big data visualization and spatial computing in precision...
TRANSCRIPT
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Alexandros Sigaras | @AlexSigarasSenior Research Associate in Computational BiomedicineWeill Cornell Medicine
Biomedical Big Data Summer Bootcamp 2019
Weill Cornell Medicine06.19.2019
Big Data Visualization and Spatial Computing in Precision Medicine
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PrecisionMedicine
“The right treatment, for the right person,
at the right time”
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The New style of tailored treatment
http://meyercancer.weill.cornell.edu/news/2015-01-22/new-style-tailored-treatment
Irene Price | 76y Female
• 2009 | Diagnosed with Bladder Cancer; initially followed traditional treatment showing signs of success
• Relapse | High-grade urothelial carcinoma in bladder and several lymph nodes
• Cystectomy (Bladder removal), sample sent for Genetic Analysis (WES)
• Underwent Radiation Therapy, Genetic Analysis Results showed HER2 Amplification (mutation common in breast cancer)
• Relapse | Signs of metastasis to the liver• Chemotherapy targeted treatment | 8 cycles with
Taxol and Herceptin• Disease free since Nov 2014
Medical History
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Precision MedicineImpact
Dr. Kevin Holcomb and Ronda Kotelchuck
https://healthmatters.nyp.org/amazing-things-ronda-kotelchuck/
“I love Dr. Holcomb… He’s very reasonable, and he respects the patient. We really do make decisions jointly.”
Ronda Kotelchuck
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Artificial Intelligencein Healthcare
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PMKB
Huang et al “The cancer precision medicine knowledge base for structured clinical-grade mutations and interpretations” JAMIA 2017
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CNN Smoothie
P Khosravi et al. “Deep Convolutional Neural Networks Enable Discrimination of Heterogeneous Digital Pathology Images” EBioMedicine 2018
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CNN Smoothie
P Khosravi et al. “Deep Convolutional Neural Networks Enable Discrimination of Heterogeneous Digital Pathology Images” EBioMedicine 2018
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Spatial Computing in Medicine
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Reality-VirtualityContinuum
Milgram, Paul, et al. "Augmented reality: A class of displays on the reality-virtualitycontinuum." Telemanipulator and telepresence technologies. International Society for Optics and Photonics, 1995.
PhysicalReality (PR)
VirtualReality (VR)
AugmentedReality (AR)
AugmentedVirtuality (AV)
Mixed Reality (MR)
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AugmentedReality
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MixedReality
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Visualizing Cancer Drug Networks
Gayvert, Kaitlyn M., et al. "A computational drug repositioning approach for targeting oncogenic transcription factors." Cell reports 15.11 (2016): 2348-2356.
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Tumor BoardUsing Mixed Reality across the world
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https://twitter.com/AlexSigaras/status/897242543276138496
Realtime collaborationin Mixed Reality
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Realtime collaborationin Mixed Reality
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https://twitter.com/AlexSigaras/status/835210917746966529
Physicsin Mixed Reality
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Caryl and Israel Englander Institute for Precision Medicine
23
eipm.weill.cornell.edu