Bio Base Europe Pilot Plant:

Lieve Hoflack, PhDProject Manager

Industrial Biotechnology and bioeconomy innovation tool towards commercialisation

The Sector: Industrial Biotechnology & Bio Based Economy

Bio Based Economy from fossil to renewable resources

The Sector: Industrial Biotechnology & Bio Based Economy

Biotechnology is the use of biological

processes, organisms, or systems to manufacture products intended to improve the quality of human life

The Sector: Industrial Biotechnology & Bio Based Economy

The “colours” of Biotechnology:

Red Biotechnology medical biotechnology:

e.g. vaccines, inuline

Green Biotechnology plant biotechnology :e.g. plant resistant to insects, diseases

White Biotechnology Industrial Biotechnologye.g. enzyme washing powders

The Sector: Industrial Biotechnology & Bio Based Economy

White Biotechnology : The use of microorganisms and their enzymes to produce chemical substances, materials and bio-energy from renewable resources

The Challenge:Bio economy: from “easy” to “difficult”

EuroSilo

Rodenhuizedok:300 000 ton Bio diesel200 000 m³ Bio ethanol240 MW Bio electricity

o

Vegetable oil

Sugar

Glucose

Starch

Hemicellulose

Cellulose

Lignin

Fine chemicals

Bioplastics

Base chemicals

Solvents

Biofuels

Biogas

Heat

Biomass Bioproductseasy difficult

Co

st

Val

ue

Biorefinery

The Challenge:Bio economy: from “easy” to “difficult”

The Challenge:Role of a multipurpose pilot plant

Discovery DeployDevelopment Demo

Knowledge & IP Process , Product & Market

• Process development & optimisation:

proof op concept, opex, capex

• Upscaling kg to ton scale: product

validation, market validation

• First series production: market

development

Fundamental research

Research

Laboratory scale

Development /Optimization

Demonstration

Pilot scale

Market Entry

Commercialization

Market-ready product

Gap in the innovation chain

Time

Technological risk Capital requirements

The Challenge:Role of a multipurpose pilot plant

The Answer:Project Bio Base Europe - Interreg IV Vlaanderen-Nederland

Process Hall 2: white biotech

Process Hall 3: Green Chemistry

(ATEX)

Lab Hall 1: fermentation,

analysisMaintenance Hall

Process Hall 1: pretreatment and

biocatalysis

Process Hall 1

Biomass pretreatment, biocatalysis, DSP

Process Hall 2

Fermentations and DSP

Process Hall 2

Fermentations and DSP

Process Hall 3

Green chemistry, gas- and anaerobic fermentation, ATEX proof DSP

Process Hall 3

Gas-fermentation

Laboratory

Tech transfer, analysis, process development

The Result:Bio Base Europe Pilot Plant

oMulti-purpose pilot facility for bio-based products and processes in Ghent (Belgium)

o Independent organisation without industrial shareholders oCurrent number of employees: 48oNo industrial shareholders

The Result:Our Unique Selling Proposition:

‘A flexible and diverse pilot plant that covers the whole proces, from green resource to final product, under one roof’

Bio-catalysis Fermentation Green chemistry

Raw materialsUpstream

Processing

Downstream

Processing

Final

products

The Result:What we do

PRIVATELY FUNDED PROJECTS

PUBLICLY FUNDED PROJECTS:Technology development, scale up and Creating awareness & building new value chains

o (financial) stabilityo building expertiseo communication/ publicity

Bio-surfactantsSpecialty carbohydrates

Anaerobic and gas fermentations Development of a

2nd generation bio-economy in Belgium

FP7 & Horizon2020: NOVOSIDES (Biocatalysis)BIOSURFING (Biosurfactants)IB2Market (Biosurfactans & special carboh)NANO3BIO (Chitosan) 2G-BIOPIC (2nd generation ethanol)MARISURF (Marine biosurfactants) ERIFORE (Circular Forest Bioeconomy)SUPERBIO (voucher for service)REHAP (wheat straw and wood to chemicals)DAFIA (MSW and marine waste to chemicals)FALCON (lignin for fuels and chemicals)NanoPack (Antimicrobial Packaging)

BBI-JUPULP2VALUE (sugarbeet pulp to chemicals) CARBOSURF (biosurfactants & specialty carbohydrates)DEMETER (Enzyme production for AD)

