benign prostatic hyperplasia etiology, incidence, symptoms, evaluation
TRANSCRIPT
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Benign Prostatic HyperplasiaEtiology, Incidence, Symptoms, Evaluation.
Dr. Wajeed gul BangashDr. Wajeed gul BangashPG Ms UrologyPG Ms UrologySupervised bySupervised by Prof. Dr Khursheed AnwarProf. Dr Khursheed Anwar
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Prostate Gland
What is the Prostate?
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Developmental Background
Develop as series of ENDODERMAL BUDS….Lining of Primitive Urethra….adjacent part of UrogenitalSinus
03 month of intrauterine lifeSurronding Mesenchyme condense
….Stroma of gland
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Histolgy(zonal anatomy)
03 zones % Cap Peripheral zone 70% 60-70% Central zone 25% 10-20% Trasition zone 05% 05-10%BPH originate in TRANSITION Zone
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Normal
Zonal origin of BPH
Transition zone
Peripheral zone Central
zone
Urethra
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Prostate
An accessory gland of male reproductive system
Conical & firm…below neck of BladderSurroundes commencement of male
urethraIn Female represented by Paraurethral
gland( of SKENE)
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Understanding the prostate
Walnut-shaped gland that forms part of the male reproductive system
Surrounds the urethra - the tube that carries urine from the bladder out of the body
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Secretes semen which carries sperm
During orgasm, prostate muscles contract and propel ejaculate out of the penis
Understanding the prostate
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SITUATION
Lesser pelviseBelow neck of U bladderBehind lower part of pubic symphysis
(space of Retizus) & upper part of pubic arch n in front of ampulla of rectum (Denonvilliers fascia).
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Prostate Gland
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Prostate Gland
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Shape, Size, Weight
Inverted coneMeasurment 03-04cm at base 04-06cm Cephalocaudal 02-03cm Antero-posteriorWeight 08-20 gm
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Male Urogenital System
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Gross Feature
Apex..directed down ward..Urogenital Diaphargm…Perineal body….Anus
Base…upward..surround neck of bladder…mark by circular grove (lodges veins of vesical & Prostic plexuses)
04 surfaces (Anterior, Posterior(ejaculatory duct) 02 inferolateral
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LOBES
Urethra & ejaculatory D …05 lobes Anterior L …small isthmus…small or NO
Glandular tissue(seldom ADENOMA) Posterior L…lies behind Median l n
E.D….Adenoma never occurs…?primary Ca start here
Median L behind upper part Urethra…front E.D…Uvula vesicae…much gladular T…ADENOMA
Lateral L…enough G tissue…Adenoma in old age
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Capsules of prostate
True capsule…deep to false..continous wz stroma of gland….no venous plexues
False capsule…outer…derived 4rm pelvic fascia..prostatic venous plexues in it…posteriorly avascular…
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Prostate gland
Blood Supply Brs..inferior vesicle
middle rectal, internal pudendle aa.
Forms Larger outer SUBCAPSULAR plxs
Small inner(periurethral plxs)
Venous supply Rich at base, sides Plexs communicate..vesicle p &
internal pudendle v…..vesicle &internal iliac vein
Valveless connection b/w prostatic &vesicle v….Cap ….vertebral columes, skull
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Lymphatic supply
Internal iliac, sacral nodes, partly external iliac nodes
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Nerve supply
Sympathatic & parasympathatic(sensory impulses relay Lower three
lumber & upper sacral segments)
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Peripheral zone
Transition zone
Urethra
What is Benign Prostatic Hyperplasia?
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Peripheral zone
Transition zone
Urethra
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What is BPH?
Benign prostatic hyperplasia (BPH) is defined as a benign enlargement of the prostate gland caused by the growth of new cells
One of the most common conditions affecting older men which can lead to LUTS
Advancing age and testicular androgens play a central role
Age related enlargement of the prostate seen in men with BPH may be caused by increased cellular proliferation combined with a decreased rate of apoptosis
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Cause of BPH
The primary androgenic stimulator of prostate growth is dihydrotestosterone (DHT)
DHT is produced from testosterone via the 5alpha-reductase (5AR) isoenzymes type I and II
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Regulation of cell growth
DHT-androgen receptor complex
Growth factors
Unbalanced
DHT T
5AR (I and II)
Serum DHT Serum testosterone (T)
Prostatecell
IncreasedCell growth
Cell death
Adapted from Kirby RS, McConnell. Benign Prostatic Hyperplasia. Health Press Ltd, 1999
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Type I and type II isoenzyme distribution
Sebaceous glands
Liver
LiverProstate
Type I
Brain
Skin
Prostate
Genital tissues (genital skin and epididymis)
Seminal vesicles
Type II
Anderson JB et al. Eur Urol 2001; 39: 390–399 Bartsch G et al. Eur Urol 2000; 37: 367–380
Thigpen AE et al. J Clin Invest 1993; 92: 903–910
Scalp
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Pathology
Transition zone…hyperplastic processMicroscopically…nodular growth pattren…
composed of Stroma, EpitheliumStroma composed…collagen, smooth
muscleExplain potential responsivness to medical
therapySmooth M(alpha blocker) epithelium(5-
alpa reductase inhibitors)
