beauty category map · 2020. 8. 19. · •exercise •diet •sleep •stress •microbiome...

Information Classification: General

Beauty Category Map

“We are shifting channels and preferences that are profoundly changing the industry. We aren’t simply moving from point A to point B, change is

flowing like the current of the ocean.”

Fabrizio Freda, President & CEO of Estee Lauder

http://www.esteelauder.com/


Multifaceted Etiology of Ageing


Eliminate damaged cells

Reactivate Telomeres

Epigenetic Intervention

Activate Chaperone and Proteolytic systems

Dietary Restriction, IIS & mTOR inhibition, AMPK and sirtuin activation

Clearance of Senescent cells

Stem Cell therapies

Anti-inflammatories, Rejuvenation factors

Mitochondrial Biogenesis

9 Hallmarks of Ageing


Eliminate damaged cellsGlutathione

Pomegranate, Glisodin

Reactivate TelomeresResveratrol

Olive leaf, AstragalusGlutathione, Pterostilbene

Epigenetic InterventionProbiotics

MicronutrientsOenothera laciniata

Activate Chaperone and Proteolytic systems

ETAS®Ergothioneine, ATP,

HMB/ Vitamin D

Dietary Restriction, IIS & mTORinhibition, AMPK and sirtuin activation

Mango extract/ fermentationBlack turmeric, Niagen

Clearance of Senescent cellsMushroom, Seaweed,

Pu-erh tea extract

Stem Cell therapiesPolyphenols

Astragalus, green tea, gojiVitamin D

CarnosineLactobacillusBlueberry

Astragalus, AngelicaPterostilbene

Anti-inflammatories, Rejuvenation factors

Avogen, SetriaPanduratin, alpha-lipoic acid

Mitochondrial BiogenesisPQQ, Amla, Apple Extract, B3,

Resveratrol, Ergothioneine

9 Hallmarks of Ageing


Lifestyle and Environmental Factors of Aging

• Sun exposure

• Smoking

• Exercise

• Diet

• Sleep

• Stress

• Microbiome

• Pollution

Beauty category map: exploring the future of the beauty market and introducing new points of entry based upon emerging science•Scientific evidence supporting a multifunctional approach to beauty and ageing, from cellular health to lifestyle interventions•Consumer behavior and science: where it is dissecting and where it is diverging•Giving consumers what they want today and developing products forthe future that they don’t know they need yet


• Telomere “science”• Mitochondrial efficiency & rejuvenation• AGEs (Advanced Glycation End Products)• MOA as a story/ How it works• Membrane integrity• Endoplasmic Reticulum• Gene Expression/• Epigenetics• Speed of Action• Sirtuin enzymes• Safety MOA

Health on a Cellular LevelMechanism of action enhances the story


Beauty Within MapSkin Health• Repair/ Rebuild• Rejuvenation/ Regenerate• Prevention/ Protect• Pigmentation/ hormonal/

exfoliating/ strength/ • Skin Detoxification• Moisture/ Hydration• Erythema• Radiant• Dark circles• Spots, freckles,• Keratin• Fibroblast stimulation• Atopic dermatitis• Allergy• Tone/ Texture• Environmental/ Winter

Wrinkle MOA treatments• Melanin overproduction• Collagen/ elastin

degradation• Microcirculation• Photoaging• Ceremides• Crepey

Aging Mechanisms• Sun/ UV• Stress• Pollution• Poor diet• Menopause• Tobacco• Sarcopenia• Metalloproteinases• Exceptional Skin Agers

Metabolic Reconditioning• Prebiotic/ Probiotic (HU 58)• Metabolism enhancing• Reprogramming• Livaux• SCFA modulation

Weight Management• White fat to brown fat conversion• Short chain fatty acid metabolism• Cellulite

Beauty Sleep• Restorative Sleep• Calming• Nightly Multi vs Daily Multi

Hair• Grey hair• More hair• Vibrant hair factors• Lashes and brows• Hair Loss• Hair Strength• Scalp Health

Nails• Brittle nails• Dull• Nail growth• Fungal infections• Paronychia• Pitting

Digestion• Sexy Fiber• Ammonia oxidizing bacteria

(AOB)• Dysbiosis• Bloating• Probiotics/ allgergies• Detox/ Purification/

Cleansing

Eye Health• Dry eye• Bags• Brightness• Wrinkles

Active Lifestyle• Sarcopenia• Fatigue

Circulation• Vein health• Microcirculation


Age Defying/ Anti-Aging

Cellular healthMitochondria

ERStimulate heat shock protein

NootropicsTelomeres

StressSarcopenia

Active LifestyleFatigue

Vein Health


SIRT Enzymes the Longevity Gate Keepers

• powerfully reverses leptin resistance• supports mitochondrial function• increase NAD in the cell• increases sensitivity to T3 (thyroid) • increases estrogen function• increases sensitivity to vitamin D• inhibits IGF-1 • inhibits mTOR• protects you from nitric oxide.• probably increases adiponectin release• beneficial effects on blood lipids• regulates the strength (amplitude) and the

duration of circadian gene expression• supports healthy skin

Sirtuins may act as metabolic sensors, using intracellular metabolites such as NAD and short-chain carbon fragments such as acetyl coenzyme A to modulate mitochondrial function to match nutrient supply. SIRT enzymes “turn off” certain genes that promote aging, such as those involved in inflammation, in fat synthesis and storage, and in blood sugar management

Low SIRT leads to • Neurodegeneration in the brain• Vascular inflammation• Increased fat storage in the liver• Increased insulin resistance• Increased fat production and deposition in white adipose tissue• Fatigue, loss of muscle strength, and fatty infiltration of muscles


CategoryIngredient Description Trade Name Company Claims MOA

AGEs/ weight management

Benfotiamine/ S-benzoylthiamine-O-monophosphate) is an analogue of Vitamin B1, also known as Thiamine. BenfoPure®

HamariChemicals, Ltd

Helps reduce the formation of Advanced Glycation End products (AGEs). Higher bioavailability and metabolic activity than ThiamineSupports healthy nerve function in people with hyperglycemiaSupports normal healthy kidney function. Helps maintain normal endothelial function, and structure, which is associated with optimal cardiovascular health. Assists the body in responding to the toxic breakdown compounds of excess sugar Reduces elevated levels of intracellular glucose and the potential for AGE (Advanced Glycation End-Products) formation

Benfotiamine is a lipid-soluble compound that is more readily available for nutritional use and is significantly more active than traditional forms of Thiamine. Stimulates transketolase, an enzyme that helps convert the toxic compounds to harmless ones. Benfotiamine is digested in the gastrointestinal tract to a form which is more lipid-soluble than thiamine which permits this Benfotiamine-form to readily cross cell membranes in the intestines and enter the blood stream. A significant percentage of this lipid-soluble form is captured within red blood cells, where it is converted to free Thiamine as needed by the body. The bioavailability of Thiamine in blood plasma is reported to be approximately 3.6 times greater after a dose of Benfotiaminethan after a dose of Thiamine.

Aging brain health Caviar oil Romega Arctic NutritionPhospholipid bound. Novel source of DHA phospholipid bound omega 3. Easily digestible and oxidatively stable. Anti-inflmmatory.