INTERREG: Bio Base EuropeBio Base NWE (vouchers)BioHArT (lignin to aromatics)BioBase4SME (training & voucher)SmartPilots (multifunctional pilots)Enterprise Flanders: BIOCLUSTER (renewable products)BIOKATALYSE (biocatalysis)Ghent Syngas cluster (syngas to chemicals)DEMOPROBIO (in situ product recovery linked

to ABE fermentation)

IWT: VISIONS (2nd generation technologies for organic waste streams)

CONSORTIA-BASED PROJECTS:Technology development, scale up and

building new value chains

Biosurfactants carbohydrates 2G technology gas fermentation

Sides streams as such: Butanol from whiskey draff & pot ale

• Scottish SME, university spin-off

• Raw materials:– Draff: the residue of husks after fermentation of the grain

– Pot ale: residue in the pot after distillation

• Partnered with BBEPP for scale up after Bio Base NWE coupon

• Awarded Europe’s most innovative SME & other awards

• £11million grant from Department for Transport to build a whiskey based demo bio refinery for advanced biofuel

Side streams as such:Anaerobic digestion - DEMETER

Demonstrating more efficient enzyme production to increase biogas yields• Genencor enzyme: 10% cost-reduction in biogas production from

organic waste. • Improve fermentation be cost-effective in large-scale applications

Partners: •Genencor International (NL)•Bio Base Europe Pilot Plant (BE)•Miavit (DE)•Deutsche Biomasseforschungszentrum (DE)•Organic Waste Systems (BE)•Ciaotech (IT)•Biomoer Energie (NL)

Biorefinery approach - woodERIFORE

European Research Infrastructure for Circular Forest Bioeconomyhttp://erifore.eu/

Funded by the research and innovation programme ‘Horizon 2020’ of the European Union under the Grant Agreement no 654371

Biorefinery approach – wood & strawREHAP

Systemic approach to Reduce Energy demand and CO2 emissions of processes that transform agroforestry waste into High Added value Products

Sugars +Tannins

Lignin +Sugars

BioPUR insulationWooden boards

CementThermoplastic PU Adhesives

Funded by the research and innovation programme ‘Horizon 2020’ of the European Union under the Grant Agreement no 723670

Partners: •TECNALIA (ES)•VTT (FI)•Universitaet Augsburg (DE)•Financiera Maderera SA (ES)•D’Appolonia SPA (IT)•Collanti concorede sprl (IT)•Foresa (ES)•Rampf eco solutions GMBH & Co KG (DE)

•Insight publishers limited (UK)•Lafarge centre de recherche SAS (FR)•Bio Base Europe Pilot Plant (BE)•Novamont SPA (IT)•Cromogenia units SA (ES)•Biochemtex SPA (IT)•Biosyncaucho SL (ES)•Fundacion Cartif (ES)

Biorefinery approach – straw & wood2G BIOPIC

2nd Generation Bioethanol production based on Organosolv Process at atmospheric Conditions

Funded by the research and innovation programme ‘Horizon 2020’ of the European Union under the Grant Agreement no 723670

Carbosurfproject

Use of 2nd Generation sugars (C6 fraction from 2G BIOBIC/CIMV) for fermentation processes to produce the Sophorolipid biosurfactant

• Fermentation with yeast Starmerella bombicola

• Solving technical bottlenecks• Produce sufficient amounts of new products for application

testing

Carbosurf: Glycolipid biosurfactants and specialty carbohydrates

Biorefinery approach – straw & wood2G BIOPIC

2nd Generation Bioethanol production based on Organosolv Process at atmospheric Conditions

Funded by the research and innovation programme ‘Horizon 2020’ of the European Union under the Grant Agreement no 723670

Carbosurfproject

Biorefinery approach – ligninBIOHArT

Biorizon Innovation and Upscaling of Renewable Aromatics Technology• Shale gas cracking replacing petroleum cracking: lower output of C3 - C5

aromatics (building blocks to make e.g synthetic rubber and nylon 6.6)• Wood, sugars and lignin can be converted into aromatics

Biorefinery approach – ligninFALCON

Funded by the research and innovation programme ‘Horizon 2020’ of the European Union under the Grant Agreement no 720198

LIGNIN LIGNIN OIL

MARINE FUEL

FUEL ADDITIVES

CHEMICAL BUILDING BLOCKS

Fuel and chemicals from lignin through enzymatic and chemical conversion

Partners: •Koninklijke Nederlandse Akademie van Wetenschappen (NL)•Helsingin Yliopisto (FI)•Progression-industry BV (NL)•SUPREN (DE)

•Winterthur Gas & Diesel AG (CH)•Total Marketing Services(FR)•Italian Bio Products SRL (IT)•METGEN OY (FI) •Bio Base Europe Pilot Plant (BE)

Biorefinery approach – sugar beet pulp PULP2VALUE (BBI-JU)

Biorefinery approach – MSW & fish waste

Funded by the research and innovation programme ‘Horizon 2020’ of the European Union under the Grant Agreement no 720770

Biomacromolecules from municipal solid bio-waste fractions and fish waste for high added value applications.

