biohealth informatics group 1 owl, hl7, snomed, and uml making models managable alan rector,...
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OWL, HL7, SNOMED, and UMLOWL, HL7, SNOMED, and UMLMaking Models ManagableMaking Models Managable
Alan Rector, University of ManchesterAlan Rector, University of Manchester
Tom Marley, University of SalfordTom Marley, University of Salford
[email protected]@[email protected]@salford.ac.uk
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HL7 & SNOMED: HL7 & SNOMED: Issues for sustainable implementationIssues for sustainable implementation
► HL7HL7
► Variable structure leading to difficult maintenanceVariable structure leading to difficult maintenance
►How to the same thing the same way or know the reason whyHow to the same thing the same way or know the reason why
►Finding standard ways of saying things - ‘recipes’ for developersFinding standard ways of saying things - ‘recipes’ for developers
►(See also Tom Marley’s recent note)(See also Tom Marley’s recent note)
► Modularisation and Re-use of ModulesModularisation and Re-use of Modules
►The semantics of ‘cloned classes’The semantics of ‘cloned classes’
► Expressing constraintsExpressing constraints
►Including “The grey text boxes”Including “The grey text boxes”
► SNOMEDSNOMED
► ContextContext
► NegationNegation
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HL7 + SNOMED IssuesHL7 + SNOMED Issues
► Interaction of HL7 & SNOMEDInteraction of HL7 & SNOMED► Binding, mutual constraints, Negation & NULL valuesBinding, mutual constraints, Negation & NULL values
► Complexity and documentationComplexity and documentation
► Co-evolutionCo-evolution
►How to know the effects of changesHow to know the effects of changes
►How to manage regression/conformance testingHow to manage regression/conformance testing
► A DL based terminology nested in an UML A DL based terminology nested in an UML type model but developed independently\type model but developed independently\
► An almost unique problem to HealthcareAn almost unique problem to Healthcare
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The experiment: The experiment: A Feasibility studyA Feasibility study
► Could the pharmacy examples be Could the pharmacy examples be represented in OWL:represented in OWL:
► So as to capture all the contents of the RMIMs etc So as to capture all the contents of the RMIMs etc themselves?themselves?
► So as to represent the bindings to SNOMED?So as to represent the bindings to SNOMED?
► So as to capture the constraints in ‘grey boxes’ on the So as to capture the constraints in ‘grey boxes’ on the RMIM diagrams?RMIM diagrams?
► So as to support factoring into modules & indexing?So as to support factoring into modules & indexing?
► So as to allow regression/conformance testing?So as to allow regression/conformance testing?
► To be done using existing toolsTo be done using existing tools► Specialised user environment required for any Specialised user environment required for any
production workproduction work
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The main conclusion:The main conclusion:There is a problem,There is a problem,Current tooling will not solve itCurrent tooling will not solve it
► The issue is variability between models rather than The issue is variability between models rather than constraintsconstraints
► Constraints we can manage, but…Constraints we can manage, but…
► Patterns are only approximately followedPatterns are only approximately followed► Only as systematic as human beings using copy & pasteOnly as systematic as human beings using copy & paste
► There are no generic models or formal mechanisms for specialisationThere are no generic models or formal mechanisms for specialisation
► Information is not always in the same place Information is not always in the same place
►e.g.: “Dosage instructions” vs “Timing Instructions”, e.g.: “Dosage instructions” vs “Timing Instructions”,
► If there is a clear difference? it is not documented, If there is a clear difference? it is not documented, let alone formally specifiedlet alone formally specified
► Maintenance will therefore be difficult or impossibleMaintenance will therefore be difficult or impossible► Cannot predict effects of changesCannot predict effects of changes
► Costs will be difficult to controlCosts will be difficult to control… … and this was only for one domain developed by a small teamand this was only for one domain developed by a small team
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The main conclusion:The main conclusion:There is a problem,There is a problem,Current tooling will not solve itCurrent tooling will not solve it
► Investment in new technology is necessary to manage the Investment in new technology is necessary to manage the problemsproblems
► OWL could address these problems and meet other requirementsOWL could address these problems and meet other requirements
► (with significant new tooling)(with significant new tooling)
