1.VITRTUS CFD OF THE BLOOD FLOW IN THE CLOUD JAKUB POLA SOFTWARE DEVELOPER, VRATIS LTD.

2. HEART DIAGNOSIS Non-invasive: X-Ray Computer Tomography. Magnetic Resonance Imaging. Electrocardiography. Invasive: Angiography. Fractional Flow Reserve.2 | PRESENTATION TITLE | NOVEMBER 14, 2013 | CONFIDENTIAL 3. HEART DIAGNOSIS FRACTIONAL FLOW RESERVE EXAMPLE COURAGE, FAME2: FFR VALUEStent implantationDrug therapy DeFACTO (2012):FFR 3 | PRESENTATION TITLE | NOVEMBER 14, 2013 | CONFIDENTIALFFR CT 4. COMPUTATIONAL FLUID DYNAMICS FRAMEWORK Solve Navier Stokes equations Procedure: Preprocessing: Definition of the geometry. Generation of volumetric mesh. Definition of physical model. Definition of boundary conditions. Simulation: iterative solvers. Post-processing: Analysis Visualisation How to obtain geometry and create a mesh? How to solve the problem fast and efficiently? 4 | PRESENTATION TITLE | NOVEMBER 14, 2013 | CONFIDENTIAL 5. CFD IN MEDICINE Stent graft design: Determination of proper shape of the stent graft Design of heart valves: Determination of shape and biological and mechanical properties Drug delivery: Determination of the delivery device Determination of the drug state5 | PRESENTATION TITLE | NOVEMBER 14, 2013 | CONFIDENTIAL 6. VIRTUS: OVERVIEW Mesh storage formatUser InterfaceDatabasePACS Software as a ServiceActive Mesh6 | PRESENTATION TITLE | NOVEMBER 14, 2013 | CONFIDENTIALCalculations 7. VIRTUS: WORKFLOWCT / MRI ScanningSegmentationCFD Simulation 7 | PRESENTATION TITLE | NOVEMBER 14, 2013 | CONFIDENTIALMeshingPost-processing / Visualisation 8. VIRTUS: ARCHITECTURESTLSegmentation CT/MRIV MeshSurface representation of volumetric meshSimulation4 txt config filesSet boundary conditionsVisualization8 | PRESENTATION TITLE | NOVEMBER 14, 2013 | CONFIDENTIALGeneration of Volumetric Mesh (NETGEN)surface & U, p, WSSSimulation 9. VIRTUS: GRAPHIC USER INTERFACE9 | PRESENTATION TITLE | NOVEMBER 14, 2013 | CONFIDENTIAL 10. VIRTUS: ARCHITECTURESTLSegmentation CT/MRIV MeshSurface representation of volumetric meshSimulation4 txt config filesSet boundary conditionsVisualization10 | PRESENTATION TITLE | NOVEMBER 14, 2013 | CONFIDENTIALGeneration of Volumetric Mesh (NETGEN)surface & U, p, WSSSimulation 11. VIRTUS: SEGMENTATION Create 3D model from series of images. Very time consuming task. Require mesh modeling to: fix the errors in the mesh prepare mesh to generate volumetric mesh11 | PRESENTATION TITLE | NOVEMBER 14, 2013 | CONFIDENTIAL 12. VIRTUS: SEGMENTATION ACTIVE MESH Input: CT or MRI scans in DICOM format. Outputs: Surface mesh in STL format. Volumetric mesh in OpenFOAM format. Real-time procedure. Fasat algorithm. Many mesh editing tools: Global/local mesh smoothing. Cut Mesh. Freeze Mesh. Push Mesh. Define Flow Inlets and Outlets Automated determination of artery centerline(s) 12 | PRESENTATION TITLE | NOVEMBER 14, 2013 | CONFIDENTIAL 13. VIRTUS: MESHING MODULE13 | PRESENTATION TITLE | NOVEMBER 14, 2013 | CONFIDENTIAL 14. VIRTUS: ARCHITECTURESTLSegmentation CT/MRIV MeshSurface representation of volumetric meshSimulation4 txt config filesSet boundary conditionsVisualization14 | PRESENTATION TITLE | NOVEMBER 14, 2013 | CONFIDENTIALGeneration of Volumetric Mesh (NETGEN)surface & U, p, WSSSimulation 15. VIRTUS: SIMULATION MODULE USER SIDE Just two steps: Type of simulation: Transient flows. Steady-state flows. Inlet boundary condition: Inlet velocity. Inlet pressure. Point and click procedure Configuration Just four txt files15 | PRESENTATION TITLE | NOVEMBER 14, 2013 | CONFIDENTIAL 16. VIRTUS: SIMULATION MODULE USER SIDE16 | PRESENTATION TITLE | NOVEMBER 14, 2013 | CONFIDENTIAL 17. VIRTUS: SIMULATION MODULE