biotechnology presentation of astrazeneca
DESCRIPTION
This presentation lists several aspects of AstraZeneca. It lists some of the recent pipelines, drugs, etc.TRANSCRIPT
A Global Research-Based Pharmaceutical Company
By: Stephen BoustShannon KeenanJonathan Lym
Founding Founded on April 6, 1999
Merger between Astra AB and Zeneca Group PLC
Founding Goals Achievements and Service
Current Products
Pipeline Products
Future Outlook Questions
Zeneca Group PLC Large focus on pharmaceuticals,
agricultural chemicals, and specialty chemicals.
Oncology drugs produced: Casodex, Nolvadex, and Zoladex.
Astra AB Sweden’s main produce
of penicillin and xylocaine
AstraZeneca’s Goals Research, development, and commercialization in
the fields of : Cancer Cardiology Pulmonology Gastroenterology Immunology Neuroscience
Founding Goals Achievements and Service
Current Products
Pipeline Products
Future Outlook Questions
Notable Achievements and Service Seventh largest pharmaceutical company in the world
Four products in top 100 drugs based on sales in the U.S.
Scrip Intelligence Award for “Best Partnership Alliance” for 4 consecutive years
AstraZeneca Nobel Medicine Initiative Spread awareness about Noble Prize
winners in physiology and medicine
Young Health Program: Educate adolescents globally about health issues
Founding Goals Achievements and Service
Current Products
Pipeline Products
Future Outlook Questions
Nexium (Esomeprazole) AstraZeneca’s most successful drug: #2 in
sales for U.S. Pharmaceuticals
Treats acid reflux and stomach ulcers
Heals erosive esophagitis and may prevent cancer of the esophagus
How it works: proton pump inhibitor Reduces production of stomach acid by acting
as a competitive inhibitor of proton pumps
Only S-isomer of Esomeprazole to increase effectiveness
Founding Goals Achievements and Service
Current Products
Pipeline Products
Future Outlook Questions
Crestor (Rosuvastatin Calcium) Ranked fifth in U.S. Pharmaceutical Sales
Treats high cholesterol and reduces risk of heart disease, heart attack, and stroke
It is a statin- an HMG-CoA reductase inhibitor HMG-CoA reductase is the rate-limiting
enzyme in the production of cholesterol in liver cells.
Contains a polar methane sulfonamide side group which allows for stronger binding to active site of HMGR
Founding Goals Achievements and Service
Current Products
Pipeline Products
Future Outlook Questions
Pipeline: AZD5363 Currently in phase one clinical trials
Targets solid tumors
ATP-competetive inhibitor of Akt, a protein kinase in the PI3K signaling pathway This pathway is responsible for cell death and survival,
cell migration, and metabolism Cancer can occur when Akt is over-activated
Shows highest sensitivity to breast cancer and prostate cancer cell lines
Founding Goals Achievements and Service
Current Products
Pipeline Products
Future Outlook Questions
P13K Pathway
Founding Goals Achievements and Service
Current Products
Pipeline Products
Future Outlook Questions
Pipeline: Lesinurad Currently in phase three clinical trials
Treats Gout- inflammatory arthritis in the metatarsal phalangeal joint of the big toe Caused by uric acid build-up in the
blood
Selective inhibitor of URAT1 and blocks urate reabsorption in the renal proximal tubule.
Founding Goals Achievements and Service
Current Products
Pipeline Products
Future Outlook Questions
AstraZeneca’s Future Outlook Currently, AstraZeneca is facing some hardship
Patent expiration of blockbuster drugs
Scandal: Bribed generic drugmakers to postpone release of generic forms of Nexium
Job layoffs in sales, administrative, and manufacturing sectors expected
Plans to overcome these hardships through collaboration and investing in other companies
Founding Goals Achievements and Service
Current Products
Pipeline Products
Future Outlook Questions
Questions?
Founding Goals Achievements and Service
Current Products
Pipeline Products
Future Outlook Questions