► The main benefit of using OWL would be to improve & The main benefit of using OWL would be to improve & formalise of modelling toformalise of modelling to
► Lower maintenance costsLower maintenance costs
► Let models scaleLet models scale
► Reduce risk of catastrophic failureReduce risk of catastrophic failure
► Improve conformance of implementationsImprove conformance of implementations
► Ultimately, to make development faster and cheaperUltimately, to make development faster and cheaper
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Specific results: Specific results: More More successful than successful than anticipated anticipated
► We know it can be doneWe know it can be done
► Succeeded in initial version on content, binding, and Succeeded in initial version on content, binding, and constraintsconstraints
► Separate study on factoring Separate study on factoring
► Primary difficulty is understanding HL7 rather than Primary difficulty is understanding HL7 rather than representation in OWLrepresentation in OWL
► Revised binding and alternative representation of SNOMED Revised binding and alternative representation of SNOMED developed subsequentlydeveloped subsequently
► Covers additional requirements for binding presented subsequently: Covers additional requirements for binding presented subsequently:
►Specified code setSpecified code set
►All descendants of a given codeAll descendants of a given code
►Any boolean combination of aboveAny boolean combination of above
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Cut to HTML Report HereCut to HTML Report Here
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► What is OWL? What is OWL?
► What is ProtWhat is Protééggéé
► What does OWL do?What does OWL do?
► What part of the problem might they What part of the problem might they address?address?
► What parts of the problem could it not address?What parts of the problem could it not address?
► What would a programme using OWL look like?What would a programme using OWL look like?
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What is OWL? What is OWL?
► A general representation language and standardA general representation language and standard► A standard way to use Description Logic TechnologyA standard way to use Description Logic Technology
► Language FeaturesLanguage Features► A superset of UML class models as used in HL7A superset of UML class models as used in HL7
► True negation, and, or, cardinality, local and global range/domainTrue negation, and, or, cardinality, local and global range/domain
► Rigorous semanticsRigorous semantics
► UseUse► Compositional and modularCompositional and modular
►Definitions to link modulesDefinitions to link modules
►Well defined normalisation procedureWell defined normalisation procedure
►Namespace mechanismNamespace mechanism
►FeaturesFeatures
► A uniform rule mechanism for both classes and instanceA uniform rule mechanism for both classes and instance
► Standards backing and toolsStandards backing and tools
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What is ProtWhat is Protééggéé
► A plug and play environment for intelligent A plug and play environment for intelligent information systemsinformation systems
► Probably the most widely used OWL Probably the most widely used OWL development environmentdevelopment environment
► Several interfaces developed for different groups of Several interfaces developed for different groups of usersusers
► Several backends for different applicationsSeveral backends for different applications
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What does OWL do?What does OWL do?
► Imposes & checks consistency, locally and globallyImposes & checks consistency, locally and globally► Do subclasses conform to superclass requirements?Do subclasses conform to superclass requirements?
► Does each class conform to overall constraints?Does each class conform to overall constraints?
►Difficult even with the ETP set of tens of messagesDifficult even with the ETP set of tens of messages
► How to achieve for thousands of messages?How to achieve for thousands of messages?
► ClassifiesClassifies► Manages muiltiple hierarchies Manages muiltiple hierarchies
► Indexes & composes subtemplatesIndexes & composes subtemplates► A natural effect of classificationA natural effect of classification
► Manages combinatorial explosionsManages combinatorial explosions► By dealing with each axis separatelyBy dealing with each axis separately
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Example: Decomposing Example: Decomposing Pharmacy Acts (MIM v4.0.01)Pharmacy Acts (MIM v4.0.01)
RecommendRecommend AdministerAdminister Single doseSingle dose AbortedAborted
RequestRequest SupplySupply CourseCourse (Completed)(Completed)
PlanPlan (Active)(Active)
PerformPerform
Apparently 1 family; 4 axes8 selected from 48 possible. Why? Which are legal? Which make no difference?e.g. Can one plan supply? Abort a request for administration?
