PackAge 2011 CONFERENCE

A PRESENTATION ON

Barrier Packaging of Pharmaceuticalsg g

FocusFocus

BLISTER PACKAGINGBLISTER PACKAGING

Benefits of a Blister Packs

• Convenient , easy to use and safe• Increases compliance and adherence• Easy to dispense• Product protection• Cost effective• Child resistant / Senior friendly• Improved Pharmacy efficiency• Alleviates space and inventory concerns

Other Benefits

Marketing Differentiation• Compact clear blisters ensures product visibility• Compact clear blisters ensures product visibility• Additional Branding on packs• Pack Innovation e.g Burgo pack.Shell Pack,Calender packPack Innovation e.g Burgo pack.Shell Pack,Calender pack

Calender pack

Shell pack

Burgo pack Calender pack

World Pharmaceutical Packaging Demand

World PharmaBlister Packaging demand

1997 2002 2007 2012

2501 3545 4890 6590demand

Blister Packaging Film Types

• Thermoforming Films• PVC• PVC• PVC/PVdC• PVC / Aclar• APET , PET–G• PP/COC/PP • BarexBarex

• Cold Forming Films• OPA/ALU/PVC• OPA / ALU/HSL ( tropical Blister)

Blister Packaging Classification-Barrier

Low Barrier • PVCPVC• APET , PET –G• PP

• Medium Barrier• PVC/PVdCPVC/PVdC• COC

• High & Ultra High Barrier• PVC / Aclar • Cold Forming Foils• Cold Forming Foils

Blister Packaging Classification-Type

Halogen Free Films • PP• PP• Barex ( PAN) • PP/COC/PP• APET , PET –G, GAG PET

New Generation FilmsNew Generation Films• Ultra High Barrier PVdC (Ultrsafe)• Galaxy – (New Innovation by ACG)• Alukbliss – ( Innovation by ACG)

PVC – Mono Layer Films

PVC – Poly Vinyl ChlorideLow Barrier Films suitable for stable moleculesLow Barrier Films suitable for stable molecules

Cost effective blister packaging option

Amorphous in natureAmorphous in nature

WVTR 3.5 g/m²/day

Calendered films available in range of coloursg

Long shelf life.

PVdC Coated PVC

PVC/PVdC

M d t O B i•Moderate Oxygen Barrier.•Range of barrier is available from 0.70-0.35 g/m²/day depend on gsm g y p gof coating.

PVC/PVdC/PVCPVC/PVdC/PVC

•Cross migration is low.N ti ki•No conveyer sticking.

•No abrasion to PVdC coating.

PVC /PE /PVdC – Tripac Films

PVC / PE / PVdC - Tripac

M d t M i t B iModerate Moisture Barrier

The PE layer improves Blister formation

Higher post forming barrier due to uniform thickness on cavity

UltraSafe - Ultra High Barrier

New Generation PVdC Barrier Films

Ultra High Barrier propertiesAvailable in 120 gsmSuitable for Rotary and Flat Bed Blister MachinesSuitable for Rotary and Flat Bed Blister Machines

Aclar - The Ultimate Barrier

Excellent barrier properties againsttwater vapor

Ideal for hygroscopic products

Improves strength and formation ofblister

Various PVC thickness and Aclargrades give flexibility and desiredWVTR characteristic

PVC / Aclar - Laminates

Crystal clear packing

Chemically and bio-chemically inert

Extended Shelf Life

Design and Marketing Flexibility

Transparent to UV radiationTransparent to UV radiation

Non ageing

For High and Ultra-High moisture Barrier

Aclar – RangeAclar Variant Thickness in WVTR

Micron g/m²/day(PVC/Aclar)

Rx 160 15 µm 0 41Rx 160 15 µm 0.41

Rx 20 e20 µm 0.29

Rx 20 e

SupRx 900 23 µm 0.23

UltRx 2000 51 µm 0.15UltRx 3000 76 µm 0.07UltRx 4000 102 µm 0.05UltRx 6000 152 µm Under development

Aclar – Variants

Pet – G / Aclar • PVC Free film

Good Clarity• Good Clarity

Aclar / EVOH / Aclar• Oxygen and Moisture barrier

PVC / Aclar / PVC• lower cross migration• Lay flat blisters• Lower abrasion to Aclar.Lower abrasion to Aclar.

