bio boot camp biochemistry: topic 1 bio a.2 the chemical basis for life describe how the unique...
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Bio Boot Camp
Biochemistry: TOPIC 1
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Bio A.2 The Chemical Basis for Life
• Describe how the unique properties of water support life on Earth (freezing point, high specific heat, cohesion)
• Describe and interpret relationships between structure and function at various levels of biochemical organization (atoms, molecules, macromolecules)– Explain how C is uniquely suited to form
biological macromolecules– Describe how macromolecules form from
monomers– Compare the structure and function of
carbs, lipids, proteins and nucleic acids
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Bio A.2 The Chemical Basis for Life• Explain how enzymes regulate
biochemical reactions within a cell– Describe the role of an enzyme as a
catalyst in regulating a specific biochemical reaction
– Explain how factors such as pH, temp, and concentration can affect enzyme function
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Properties of Water1. Is a polar covalent molecule 2. Is the universal solvent due
to its polarity. Polar covalent compounds (like glucose) and ionic compounds (like salt) can easily go into solution in water.
3. Has a high specific heat. It is slow to heat up and also slow to cool down. This acts as an insulator in living organisms since the majority of their living tissue is water.
4. When water freezes, it expands and therefore floats. Ice is less dense than water. This provides an insulation to the organisms in the water. The water below will be at 4`C (if ice is above it)
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Water – Unique Properties
• Adhesion: Water sticks to other substances
• Cohesion: water sticks to water
• Capillary actions: Water climbs up. – Ex. Plant roots to 400 feet
up. • Surface Tension: Water
spiders can walk on water. Water sticks together so tightly, causes a tension so certain things can “float”
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Water• The cohesive forces between
liquid molecules are responsible for the phenomenon known as surface tension. The molecules at the surface do not have other like molecules on all sides of them and consequently they cohere more strongly to those directly associated with them on the surface. This forms a surface "film" which makes it more difficult to move an object through the surface than to move it when it is completely submersed.
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Facts about water
• Water resists changes to temperature.
• Water expands when it freezes• Water is less dense as a solid oppose
to a liquid. Ice floats• High Specific Heat: able to absorb a
lot of heat before it gets hot• Universal Solvent
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Inorganic
• Water is an inorganic molecule: chemical compounds that do not contain carbon as the principle element (exception CO2)
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Chemistry of Life• Organic molecules: molecules that
contain carbon atoms and H atoms• C atoms are versatile building blocks
– 4 stable covalent bonds (4 valence e-)– C atoms can bond other C atoms or
other atoms
HHC
H
H
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Carbon
• Atomic number of 6. – 2 electrons in the 1st orbital and 4
remaining in the valance orbital.– 4 unpaired will form 4 covalent
bonds
• By bonding with other carbons in chains, rings, single, double and triple bonds, carbon, it can make all sorts of molecules
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Covalent bond –electrons are SHARED
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Carbon double bond
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Carbon (and nitrogen) triple bond
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Carbon Chains
Branched chain
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Carbon rings
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Carbon variety
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Monomer and Polymer
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Monomers are like legos…
• You can put them together in whatever way you dream up!
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Macromolecules• Smaller organic molecules join
together by covalent bonds to form larger molecules– built by linking repeating building blocks
in a chain
• 4 major classes of macromolecules:– carbohydrates– lipids– proteins– nucleic acids
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Condensation Reaction (Dehydration Synthesis – removing water to make)
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Carbohydrate (CH20)
Monosaccharide, the monomer of a carbohydrate
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Carbohydrates• Carbohydrates are composed of C, H,
Ocarbo - hydr - ate
CH2O
(CH2O)x C6H12O6
• Building block molecules or monomers = MONOSACCHARIDES
(glucose)
C6H12O6(CH2O)x
sugar sugar sugar sugar sugar sugar sugarsugar
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Carbohydrate Polymers – monomers linked together by
dehydration synthesis
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Functions of Carbohydrates • Monosaccharides
– Glucose: quick energy• Polysaccharides
– starch• energy storage in plants
– glycogen• energy storage in animals
– in liver & muscles
– cellulose• structure in plants
– cell walls
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Cellulose
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Glycogen use and storage
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Lipids
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Lipids
• Function:– energy storage – cell membrane– insulates body
• think whale blubber!