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Enter in Tool, Classify structureEnter in Tool, Classify structure
Is this what was intended?
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OWL based systems: OWL based systems: Conceptual LegoConceptual Lego
recommended
request
event
aborted
completed
ProcedureObservation
MedicationRole
PersonParticipation
AdministerSupply
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OWL based systems: OWL based systems: Conceptual LegoConceptual Lego
“Request for Medication Administration aborted”
“Performance of medcation administration”
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Logical Constructs Logical Constructs build complex concepts build complex concepts from modularisedfrom modularisedprimitivesprimitives
“Mood”Act
Substance
Status
Disease
Request for|administration ofSteroid
Completed request forAdministration of Steroid
Completed request for administrationOf steroid for Asthma
“Request for Administration”
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Normalising (untangling) OWL Normalising (untangling) OWL ModelsModels
ActStatus
MoodAct Status
mood
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Today’s demonstrationToday’s demonstration
► Introduction to UML and HL7 in OWLIntroduction to UML and HL7 in OWL
► Composition and factoringComposition and factoring
► ConstraintsConstraints
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Basic conventions (1)Basic conventions (1)
► All submodels and clones are sublcassesAll submodels and clones are sublcasses
► All associations and attributes are expressed All associations and attributes are expressed as OWL propertiesas OWL properties
► All relevant properties are subproperties of All relevant properties are subproperties of “demo:has_item”“demo:has_item”
► ““Unfolding” along Unfolding” along demo:has_item demo:has_item gives the submodel gives the submodel skeletonskeleton
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Everything in OWL is Everything in OWL is expressed by subclassing:expressed by subclassing:Part of the Act Class HierarchyPart of the Act Class Hierarchy
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All associations & attributes All associations & attributes are expressed as subproperties are expressed as subproperties of of demo:has_item:demo:has_item:Part of the properties hierarchyPart of the properties hierarchy
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““Unfolding along Unfolding along demo:has_itemdemo:has_item gives the gives the skeleton of the messageskeleton of the message
Unfolding:
The Message skeletonNot to be confused with
The class hierarchy
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Basic Conventions (2)Basic Conventions (2)
► Modules are marked by namespaces: e.g. Modules are marked by namespaces: e.g. “npfit:”, “hl7:”, etc.“npfit:”, “hl7:”, etc.
► The SNOMED structure is modelled as in HL7 The SNOMED structure is modelled as in HL7 messagesmessages
► SNOMED qualifier structures are represented in the SNOMED qualifier structures are represented in the same way as any other classsame way as any other class
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Basic Conventions (3)Basic Conventions (3)
► Everything in OWL is expressed by Everything in OWL is expressed by subclassingsubclassing
► If a subclass has a definition, then it behaves as a rule, If a subclass has a definition, then it behaves as a rule, e.g. e.g.
IF anything satisfies the definition IF anything satisfies the definition THEN it must satisfy the necessary conditionsTHEN it must satisfy the necessary conditions
► Definitions are expressed as “necessary and sufficient” Definitions are expressed as “necessary and sufficient” conditionsconditions
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Can have multiple definitions -Can have multiple definitions -Equivalent to if and only ifEquivalent to if and only if
► Useful for managing HL7/SNOMED mutual constraintsUseful for managing HL7/SNOMED mutual constraints
► IF anything satisfies IF anything satisfies anyany of the definitions of the definitionsTHEN it must satisfy THEN it must satisfy allall of the definitions AND of the definitions AND it must satisfy the necessary conditions it must satisfy the necessary conditions
► Anything thatAnything that► has an Act_Code with a SNOMED context of Active (including has an Act_Code with a SNOMED context of Active (including
descendents)descendents)
►must have an Act_status_code of Active (including any descendents) must have an Act_status_code of Active (including any descendents)
► AND vice versa. AND vice versa.