Anti-inflammatory. Abundant in choline derived phospholipids an important neurotransmitter. Clinically proven rapid absorption into the blood stream and tissues.

AMPKGynostemmapentaphyllum ActivAMP® Gencor

Promotes Longevity And Reduces Fat Storage. AMPK is more activated and helps protect against obesity4 and diabetes. The "immortality" herb. Emulates calorie restriction.

Increase AMPK activity. Adenosine monophosphate-activated protein kinase. Reverse the cellular depletion of the critical AMPK enzyme. May improve allergies. Shuttles excess fats into the mitochondria to be utilized for energy and safe disposal.

AMPK Fingerroot extract PanduratinCan reduce body fats. Can help maintain skin health from skin damage by UV light

Anti-obesity efficacy is mediated through AMPK signaling. Boesenbergiapandurata)

Anti-Aging/ Mitochondiral

Pyrroloquinoline quinone (PQQ) MicroPQQ® BioActives LLC

Slow the aging process. Increase energy levels. Improve cognitive function. Alleviate occasional stress and sleeplessness. Support mitochondrial health and cellular energy production, and to protect the body from oxidative stress. Most notably, PQQ stimulates the spontaneous growth of new mitochondria in aging cells, and activates genes that govern mitochondrial reproduction, protection, and repair. Improved Absorption. 12-Hour Sustained Release

It supports the health and proliferation of mitochondria, which generate the energy cells need to function efficiently. Because the degradation of mitochondria is a key contributing factor to physiological aging in humans. Affects cell-signaling pathways involved in cell growth, differentiation and survival. Protects existing mitochondria from damage. Helps generate new mitochondria. Protect nerve cells.

Anti-Aging/ SIR2 / telomere

Polyphenols from grapevine and olive leaf Telos95®

Certified Nutraceuticals

Halts telomere shortening. Supports healthy Logevity. Supports Telomere health. Rejuvenates healthy cells SIR2 Protein and Telomere maintenance in relation to the aging process.

Anti-Aging

Avocado extract powder/ Perseaamericana Avogen

Avogen/ LongzeBiotechnology

TAvogen™ is the first small molecule approach that engages the extracellular matrix to help renormalize errors. he extracellular matrix (ECM) is the dynamic regulator of cell functions everywhere in the body. Aging, stress and inflammation cause ECM deterioration and clinical disorders follow.

The ECM is now recognized as a key player in many clinical and subclinical events. It represents a new class of substances (NORMS) that are not anti-inflammatory agents or immune suppressors but instead act to normalize day-to-day functions in the ECM. The effects of renormalization are rapid, well-tolerated, without side effects and continuing.

Anti-AgingResveratrol, catechin, quercetin Querveratin™ Midlife

Reduce skin roughness, lines, sagging, irregular pigmentation and improved skin elasticity scavenging of free radicals

Anti-smoking OPC Oligopin® Purextract

Support healthy post-meal blood glucose and lipid levels.Reduce visceral fat. Lessen skin wrinkles and brown spots. Help decrease fatigue and improve endurance.

Increase production of nitric oxide, improving circulation. Neutralize free radicals. Reduce UVB-induced COX-2, to protect cell health. Support healthy levels of inflammatory cytokines. Inhibit the enzyme collagenase, promoting skin health


Category Ingredient Description Trade Name Company Claims MOA

Brain HealthHydrolyzed Coastal Jellyfish

Collagen Types I.II.V. KollaJell Brain function in age-related neurological issues.

Hormone

RHEUM RHAPONTICUM EXTACT STANDARDIZED TO 54% RHAPONTICIN & 27% DEOXYRHAPONTICIN ERr 731® AGG

Safe, effective relief for symptoms associated with menopause, including hot flashes. ERr 731® has been demonstrated to relieve hot flashes to a similar extent as estrogen-based therapies and exceed reported results of other phytoestrogen and botanical approaches.

Hormone soybean isoflavones Solgen™ Midlife

Mitochondria health/ Sirtuins

Nicotinamide Riboside. (metabolite) of Vitamin B3 Niagen® Chromadex

Restoring mitochondrial function. Supports energy production. Increases NAD+ levels in cells and tissues. Supports healthy skin*Promotes mitochondrial function which is an important component of aging. Promotes beneficial effects on blood lipids by maintaining healthy cholesterol levels already within normal range.

Elevates levels of NAD+ in the blood. Restored NAD+. powerful NAD+ precursor and a Sirtuin activator with the potential to protect mitochondrial health. Model (animal) studies have shown that this could be an effective means to slow down the aging process by restoring mitochondrial function. Sirtuins.

MitochondrialPyrroloquinoline quinone (PQQ)

BioPQQ PQQMax

MGC MTC Industries

Three pillars to brain health: support nerve growth factor, increase mitochondria, antioxidant. Studies show that PQQ possesses powerful free radical–scavenging capacity and provides the mitochondria with superior antioxidant protection. Unlike other antioxidants, PQQ’s molecular stability allows it to carry out thousands of electron transfers without undergoing molecular breakdown. While protecting mitochondria from oxidative stress is good, that fact that PQQ can promote mitochondrial biogenesis is even better.

PQQ activates a “master regulator” that directly stimulates genes that enhance mitochondrial and cellular respiration, growth, and reproduction. PQQ triggers the CREB signaling protein to stimulate the growth of new mitochondria. PQQ regulates a cell signaling protein called DJ-1. DJ-1 is intrinsically involved in cell function and survival, has been shown to be of particular importance to brain health and function. stimulates the production and release of nerve growth factor in cells that support neurons in the brain. Neurons are electrically excitable brain cells involved in cognition. Promoting healthy neurons is a good way to improve thinking and protect your brain for aging.

Mitochondrial

ancient peat (fossilized plants) and a proprietary apple extract ElevATP® Futureceuticals

Helps improve athletic performance and body composition. Promotes increased power output and training volume. Helps reduce performance decrements associated with overreachingSupports increased lean muscle and strength

Increase mitochondrial energy, strength, power and performance in resistance-trained athletes. (Functional study published in BMC Complementary and Alternative Medicine, July 2016.) Stimulate ATP.

Mitochondrial health Emblica officinalis (Amla) Saberry® Sabinsa

Improves antioxidant defense in aging patients. Ixhibit 5-alpha reductase inhibitory activity (about 80% inhibition at a concentration of 250 µg/ml). Significant potential as a UVA and UVB protectant.

Increased procollagen type I C-peptide (PIP) and tissue inhibitor of metalloproteinase-1 (TIMP-1) production, and decreased MMP-1 production, concomitant with elevated mitochondrial activity in the fibroblast, in a concentration dependent manner.

Mitochondrial health L-Ergothioneine ErgoActive™

MironovaTetrahedron Blue California

Super antioxidant. Anti-aging. Anti-inflammatoryEGT-transporter is expressed specifically in key cells and tissues that are highly sensitive to ageing, free radical damage and inflammation

Potent intra-mitochondrial antioxidant. Delivered to cells that are the most subject to oxidative stress and decline.

Sarcopenia OPC Oligopin PurextractCounteract muscle degredation. Reduce muscle fiber destruction from oxidative stress. Muscle cell protection.

