blok1 histo epitel

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HISTOLOGYHISTOLOGY

THE CELL AND CONNECTIVE TISSUE

EXPLANATION INCLUDES:

1.EPITHELIAL & GLANDULA

2.MUSCLE3. CONNECTIVE TISSUE / ADIPOSE

4. NERVOUS TISSUE

5.CARTILAGE AND BONES

6. BLOOD

j!".#.2$15



STRU%TUR SELSTRU%TUR SEL

NUCLEUS & CYTOPLASMA

Cell membrane

Nucleus: '!()*+,"-"'0-"'.*),"*-

"'0 0"00. Cytoplasm:mitochondria,ribosome,endoplasmicreticulum,endosome,golgicomplex,lysosom,peroxisomes

-'0"+()0-'0"+(,0 Cytoskeleton: ),'(,,-),'(+0-,*)0"+

C,,* *" *70*



mitochRough reticulum centriolesMembran sel

S+(8+( 0S+(8+( 0

lysosom nucleolus

Smooth

reticulu

cytoplasma

Golgi

compl




MEMBRAN SEL )0(*8*" LIPID BILA9ER NUCLEUSDNA- )*+0(, 70"0+,8 0 +0)*+ ,"+0,

(+0,"-,"+0* RNA

+ RNA-) RNA-( RNA; &8*+*,*, 0"<,)

MITOCHONDRIA)0( 0"0(, "+8 (0*8,,8,),*-8)"0" 0(,, (+0,"P(,";-ATP-'*,)*+.

ENDOPLASMIC RETICULUM(7*"0 +0(0*(

**) ,+*)*-+0(,(, *(, ( (7!;ER=ribosom *" smooth;ER L9SOSOMES "7, >,70+,0 ?+0)@ 8*(0"*

+0(**+ 3$ 0"<,) !,(,+,8.




ENDOSOME : TEMPAT PROSESENDOSITOSIS-PHAGOSITOSIS-AUTO

PHAGOSITOSIS- POMPA PROTON H;

PEROXISOMES: EN9M OXIDATIVE 07:URATE OXIDASE-CATALASE;-"7,0+8,,8*,-0)0"+8*" (*,'* 0*

0.7 0(,0 & !?(70" 0(,0; PROTESOME " "7, 07(**, (+0,",+



M0'!*",) +!0 '0M0'!*",) +!0 '0

S,8 0

*0 G1-G2-S-M

G$- ,8"+(0! (+0," #yclins

P0)0*!*" 0: ,"+0(*0-),+,-)0,,

E",+, ,*7, 2: ,",+, & !*7,+,

%0)*+,*" 0 ,*7, 2 : *+, *" "0'(,

M0)(*" 0 +: L,, ,*?0(

DNA **) "'0

P(+0," ,"+0, **) 0



POPULASI SEL DAN ASE SI%LUS SELPOPULASI SEL DAN ASE SI%LUS SEL

MITOSIS SINTESIS

GROFTH

G2

G 1

S M

G 0

on

!i"i!ing

cell



STRU%TUR ANTAR SELSTRU%TUR ANTAR SEL

1.PADA SEL EPITEL TERDAPAT $O%ESI SE& ME&&'I SE& MEM(RN #E&&

D%ESION MO&E#'&E) MEMBENTU%

SUATU >UNCTIONAL COMPLEXES@ 9ANGTDD : ONULA OCCLUDENS-ONULA

ADHERENS-DESMOSOME DAN GAP

UNCTION

2.PADA ARINGAN TERDAPAT AT ANTAR

SEL MATRIX EXTRACELL = *RO'ND

S'(STN#E ; DAN EXTR#E&& +I(ERS



EPITEL DAN %ELENAREPITEL DAN %ELENAR

EPITE& TER(*I TS:1. GEPENG BERLAPIS & TA% BERLAPIS

2. %UBIS BERLAPIS & TA% BERLAPIS

3. TORA% BERTING%AT / CILIA- GOBLET4. TRANSISIONAL

$E&ENR TER(*I TS"

$E&ENR &'D% - *&ND'& S&I.TORI'S) $E&ENR $ERIN*T - *&ND'& S'DORI+ER)

$E&ENR S'S' - *&ND'& MMME)



EPITEL SELAPIS GEPENGEPITEL SELAPIS GEPENG

ENDOTEL; ENDOTEL;

EPITEL GEPENG



STRATIIED SUAMOUSSTRATIIED SUAMOUS

EPITHELIUMEPITHELIUM



E,+0 0(*, 700"7 0(+*"8E,+0 0(*, 700"7 0(+*"8 %ERATINIED; %ERATINIED;

O(7*" : 8,+ +0*

0,0(),

0(),



S0*, 8,S0*, 8,



E,+0 0*, 8,E,+0 0*, 8,

EPITEL %UBIS



BERLAPIS %UBISBERLAPIS %UBIS



E,+0 0*, +(*8E,+0 0*, +(*8

EPITEL TORA%



S0*, +(*8-',,*-70+S0*, +(*8-',,*-70+



E,+0 0(+,"78*+ +(*8 ',,*E,+0 0(+,"78*+ +(*8 ',,*

EP.BERTING%AT

TORA%CILIA



E,+0 +(*",,"*E,+0 +(*",,"*

EPITEL TRANSISIONAL



T0(,)* 8*,!



