purified with ammonium sulphate precipitation from human serum. Then, IC50 values were determined from Activity%/[I] graphs for sulfonamide derivatives which showed in vitro inhibitory effects on human serum AChE enzyme activity were indicated. In addition. We determined Ki values and inhibition types for sulfonamide derivatives from Lineweaver-Burk graphs. Keywords: Inhibitors, enzyme, AChE, sulfonamide ID 2062


101

Evaluation of Gross Alpha and Gross Beta Activity Concentration in Marine Sediments in the Altınova (Yalova/TURKEY)

K. Bayrak1, E. Kam1 and Z. Ü. Yümün2

1Yildiz Technical University, Faculty of Arts and Sciences, Physics Department, Davutpaşa Campus, 34220 Esenler/ İstanbul, TURKEY, [email protected]

2Namik Kemal University, Corlu Engineering Faculty, Environmental Engineering Department, 59860, Corlu, Tekirdag, Turkey

Abstract: This study was conducted to determine the total radiation level of the sedimentation of Altınova region. For this purpose, 6 sediment samples were taken from different locations of the region. Sediment samples collected were ready for counting at the end of the some operations such as drying and grinding. The 6 sediment samples that were ready to be counted were counted with the computer-controlled 10-channel low-level LB770 counter. The highest and lowest values of the total alpha concentration of the censored sediment samples were measured as 309 ± 13 - 129 ± 26, respectively. At the same time, When the concentrations of beta were examined, the highest and lowest values were found to be 914 ± 40 - 508 ± 51, respectively. The total alpha radioactivity value of the sediment samples was calculated as 211 ± 21 Bq / kg while the beta activity was calculated as 717.7 ± 60 Bq / kg. Keywords: Altınova, Sediment, Gross alpha, Gross beta. ID 3001

book of abstracts - intsaicfas2017.intsa.org/belg/icfas2017_abstract_book_100917.pdf · book of...

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