banting & best diabetes centre · 6 banting & best diabetes centre 2014-2015 annual report...

Banting & Best DiaBetes Centre

annUaL rePOrt July 2014 - June 2015

CONTENTS 3. ViSiON aNd MiSSiON

4. COMMiTTEES

6. dirECTOr’S rEpOrT

7. rESEarCh prOgraMS aNd ENabliNg plaTfOrMSDiscovery Research Programs

Applied Research Programs

Enabling Platforms

15. MEMbErShip

16. fiNaNCES 17. fuNdiNg prOgraMS aNd fuNdiNg dECiSiONS

Funding Programs For TraineesAnnual Trainee Awards Charles Hollenberg Summer Studentship Program Graduate Studentships Post-doctoral Fellowships

Trainee Travel Awards

Funding Programs For FaculTy and HealTH ProFessionalsArchie Sopman Diabetes Research and Education Awards 2014

AstraZeneca Impact Challenge Grant: Cardiovascular/Diabetes

BBDC-Novo Nordisk Chair in Incretin Biology

Diabetes Educator of the Year Award 2014

Reuben & Helene Dennis Scholar in Diabetes Research

Sun Life Financial Equipment Grants for Diabetes Research

Sun Life Financial Impact Challenge Grant – Diabetes in Developing Countries

Sun Life Financial Impact Challenge Grant – Education and Knowledge Translation: Emphasis on the Community Pharmacist

Sun Life Financial New Investigator Award

Sun Life Financial Pilot and Feasibility Grants

29. EduCaTiONal aCTiViTiES1st BBDC-Joslin Diabetes Center Conference: Nutrients, the Digestive Tract and Diabete

Annual Scientific Day

Charles Hollenberg Summer Studentship Program: Weekly Seminar Series and Mini-conference 2015

Diabetes Update 2015

BBDC Seminar Series (in conjunction with City-wide Endocrine Rounds)

39. COrE labOraTOry

40. COMMuNiCaTiONS aNd publiCaTiON

42. Our SuppOrTErS 43. aCkNOwlEdgEMENTS

Our ViSiONAs Canada’s leading centre of excellence for innovation in diabetes research, education, and clinical care, we will tangibly impact diabetes prevention and outcomes in Canada and globally.

Our MiSSiONWe bring together researchers across multiple University of Toronto affiliated disciplines to: Develop novel treatment paths

to cure diabetes or prevent its complications

Identify innovative ways to manage diabetes and improve the lives of those living with the disease

The BBDC was established in 1978 as an Extra-Departmental Unit of the Faculty of Medicine, University of Toronto with the primary objective of advancing diabetes research, education, and care.

We currently offer several studentships, fellowships, grants and other support for qualified individuals involved in diabetes research, education and care at the University of Toronto and its affiliated institutions. In addition, we host several educational events for researchers and diabetes healthcare providers.

ViSiON +

MissiOn

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Banting & Best Diabetes CentreUNIVERSITY OF TORONTO

2014-2015 ANNUAL REPORT 3

EXECuTiVE COMMiTTEEdirecTor and cHair: Dr. Gary Lewis, Department of Medicine, Division

of Endocrinology & Metabolism, and Department of Physiology*Dr. Khosrow Adeli, Departments of Biochemistry*, and Laboratory Medicine

& Pathobiology*Dr. Alison Buchan, Vice Dean, Research and International Relations, Faculty

of Medicine*Dr. George Fantus, Department of Medicine, Division of Endocrinology

& Metabolism, and Department of Physiology*; BBDC Core Laboratory Director

Dr. Richard Gilbert, Department of Medicine, Division of Endocrinology & Metabolism*

Dr. Tony Lam, Departments of Medicine and Physiology*Dr. Lorraine Lipscombe, Department of Medicine*, and Department of

Health Policy, Management and Evaluation*Dr. Julia Lowe, Department of Medicine, Division of Endocrinology

& Metabolism*Dr. Bruce Perkins, Department of Medicine, Division of Endocrinology

& Metabolism*Dr. Rene Wong, Department of Medicine, Division of Endocrinology

& Metabolism*Dr. Minna Woo, Department of Medicine, Division of Endocrinology

& Metabolism*

The governance structure of the BBDC consists of a Director and Executive Committee who ensure that the goals of the Centre are appropriately implemented. The Executive Committee provides leadership and representation for the University of Toronto diabetes research and care community.

diSCOVEry rESEarCh STEEriNg COMMiTTEEcHair: Dr. Gary Lewis, Department of Medicine, Division of Endocrinology