Modulate the stress chaperone heat shock protein (main protector of muscle necrosis). Early regulator of ROS events in muscle cells. Suppress overactivity (up-regulation) of Calpain activity (calcium dependent protease critical to satellite cell function.)

Skin health/ Sarcopenia/ hormone modulation

Pomegranate (Punica granatum) extract, standardized to > 40% punicosides > 30% punicalagins P40PTM Nektium

Reduction of neurodegenerative disorders, protection of skeletal muscle mass, maintenance of microbiota and positive effects on cardiovascular and metabolic health.

Maintains healthy blood pressure. May prevent cardiac disordersMaintains blood glucose homeostasis. Antioxidant Anti-inflammatory


CategoryIngredient Description Trade Name Company Claims MOA

Skin health astaxanthin

MicroActive Astaxanthin MayPro 2.5X bioavailability, 12X release

Anti- Smoking/ Anti-aging

Lippia citriodora extract, Verbascoside Lemon Verbena Acteos 10P ABR Research

Healthy menopause. Resist PMS. Modulate better sleep and irritability. Antispasmodic. Enhance diuresis.

Significant reduction of malondialdehyde/ lipid oxidation. Significant increase of IgA (+15%) and IgG (+19%).

Resveratrol Dark Chocolate ReChoc

Cambridge Chocolate Technologies/ Lycotec

Proprietary PolyFount fortification ensures optimal uptake of polyphenols in the blood. Patent pending production method is controlled and tested in humnas. Elevates epicatechins and resveratrol for up to 6 hours. 95 ng/ ml epicatechins + 180 ng/ ml resveratrol

SIRT1/ cell protection Mango powder Careless™ Vital Solutions

Helps support successful dieting by decreasing fat and calorie intake. Increase maintenance of muscle mass and physical energy during aging.

Actives enzyme SIRT1 to detect dietary intake and modulate metabolic processes promoting energy homeostatis and cell proliferation. Stimulate metabolism and circulation.

SIRT1

Black turmeric extract

(Kaempferia parviflora) Situmax® MayProSupport healthy aging. Inhibit weight gain. Reduce visceral fat reduction. Healthy blood blucose. Stimulates SIRT1 activation

100% Chicken Sternum Hydrolyzed Collagen Type II kollaGen II-xs

Higher molecular weight for optimum absorption; major component of hyaline joint cartilage; naturally occurring mucopolysaccharides: hyaluronic acid, chondroitin, and glucosamine.

Grapevine extract antioxidant Reverse-vine

Newly discovered trans-e-viniferin, considered to have high antioxidant value.

Vision/ Antioxidant astaxanthin

AstaMax/ AstaReal MTC industries

Improved vision. Natural body detox. Reduced risk of cardiovascular disease. Increased energy levels. A stronger immune system. Improved skin elasticity and texture

Dihydroquercetin

BC-DHQ (Dihydroquercetin) Blue California

The antioxidative activity of dihydroquercetin or taxifolin far exceeds that of more common antioxidants such as tocopherols (vitamin E), ascorbic acid (vitamin C), or other flavonoids.

Skin health/ Hormone Pomegranate, ellagic acid P-estro HL HL Science

Climacterium improvement, decrease in monopause symptoms. Decrease in abdominal fat and cholesterol.

Panmol®NADHCognitive health, energy, alterness, memory and concentration support

French maritime pine bark/ OPC Pycnogenol®

Horphag Research

rutinoside extract derived from citric fruit CORDIART™ BioActor

Activate endothelial nitric oxide production, inducing vasodilation to support healthy circulation.

GliSODin® Isocell Support healthy arterial function and structure Boosting most powerful antioxicant enzymes, SOD and catalase


Skin HealthGeneral Skin Health/ Maintenance

Collagen Mechanisms

Skin Elasticity

Environment/ Pollution/ Tobacco

Tone/ Texture/ Radiance

Skin Whitening/ Brightening

Fine Lines and Wrinkles

Skin Detoxification

Atopic Dermatitis/ Allergy

Pigmentation/ Age spots/ Freckles/ Erythema/ Melanin

Suncare Photo-Aging

Microcirculation


Skin Health/ Anti-Aging

Collagen restore/ Protect/ Wrinkles

• Juvecol• Verisol• Biocell• Collactive• Florabella• Naticol• Alluvia• TruMarine

Skin MicroCirculation• Biocell• Cocoa Flavanoids• Propionyl-L-Carnitine• Oligonol

Pigmentation/ Block Melanin

• L-cysteine• Vitamin C• Florabella• Uva ursi• ApplePhenon• Setria• SkinAx• OLME

Hydration• Ceratiq• LipoWheat• Florabella• GreenNag• Ceremides• Ceramosides

Mitochondrial Function• Biocell• Niagen• PQQ• ElevATP

Skin Detoxification• Probiotics• Milk Thistle• Picroliv• Prebiotic• Artichoke• L-methionine

Environmental/ Seasonal/ Smoking

• Hydroliv• Cocoa Flavanoids• Oligopin• Green tea• Acetos 10

9Atopic dermatitis/ Allergy• Probiotics• Olive leaf/ fruit• Boswellia/ Quince• Quail egg extract

SuncareOpextanLycodermPycnogenolCocoa flavonoidsCollagen-Tripep20Red Orange ComplexVitaSAstaxanthinEcklonia cavaPanduratinFernBlock

Skin Health• Opextran• L-92 lactic acid

bacteria• B1


Suncare/ Photoaging

CategoryIngredient Description

Trade Name Company Dose Claims MOA

Photoaging Cocoa flavonoids Not specificBarry Callebaut

320 mg total cocoa flavanols/d. prevention of the progression of photoageing

24-wk, randomized, double-blind, placebo-controlled. Asian women with prominent wrinkles

PhotoagingLingostem/ lingonberry (Vaccinium vitis-idaea)/ Lingostem™

Centerchem/ Provital Group Topical

Lingonberry stem cells designed to prevent and reverse photoaging, mimicking one of nature’s solutions to fight damaging effects of solar radiation in plants.

Plant stem cells. Counteracts and prevents UV & IR effects. Has a multiple anti-photoaging strategy. Improves all the visible signs of photoaging.

PhotoagingFrench maritime pine bark/ OPC Pycnogenol®

HorphagResearch

1.1 to 1.66 mg/ kg per day

Natural anti-aging. Healthy circulation and vascular function.

Support healthy cell membranes, promotes normal DNA function, inhibits inflammatory factors, and helps to suppress free radical activity. Healthy metabolism of glucose.

Photoaging Olive polyphenols Opextan Indena 160 mg

Support skin health. Protect from sun damage. Showed an averaged 16.45% increase of MED (Minimal ErythemalDose) compared to before the treatment.

Potent free radical scavenger activity. Prevent lipid peroxidation

Photoaging

Three red orange varieties Sicilian red oranges (Citrus sinensis var. Moro, Sanguinello, Tarocco) extract (fruit and peel)

Red Orange Complex® Bionap S.r.l.

200 mg/ day

Supports natural immune response to UV exposurePromotes healthy DNA function before, during and after UV exposure. Encourages protective ATP production. Boosts cellular energy.