► Anything satisfying either of the aboveAnything satisfying either of the above
► must have a pertinent information request. must have a pertinent information request.
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Example in ToolExample in Tool
“Definitions”:necessary &
sufficient
“Description:”Necessary conditions
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Everything in OWL is checked Everything in OWL is checked by the ‘Classifier’by the ‘Classifier’(aka ‘Reasoner’)(aka ‘Reasoner’)
► The classifier serves three functions:The classifier serves three functions:► To check consistency To check consistency
►that the strict classification hierarchy and constraints are that the strict classification hierarchy and constraints are maintained maintained
►That all unit tests come out as expectedThat all unit tests come out as expected
► To create a multiple hierarchy and combine To create a multiple hierarchy and combine subtemplatessubtemplates
►Classes moved under each definition that they fitClasses moved under each definition that they fit
► To index classes To index classes
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(sub)Templates are just OWL (sub)Templates are just OWL classes that can be combinedclasses that can be combinedby the classifierby the classifier
► Call them “factors”Call them “factors”► Medication_factorMedication_factor
► Completed_factorCompleted_factor
► Administration_factorAdministration_factor
► Request_factorRequest_factor
► Together they form aTogether they form aCompleted_request_for_Medication Completed_request_for_Medication
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The example templates in the The example templates in the tooltool
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Classification: Graphics viewClassification: Graphics view(simpler case)(simpler case)
before
after
(defined classes in orange)
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The example: The example: Before classification:Before classification:Four parents, simple structureFour parents, simple structure
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After classification:After classification:Polyhierarchy of parents Polyhierarchy of parents
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Put them together to formPut them together to formrequired sublcassrequired sublcass
If inheritance doesn’t work when checked by the classifier,
then something is broken
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Adding unit testing to Adding unit testing to classificationclassification
► Create “probe” classes to test constraintsCreate “probe” classes to test constraints
► Classes that violate constraints to test that they constrainClasses that violate constraints to test that they constrain
► Classes that are just outside constraints to check that they are Classes that are just outside constraints to check that they are not caught accidentally.not caught accidentally.
► Mark each class with expectationsMark each class with expectations
► Run tests after classification for conformance/regression Run tests after classification for conformance/regression testingtesting
List of Unit Tests - green checks indicate passed - red indicates inconsistent - green + red indicates deliberately inconsistent
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Other Benefits: OwlDoc Other Benefits: OwlDoc
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The SNOMED Binding ProblemThe SNOMED Binding Problem
► Which codes to use where?Which codes to use where?► Code set specificationCode set specification
►Sets of specified codesSets of specified codes
►Expressions specifying large sets codesExpressions specifying large sets codes
►Boolean combinations of aboveBoolean combinations of above
► Mutual constraints between HL7 & SNOMEDMutual constraints between HL7 & SNOMED► HL7 mood, status, etc. codesHL7 mood, status, etc. codes
► SNOMED context model SNOMED context model
► Code, Value, and Target attributesCode, Value, and Target attributes
►(Controversies between USA and UK) (Controversies between USA and UK)
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Observation classObservation class
Kernel clinical notionTerminology/Ontology
Context model
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Example ontology nested in the Example ontology nested in the EHREHR
the ehr (hl7 rim)[moodCode=“Event” subject=“Relative” code={ } ]diabetes (subject person_in_family)
the ontology (snomed-ct) <family_hx (assoc_find Diabetes)> the combined meaning
What is legal? Required? Mandatory?What is legal? Required? Mandatory?……
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One of David Markwell’s rules One of David Markwell’s rules from Terminfo:from Terminfo:mood=EVN mood=EVN subject_relationship= subject_relationship= Person OR New Person OR New
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One of David Markwell’s rules One of David Markwell’s rules in OWLin OWLFully expanded versionFully expanded version
If you really want to you can say it all in one long expression;Alternatively you can name every step;or anywhere in between