& Metabolism, and Department of Physiology*Dr. Khosrow Adeli, Leader, Nutrients, the Digestive Tract and Diabetes ProgramDr. George Fantus, Leader, Prevention and Therapy of Diabetic

Complications ProgramDr. Michael Farkouh, Leader, Diabetes and Heart Disease ProgramDr. Denice Feig, Leader, Diabetes in Pregnancy Study GroupDr. Tony Lam, Associate Director of Research, BBDCDr. Michael Wheeler, Leader, Islet/Stem Cell Biology Program

This committee is primarily made up of the leadership of the Discovery Research Programs. Their purpose is to coordinate activities in these programs and promote collaboration between the Discovery Research and Applied Research Programs.

appliEd rESEarCh STEEriNg COMMiTTEEcHair: Dr. Gary Lewis, Department of Medicine, Division of

Endocrinology & Metabolism, and Department of Physiology*Dr. Lorraine Lipscombe, Leader, Vulnerable Populations/Population Health ProgramDr. Julia Lowe, Leader, International Diabetes Outreach ProgramDr. Lori MacCallum, Program Director, Knowledge Translation and

Optimizing Care Models; Leslie Dan Faculty of Pharmacy*Dr. Rene Wong, Leader, Continuing Health Education and Professional

Development Program and Committee

This committee is made up of the leadership of the Applied Research Programs. Their purpose is to coordinate activities in these programs and promote collaboration between the Applied Research and Discovery Research Programs.

TraiNiNg aNd rESEarCh EXCEllENCE COMMiTTEEcHair: Dr. Tony Lam, Associate Director of Research, BBDC; Departments

of Medicine and Physiology*Dr. Andrew Advani, Department of Medicine, Division of Endocrinology

& Metabolism*Dr. Richard Bazinet, Department of Nutritional Sciences*Dr. David Cherney, Department of Medicine, Division of Nephrology*Dr. Carolyn Cummins, Faculty of Pharmacy*Dr. Herbert Gaisano, Departments of Medicine* and Physiology*Dr. Margaret Hahn, Department of Psychiatry*Dr. Cristina Nostro, Department of Physiology*Dr. Jonathan Rocheleau, Institute of Biomaterials and Biomedical Engineering*Dr. Daniel Winer, Department of Laboratory Medicine and Pathobiology*

This committee implements the scientific review of BBDC funding programs, develops the Annual Scientific Day program, and selects speakers for the BBDC Seminar Series.

CONTiNuiNg hEalTh EduCaTiON aNd prOfESSiONal dEVElOpMENT COMMiTTEEcHair: Dr. Rene Wong, Department of Medicine, Division of Endocrinology

& Metabolism*Mrs. Leigh Caplan, Diabetes Educator, Sunnybrook Health Sciences CentreDr. Jeremy Gilbert, Department of Medicine, Division of Endocrinology

& Metabolism*Mr. Henry Halapy, Diabetes Pharmacist, St. Michael’s HospitalDr. Lori MacCallum, Program Director, Knowledge Translation and

Optimizing Care Model; Leslie Dan Faculty of Pharmacy*Ms. Jasmine Montreuil, Registered Dietitian, North York Family Health TeamDr. Phillip Segal, Department of Medicine, Division of Endocrinology

& Metabolism*

This committee organizes continuing health education in diabetes for the health care team and reviews applications for various BBDC funding programs.

* University of Toronto

paST aNd prESENT dirECTOrSdr. gary f. lEwiS (2011 – present)

dr. daNiEl J. druCkEr (2000-2011)

dr. bErNard ZiNMaN (1993-2000)

dr. CharlES h. hOllENbErg (1981-1993)

dr. Edward a. SEllErS (1978-1981) A personal friend of the co-discoverer of insulin, Dr. Charles Best

COMMiTTEES (July 2014 TO JuNE 2015) “ We are

graTEful TO Our COMMiTTEE MEMbErS WhO vOLUnteer their tiMe tO aDvanCe the MissiOn Of the BBDC.”

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Banting & Best DiaBetes Centre 2014-2015 annUaL rePOrt 4 5

The BBDC brings together over 100 researchers from multiple health and biomedical disciplines from across the University of Toronto and its affiliated institutions to develop novel treatment paths to prevent and manage diabetes and prevent its complications through excellence and innovation in research, education and clinical care.

