Biofluid Mechanics and Bioheat Transfer

Malisa Sarntinoranont, Ph.D.

Associate Professor

Department of Aerospace & Mechanical Engineering

University of Florida

Tissue BiomechanicsLaboratoryTissue BiomechanicsLaboratory

Biofluid Mechanics & Bioheat Transfer

EGM4592: 3 credit hour undergraduate elective course Counts towards Biomechanics Certificate offered

through Mechanical Engineering Enrollment 15-25 senior/juniors Times taught = 4

EGM6855: 3 credit hour graduate elective course Enrollment 7 Times taught = once

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Teaching Goals

My goal in teaching this class is to enable students to apply analysis tools learned in core engineering courses (fluid mechanics and heat transfer) to specific problems of the cardiovascular and temperature regulation systems in the human body.

Problems at various scales are presented and broken down by analysis

non-Newtonian flow through large blood vessels

red blood cell flow through individual capillaries

Students learn current trends in biomedical through final research papers and class presentations.

Graduate level class: modified the course content to include more challenging problems in the field, and greater focus was given to advanced analysis and experimental tools.

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Syllabus

Textbooks

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Syllabus continued.

Greater emphasis on biofluids (~8 weeks) compared with bioheat transfer (~5 weeks)

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Biofluid topics

Basic physiology Rheology of Blood (different

constitutive equations) Governing equations of flow Viscous flow through tubes (e.g.,

Poiseuille flow) Stenosis Bifurcations Oscillating flows Elastic tubes & wave propagation Capillary flow Flow through heart valves Extracellular flows & lymphatic

drainage

Bioheat Transfer topics

Review modes of heat transfer Conservation of energy Bioheat equation Single vessel and paired vessel

analysis

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Projects

Journal Paper Review (graduate class) One student presented a paper review for class discussion each week Provide students insight of the boundaries of current knowledge

CFD simulation: COMSOL stenosis problem

Term paper & presentation Students learn current trends in biomedical engineering (from roller coasters to the effects

of space flight)

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Outcomes & Student Feedback

Positive: Students appreciate really understanding & practicing basic fluid dynamic problems (They are generally weak or insecure of their abilities at the start of term)

Positive: Given the limitations of analytical solutions for biomedical applications, computational models provide a more realistic problem-solving scenario which is more satisfying for students

Weakness: Need to emphasize more cell response-related topics:- Immune response/biocompatibility, e.g. thrombosis- Mechanobiology/tissue remodeling, e.g. restenosis

10Thank You!