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Limitations of OWL:Limitations of OWL:“ it doesn’t make the coffee”“ it doesn’t make the coffee”
► Object-attribute-value triples onlyObject-attribute-value triples onlyNo variables, No n-ary relationsNo variables, No n-ary relations
► Did not limit this studyDid not limit this studyClose match to UML limitations (as used in HL7)Close match to UML limitations (as used in HL7)
► Strictly first orderStrictly first order► How HL7 represents SNOMED rather than being “SNOMED in OWL”How HL7 represents SNOMED rather than being “SNOMED in OWL”
► Open World - advantage and disadvantageOpen World - advantage and disadvantage► Requires explicit closure axioms when translating from databasesRequires explicit closure axioms when translating from databases
► A new technology, and a new application of that technologyA new technology, and a new application of that technology► Needs tools and trainingNeeds tools and training
► Numeric ranges and strings new and not tested in this Numeric ranges and strings new and not tested in this validationvalidation
► A strictly temporary problem, now almost resolved.A strictly temporary problem, now almost resolved.
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What might a process using What might a process using OWL for subtempates be like in OWL for subtempates be like in production?production?
► For message design and validationFor message design and validation► In a ‘steady state’In a ‘steady state’
► For message re-design and validationFor message re-design and validation► As a migration pathAs a migration path
► For instance validationFor instance validation► At run time At run time
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For message design and For message design and validationvalidation
► A two phase processA two phase process
► Subtemplate design Subtemplate design
►Create subtemplates / re-usable models and index themCreate subtemplates / re-usable models and index them
►Test by combining to create exemplar messagesTest by combining to create exemplar messages
►Validate, classify and commit resultsValidate, classify and commit results
►Document, publish and add to repositoryDocument, publish and add to repository
► Message designMessage design
►Identify subtemplates via indexIdentify subtemplates via index
►Combine and check consistency with classifierCombine and check consistency with classifier
►Refine / specialise as neededRefine / specialise as needed
►Report and negotiate any changes to templatesReport and negotiate any changes to templates
►Validate, classify & commit resultsValidate, classify & commit results
►Document, publish and add to repository Document, publish and add to repository
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Template & Message design Template & Message design two phases / cyclestwo phases / cycles
Message developmentQuick turn around
Modest expertise requiredHighly specialised but restricted tools
Problems fed to subtemplate / pattern developers
Re-usable subtemplates and pattern developmentSlower turn aroundMore expertise requiredMore general less restricted toolsRespond to new requirements & problems
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What might a process involving What might a process involving OWL be like in transition:OWL be like in transition:
► For message re-design and validationFor message re-design and validation► Import of families of representations from MIF to OWLImport of families of representations from MIF to OWL
► Rearrangement and editing in OWL using special tools Rearrangement and editing in OWL using special tools and scriptsand scripts
►Addition of editorial informationAddition of editorial information
►Refactoring and indexing as appropriateRefactoring and indexing as appropriate
► Classification for validation and organisationClassification for validation and organisation
► Commitment of classification resultsCommitment of classification results
► Export to MIF (or XMI …)Export to MIF (or XMI …)
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Validating instancesValidating instances
► Method 1: guaranteed completeMethod 1: guaranteed complete► Transform to include ‘closure’ axiomsTransform to include ‘closure’ axioms
►Assert that missing data is really missingAssert that missing data is really missing
► Classify and register errorsClassify and register errors
► Takes SNOMED structures into account automaticallyTakes SNOMED structures into account automatically
►Highly desirable for SNOMED binding constraintsHighly desirable for SNOMED binding constraints
► Method 2:Method 2:► Generate structural rules from OWLGenerate structural rules from OWL
► Test instances with structural rulesTest instances with structural rules
► Adequate for numeric ranges and string patternsAdequate for numeric ranges and string patterns
►Difficult for complex SNOMED-HL7 mutual constraintsDifficult for complex SNOMED-HL7 mutual constraints
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How big does it have to be?How big does it have to be?Would it scale?Would it scale?
