Biostatistics and Data Management CenterMay 3, 2023

Report from the Biostatistics and

Data Management CenterConstantine Gatsonis, PhD

ACRIN Biostatistics and Data Management CenterBrown University

Providence, RI

Biostatistics and Data Management Center

Major emphasis on developing and launching new studies: Cancer: 6681, 6682, 6683, 6684, 6685, 6686, 6687,

6688, 6689, 6690, 6691

Cardiovascular: 4005

Analysis for primary and secondary papers and abstracts in several protocols: 6652, 6654, 6657, 6660, 6661, 6664, 6665, 6666, 6667,

6668, 6673, 6677, 6683

BDMC 2008-2009: Highlights

Biostatistics and Data Management Center

Imaging-based biomarkers for predicting response to therapy and long term outcomes. Majority of new studies

CAD evaluation. Accuracy in diagnosis and staging. Diagnostic test impact on outcomes.

Significant methodologic and practical challenges

Themes of new studies

Biostatistics and Data Management Center

Cu64-ATSM PET for cervical cancer (6682)

FMISO in glioblastoma (6684)

DCE-MRI, DSC-MRI in glioblastoma(6686)

F-Fluoride PET in prostate cancer (6687)

FLT PET in breast cancer (6688)

FLT PET and DCE-MRI in glioblastoma (6689)

Optimal imaging in breast cancer (6691)

Predicting response

Biostatistics and Data Management Center

CAD for CT Colonography (6681)

CAD for mammography (6683)

PET/CT for head and neck cancer (6685)

CDE-MRI and DCE-CT for HCC in liver transplant candidates (6690)

Accuracy: diagnosis and staging

Biostatistics and Data Management Center

CT angiography in the emergency room: Randomized comparison to usual care (4005).

Preoperative MRI for women with breast cancer: Randomized study of impact on surgical outcomes, recurrence, quality of life and cost. (in development)

Impact on outcomes

Biostatistics and Data Management Center

Analysis for primary and secondary papers and abstracts in several protocols: 6652, 6654, 6657, 6660, 6661, 6664, 6665, 6666,

6667, 6668, 6673, 6677, 6683

Solid presence at RSNA.

Abstracts at ASCO and other conferences.

Publications volume needs to increase. Paper writing needs more attention and energy.

Analysis and publications

Biostatistics and Data Management Center

Needs identified (from last year’s presentation):

• Fully electronic data management

• Improved data entry capabilities

• Automated system for tracking data queries.

Progress update:• Finally close to making decisions on choice of

new system.

• Transition will be a significant undertaking.

Informatics and Data Management

Biostatistics and Data Management Center

It has been quite a ride!