basketcentrifuge-chao turney zoratto
TRANSCRIPT
Basket CentrifugeApplications in Insulin Production
Catherine ChaoDanielle TurneyDana Zoratto
Background
Purpose: to remove the WFI and insulin from the insulin crystal
Basket Centrifuge Criteria
Separation Liquid-SolidSolids Content 5 - 60%Particle Size 5 - 10,000 µmG-Force 300 – 1500Rotational Speed 2000 rpm maxDiameter 1500 mm maxDepth 1000 mm
Basket Centrifuge Operation
Feed Slurry
Spin Dry Wash
Discharge
Spin Dry
General Operation:
Process Options:Operation:• Batch• Semi-Continuous
Modes of Discharge:• Centrifuge stopped• Centrifuge decelerated to slow
speed• Discharge at full speed
Basket Centrifuge Types
Perforated Basket Centrifuge• Filtration• High solid concentration • Dewatering necessary
Imperforate Basket Centrifuge• Sedimentation• High solid concentration• Dewatering not necessary
Centrifuge Type Selection
• Vertical Perforate Basket Centrifuge
Solid Inlet Content 35.2% (by mass)
Inlet Flow 1.44 L/hInsulin Crystal Size
125x125x80 µm (minimum)180x180x160 µm (maximum)
Process Specifications:
Type Selection:
Justification of Selection
Schematic Diagram of a Basket Centrifuge
Performance Specifications of Various Centrifuges
Vertical Basket Centrifuge
Filter Area 2 – 5 m2
Filter Specification 37 - 3000 µm Diameter-to-height Ratio 1:1 – 3:1Acceleration 900 – 1800 rpmCost (USD) 7702.8 +
143,279*[Diameter (m)]
Centrifuge Specifications:
• carbon or stainless steel• Monel• Inconel• Titanium• rubber and plastic coatings (various)
Materials of Construction:
Vertical Basket Centrifuge
Slow-load Slurry Through Pipe Acceleratio
nDeceleration
Discharge Through Bottom
Cake Removal
Operation Flow Diagram:
• Batch Operation• Cake removal: single or multiple ploughs between cycles• High solids recovery in retentate• High wash efficiency• Loading and discharge at reduced speeds
System Specifications:
Model Selection
Basket Centrifuge
Perforated
Imperforate
Vertical(discharge at low speed)
Horizontal(discharge at high speed)
Batch(discharge while stopped)
Krauss-Maffei PT Vertical Centrifuge VZU
Broadbent IPD Deep Basket Centrifuge
Krauss-Maffei PT
Size: 1000 x 630 mmCapacity: 250 LFeed Requirement: >3% solids (mass)Materials: Stainless steel
Nickel-based alloys, Titanium Rubber-lined steel Special materials
Filtering Surface: 2.0 m2
Max Speed: 1250 rpm
Weight: 3800 kg
Price: request pending - $150, 980 (Equation)
Vertical Centrifuge VZU
Broadbent IPD
Size: 260 x 160 mm
Capacity: 5.6 L
Materials: stainless steels Hastelloy Fluorocarbon
coatings
Filtering Surface: 0.13 m2
Max Speed: 3000 rpm
Centrifugal Factor: 1300 g
Deep Basket Centrifuge
Motor Power: 0.75 kW
Weight: 130 kg
Price: Request pending - $44,955 (Equation)
Recommendations
• Broadbent IPD Ideal performance for process Commonly used in related industry Smaller, more appropriate size than KMPT model
Centrifuge Recommendation:
Operation and Maintenance: • 2 installed in parallel (final purification step)
• Frequent overhaul and maintenance• Residence time dependant on inlet flowrates and
composition With given data, residence time = 3.9 hours
• Average cycle time: request pending Number of multiple cycles will depend on cycle times
Thank you.
Questions?