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Biohazard ContainmentFacilitiesPlanning & Design Considerations

Part 2: Design Concepts

Janet Baum, AIA

Biohazard ContainmentFacilitiesPlanning & Design Considerations

Part 2: Design Concepts

Janet Baum, AIA

• Hazard zoning• Egress in direction of lower hazard• Zone from clean to dirty• Separate hazards that may interact• Isolate highest hazard processes and agents

Prep LabPrep LabExit

Highest HazardLowest Hazard

Air Flow Contaminated

Hot ZoneHot ZoneHazard

BSL-3 Facility Planning IssuesDesign Concepts

Enter

• One-way passage• Enter BSL-3 lab from one passage, exit from another• Sequential work flow, if possible• Reduce intersections in circulation pathways

Path of Travel

ENTRY

EXIT

Process#1

Process#1

Process#5

Process#5

Process#4

Process#4

Process#3

Process#3

Process#2

Process#2


• Suites

• Cluster support functions around basic BSL-3 work zone to reduce distances between functional zones

• Good for repetitive functions and processes


Cell CultureRooms

Air Lock

Accessioning

Decon

BSL-3

Equipment

SamplePrep

BSL-3

Decon

Degown

ALBSL-2

AL

Gown

CellCulture

BSL-3

Decon

Degown /Shower

AL

BSL-2 AL

Gown

BSL-3 CellCulture

MicroTestAL

Graphic Program Blocking Diagram


BSL-3

Decon

Degown

AL

BSL-2 AL

Gown

BSL-3 CellCulture

MicroTestAL

Flow Diagram

Personnel Supplies

Infectious Agent / Waste MaterialAnimals


• Locate biosafety cabinets and fume hoods out of traffic

• Develop understanding on how to deal with emergencies within BSL-3

• Understand how to manage emergencies from outside

• Investigate how BSL-3 can expand in future



Expansion Options

• Understand how laboratory can be cleaned easily

– Shape of each space is simple (minimize corners)

– Finishes are seamless, smooth and coved

– Equipment is located so floor can be cleaned

• Understand overall health & safety issues in BSL-3

– Ergonomics

– Visibility of all parts of lab

– Communications

– Safety equipment located in critical areas


ABSL-3 - Canada


Renovated garage with BSL-3+ for HIV test kit production


Autoclave

Autoclave

Renovated research building for HIV research - large-scale


AFIP BSL-3


Emerg.Exit

Gas Cylinder Closet

Entry

GownJCl WCShower

BSL-3 Lab

EquipmentLab

AutoclaveAir

LockMechanical

PrepLab

Equipment

FumeHood

University of Kentucky ABSL-3


KUMC ABSL-3


GownsLockersShower

Entry/Exit

Saint Louis University BSL-3


University of SD BSL-3


University of SD ABSL-3


State of New Mexico BSL-4


State of New Mexico BSL-3 Autopsy


Confidential Client - ABSL-3


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