The BBDC Strategic Plan (2012-2016) represented an ambitious leap forward in developing new platforms for translating discovery into prac-tice by networking across Toronto institutions and beyond. All projects are focused on measurable impact for patients, care-providers, vulnerable communities, policy-makers and health system leaders. Now in the fourth year since implementation of the strate-gic plan, we are pleased to provide a progress report of BBDC activities. 2014/2015 was a very productive year for the Centre. Below are some of the major highlights:

The BBDC in collaboration with the Joslin Diabetes Center held its first annual conference in Toronto on Nutrients, the Digestive Tract and Diabetes. The event brought together researchers of the BBDC, the Joslin Diabetes Center, and other interna-tional research organizations to address the latest developments in this impor-tant field in diabetes research.

The BBDC held another very success-ful Diabetes Update in March 2015 at the Metro Toronto Convention Centre, with over 500 health professionals from across Ontario in attendance.

The Knowledge Translation and Op-timizing Care Models Program published

its Guidebook for Pharmacists on Diabetes Management across the country in both English and French language versions. The Guidebook provides pharmacists with a comprehensive and easy-to-use resource for supporting optimal patient education and decisions regarding diabe-tes, further fostering an interdisciplinary health team approach to diabetes care. The program also launched a Diabetes Pharmacists Network website as a way to bring together pharmacists from across Canada interested in the care of patients with diabetes.

The BBDC entered into a first-of-its kind partnership with the Kangbuk Samsung Medical Centre in Seoul, South Korea to help them become Asia’s top centre for diabetes treat-ment, research and education. Fel-lows from South Korea will travel to Toronto to receive hands-on training under the guidance of BBDC’s world-renowned researchers and will then take this knowledge back to Kangbuk Samsung Hospital to help establish an advanced diabetes program there.

We are grateful that the BBDC has been and will be the beneficiary of a significant amount of funding:A $1M contribution was received from AstraZeneca. A portion of the investment –$750,000 – established the AstraZeneca Impact Challenge Grants, providing grants for research into the relationship between heart disease and diabetes at the BBDC and the Heart and Stroke/Richard Lewar Centre of Excellence in Cardiovascular Re-search. A further $250,000 will support the Knowledge Translation and Opti-mizing Care Models Program which provides pharmacists with education and tools to more effectively support their diabetes patients.

The Toronto General and Western Hospital Foundation received a $1M donation from an anonymous donor which will fund the BBDC’s $1M Transformational Diabetes Team Re-search Grant program.

Sun Life Financial committed $500,000 to expand the Pilot and Feasibility Grants, Equipment Grants, and the New Investi-gator Award programs, as well as to sup-port two new Impact Challenge Grants.

Janssen Canada generously provided $50,000 in support of the BBDC’s post-doctoral fellowships program.

gary f. lEwiS, Md, frCpCDirector, Banting & Best Diabetes CentreProfessor, Departments of Medicine and PhysiologyDirector, Division of Endocrinology and MetabolismSun Life Financial Chair in DiabetesDrucker Family Chair in Diabetes Research

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Banting & Best DiaBetes Centre6 2014-2015 ANNUAL REPORT 7

http://www.bbdc.org/about-us/5-year-vision-plan

iSlET/STEM CEll biOlOgyThe Islet Centre provides a platform for researchers from a range of disciplines to study the role of the pancreatic islet cell as a key cause and target for treatment of type-1 and type-2 diabetes mellitus. The Islet Program builds upon existing infra-structure and CFI funding success of the University Health Network (UHN) and dynamic collaborations amongst UHN scientists, including the McEwen Centre for Regenerative Medicine, to accelerate research into the prevention and treatment of this disease. The program plays a prominent role in the ability of UHN researchers to uncover molecular and physiological determinants of type 1 and type 2 diabetes and accelerate the establishment of an unlimited source of insulin-producing pan-creatic cells from stem cells that can rapidly be moved to the clinic to treat diabetes. This research program will create a centralized, multi-modal diabetes research facil-ity at the University Health Network (UHN).

recenT Program acTiviTies In 2015, the UHN received over $3 million of funding to establish a dedicated Human Islet Cell Isolation Facility, which is located on the 4th floor of the Max Bell Research Centre adjacent to the new McEwen Centre Human Develop-ment and Disease Facility and Program. The facility will provide researchers with a local source of healthy human islet cells. Through a partnership with the McEwen Centre’s Human Development and Disease Facility, it will also provide access to specialized assays and reagents to assess islet and stem-cell-derived islet cell function. The facility is now fully operational and has entered a training and development phase of operation until approximately March 2016. It is antici-pated that the routine production of high quality research islets will commence by September 2016.

the BBDC’s five Discovery research Programs fill critical gaps in finding novel therapies to cure or treat diabetes. in bringing together world class researchers from multiple disciplines, they are focused on taking on highly innovative, high risk research questions. they include research programs that support our strategic priorities of curing diabetes and eliminating diabetic complications. More information on these programs can be viewed on the BBDC’s website www.bbdc.org.