Significant role in boosting the production of ATP (adenosine triphosphate), the energy releasing molecule that fuels all your cells and powers their intracellular machinery. This is especially important as ultraviolet exposure can affect production of ATP in skin cells,


Photoaging

Skin-grade tomato extract and carnosic acid Lycoderm™ Lycored 6mg/ day

Protects the skin from DNA damage due to sun exposureHelps maintain the skin’s ability to protect against photoageing Increases skin smoothness, density, and thickness. Helps prevent damage caused by sunlight

Normal skin cell recovery after incidental sun exposure while also maintaining healthy skin texture and tone. Support the dermal barrier function; Minimize the effects of reactive oxygen species (ROS). It accumulates and metabolizes in the skin, providing a first line of defense against damageing UV light.

Photoaging Astaxanthin + fish Collagen Cyanotech

2mg/ 3000mg/ day

Improvement in skin elasticity began to be noticeable in the upplement group at 4 weeks. n improve elasticity and barrier integrity in photoaged human facial skin

480 mg of medium chain triglycerides and 20 mg of dark red lipid extract. of Haematococcus pluvialis microalgae, standardized with safflower oil to yield a minimum 5% content of astaxanthin(1 mg of astaxanthin per capsule). Expressions of procollagen type I, fibrillin-1, matrix metalloproteinase (MMP)-1, and MMP-12 were evaluated

PhotoagingPhlorotannin Eckstolonol from Ecklonia Cava None N/A

prevent UV-B induced skin cell damage. Strong antioxidant support from algae.

Photodamage/ Pigmentation/ Collagen/ build

Polypodium leucotomosextract/ Calagualine FernBlock SuanFarma

Stimulate collagen expression (type I, II, and V) Inhibit cellular changes in the skin that can lead to premature ageing from outdoor activity and it also works to promote healthy DNA function before, during and after ultraviolet exposure.

Effects occurred in control cells, and persisted during UV irradiation. Enhancement of p53 expression in skin cells following the combination of UV radiation and PL ingestion. A protective trend has also been noted in regards to MMP proteins in vitro, where MMP1-3 were all inhibited. Anti-oxidant properties have been noted in vitro with Polypodum leucotomos(PL) including Superoxide, Hydroxy, Lipid peroxides, and ROS

Suncare/ Photoaging


• Fernblock®: Multiple MOAs: MMP inhibition, stimulate collagen synthesis, protect against UV light. (HelioCare, Walgreens)

• Lycoderm®: Great mechanism. Widely distributed, but new patent for claims. Benefit takes too long, but they are running a new consume study.

• Opextan®: Reduces oxidative stress and skin sensitivity to UV light.

• Cocoa flavonols: Study in Asian women who already had wrinkles. Prevented the progression of photoaging.

Suncare/ PhotoAging


Hydration/ Moisture



Hydration PhytoceramidesCeratiq™ Phytoceramides

Robertet Group

• Clinical support for improved skin hydration• Restores skin barrier function • Helps prevent skin drynessin winter. Non-GMO, Non-Allergenic. Perfect for beauty drink formulations

A natural, vegan source of ceramides – a class of lipids known as ‘the skin’s natural sealant. Ceramides are very important in skin hydration, representing 35 to 40% of intercellular cement.

Hydration Hyaluronic acid various various 240 mg

Hydration Ceremides Various Seppic/ 350 mg

Ceramides provide continuous maintenance for skin and allow it to sustain its healthy protective function and vital moisture. Provide continuous maintenance for skin and allow it to sustain its healthy protective function and vital moisture. Youthful skin from within.

inhibit the elastase enzymes that destroy the skin's elastin. restoring structure to human skin.

Hydration / Protect fibroblasts Phytoceremides LipoWheat™

Robertet Group 350 mg

After 3 months reduced the appearance of crow's feet. Reduced wrinkle depth. Protects skin’s fibroblasts and enhance skin’s appearance.

Improves skin barrier and ability to hold moisture in. Increase hydration by 65%. 95% of women saw an improvement.

Hydration/ Elasiticity/ Pigmentation

Sakura flower/ advanced glycation endpoints (AGEs) Florabella MayPro 150mg

Significantly reduces AGE production. Maintains skin elasticity.Reduces skin moisture loss. Increases skin smoothness. Reduces pore size. Evens complexion, minimizing brown spots and redness

inhibits advanced glycation endproducts (AGEs) known to contribute to metabolic syndrome

Moisture/ Elasticity N-acetylglucosamine (NAC) GreenNag Amicogen Increase moisture and skin elasticity. 3X higher bioavailability. Precursor of hyaluronic acid.


Pigmentation/ Age spots/ Freckles/ Erythema



Pigmentation immature green apple ApplePhenon® BGG 300-600mg Skin Whitening

Pigmentation/ Wrinkles

Uva ursi/ Arctostaphylosuva-ursi. dry leaf extract containing 105mg arbutin 472.5mg Skin lightening. Skin Whitening. Skin brightening. Blocks melanin

Pigmentation/ Wrinkles Liposomal glutathione Setria® Kyowa Hakko 250mg- 450mg

Skin whitening. Brighten and lighten skin. Manufactured in Japan. Wrinkle reduction. Helps protect cells in the body from the damaging effects of oxidative stress and toxins

It helps eliminate toxins, ingested chemicals, and potential carcinogens that the body has already absorbed. It intercepts and neutralizes toxins in the GI tract before they are even absorbed.

Pigmentation/ Skin Protection/ Dark circles

Vitis vinifera extract, Cucumis melo L. extract, coated vitamin C, zinc citrate SKINAX²™ ActivInside 150mg/ day

Element graphique Protects skin fibers to preserve elasticity and suppleness and decrease dark circles. Reduces skin hyperpigmentation.

Regulates melanin synthesis for an optimized and homogeneous skin color and a reduction of hyperpigmented spots. Element graphique Improves blood circulation to fully oxygenate, nourish and hydrate the skin. Element graphique Provides antioxidant protection to preserve skin cell integrity.

Pigmentation/ Wrinkles

Oenothera laciniata methanolextract (OLME)

Inhibition of tyrosinase activity and down-regulation of tyrosinase, TRP-1, TRP-2, and MITF-M mRNA expression.


Beauty Sleep

Restorative SleepCalming

Nightly Sleep Multi Circadian Rhythm


Grey hairThin Hair

Vibrant Hair FactorsLashes and Brows

Hair LossHair StrengthScalp Health

HairBrittle nails

DullNail growth

Fungal infectionsParonychia

Pitting

Nails


Category Ingredient Description Trade Name Company Claims MOA

Hair

miliacin (extracted from whole millet seeds, (Panicum miliaceum); and polar lipids (extracted from wheat grain, Keranat® Robertet Group

Improves hair brightness, volume and beauty” Innovative and natural solution to effectively fight against hair loss and to restore its beauty and radiance. 91 % of KERANAT group subjects have observed a decrease of hair loss. 75 % noticed an improvement of hair brightness/ softness. Fight against hair loss. Hair beauty / brightness. Hair density and volume.

