biodegradable sustained release drug delivery systems … · 2018. 1. 5. · systems implant...
TRANSCRIPT
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Biodegradable Sustained Release Drug
Delivery Systems Fabricated using a
Dissolvable Hydrogel Template Technology
for the Treatment of Ocular Indications
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Financial Disclosures
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Presentation Overview
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Drawback of Current Microparticle Technology Broad Particle Size Distribution
Current Microemulsion
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Advantages of Ohr SR Microfabrication Narrow Particle Size Distribution
Current Microemulsion
Ohr SR Microfabrication
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Ohr Technology vs. Other Ocular SR Systems
Characteristic
Bevacizumab Ranibizumab Aflibercept
External Systems
Implant Systems
Micro-emulsion
Ohr
Injectable through small gauge needle + + - - + + +
Sustained release (4-6 months) - - + + + + + +
Biodegradable: Does not require removal + + - - - - + + + +
Initial release is controlled and tunable - - - - - - + - + +
Simple formulation and process designed for fragile biologics
+ + + + - - + +
High drug loading capability - - - + - + +
Load different drugs into same particle - - - - - - - - + +
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Microfabricated Microparticles Using a
Dissolvable Hydrogel Template Microparticles are Released by Dissolving Hydrogel Template in Water
Hydrogel template
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Gaudana R, Ananthula HK, Parenky A, Mitra AK. Ocular Drug Delivery. The AAPS Journal. 2010;12(3):348-360.
Routes of Administration
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Ohr Sustained Release Therapeutics
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Ophthalmic Indication: Glaucoma Tunable release capabilities for a hydrophilic drug molecule
Burst Release
1 Month 3 Month 4 Month
Different formulations to meet desired target profiles
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Ophthalmic Indication: Glaucoma Layering process reduces burst release for a hydrophilic drug molecule
Layered Formulations
Non-Layered Formulation
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Ophthalmic Indication: Glaucoma Layering process reduces burst release
Burst Release
1 Month 3 Month 4 Month
Before Layering
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Ophthalmic Indication: Inflammation Tunable release profile obtained using biodegradable polymers
Polymer B
Polymer A
Polymer
A+B
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Ophthalmic Indication: Steroid-Induced Glaucoma Sustained release obtained for a hydrophobic drug molecule
OHR1031
57% Drug Load
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Ophthalmic Indication: Retinal Diseases Sustained release obtained for a biologic ~150 kDa
0 1 2 3
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Polymer 1
Polymer 2
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Summary
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