SERVER SIDE Three ways to execute simulation: Using CPU in parallel mode. Using CPU + GPU in parallel mode. Using GPU only.17 | PRESENTATION TITLE | NOVEMBER 14, 2013 | CONFIDENTIAL 18. VIRTUS: SIMULATION MODULE SERVER SIDE: CPUCPU Read meshAssembly matrices Ax=b ~33% No Conv erged ?Yes Finalize18 | PRESENTATION TITLE | NOVEMBER 14, 2013 | CONFIDENTIALSolve Ax=b~66% 19. VIRTUS: SIMULATION MODULE SERVER SIDE: CPU + GPUCPUPCIGPURead meshAssembly matrices Ax=bNoConv erged ?Yes Finalize19 | PRESENTATION TITLE | NOVEMBER 14, 2013 | CONFIDENTIALAx=bxSolve Ax=b 20. VIRTUS: SPEEDIT TOOLKIT Solvers: Conjugate Gradient. Bi-Conjugate Gradient. Preconditioners: Diagonal. Approximate Inverse. Algebraic Multigrid with Smoothed Aggregation (CUSP). Support for Multi-GPU. Platforms: OpenCL. CUDA.20 | PRESENTATION TITLE | NOVEMBER 14, 2013 | CONFIDENTIAL 21. VIRTUS: SIMULATION MODULE SERVER SIDE: CPU + GPUCPUPCIGPURead meshAssembly matrices Ax=bNoConv erged ?Yes Finalize21 | PRESENTATION TITLE | NOVEMBER 14, 2013 | CONFIDENTIALAx=bxSolve Ax=b 22. VIRTUS: SIMULATION MODULE SERVER SIDE: GPUCPU Read meshPCIGPUMesh Assembly matrices Ax=bNoFinalize22 | PRESENTATION TITLE | NOVEMBER 14, 2013 | CONFIDENTIALxSolve Ax=bConv erged ?Yes 23. VIRTUS: SPEEDIT FLOW Full GPU implementation of: PISO (Pressure Implicit with Split Operator) transient solver for incompressible flows. SIMPLE (Semi-implicit Method for Pressure Linked Equations): Steady-state solver for incompressible flows. Boundary Conditions: Zero Gradient Time dependent and Fixed value. Adjustable time step. Roadmap: Support for OpenCL Turbulence (RANS, kOmegaSST model) Support for Multi-GPU 23 | PRESENTATION TITLE | NOVEMBER 14, 2013 | CONFIDENTIAL 24. SPEEDIT FLOW TEST CASES U-shaped pipe Radius 1in 4M hex cells Transient flow simulation: U(t) = Asin(t) + B Steady-state simulation Re = 100 Re = 1000 Basilar artery*: 2M hex cells Transient flow. Two heart cycles.* Geometry obtained from AneuriskWeb project. Emory University, Department of Math&CS, 2012 24 | PRESENTATION TITLE | NOVEMBER 14, 2013 | CONFIDENTIAL 25. SPEEDIT FLOW: U-SHAPED PIPE SIMULATION EXECUTION TIME25 | PRESENTATION TITLE | NOVEMBER 14, 2013 | CONFIDENTIAL 26. SPEEDIT FLOW: U-SHAPED PIPE ACCELERATION RATIO26 | PRESENTATION TITLE | NOVEMBER 14, 2013 | CONFIDENTIAL 27. SPEEDIT FLOW: BASILAR ARTERY SIMULATION EXECUTION TIME27 | PRESENTATION TITLE | NOVEMBER 14, 2013 | CONFIDENTIAL 28. SPEEDIT FLOW: BASILAR ARTERY ACCELERATION RATIO28 | PRESENTATION TITLE | NOVEMBER 14, 2013 | CONFIDENTIAL 29. VIRTUS: ARCHITECTURESTLSegmentation CT/MRIV MeshSurface representation of volumetric meshSimulation4 txt config filesSet boundary conditionsVisualization29 | PRESENTATION TITLE | NOVEMBER 14, 2013 | CONFIDENTIALGeneration of Volumetric Mesh (NETGEN)surface & U, p, WSSSimulation 30. VRATIS: VISUALIZATION MODULE30 | PRESENTATION TITLE | NOVEMBER 14, 2013 | CONFIDENTIAL 31. SUMMARY VIRTUS is a platform for personalized medicine and CFD based diagnosis. Cloud-based approach simplifies the usage. GPU reduces time-to-solution.31 | PRESENTATION TITLE | NOVEMBER 14, 2013 | CONFIDENTIAL 32. Questions? Comments? Jakub Pola jakub.pola@vratis.com virtus.vratis.com Acknowledemnents: Vratis: Wojciech Tarnawski, Lukasz Miroslaw, Pawel Czubinski Wroclaw Uni.: Zbigniew Koza, Piotr Olkiewicz Wroclaw Uni. of Technology: Tadeusz Tomczak, Andrzej Kosior32 | PRESENTATION TITLE | NOVEMBER 14, 2013 | CONFIDENTIAL 33. DISCLAIMER & ATTRIBUTIONThe information presented in this document is for informational purposes only and may contain technical inaccuracies, omissions and typographical errors. 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