beta oxidation
TRANSCRIPT
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Fatty acid Catabolism(b-oxidation)
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Import of acyl-CoA into mitochondria
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b-oxidation
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b-oxidation
• B-oxidation of palmitate (C16:0) yields 106
molecules of ATP
• C 16:0-CoA + 7 FAD + 7 NAD+ + 7 H20 + 7 CoA 8
acetyl-CoA + 7 FADH2 + 7 NADH + 7 H+
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2.5 ATPs per NADH = 17.5
1.5 ATPs per FADH2 = 10.5
10 ATPs per acetyl-CoA = 80
Total = 108 ATPs
• 2 ATP equivalents (ATP AMP + PPi, PPi 2 Pi)
consumed during activation of palmitate to acyl-
CoA
• Net yield = 106 ATPs
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Acyl-CoA Dehydrogenase
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X
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b-oxidation of odd chain fatty acids
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b-oxidation of unsaturated fatty acids
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b-oxidation of fatty acids with even numbered double bonds
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Formation of ketone bodies
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Re-utilization of
ketone bodies
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