COLD FORM BASE FOILSCOLD FORM BASE FOILS

• StructureOPA 25µ/Alu45µ/PVC60µ• Ultra high barrier properties• Ultra high barrier properties• Suitable for all climatic zones• Excellent delamination resistance• DMF approved material

Tropical BlisterTropical Blister• Cold-formable• It can withstand to low and high

temperatureste pe atu es• Typical lacquer sealing to: PVC, PVdC,PP• High barrier to light moisture oxygen and• High barrier to light, moisture, oxygen and

other gases

Non Halogenated filmsNon Halogenated films

(NON PVC OPTIONS)(NON PVC OPTIONS)

Barex – Gas Barrier FilmsComposite of Barex & PolypropyleneComposite of Barex  & Polypropylene

Excellent Gas Barrier from Oxygen, Nitrogen, & Carbon Di idDioxide

Retains Aroma

High Impact Strength

High resistance to solvents & aggressive ‘hard to hold’ liquids

Thermoformable on con entional blister packing machinesThermoformable on conventional blister packing machines

OTR is 105 cc/m2/day @ 25 Deg.C. & 100% RH

Barex

Features 

High impact strengthHigh impact strengthRetains  aromaHigh resistant to solvents & aggressive “hard to hold” liquids.E ll t b i f O Nit d C bExcellent gas barrier from Oxygen, Nitrogen and Carbondioxide.     

Properties  (Barex 250μ)

Density: 1 15g/cm³Density: 1.15g/cmMVTR(38⁰C,90%RH):3.5g/m²/dayOTR(23 ⁰C.100%RH):1.55cc/m²/day

PP/COC/PP

• High clarity• Density is 1 00 gm/cm3 hence higher yield• Density is 1.00 gm/cm3 hence higher yield• Thermoforming range is 120 to 160 Deg.C.

WVTR i 0 2 t 0 4 / 2/d @38 D C &• WVTR is 0.2 to 0.4 gm/m2/day @38 Deg.C. & 90 % RH

Polypropylene

• Thermoformable• FDA Compliant• FDA Compliant• Low density (0.9 gm/cm3) hence high yield

WVTR 1 15 / 2/d @ 38 D C & 90 %• WVTR 1.15 gm/m2/day @ 38 Deg.C. & 90 % RHOTR is 320 cc/m2/day @23 Deg C & 100 %• OTR is 320 cc/m2/day @23 Deg.C. & 100 % RH

PETG films

• Excellent thermoformability• High gloss & superb clarity,• Sterlisable (Ethylene Oxide / Gamma radiation)• Excellent printability• MVTR is 14 to 16 gm/m2/day• PETG/ Aclar laminate provides excellent barrier• Made under license at Eastman Chemicals

APET based Films

• Eco-friendly material• Thermoforming range 121oC to 154oC• MVTR – 5.0 g /m2/ day at 38oC, 90% RHg y ,• OTR – 10.0 cc/m2/ day at 23oC, 0% RH• Well suited for Filling & Sealing machines• Well suited for Filling & Sealing machines.• Excellent printability• High clarity

Beyond Blister PackingBeyond Blister Packing

Unit Dose & Suppository PackingUnit Dose & Suppository Packing

PVC / PE – SUPPOS

• PVC/PE – SUPPOS are PVC / PE Laminates that are unique Peelable/Sealable composites

U i l l bl d l bl f Fill l li• Uniquely sealable and peelable on any form Fill seal line

• Complete range of 100/30 to 300/ 50 PVC / PE available

• Proprietary PE allows effective sealing and easy peel

• For moisture sensitive suppository PVdC coated SUPPOS film alsoFor moisture sensitive suppository PVdC coated SUPPOS film also available ( Typically 40 gsm)

• Available in Printed

• Random Printed• Register printed• Distortion Printed

Your trusted partner for Barrier Packaging SolutionsYour trusted partner for Barrier Packaging Solutions

Overview ACG Pharmapack

A leading innovation-driven and world-class manufacturer of all pharmaceutical barrier films

One-stop shop for all Pharma Barrier Packaging films.

DMF Registered with the US FDA.g

Registered with SFDA (China) & Canada Health Dept.

Exporter to more than 65 countries

Integrated Facility ensuring traceability

• ISO 9002 / 14001 / 22000 certified

Thank YouThank You