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Classification of Medical Therapyand Recommended Dosage in BPH. Classification Oral Dosage Alpha-blockersNonselectivePhenoxybenzamine 10 mg twice a dayAlpha-1, short-actingPrazosin 2 mg twice a dayAlpha-1, long-actingTerazosin 5 or 10 mg dailyDoxazosin 4 or 8 mg dailyAlpha-1a selectiveTamsulosin 0.4 or 0.8 mg dailyAlfuzosin 10 mg daily5-alpha-reductase inhibitorsFinasteride 5 mg dailyDutasteride 0.5 mg dailySubcutaneous implant YearlyTriptorelin pamoate 3.75 mg every month
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Pathophysiologh of BPH
Symptom…obstractive / secondry response to BOO
Obstractive component…Mechanical / dynamic obstraction
Mechanical obs: as bph…intrusion into urethral lumen…lead to high bladder outlet resistence
Dynamic obs: alpha1 mediated smooth muscle contraction occur…variable symptoms…bladder outlet obs occur…use alpha blocker…dec tone..dec in outlet resistence
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Causes of BOO
In Men BPH (major) Urethral stricture,
malignant enlargment prostate(less common)
In female Less common Pelvic
prolapse (cystocele,rectocele,uterine)…directly compress urethra..U stricture, U diverticulm
Fowler,s syndrom Pelvic masses
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BPH: symptoms
Symptoms associated with BPH include the OBSTRACTIVE and IRRITATIVE symptoms
LUTS is not specific to BPH – not all men with LUTS have BPH and not all men with BPH have LUTS
Cunningham GR et al. Epidemiology and pathogenesis of benignprostatic hyperplasia. Up To Date Literature Review, Apr 29; 1998
EAU BPH guidelines. Madersbacher S et al. Eur Urol 2004; 46: 547–554
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Symptom type Symptom
Obstructive (voiding) Weak urinary stream
Prolonged voiding
Abdominal straining
Hesitancy
Intermittency
Incomplete bladder emptying
Terminal and post-void dribbling
Irritative Frequency
Nocturia
Urgency
Incontinence
Associated symptoms Dysuria
Haematuria
Haematospermia
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IPSS by AUA( Barry & colleagues early 1990s)
Incomplete emptying Frequency Intermetency Urgency Weak stream Straining Nocturia
0 1 2 3 4 5 0 1 2 3 4 5 0 1 2 3 4 5 0 1 2 3 4 5 0 1 2 3 4 5 0 1 2 3 4 5 0 1 2 3 4 5 Total= 35
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Total IPSS* score indicates symptom severity
IPSS Score
Symptom severity
Symptom description
0–7 Mild Little bother, reasonable urine flow and low residual volume
8–19 Moderate Bothersome, reduced residual volume but no evidence of complications
20-35 Severe Complications of obstruction
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•A detailed Focused history Urinary tract
(Exclude)
UTI,sNeurogenic Bladder
Urethral strictureProstate cancer
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ASSESSMENT
Recommended investigations(EAU guidelines)
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Medical history Recommended
Symptom score Recommended
Physical examination including digital rectal examination (DRE)
Recommended
Prostate specific antigen (PSA)
Recommended
EAU 2004 recommendations regarding initial assessment of BPH
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Creatinine measurement
Recommended
Urinalysis Recommended
Flow rates Recommended
Post-void residual volume
Recommended
Pressure flow studies
Optional
Imaging of the upper urinary tract
Optional
Imaging of the prostate
Optional
Voiding charts Optional
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PSA
PSA is a protein produced almost exclusively in the epithelial cells of the prostate
Elevated levels of PSA signify change in the prostate typically caused by: BPH Prostate cancer Prostatitis ? Ageing Instrumentation
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Guideline recommendations
A PSA-test should be offered to those with at least a 10-year life expectancy and for whom knowledge of the presence of prostate cancer would change management
PSA can be used to evaluate the risks of either requiring surgery or developing AUR
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Factors influencing the serum levels of PSA
architecture of the prostatic gland is disrupted PSA will ‘leak’ into the circulation prostatic carcinoma, BPH, prostatitis and after
urinary retention PSA is not considered as being cancer-specific,
but organ-specific PSA serum elevations occur in biopsy of the
prostate gland and ejaculation , small and clinically insignificant changes occur after DRE.
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Two other important factors, age and raceAfrican-Americans with no evidence of
prostate carcinoma have higher PSA values after their fourth decade of life.
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Age-Adjusted Reference Ranges For PSA
Age (y) PSA Normal Ranges
(ng/ml) 40–49 0–2.5 50–59 0–3.5 60–69 0–4.5 70–79 0–6.5 Data from Oesterling JE et al: Serum prostate-specific antigen in a community-based population of healthy men. Establishment of age-specific reference ranges. JAMA 1993;270:860.
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BPH-Complications:
1. Urethral compression2. Ball valve mechanism3. Bladder hypertrophy4. Trabeculation5. Diverticula formation6. Hydroureter – bilateral7. Hydronephrosis
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BPH-Bladder Gross – Identify Cues?
Trabeculations Hypertrophy of wall Stone - urolithiasis Inflammation Median lobe- ball valve. Enlarged prostate.
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BPH-Bladder morphology:
Hypertrophy Trabeculation Median lobe
protrusion.
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Benign Prostatic Hyperplasia:
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Normal Prostate:
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Nodular BPH:
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THE END