Partners: •AIMPLAS (ES)•Politecnico di Torino (IT)•SINTEF (NO)•Danmarks tekniske universitet (DK)•IRCELYON (FR)•Nutrimar (NO)•Innovacio i recerca industrial i sostenible (ES)•Biotrend (PT)•Daren Laboratories & scientific consultants (IL)•Mine plastik endustriyel urunler ve sert maden kimya ltd sirekti (TR)•Bio Base Europe Pilot Plant (BE)•Biopolis (ES)•ARKEMA (FR)•Farmamak ambalaj (TR)•NNFCC (UK)

BioBase4SME: Supporting bio-innovation in North-West Europe

• We support SMEs and start-ups in the biobased sector – training & networking

• We offer financial support towards services that can help the company to bring their innovation to market: €100 K max, 50-100% funded

How can we help your idea forward?

Available trainings and services

1. Technical assistance such as process development and scale-up to pilot scale

2. Life Cycle Assessment3. Application testing4. Market research, feedstock analysis, techno-

economic evaluation5. Social acceptance6. Business planning and business plan support

is an open innovation pilot and demonstration facility fro process development, scale-up and custom manufacturing of bio-based products and processes from lab to multi ton scale.

NNFCC provides strategic business consultancy in the biobased economy.The company mission is to provide clients with a holistic view of feedstock, technology, policy, and market development across the bioeconomy, enabling them to make informed business decisions and develop sustainable business strategies. NNFCC provides a range of facilitation and advisory services to Government, Industry and Academia. Services include; Market analysis, feedstock planning, sustainability strategy development, technoeconomic appraisal and policy and regulatory support.

Research teams in this Material Research and Development Centre are mainly involved in activities linked to biobased products: bioplastics, white biotechnology... It has a Life Cycle Analysis (LCA) team that has developed a vast expertise in using LCA tools for evaluating the environmental performance of innovations with the aim to assess at R&D stage the final environmental impacts associated with final product's life of the project.

REWIN West-Brabant, the regional development company, boosts the regional economy by stimulating businesses to invest in West Brabant.REWIN provides support with establishing and/or relocating both offices and businessesREWIN reinforces the following key sectors:- Logistics- Maintenance- Biobased Economy

Association of 27 Chambers of agriculture developing cooperation projects on new subjects where agriculture is not yet involved: bio-based products, biomass, use and transformation of agricultural by-products, energy, ICT, advisory, rural development. The association works with local governments, VSE & SME to create new rural and perurbanactivities.

Association des Chambres d’Agriculture de

l’Arc Atlantique (AC3A)

TCBB RESOURCE has a network of university research groups, SMEs, and state agencies working on developing the bioeconomy and bridging the gap between lab-scale and pre-commercial innovation. TCBB RESOURCE is a partner in the Irish Department of Agriculture, Food and the Marine-funded project BioÉire to advise on a national bioeconomy strategy.

Contact: Bart Bonsall & Pádraic Ó Huiginn

CLUSTER INDUSTRIELLE BIOTECHNOLOGIE

CLIB is an "Open Innovation Cluster" for the bioeconomy with focus on industrial biotechnology. Comprises of 100 members recruit from academia, finance and industry. Identification of unusual value chains within the bioeconomy is a major task of this cluster. Another task is to inform policy makers about chances the bioeconomy offers and to signal challenges to overcome.

is a non-profit organisation supporting the development of sustainable biobased activities and resulting economic growth in the region of Ghent, Belgium. Ghent Bio-Economy Valley promotes the development of the biobasedeconomy of the future through collaborative programs, joint initiatives and synergy creation between the partners in the fields of Research & Development, structural measures and policy, industrial integration and communication towards the general public.

How to apply?

Questions?

Lieve Hoflack Project Manager

Bio Base Europe Pilot Plant Rodenhuizekaai 1, 9042 Gent, Belgium

T.: +32 9 335 70 01 M.: +32 494 47 68 68

lieve.hoflack@bbeu.orgwww.bbeu.org/pilotplant