biosensors and how they are changing the world. what are they? a device that utilizes biological...
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Biosensors
And how they are changing the world
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What are they?
A device that utilizes biological components to indicate the amount of a biomaterial
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Breakdown of Components.
Bioreceptor- detects analyte Transducer- converts into readable form Reader Device- displays information
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Biosensors in the Future What should a biosensor be?
Portable, easy to use, small Easy to be manufactured in mass
quantities Low cost, affordable Rapid results Satisfy a large market
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Military Use
The military has funded research into biosensors
Mine sensing bacteria Monitoring gasses on the battlefield Detecting air-borne pathogens To counter Bio-terrorism
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Agriculture
Detecting heavy metal ions, arsenic, ammonia in water sources
Brazilian researchers developing a pesticide detector
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Medical
Detecting bladder cancer and lyme disease
“Artificial Skin” using flexible biosensors that can aid in prosthetics
Glucose and Pregnancy Tests Cholesterol Test was a failure
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Design Project
Factor VIII producing E. coli
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What is Hemophilia A
Hemophilia affects the ability of the body to control blood clotting or coagulation
Hemophilia A is a genetic blood disorder that is caused by a Factor VIII deficiency
Hemophilia affects more than 17,000 people in the United States
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Current Treatment Options
Replacement therapy Desmopressin Antifibrinolytic Medicine
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Proposal
Using E. coli, create a topical creme containing bacteria engineered to
produce clotting factor VIII in order to help close external wounds for people
with Hemophilia A
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LuxS
ABC Transporter
Al-2
ATP
ADP
LsrR
LsrRPP
Factor VIII
ATPADP
Factor VIII molecules
Export
ATP ADP
LuxS Porcine Coagulation Factor VIII
LSR Transport Cassette
Fibrin
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Advantages
Low Risk, using Pig Factor VIII No chance of blood-transmitted disease Works even with antibodies and inhibitors Site Specific No Injection required
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Improvements
Kill Switch Does not solve internal bleeding Separate design needed for Hemophilia B