KERANAT acts directly on dermal papilla, the biological engine of hair, to stimulate cell division and growth factors excretion that maintain hair ingrowth phase. Patented natural active ingredient, source of vectorizedmiliacin, Keranat ® has been developed for food supplements for the hair. Boost cell proliferation.

Nail health Collagen Verisol Gelita

Faster nail growth with reportedly less chipping of fingernails. Statistically significant improvement in nail growth after 3 months of treatment. Notable improvement in nail peeling and a clearly decreased nail edge irregularity.

Influences skin’s collagen metabolism directly from the inside. . 80 % of the patients were completely satisfied and satisfied with VERISOL® treatment. 75 % of the women perceive their nails as longer, 71 % said their nails grew faster and became longer.

Nail health Collagen tripeptides from fish skinCollagen-Tripep20 Amicogen

Controls loss of skin moisture and improves elasticity and wrinkles. Effect on bone and joing protection against damage and improved recover. Helps hair and nail health.

High content of GPH (Glycine-Proline-Hydroxyproline). Better and faster absorption than other collagen peptides. More pronounced improvement in wrinkles and moisturizing than other collagens

Hair loss prevention Pine bark extract, pine phytosterols Phytopin Purextract

Resisting cell ageing, protecting natural elastins and collagens, depigmentation, and stimulating microcirculation).

Regulate melanogenesis and its depigmenting action. It also helps improve the aspect of the skin by strengthening connective support tissues in this way contributing to the reduction of cellulite.

Hair regrowthLaminaria japonica/ Cistanchetubulosa None Various Supports hair growth and hair growth thickness

Hair regrowthecklonia cava enzymatic extract (35% Dieckol) varies various

Stimulate hair growth by the proliferation of DPC and/or the inhibition of 5α-reductase activity.

Promoted proliferation of Dermal Papillae cells by 113.5% of control. This hair promoting effect was abolished when incubated with tolbutamide(an inhibitor of potassium channels), which establishes that Ecklonia Cava has similar mechanisms to Minoxidil

Structural support Solubilized keratin

Cynatine® HNS Plus

Roxlor/ Gee Lawson

Reduce hair loss from washing, improve hair strength and improve the brightness and luster of hair.. 11.5% reduction in wrinkles and substantial improvement of almost 50% in hair brightness and luster. Reduces fine lines and wrinkles through its zinc and copper complexes bound to proteins. Promotes firmness and elasticity in skin by Improves the brightness and radiance of skin.

Bond with hair in the body and has been shown to binding with the nail and providing improved strength, elasticity and moisture retention. natural antioxidant properties and its ability to promote SOD and glutathione production. Improves the protein structure and improving moisture retention. Reduces redness from inflammation or sensitive skin by blocking PGE2 production

Structural support choline-stabilized OrthoSilicic Acid ch-OSA®

BIO MINERALS NV

Its capacity to generate collagen with your own DNA fingerprint makes ch-OSA the genuine breakthrough in collagen. Thickens and strengthens hair and nails. Regular orthosilicic acid (OSA) has to be stabilized to avoid polymerization, a process that decreases bioavailability. ch-OSA’s patented choline-stabilization technology prevents polymers from forming and ensures OSA’s optimal absorption. Choline-stabilization is the most advanced OSA stabilization technology known today. Reduces Fine Lines and Wrinkles. Thickens and Strengthens Hair & Nails

Sructural influence on keratin fibers on hair follicle. It is embedded in a collagen rich matrix, improved stimulation of collagen synthesis . Flow of nutrients to the hair follicle resulting in more keratin formation. Most of the hair structure arises from epidermal keratinocytes, a specialized population of fibroblasts called the dermal papilla controls hair growth/ volume. Increased collagen synthesis in fibroblasts of the dermal papillaand volume of dermal papilla resulting in bigger cross-sectional area of newly formed hair shaft. Activity of prolyl hydroxylase, the enzyme required for the hydroxylation of proline to form hydroxyproline, is dependent on silicon; collagen synthesis is silicon-dependent.

Hair careProbiotic blend + organic selenium and fermented soy Bifitrichol™ Probiotical Help support healthy thick hair. Fight hair loss. Supports healthy gut response and diverse microflora.

Gray Hair keratin peptides + melanin MelaSoleil™ RoxlorHair growth Polygonum multiflorum varies varies Increase hair growth. Prevent hair loss. Hair growth promotion via expression o fFGF-7Hair growth, gray hair

Lignan derived from sesame seeds (Sesamum indicum) Sesamin Maypro

Help prevent hair loss. Increase hair thickness. Help preserve hair pigmentation.

Potential of sesamin extracted from the sesame seeds for genetically hairloss and canities treatments.


• ch-OSA®: Stabilized form of orthosilicic acid. Modulates keratinocytes. Stimulates collagen synthesis. Patented.

• Sesamin: Helps prevent hair loss. Helps preserve hair pigmentation. (Foti, catalase, PABA)

• Keranat™ : Acts directly on dermal papilla, the biological engine of hair, to stimulate cell division and growth factors excretion that maintain hair in growth phase.

• Cynatine®HNS: Promotes skin elasticity and firmness. Prevents hair loss when washing.

• ActriSAVE ™ : Hormonal balancing effect of cactus flower flavonoids (isorhamnetinand derivatives) can produce a synergistic protective effect in sebocytes and hair dermal papilla cells against the alterations involved in acne and alopecia

Hair & Nails


Eye HealthDry eye

BagsBrightnessWrinkles

Dark Circles


Eye Nutrients for Vision and Dark Circles

CategoryIngredient Description Trade NameCompany Dose Claims MOA

Dry Eye Macquiberry MaquiBright® Maqui New Life/ Oryza 60 mg

Protect the tear-producing glands of the eyes. 45% increase in tear production. Reduce the need for artifical tears.

Delphinidin encourages the body's natural defenses against chemical and light stimulation and UV light.

Computer vision Lutein esters/ zeaxanthin Lutemax 20:20 Omniactives 20 mg

Protects against damaging device bluelight. Protect from digital glare, eye fatigue. Improve visual performance and mental processing speeds. Supports brain function.

Protects against damaging device bluelight. Increases BDNF. Rebuilds filter over the eye. Directly deposits on the surface of the eye.

Dry Eye Lactoferrin various Pharmachem 300 mg

Improved tear quality after eye surgery. Oral lactoferrin shows the ability to ease ocular inflammation and reduces the occurrence of dry eyes after surgery.

Naturally contain a glycoprotein complex. Anti-microbial. Stimulate tears, release mucin and help wound healing.

Probiotic/ topical/ dark circles

(Bacillus coagulansGBI-30. 6086 Bonicel™ Ganeden

Bonicel reduced the appearance of seven signs of aging, reducing the appearance of fine lines, wrinkles, pore size and the appearance of redness while increasing skin moisture and elasticity. May have skin firming and antiwrinkle activity. Naturally derived L+ Lactic acid Bacteriocins, Enzymes

Reduces skin inflammation. Improves skin elasticity, moisturization. Reduces the appearance of fine lines & wrinkles, roughness, pore size, redness. Reduces under eye puffiness. increase the expression of a gene relating to collagen production.

