beginning of the chapter oxidative stress, substances and genetics (toxo sensor) 30
TRANSCRIPT
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Beginning of the chapterOxidative stress, substances and genetics
(Toxo Sensor)
30
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OXIDATIVE STRESS
Free radicals damage the cells
OXIDATIVE OXIDATIVE STRESSSTRESS
Free radicalsFree radicals
AGEINGAGEINGCANCERCANCER
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OXIDATIVE STRESS
Free radicals damage the cells
CYTOPLASM OF A CELL
Superoxide
Hydrogen peroxide
SOD2SOD2
SOD1SOD1
SOD3SOD3
5% oxygen5% oxygen
MITOCHONDRIA
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OXIDATIVE STRESS
Free radicals
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OXIDATIVE STRESS
GPX1 – a selenoprotein
GPX1GPX1
GPX1GPX1Selenium
Free Free radicalsradicals
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OXIDATIVE STRESS
GPX1 – a selenoprotein
GPX1GPX1
GPX1GPX1
SeleniumFree Free radicalsradicals
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OXIDATIVE STRESS
GPX1 – a selenoprotein
GPX1GPX1
GPX1GPX1
Selenium
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OXIDATIVE STRESS
GPX1 – a selenoprotein
GPX1GPX1
GPX1GPX1
NeutralisedNeutralised
Selenium
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OXIDATIVE STRESS
Selenium deficiency and GPX1
Selenium deficiency30% Activity
More selenium70% Activity
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OXIDATIVE STRESS
Polymorphism in the GPX1 gene
GPX1GPX1
GPX1GPX1
Free Free radicalsradicals
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OXIDATIVE STRESS
GPX1GPX1
GPX1GPX1
Free Free radicalsradicals
Selenium
Polymorphism in the GPX1 gene
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OXIDATIVE STRESS
GPX1GPX1
GPX1GPX1
Poorer binding Poorer binding (for example, 50% worse)(for example, 50% worse)Selenium
Polymorphism in the GPX1 gene
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OXIDATIVE STRESS
Normal levels of Selenium
35% Activity
More selenium60% Activity
Polymorphism in the GPX1 gene
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OXIDATIVE STRESS
Free radicals
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OXIDATIVE STRESS
Coenzyme Q10
Q10Q10
NQO1 NQO1
Q10Q10
UBIUBIUBIUBI Free Free radicalsradicals
Q10 – No effectQ10 – No effect
UbiquinolUbiquinolantioxidant effectantioxidant effect UBIUBIUBIUBI
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OXIDATIVE STRESS
Free radicals
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OXIDATIVE STRESS
Coenzyme Q10
Q10Q10
NQO1 NQO1
Free Free radicalsradicals
Q10 – No effectQ10 – No effect
Q10Q10
UBIUBIUBIUBI
UBIUBIUBIUBI
UBIUBIUBIUBI
UBIUBIUBIUBI UBIUBIUBIUBI
UBIUBIUBIUBIUBIUBIUBIUBI
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OXIDATIVE STRESS
Coenzyme Q10
Q10Q10
NQO1 NQO1
Free Free radicalsradicals
Q10 – No effectQ10 – No effect
Q10Q10
CC
EE
ALAALA
CCEE
EE ALAALACC
ALAALA
EE
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OXIDATIVE STRESS
Oxidative stress, what to do now?
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RECOMMENDATIONSRECOMMENDATIONS
1)1)Antioxidant-rich dietAntioxidant-rich diet2)2)Additional intake of free-radical scavengersAdditional intake of free-radical scavengers
1)1) Vitamin CVitamin C2)2) Vitamin EVitamin E3)3) ß-caroteneß-carotene4)4) Alpha lipoic acid Alpha lipoic acid 5)5) Coenzyme Q10? Coenzyme Q10? Ubiquinol?Ubiquinol?6)6) Selenium – how much? GPX1-geneSelenium – how much? GPX1-gene
3)3)2 2 Cups of coffee/day for 7 delay of the breast cancer Cups of coffee/day for 7 delay of the breast cancer occurrence?occurrence?
OXIDATIVE STRESS
Oxidative stress, what to do now?
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SUBSTANCES
The effect of various substances on our body
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SUBSTANCES
The effect of various substances on our body
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End of the chapterOxidative stress, substances and genetics
(Toxo Sensor)
30