• Examples– Fats, Oils, Waxes, and
steroids
inside cell
outside cell
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Molecular Structure of Fat
not a chain (polymer) = just a “big fat molecule”
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Cell membrane phospholipids
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Protein
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Proteins• Function: worker molecules
– many, many functions•hormones
– signals from one body system to another– insulin
•movement– muscle
•enzymes– help chemical reactions
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Proteins
• Building block =
aminoacid
aminoacid–
aminoacid–
aminoacid–
aminoacid–
—N—H
H
H|
—C—|
C—OH
||O
variable group
amino acids
20 different amino acidsPeptide bond
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Nucleic Acid
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DNADNA
Nucleic Acids• Function:
– genetic material DNA and RNA•stores information
– genes– blueprint for new cells
•transfers information– blueprint for building proteins– DNA RNA protein
proteinsproteins
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Nucleic Acids
• Building block =nucleotides
5 different nucleotides different nitrogen bases A, T, C, G, U
nucleotide – nucleotide – nucleotide – nucleotide
phosphate
sugar N base
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• This is dehydration synthesis. – Removing water (dehydration)– To make (synthesis)– During this type of reaction, a water molecule is
removed (an –OH from one simple monomer and an –H from another to form a water molecule.
– This joins two monomers together to form a polymer.
Monomer called Glucose
Glucose + Glucose = Maltose
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Use the diagram below to answer the question. Chemical Reaction HO – 1 – 2 – 3 – H + HO – 4 - H HO – 1 – 2 – 3 – 4 – H + H2OThe diagram shows a reaction that forms a polymer from two monomers. What is this type of reaction called?
A.GlycolysisB.HydrolysisC.PhotosynthesisD.Dehydration synthesis
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Enzymes• Enzymes are not changed by the
reaction– Enzymes are specific, they fit to their
substrates like a lock and key– used only temporarily then reused– Provide a site for reaction (active site)
enzyme
substrate product
active site
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Catalyst/Enzyme• Speeds up chemical reactions by lowering
activation energy
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Enzyme
• Fit together like a LOCK AND KEY
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Factors that affect enzyme activity pH
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Factors that affect enzyme activity Temperature
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Factors that affect enzyme activity Concentration
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Two molecules join together to make a macromolecule with the removal of water. This type of reaction is called?
A. GlycolysisB. HydrolysisC. PhotosynthesisD. Dehydration synthesis.
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A scientist observed that, when the pH of the environment surrounding an enzyme is changed the rate
the enzyme catalyzes a reaction greatly decreases. Which statement best describes how a change in pH can
affect an enzyme?
A. A pH change can cause the enzyme to change its shape
B. A pH change can remove energy necessary to activate an enzyme
C. A pH change can add new molecules to the structures of the enzyme
D. A pH change can cause an enzyme to react with a different substrate.
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Substance A is converted to substance B in a metabolic reaction. Which statement best
describes the role of an enzyme during this reaction?
A. It adjusts the pH of the reaction medium
B. It provides energy to carry out the reaction
C. It dissolves substance A in the reaction medium
D. It speeds up the reaction without being consumed.
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Carbohydrates and proteins are two types of macromolecules. Which functional
characteristic of proteins distinguished them from carbohydrates?
A. Large amounts of stored informationB. Ability to catalyze biochemical
reactionsC. Efficient storage of usable chemical
energyD. Tendency to make cell membranes
hydrophobic
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Practice Questions
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Practice Questions
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Practice Questions
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Practice Questions
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Practice Questions
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Practice Questions
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Practice Questions
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Practice Questions