Skin protect/ Anti-cellulite/ Dark circles

Maritime pine bark extract/ OPC (oligomeric proanthocyanidin Cosmythic Purextract

40-100mg/ day

Reduction in the intensity of dark spots. Inhibition of melanin production - depigmentation. Enhanced skin tone and elasticity. Reduction in the number and depth of wrinkles and fine lines.

Regulate melanogenesis and its depigmenting action. Helps improve the aspect of the skin by strengthening connective support tissues in this way contributing to the reduction of cellulite.

Pigmentation/ Skin Protection/ Dark circles

Vitis vinifera extract, Cucumis melo L. extract SKINAX²™ ActivInside 150mg/ day

Element graphique Protects skin fibers to preserve elasticity and suppleness and decrease dark circles. Reduces skin hyperpigmentation.

Regulates melanin synthesis for an optimized and homogeneous skin color Reduces hyperpigmentedspots. Vitis vinifera extract, Cucumis melo L. extract, coated vitamin C, zinc citrate


DigestionProbiotics for skin health

Sexy Fiber/ Fiber+ Protein/ ClearDysbiosis/ Bloating

Detoxification: liver, skin, toxinsProbiotics/ Allergies

Detox/ Purification/ Cleansing


Digestion Ingredients related to beauty/ allergyCategory

Ingredient Description Trade Name CompanyDose Claims MOA

Prebiotic/ Allergy

Actinidia deliciosa, fruit powder ACTAZIN™ Anagenix IP varies

Soluble and insoluble fibre, for bowel regularity. Polyphenolics, which provide micronutrients needed by your immune system. Actinidin, a Kiwi-unique proteolytic enzyme that enhances protein digestion. Help with weight control.

Polyphenolics, Actinidin enzyme, soluble and insolubel fiber, prebiotic activity. 4 way action to support the guts

Detoxification

Artichoke leaf ext. Cynara cardunculus Altilix™ Bionap

100-200 mg/ day

Diuretic and detoxifying activities. improve bile formation and ameliorate digestion, bowel function and hepatoprotective activity

Inhibition of induced oxidative stress. Hepatoprotective and antioxidant activity. Choleretic-cholagogue activity

Detoxification organic tea variousWorlee, various 1 tea bag Gentle liver and skin detox

Organic peppermint, licorice, spearmint, ginger, burdock, dadelion, sage, milk thistle.

Prebioticanimal-free, safe and non-allergic chitosan

Slim MED™ ADVANCED Class Iib medical device Kitozyme 2-3g/day

A change in weight: up to -5.9kgA flat belly effect > change in abdominal circumference: up to -8cm. Treatment and prevention of overweight diseases.A superior solution without lifestyle modification

Binds up to 42% of dietary fats. An immediate action led by a faster solubilisation of chitosan in the stomach. Produces by an improved emulsion that is less likely to leak entrapped fats and increases the oil-holding capacity.

Prebiotic

animal-free, safe and non-allergic chitosan, plus vitamin C

Slim MED™ FORTE Class IIb medical device Kitozyme 2-3g/day

A change in weight: up to -5.9kgA flat belly effect > change in abdominal circumference: up to -8cm. Restores a healthy gut microflora involved in a host of energy balance and intestinal functions

Binds up to 42% of dietary fats. An immediate action led by a faster solubilisation of chitosan in the stomach. Produces by an improved emulsion that is less likely to leak entrapped fats and increases the oil-holding capacity.

Weight Managementxylooligosaccharides or XOS PreticX™ Life Bridge, LLC1.2 grams

Supports healthy balance of gut bacteria in favor of the ratio that is found in slim people SFCA production via bacteriocides fermentation

Prebiotic Xylooligosaccharides XOS95™PrenexusHealth 1.5g

Only organic XOS. Stimulates the growth of Bifidobacteria and Lactobacilli Supports the microbiome health.

Lumen & villi Health Nucleotides Nucleotides 60% Nexira variesPrebiotic effect. Improve intestinal integrity. Support cellular metabolism.

Proliferation and differentiation of intestinal cells. Mucosal growth.

Skincare Lactobacillus strain Floratopic® Probiotical varies Improve the symptoms of atopic dermatitis Support the immune system

GI function LP299V lactobacilli Digestis® Probi varies Reduce bloating and gas. General GI health.Survives gastric acid. Colonizes the whole gut. Promotes healthy bacterial gastric ecosystem.

AllergyL. plantarum P17630 and L. paracasei I1688 Acticoa® EndolaCoa® Proge Farm varies

Support the immune system in fighting against allergic disease.

Cocoa phenols have been shown to change the microbiota composition and promote Lactobacilli growth

Detoxification L-Methionine Bio-L-Methionine cJ Bio/ variousL-methionine contains sulfur, biologically strengthens the structural chain in hair and nails.

Protects against free radicals and DNA damage. Support Glutathione. Lover acetaldehyde and prevent fatty liver


Bifidobacteria speciesPrevention of skin disorders – associated with immune abnormalities & improve sensitive skin

Bacillus subtilis Prevention of atopic lesions

Lactobacillus acidophilus Clinical improvement of acne

Lactobacillus bulgaricus Clinical improvement of acne

Lactobacillus casei Alleviation of skin inflammation

Lactobacillus delbreuckii Inhibition of atopic dermatitis

development. Decrease of skin sensitivity

Lactobacillus paracasei Acceleration of skin barrier function

recovery. Therapy for atopic dermatitis

Lactobacillus rhamnosus Prevention against UV-induced skin

damage. Therapy for atopic dermatitis

Lactobacillus reuteri Protection of epidermal keratinocytes

Lactobacillus salivarius Therapy for atopic dermatitis

Lactobacillus plantarum Skin hydration

Bacillus coagulans Skin hydration, wrinkle improvement, elasticity,

inflammation, redness, puffy eyes.

Probiotics Associated actions


Weight Management

Metabolic ReconditioningSCFA modulation

Metabolism EnhancingReprogramming

Brown Fat ConversionCellulite


Sophisticated Weight Management • Active SIRT1 , (known as “the longevity gene”). Recharges mitochondria — the “power plants” of the cells

• Emotional eating: serotonin increase which improves mood and may improve craving control

• Metabolic reconditioning: turning back time in the gut to restore optimal function and microbiome ratios

• Mediate AMPK: the Master Metabolic Regulator. Switches on the same mechanisms that exercise stimulates, namely fat-burning, energy producing and anti-aging metabolic processes. Regulates metabolic activity (in the liver, lipids, skeletal muscle and brain), AMPk influences glucose utilization, oxidation, and appetite.

• Inhibition of pancreatic lipase activity, an enzyme secreted in the pancreas that breaks down fat prior to absorption in the intestine

• Adiponectin mediation of metabolic processes, including the regulation of glucose and the breakdown of fatty acids for use by the body as energy.

• Acting on serotonin to modulate satiety: appetite modulation. Preliminary clinical data showed a reduction in snacking and compulsive eating behaviors.

• Sleep your way to weight loss? New research on sleep and associations with increased leptin and decreased ghrelin levels.

• Conversion of white fat to brown fat: Uncoupling Protein 1 (Ucp1) Increases Energy Expenditure in Brown Adipose Tissue

• Inhibit Lipogenesis: Inhibit the accumulation of fat into fat cells (lipogenesis) in addition to enhancing the body’s ability to break down fat cells (lipolysis).

