biotechnology as career option 2012

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Biotechnology as Career Option 2012 Choosing a Career path in 21 st Century without understanding the Industry would be as good as ship sailing in a sea without a compass Biotechnology is the research and development of innovative healthcare, agricultural, industrial and environmental products https://www.facebook.com/pages/Bioinformatics-O n-Run by BioInformaticsOnRu n

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Biotechnology Industry has changed a lot during last decade , which means moving ahead from traditional ways to more advanced technological developments2012 Biotechnology Industry is not the same as it was in 2001

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Page 1: Biotechnology as Career Option 2012

Biotechnology as Career Option 2012

Choosing a Career path in 21st Century without understanding the Industry would be as good as ship sailing in a sea without a compass

Biotechnology is the research and development of innovative healthcare, agricultural, industrial and environmental products

https://www.facebook.com/pages/Bioinformatics-On-Run

byBioInformaticsOnRun

Page 2: Biotechnology as Career Option 2012

YOUR APPROACH YOUR DECISION YOUR PASSION

Drug Discovery R&D Organizations SYSTEM Biology Companies Informatics Knowledgebase Development firms Clinical Research Organizations Seed technology and genetically modified food Biofuels Monoclonal Antibodies Environmental and industrial biotechnology Instrumentation and Equipment Out Look How to Approach

Heal the World

Fuel the world

Feed the World

Page 3: Biotechnology as Career Option 2012

That’s an Impressive introduction and I know the PROBLEMS AND CHALLENGES you

CURRENTLY FACING

PhD Students ,Postdoctoral Researchers

,Professors/Lecturers, Masters Students , Librarians, Commercial

R&D Professionals ,Undergraduates,

Academic Researchers Government /NGO researchers

Biology Informatics and Research and development Challenges

Systems Biology

The Slides will help you to understand the mechanism , workflows , and Process of different segments in life science Industry

Page 4: Biotechnology as Career Option 2012

This all Started when you try to understand the disease

When you try to understand how the gene are altered

How that affects the proteins they encode

And how these proteins Interact with each other in living cells

How those affected cell change the specific tissue they are in

And finally how the diseases affects the entire patient

Target Identification(Choose a molecule to

target with a drug) Target validation

(Test the Target and Confirm its role in

Diseases)Drug Discovery (Find a promising

Molecule (“ a Lead compound”) that could

become a drug)Early Safety Test

Perform Initial Tests on Promising Compounds

Lead optimization(Alter the Structure of

Lead Candidates to improve Properties)

Drug Discovery Science

Page 5: Biotechnology as Career Option 2012

Today Scientists are facing More Challenges

Biological network maps

Produce better small molecules

at early drug discovery stages

Complexity of biological system

Visualization

Time and Cost

Storage , retrieval and

analysis of data

Page 6: Biotechnology as Career Option 2012

Systems Biology as Savior

Systems Biology

Molecular Pathway

Whole Organism

Organs Tissues

Cells

Regulatory Networks

Omics

Modeling

Page 7: Biotechnology as Career Option 2012

Genomics

Metabolites

Proteomics

OM

ICS

MO

DELI

NG

Organ Complexit

y

Tissue

Cell

Gene translationProtein ExpressionSignaling EventMetabolite Fluxes Identify nodes of signaling networksIdentification of Interaction Partners and Protein Modifications Knockout Knock In Genes

Review of Quantitative models of the System from gene to Physiology Review of approaches for modeling diseases Computationally –based mathematical model of disease predicts patient responses to different therapies

Epigenomics

Page 8: Biotechnology as Career Option 2012

Methods to Study Proteins

Determining proteins which

are post translationaly

modified

Computational methods in

studying protein biomarkers

Establishing Protein- Protein

interactions

Determining the existence of proteins in complex mixtures

Detecting Proteins

Protein Purification

Protein Structures

Protein-DNA Interactions

Page 9: Biotechnology as Career Option 2012

Informatics Science

Literature Informatics Publications of databases of biological informationMicroarray datasheetsHigh Throughput Screening datasetsOther Experimental Data

Literature Informatics Imaging Informatics Clinical Informatics Public health Informatics

Establishing Skills in basic

molecular biology and

protein Expression

Well Developed Chemistry Skills

capable of offering end to end complex capabilities

Page 10: Biotechnology as Career Option 2012

CLINICALLY APPROVED DRUGS

Pre- Clinical Phase

Phase 0

Phase1

Phase 2

Phase 3

Post marketing

surveillance Trial

Translational research

Page 11: Biotechnology as Career Option 2012

GM CROPS /FOOD/SEEDS

Why are GM food/Crops produced and Developed????