ARINGAN PEN9AMBUNGARINGAN PEN9AMBUNG

.P. PADAT ELASTIN & COLLAGEN

.P. ARANG / ARINGAN RETI%ULER

.PEN9O%ONG:

TENDO / LIGAMENTUMTULANG RAFAN ELASTIN DAN H9ALIN

TULANG PANANG DAN PIPIH

#S#R S$L

SELMESENCH9M-IBROBLAST-IBROSIT-MASTCELL-CHONDROBLAST-CHONDROSIT-OSTEOBLAST-OSTEOSIT-OSTEOCLAST



ARINGAN PEN9AMBUNG PADATARINGAN PEN9AMBUNG PADAT

SEDIAAN :TENDO

ARINGAN %OLAGEN

IBROSIT



*(,"7*" (0+,80( *(,"7*" (0+,80(



OTOT POLOSOTOT POLOS

BENTU% USIORM- INTI DITENGAH

MELAPISI ORGAN VISCERA

INVOLUNTAR9 MUSCLE =UNCONCIOUS NERVOUS S9STEM

U%URAN BERVARIASI

UTERUS GRAVID;12 X 6$$ ) ARTERIOL 12 X 1$ )



O++ O++

I"+, 0 ++



OTOT S%ELETOTOT S%ELET

SERABUT : BENTU% SILINDRIS-PANANG*" DIAMETER BERVARIASI 1)) J 3$ ');

D,*)0+0( : 1$J1$$ µ)

U8(*" *" +0* **+ *+* KKK H?0(+(, *" A+(,

I"+, : ,+0,-,,! ,*#*! *.*(80))*;-*"?*8.

H,+7,' 0'+,": M?,(,-S*('0))*-C!"!0,) ,0-S*('*)*



O++ 800+O++ 800+

I"+, 0 ++

S0(*+ ++



SEL SARA/ AR.SARASEL SARA/ AR.SARA

SUSUNAN SARA PUSAT

SUSUNAN SARA TEPI

SUSUNAN SARA OTONOM

UNSUR SEL: SEL PIRAMID-SELMICROGLIA-SEL ASTROC9T-SEL

EPENDIM-SEL SARA MOTORIS-SELSATELIT-SEL PUR%IN9E-SCHFANNCELL



SEL SARA :A+(.(+*)*+,SEL SARA :A+(.(+*)*+,

ASTROC9T PROTOPLASMATIS CELL



S0 *(* )+(,S0 *(* )+(,



C,",'* *,'*+,"C,",'* *,'*+,"

METAPLASIA : T(*"()*, 0,+0 *, )0"j*,0"+8 0,+0 *,".'"+! )0+**, *,*" 0,+0("77* )+ ** 0(88.

PHEMPHIGUS VULGARIS : 0"?*8,+ *+,))"?*"7 ,0*8*" ,8*+*" *"+,, +0(!** 00(**

8)"0" 0)). EPIDERMOL9SIS BULLOSA : M+*, *+ *(, 70"

+0(!** 80(*+,". APOPTOSIS DAN NECROSIS.

CANCERCHEMOTHERAP9VINBLASTIN-VINCRISTINE-TAXOL; BE%ERA DENGANMENGHENTI%AN PRO&I+ERSI SEL.

IMMOTIL CILIA S9NDROME : MUTASI PROTEIN

PADA CILIA DAN LAGEL.



CLINICAL APPLICATIONCLINICAL APPLICATION

EDEM : *8)*, '*,(*" j*(,"7*" ?*"7 0(0,!*"-(0"(0 (**"7 0!,"77* 0 M*+ )0"70*(8*" !,+*)," *"08+(,"0 0()0*,,+* 8*,0( )0","78*+.

S#'R./ : 0(*(*!*" 7, *8,*+ 0,,0", ,+.C ?*"7,0(8*" "+8 (0 !?(,*, (,"0 +0(!**

0)0"+8*" +(!'*70". $E&OID : PEMBENTU%AN COLLAGEN 9ANG BERLEBIHAN

PADA PROSES PEN9EMBUHAN LU%A.NORMAL:PEN9EMBUHAN LU%A OLEH COLLAGEN T9PE 3

SELANUTN9A DIGANTI%AN OLEH T9PE 1. S/STEMI# &'P'S ER/T%EMTOS'S :0"?*8,+ *+,))"?*"7 )0"?0*8*" (**"7 j*(,"7*" 0"?*)"7.