• Reduce post-prandial glycemia: prevent or reduce insulin spikes and normalize blood sugar, reduce the effect of CHO consumption

• Calorie restriction mimics: Stimulate metabolism and circulation. activates enzymes, especially sirtuin 1, associated with energy metabolism, stress resistance, cell survival, and longevity.

• Mitochondria rejuvenation: brown fat has more mitochondrial than white fate

• Neuroslimming: enhancement of the neurons ability to support the lipolysis process by the adipocytes


Master Metabolic RegulatorAMPK


Metabolic ReconditioningGut bacteria play a critical role in a weight managment• Recent studies have shown that the amount of calories we extract from the food depends on the type

of bacteria we have in our guts• Studies of populations from all over the world show that lean people have a ratio of microflora in

commonReconditioning our metabolism:

1. Alter Bacteroidetes to Firmicutes ratio2. Get the right probiotics into our system with our meals

Lower ratio is associated with obesity, metabolic syndrome, diabetes and inflammation• Bacteroidetes love fiber - Firmicutes love sugar• Animal models and human studies confirmed that the ratio of the Bacteroidetes and Firmicutes is

altered in response to dietary changes and can be correlated to body fat mass

• The increased proportions of Firmicutes and corresponding reductions in Bacteroidetes taxa were associated with an increased energy harvest and

• increased storage of calories in adipose tissue

Combination of prebiotic and spore forming bacteria can recondition the gut in favor of the organisms found predominantly in lean people.


Animal and Human gut microbes associated with obesity

PNAS August 2, 2005 vol.102no.31; NATURE Vol 444|21/28 December2006

Proportion of Bacteroidetes and Firmicutesin the fecal microbiota of lean vs. obese mice

Relative abundance of Bacteroidetes and Firmicutes and changes during weight loss of 12 obese people


Beauty Trends More about how we feel than appearance. Great health equals optimal beauty.

• Smart Nutricosmetics/ Beauty with Brains

• Integration with lifestyle: diet, fitness, microbiome, brain health, sleep

• Skin Superfoods

• Multitasking products/ GLOW/ Skin Energy

• Personalized Beauty Inside/ Outside

• Surge of good science and high tech beauty

• Condition specific beauty: by age group, nails, skin, hair, brows, cellulite

• Beauty for Everyone: men, millennials, women of all age groups

• Beauty incubation and start up brands/ Crowd led innovation

• Acute, prophylactic and therapeutics

• Beauty from Asia

• Cannabis based beauty

• Organic/ natural/ transparent


Beauty Within• Data is emerging on probiotics for both topical and systemic use.

• Studies have examined both preventive and therapeutic options.

• Conditions include everything from beauty to specific skin conditions

• New science on microbiome and metabolome is validating the systemic use of supplements for skin health.


Beauty for Everyone: men, millennials, women of all age groups• Millennials represent and increasing segment of the beauty market and they are often early

adopters who are more likely to experiment with a variety of products.

• Men specific lines for skincare are continuing to grow and diversify. Personal skincare products are currently more developed than supplement products. As beauty within follows external beauty trends, we can expect skin health, anti-aging and hair products to continue to grow.

• How the consumer perceives the most important benefits of these products is determined by gender, commitment to other good health practices.


How Millennials are Changing Beauty• Adventure Beauty: Younger Millennial buyer is more open to experimenting with beauty products as they test what is and

isn’t their “look.” They experiment with everything from glamour to make-up free. (#nomakeup hashtag)

• Skin fitness over anti-aging. They have embraced the concept of “GLOW.”

• Millennials take an active approach to health, including skin health.

• Youtube is changing the beauty category. There are approximately 15 billion beauty related videos on Youtube and almost 1 billion reviews per month.

• The Organic/ Natural female consumer “believes” in the concept of beauty from within.

• Millennials are attracted to high tech beauty products.

• Conversely, they are also interested in natural and organic beauty options that are sourced in a sustainable and transparent way.

• Millennials don’t want you to teach them or talk at them. They want to explore, discover and participate with the brand, including crowd sourced innovation collaborations with their favorite beauty companies.

• Beauty content formats are increasing in length and sophistication to enhance and guide consumer exploration and discovery.

• Millennials believe that what they put on their skin and hair can impact their general health and the environment. They want clean ingredients and transparent brands.


Beauty Inside/ Outside

• Great opportunities for new product development and dual action products: one for the inside and one for the outside.

• The inside/ out side concept can use the same ingredient for both applications: resveratrol, probiotics, omegas, peptides, etc.

• Mostly, skincare companies are launching supplements, but there is an increase in supplement companies launching topicals.

• Barrier integrity can be mediated via both topical and systemic ingredients

• Microbiome/ Skin axis and the theory of systemic effects of microbiota and their postbiotics.


Probiotics Based Beauty• Data is emerging on probiotics for both topical and systemic use.

• Studies have examined both preventive and therapeutic options.

• Conditions include everything from beauty to specific skin conditions:

• UV protection, wrinkles reduction, psoriasis, atopic dermatitis, acne, hydration

Salem, 2018


• Pain: Lactobacillus acidophilus has shown an analgesic effect in the gut similar to that of morphine

• Ear infections: shortened duration and prevent repeat infections

• Diabetes: decrease serum cholesterol level and improve insulin sensitivity

• Allergies: allergic rhinitis, non-allergic rhinitis, atopic dermatitis (studies in children)

• Cardiovascular disease studies show a connection between the way food is digested by a person's gut bacteria and the development of atherosclerosis

• Obesity: Gram negative (Lactobacillus plantarum) bacterial population in gut also exhibited positive correlation with changes in body composition and total cholesterol level

• Atopic dermatitis and eczema: several studies have shown improvement in refractive skin conditions with probiotics

• Insulin resistance/ diabetes: emerging research on gut health and insulin resistance

• Diversigen (decoding the diversity)

• Microbiota-Gut-Brain Axis (Ecologic): Allergy, eczema, mood, UTI, antibiotic side-effects, IBD. (KGK) Probiotics and NDIs and genomic analysis.

• Skin health and wrinkle prevention, topical and oral

• Oral health including gingivitis, halitosis, throat discomfort and infection

• Carrier or mediator for other nutrients, including increasing bioavailability/ BioPairing/ Biofilms

• Epigenetic changes in the gut and probably in other tissues

• Microbiome shift in older populations that exacerbate or trigger age related diseases

The Life InsideWay beyond Gut & Immunity


Personalized Nutrition Meets Beauty

• Personalization can be by dosage form, packaging, convenience, content, demographics, lifestyle, etc.

• By gender, age, health concern, genetic profile,

• DNA testing for skin and anti-aging

• Microbiome profiling

• Apps for evaluating skin types and skin care regiments

• Individually crafted or curated solutions

• AI based algorithms


Condition Specific diet, fitness, microbiome, brain health, sleep

Conditions linked to Beauty• Sleep

• Anti-ageing

• Pollution

• UV exposure

• Stress

• Detoxification

• GI health/ microbiome

• Diet

• Exercise

• Hair

• Skin

• Nails


Cannabis Based Beauty

• Phytocannabinoid may have therapeutic value for a variety of skin conditions, including acne vulgaris, allergic contact dermatitis, asteatotic dermatitis, atopic dermatitis, hidradenitis suppurativa, Kaposi sarcoma, pruritus, psoriasis, skin cancer, and the cutaneous manifestations of systemic sclerosis.