Improve crop Protection Insect resistance Virus resistance Herbicide tolerance

The safety assessment of GM foods Allergenicity Gene Transfer Outcrossing

Examples: Drought tolerant Maize Protecting Plants against Freezing Apple genome sequencing Longer shelf life for tomatoes

Biofuels: Ethanol from Biomass

Page 12: Biotechnology as Career Option 2012

DIFFERENT ROLES TO PLAY IN BIOTECHNOLOGY INDUSTRY

Monoclonal Antibodies

MarketLarge protein

molecules produced by white blood cells that seek out and destroy harmful

foreign substances Application in many

areas of medicine and biologic science

Are used in the identification of organisms in the

bacteriology laboratory

Also used in the diagnosis of leukemia

Used in the treatment of malignancies

Page 13: Biotechnology as Career Option 2012

ENVIRONMENTAL/INDUSTRIAL BIOTECHNOLOGY MARKET

Use of microorganis

ms or biological

substances to perform

specific industrial or

manufacturing process

Living cells and Enzymes can be used to produce vitamins,

antibiotics, vaccines and proteins for medicinal purposes

Cells can be modified to

produce enzymes,

which function

biologically as catalysts

to bring about

specific biochemical

reaction

Production of chemicals, pesticides,

biofuels and biodegradabl

e plastics made from renewable

raw materials like starch, vegetable

oils, cellulose and

agricultural waste.

Page 14: Biotechnology as Career Option 2012

INSTRUMENTATION & EQUIPMENT MARKET

Instrumentation would refer to large-scale equipment such as MRI machines, ultrasound machines, immunoanalyzers and hemoanalyzers.

Devices used for surgery, such as laparascopes, endoscopes and arthoscopes. Durable equipment or DME such as medical beds or chairs, wheelchairs and canes would be part of this category.

DNA sequencers and high throughput screeners. Mass spectrometers are currently used for a variety of clinical applications. Mass spectrometry (MS) is an assessment technology that identifies the mass-to-charge ratio of charged particles

Page 15: Biotechnology as Career Option 2012

OUTLOOK

Mapping of the human genome Wave of new biologic drug product approvals by the FDA.

Genetic disorders

Metabolic

Infectious disease

Oncology

Opthalmology

Regenerative medicine

0% 10% 20% 30% 40% 50% 60% 70% 80%

Therapeutic areas offer the best in-vestment opportunities

Source::http://thomsonreuters.com/content/science/pdf/white_papers/BIO_ThomsonReuters09_study.pdf

Page 16: Biotechnology as Career Option 2012

Q. I Know Industry How to approach ?

Proper Education : To excel in biotechnology Industry you need to

have good educational background

Masters of Science ,Masters in technology, PhD is

Preferred

Have focused approach

Know your Interest /Develop Interest

Additional short course Projects and Industry Project is

Preferred

Remember Experience is advantage

Keep track of Industry , follow

trends ,Select Path

Page 17: Biotechnology as Career Option 2012

CONCLUSION Biotechnology Industry has changed a lot during last decade , which

means moving ahead from traditional ways to more advanced technological developments

2012 Biotechnology Industry is not the same as it was in 2001 Computational, Mathematics and physics knowledge additions to

Biology has opened many new windows for Investors and for Small and Mid-Sized Entrepreneurs which again playing very important role .

Many Students with Diversified Non- life science background are working for this Industry

Companies are investing more and more in Lethal Diseases which is a good sign for the Industry and the society as whole

FDI and Government policies too play a very important role and need to be regularly monitored by anyone who want to have a career in Life science Industry

Page 18: Biotechnology as Career Option 2012

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