CLINICAL APPLICATIONCLINICAL APPLICATION

GANGGUAN PADA PROSES MEIOSIS 1 DISTRIBUSI CHROMOSOM TIDA%SAMA PADA >D'*%TER #E&&0 *. :

1. DOFNS S9NDROMETERADI 3COPIES PADA CHROMOSOM 21

2. %LINEELTERS S9NDROME EXTRA

X CHROMOSOME XX9;3.TURNERS S9NDROME SINGLE X

CHROMOSOME XO;



*(.0"?.j*(*"7*(.0"?.j*(*"7



S,"7*, 7*"S,"7*, 7*"

)8*

0(*

D'+ 0'(0+(,



SEL DARAHSEL DARAH

SEL DARAH PUTIH LEU%OSIT; TDD:

BASOPHIL-EOSINOPHIL-NEUTROPHIL-

L9MOSIT-MONOC9T

SEL DARAH MERAH ER9THROC9T;



$RYTHRO%YT &' $#TRO(HIL$RYTHRO%YT &' $#TRO(HIL



S,'80 '0 *"*0),*S,'80 '0 *"*0),*



B B +



B"0 (*'+(0B"0 (*'+(0



TERIMA KASIH TERIMA KASIH

OHN.F.H.SITOHANGOHN.F.H.SITOHANG



M M +



M*+ '0M*+ '0

GENE PROCESSGENE PROCESS



GENE PROCESSGENE PROCESS

DNADNA



DNADNA

THE CHROMOSOMETHE CHROMOSOME



S0*, 8,S0*, 8,



B0(*, 700"7 0(+*"8B0(*, 700"7 0(+*"8

E,+0 0*, +(*8E,+0 0*, +(*8



E,+0 0*, +(*8E,+0 0*, +(*8

S , + 8 ,, +S , + 8 ,, +



S0*, +(*8-',,*-70+S0*, +(*8-',,*-70+

E(?+!('?+E(?+!('?+



E(?+!('?+E(?+!('?+

L08,+ ,L08,+ ,



L08,+ ,.L08,+ ,.

L9MOSITL9MOSIT



L9MOSITL9MOSIT

L08,+L08,+



L08,+L08,+

S,"7*, 7*"S,"7*, 7*"



S,"7*, 7*"S,"7*, 7*"

C0*'0 7*"C0*'0 7*"



C0*'0 7*"C0*'0 7*"

S#0*+ 7*"S#0*+ 7*"



S#0*+ 7*"S#0*+ 7*"

GLD MAMMAE , ,GLD MAMMAE , +,



GLD.MAMMAE ," *'+,0GLD.MAMMAE ," *'+,0

G )*))*0 *'+,0G )*))*0 *'+,0



G.)*))*0 *'+,0G.)*))*0 *'+,0

L9MONODUSL9MONODUS



L9MONODUSL9MONODUS

*( 0"? j*(*"7*( 0"? j*(*"7



*(.0"?.j*(*"7*(.0"?.j*(*"7

*( 0)*8 ",*'*( 0)*8 ",*'



*(.0)*8 ",*'*(.0)*8 ",*'

M*+ '0M*+ '0



M*+ '0M*+ '0

C*(+,*70C*(+,*70



C*(+,*70C*(+,*70

B*8 +*"7B*8 +*"7



B*8 +*"7B*8 +*"7

T*"7 0#**T*"7 0#**



T*"7 0#**T*"7 0#**

OVUMOVUM



OVUMOVUM



E,+0 0*, 700"7E,+0 0*, 700"7



E,+0 0*, 700"7E,+0 0*, 700"7

E,+0 0*, +(*8E,+0 0*, +(*8



E,+0 0*, +(*8E,+0 0*, +(*8

+ , , + , ,



+(*",,"*+(*",,"*

B0(+,"78*+ +(*8 70+B0(+,"78*+ +(*8 70+



B0(+,"78*+ +(*8-70+B0(+,"78*+ +(*8-70+

S0*, +(*8 ',,* 70+S0*, +(*8 ',,* 70+



S0*, +(*8-',,*-70+S0*, +(*8-',,*-70+

S0*, +(*8S0*, +(*8



S0*, +(*8S0*, +(*8

B0(*, 700"7 +*8 0(+*"8B0(*, 700"7 +*8 0(+*"8



0"+00"+0



S , + 8S , + 8



S0*, +(*8S0*, +(*8

E,+0 +(*",,"*E,+0 +(*",,"*



E,+0 +(*",,"*

O+ + O++



O++ O++

S*(* 0(,0(S*(* 0(,0(



S*(* 0(,0( S* * 0 0

C*(,*' )'0C*(,*' )'0



C*(,*' )'0

O++ j*"+"7O++ j*"+"7



O++ j*"+"7O++ j*"+"7

A+(.(+*)*+, A+(.(+*)*+,



S?"*S?"*



S0 ,(*),S0 ,(*),



S0 (8,"?0S0 (8,"?0



? ?

O,70"(7,*O,70"(7,*



O 70 7 *7 7

M+( 0" *+0M+( 0" *+0



M,8(.L"7 "0M,8(.L"7 "0



77

T*"7 0#**T*"7 0#**



77

B"0 (0*,(,"7B"0 (0*,(,"7



B"0 (0*,(,"7 0 0* 7

E'(0+(? '+E'(0+(? '+



S#0*+ 7*"S#0*+ 7*"



E'(0+(? 7*"E'(0+(? 7*"



? 7? 7

B0( 700"7 0(+*"8B0( 700"7 0(+*"8

blok1 histo epitel

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