basic concepts of immunology scott barnum, ph.d
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Basic Concepts of Immunology Scott Barnum, Ph.D. Immunology is Important to You as a Future Clinician Because:. 1.Failure of the immune system to cope with infection/trauma is the reason for many patient visits. 2.Immunological status of your patients dictates treatment decisions. - PowerPoint PPT PresentationTRANSCRIPT
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Basic Concepts ofImmunology
Scott Barnum, Ph.D.
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Immunology is Important to Youas a Future Clinician Because:
1. Failure of the immune system to cope with infection/trauma is the reason for many patient visits
2. Immunological status of your patients dictates treatment decisions
3. Need to protect yourself and your staff from infection
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Immune System Components
Cells and Organs: thymus, spleen, lymph nodes, stem cells and precursors, T and B cells, macrophages (MØ), neutrophils (PMN), dendritic cells (DC), mast cells and others
Humoral/Soluble: antibody, cytokines, complement, acute phase proteins, enzymes, antimicrobials, etc.
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Innate Versus Adaptive Immunity
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Innate Immune Mechanisms of Protecting the Host
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Innate Immune Mechanisms of Protecting the Host
Phagocytosis
Inflammation
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How Does the Innate Immune SystemRecognize Infection?
• Via Pathogen Associated Molecular Patterns (PAMPs)
• Specific receptors recognize microbial components (LPS, lipoproteins, peptidoglycan, ssRNA etc)
• These receptors are termed Pattern Recognition Receptors (PRRs)
• Examples of PRRs include: Collectins, CRP and Toll-like receptors
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Toll-like Receptors (TLRs)
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Adaptive Immunity
Active Immunity -
Passive Immunity -
Humoral Immunity -
Cell-mediated Immunity -
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Adaptive Immunity- mediated by lymphocytes
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Adaptive ImmunityCardinal Features
Specificity -
Diversity -
Memory -
Self-Limiting Response -
Recognition of Self vs. Non-self -