► SNOMEDSNOMED► Context is critical part of SNOMEDContext is critical part of SNOMED
►~1000 codes~1000 codes
► Header codes for key areas of clinical useHeader codes for key areas of clinical use
►<1000 codes<1000 codes
► Link to external server for remainderLink to external server for remainder
► HL7HL7► Only generic models needed as baseOnly generic models needed as base
► Load specific families or submodels, e.g. ETP, as Load specific families or submodels, e.g. ETP, as needed.needed.
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Next Steps:Next Steps:Address the critical problem Address the critical problem Focus on Modularity, Reducing Focus on Modularity, Reducing variability, & Re-usevariability, & Re-use
► Unified representation of one family of messages Unified representation of one family of messages ► Generic models and templatesGeneric models and templates
► ModularityModularity
► IndexingIndexing
► Integration with S-CT Context ModelIntegration with S-CT Context Model
► Produce initial tailored softwareProduce initial tailored software► Plugin for ProtégéPlugin for Protégé
►HL7ized or UMLized UI - first stepsHL7ized or UMLized UI - first steps
►Extended unfolding viewsExtended unfolding views
► Export/inport from MIFExport/inport from MIF
► Involve a few more modellersInvolve a few more modellers► Demonstrate that the method will be usable when completeDemonstrate that the method will be usable when complete
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Supplement on NegationSupplement on Negation
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Need to rationalise negation:Need to rationalise negation:
► How to say:How to say:► ““Skull fracture without intracranial haemorrhage”Skull fracture without intracranial haemorrhage”
“Skull fracture without subdural intracranial haemorrhage” “Skull fracture without subdural intracranial haemorrhage”
► ““No skull fracture”No skull fracture”
► ……
► OWL supports full negationOWL supports full negation► Can this help?Can this help?
►Wrap everything in “Clinical_situation” (label it as you will)Wrap everything in “Clinical_situation” (label it as you will)
► This also avoids the problem of splitting of information between This also avoids the problem of splitting of information between Finding and Context_Dependent_findingFinding and Context_Dependent_finding
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““Skull Fracture without Haemorrhage” becomes Skull Fracture without Haemorrhage” becomes
► Clinical_situation Clinical_situation & & includes includes SOME SOME (Finding & (Finding & has_morphology SOME Fracture & has_morphology SOME Fracture & has_site SOME Skull has_site SOME Skull)) && NOT includes SOME NOT includes SOME (Finding & (Finding & has_morphology SOME Haemorrhage & has_morphology SOME Haemorrhage & has_site SOME Skull) has_site SOME Skull)
► And the rest comes for freeAnd the rest comes for free
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DemoDemoFrom Protege-OWlFrom Protege-OWl
Given a series of definitions of the form:
And underlying definitions such as
Skull_fracture_without_intracranial_haemorrhage_situation =
Intracranial_haemorrhage_finding =
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Then a flat list of such stated definitions for:Then a flat list of such stated definitions for:
QuickTime™ and aTIFF (LZW) decompressor
are needed to see this picture.
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Will be rearranged by the OWL classifier to give the correct Will be rearranged by the OWL classifier to give the correct classification automaticallyclassification automatically
QuickTime™ and aTIFF (LZW) decompressor
are needed to see this picture.
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Supplement on alternative iota Supplement on alternative iota interfaceinterface
► Development of alternative interfaces is Development of alternative interfaces is relatively straightforward in Protégé.relatively straightforward in Protégé.
► The next slide shows part of an interface for The next slide shows part of an interface for the IOTA project developing an anaesthesia the IOTA project developing an anaesthesia terminology terminology
► Anaesthesia Patient Safety AssociationAnaesthesia Patient Safety Association
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