• Science on phytocannabinoids for dermatological purposes is emerging and is mostly pre-clinical. There is a corresponding lack of high-quality randomized, controlled trials that evaluate their effects.

• CBD can help reduce oil production and thereby have anti-acne and anti-inflammatory attributes (Olah, 2014)

• CBD found in cannabis is a more potent antioxidant than vitamin C or E, making it effective in the treatment of wrinkles and fine lines.


Thinking beyond what is “not in there.”

BETTER FOR YOU• Organic• Raw• Science based ingredients• USP• NSF• Diet friendly

BETTER FOR THE EARTH• Organic• Fair Trade• Non-GMO• Sustainable• No animal testing• Local

FREE OF• Animal By-products• Animal Testing• Gluten• Phthalates• Sulfates• Silicone• Parabens• Mineral Oil• Artificial Sweeteners• Artificial Colors• Artificial Flavors• Preservatives


Integration with lifestyle: diet, fitness, microbiome, brain health, sleep, tech, smoking , pollution, ageing

• Increased circulation carries blood to feed the skin nutrients, hormones and oxygen from the inside, which gives the skin a healthy glow and plump appearance.

• Black box beauty is hyper-futuristic and scientific. It includes: LED light facials, microcurrent and radio frequency tools, fitness and beauty apps and skin analyzers.

• 80% of black tech beauty device consumers are under 35 years old, and 30 percent are under 25

• Millennials are very experimental about the concept of beauty.

Expanding Definition of Beauty

• Anti-aging• Skin texture and tone• Longevity• GLOW• Microbiome profile• Stress/ Sleep/ Anxiety• Environmental factors

Benyacoub, 2014


Self Quantification• https://ubiome.com/

• https://mapmygut.com/

• http://www.smartdna.com.au/smartgut-microbiome-test/

• http://www.lifeextension.com/Vitamins-Supplements/Blood-Tests

• Saliva test for NO levels that show the difference before and after supplementation.

• Early adopters, fitness freaks, technology evangelists, personal-development junkies, hackers and patients suffering from a wide variety of health problems.

• Heart rate, physical activity, breath analyzers, vitamin and mineral levels, food consumption, air quality, blood oxygen levels, sleep, EKG, mood

• Why the natural products category benefits from this trend

• Amway, DNAfit and Segterra (blood biomarkers, 30 wellness, fitness, longevity and physical performance biomarkers that can be influenced by lifestyle, eat broader range of foods 20-50 per week, add supplements and micronutrients, reminders to stick to meal and supplement plan Insidetracker) use Kenkodo metabolism tracker.

http://www.microbiomeplus.com/, http://www.goliveprobiotics.com/golive-products

https://ubiome.com/

http://www.smartdna.com.au/smartgut-microbiome-test/

http://www.smartdna.com.au/smartgut-microbiome-test/

http://www.lifeextension.com/Vitamins-Supplements/Blood-Tests

http://www.microbiomeplus.com/

http://www.goliveprobiotics.com/golive-products/


Amazon HiMirror• $149 USD

• A Skincare Expert on Your Vanity. With HiMirror's advanced skin analysis technology

• Scan and track all your skincare products to see which ones are improving your skin

• Makeup Lights. Look Great. Anytime, Anywhere.

• Magnify your beauty by easily zooming in to get a nice close up. The 2x and 3x zoom ratios are the best pals to get the perfect eye line, shape your eyebrows and touch up every detail.

• Amazon Alexa Explore More Possibilities with Amazon Alexa


What’s NextEmerging Science

• Data is emerging on internal dosage forms• Data is emerging on internal dosage forms for exfoliation• Beauty from within skin care through topical application• Cellular mediation: mitochondria, endoplasmic reticulum, epigenetics, DNA, senescent cell mediation,

autophagy, telomeres.• MARS (maintenance and repair systems)• Experiential verses prophylactic anti-aging.• Nootropics are splitting into two pathways. 0 to+1 is better than -1 to 0.• Skin/ Gut/ Metabolic syndrome axis is developing.• More self measurement and tracking options


Beauty Within MapSkin Health• Repair/ Rebuild• Rejuvenation/ Regenerate• Prevention/ Protect• Pigmentation/ hormonal/

exfoliating/ strength/ • Skin Detoxification• Moisture/ Hydration• Erythema• Radiant• Dark circles• Spots, freckles,• Keratin• Fibroblast stimulation• Atopic dermatitis• Allergy• Tone/ Texture• Environmental/ Winter

Wrinkle MOA treatments• Melanin overproduction• Collagen/ elastin

degradation• Microcirculation• Photoaging• Ceremides• Crepey

Aging Mechanisms• Sun/ UV• Stress• Pollution• Poor diet• Menopause• Tobacco• Sarcopenia• Metalloproteinases• Exceptional Skin Agers

Metabolic Reconditioning• Prebiotic/ Probiotic (HU 58)• Metabolism enhancing• Reprogramming• Livaux• SCFA modulation

Weight Management• White fat to brown fat conversion• Short chain fatty acid metabolism• Cellulite

Beauty Sleep• Restorative Sleep• Calming• Nightly Multi vs Daily Multi

Hair• Grey hair• More hair• Vibrant hair factors• Lashes and brows• Hair Loss• Hair Strength• Scalp Health

Nails• Brittle nails• Dull• Nail growth• Fungal infections• Paronychia• Pitting

Digestion• Sexy Fiber• Ammonia oxidizing bacteria

(AOB)• Dysbiosis• Bloating• Probiotics/ allgergies• Detox/ Purification/

Cleansing

Eye Health• Dry eye• Bags• Brightness• Wrinkles

Active Lifestyle• Sarcopenia• Fatigue

Circulation• Vein health• Microcirculation


Jennifer CooperChief Science Officer

Jennifer Cooper has spent over 25 years in consumer healthcare, including supplement, food and over-the-counter drug companies. Jennifer has held senior technical roles in the US and Europe, including Chief Scientific Officer at Savant Science; Vice President of R&D and Quality at TCC Holding Corporation; Vice President of R&D and Quality at Dynova Labs; General Manager of Nutrition Business at Icon Health and Fitness; and, Director of Product and Business Development and Quality at US Zdrowie whose primary business interests are in Eastern Europe. Jennifer owns a healthcare consulting and market testing company, Lead Point Solutions, that has developed novel products for companies in more than a dozen countries. Jennifer has consulted on products and business development projects in North America, Europe, Mexico and Asia and has lectured all over the world at supplement and drug conferences. Jennifer’s consulting work includes several Fortune 500 and multinational healthcare corporations. Jennifer has developed over 300 new products in the areas of OTC, dermo-cosmetics, medical devices, medical foods and dietary supplements.

[email protected]

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beauty category map · 2020. 8. 19. · •exercise •diet •sleep •stress •microbiome...

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