NuTriENTS, ThE digESTiVE TraCT aNd diabETESThe research program brings together investigators from a wide-variety of disciplines, including endocrinology, gastroenterology, metabolism, neurobiology, nutrition and physiology. Through the application of cell, molecular and whole organism approaches in animal models as well as in humans, researchers examine the mechanisms underlying obesity and type 2 diabetes, as well as possible nutritional and therapeutic approaches to treat these diseases. One intestinal hormone of particular interest to members of the research group is the nutrient-stimulated incretin, glucagon-like peptide-1, which has already been successfully introduced into the clinic for the treatment of type 2 diabetes and which is under investigation for use as an anti-obesity agent. Through integration of their research expertise, and in collaboration with the CFI “3D Centre for studies on Diet, the Digestive Tract and Disease”, members of the platform will further accelerate the progression of basic science discoveries to the application of these findings in patients with obesity and diabetes.

recenT Program acTiviTies In October 2014 the BBDC co-hosted the first annual collaborative conference with the Joslin Diabetes Center. The one and a half day event which was held in Toronto focused on nutrients, the digestive tract and diabetes and brought together the two leading diabetes research centres in Canada and the United States to promote the exchange of innovative research ideas and collaboration. The complete program can be found in the Educational Activities section of this annual report.

diabETES aNd hEarT diSEaSEThe program connects multiple scientists and institutions from diverse disciplines/technology platforms to address the most challenging research questions in the prevention and treatment of cardiovascular complications of diabetes. This program’s main goal is to promote a Toronto-based, cross-site, clinical research collaboration on a central core platform. The initial focus will be on clinical trials in the following high impact research areas: diastolic heart failure, coronary artery disease, peripheral arterial disease, and inflammatory biomarkers/novel compounds.

recenT Program acTiviTies In 2013, the BBDC and the Heart & Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research in conjunction with the Vice-Dean of Research and International Relations, Faculty of Medicine established a funding program to support research initiatives focusing on diabetes and heart disease. The purpose of this funding program is to foster bench to bedside translational research with a focus on innovation and first-in man clinical trials. Earlier this year, the funding program received a generous $750,000 contribution from AstraZeneca Canada which will provide three $250,000 research grants to address the prevalence of cardiovascular disease in patients with diabetes. This funding matches the previous $750,000 contributed by the BBDC, Heart & Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research, and Faculty of Medicine, Research and International Relations that established this program in 2013. For more information on this funding program, see the AstraZeneca Impact Challenge Grants in the Funding Programs section of this annual report.

prOgraM lEadEr Dr. MiChaeL WheeLer

prOgraM lEadEr Dr. KhOsrOW aDeLi

prOgraM lEadEr Dr. MiChaeL farKOUh

diSCOVEry rESEarCh PrOgraMs


http://www.bbdc.org

prEVENTiON aNd ThErapy Of diabETiC COMpliCaTiONSThis program promotes the collaborative research of investigators involved in the field of diabetes complications at the University of Toronto and its fully affiliated academic teaching hospitals and research institutes. Through regular meetings and presentations by participating laboratories, group interactions are fostered and col-laborative research granting opportunities are facilitated. The program spans cell biology animal models and human trials featuring a comprehensive and interdis-ciplinary research program. A major focus of the program is diabetic nephropathy (kidney disease) in which the University of Toronto has an internationally recog-nized group of scientists.

recenT Program acTiviTies A BBDC-led application for a CIHR-funded SPOR (Strategy for Patient Oriented Research) National Network in Diabetes and its Related Complications was suc-cessful at the Letter of Intent stage. A full application for the competitive, $25mil-lion, five year grant will be submitted in October 2015 with results expected in January 2016.

diabETES iN prEgNaNCy STudy grOupThis program brings together researchers and clinicians from across the city’s aca-demic centres in order to foster collaboration in research in the area of Diabetes in Pregnancy. The group includes epidemiologists, trialists, health services researchers, translational and basic scientists from the endocrinology and obstetrics fields. The group meets every two months to present completed or ongoing research and to discuss controversial care issues in the area of Diabetes in Pregnancy. In order to take advantage of the large population of women seen by Mount Sinai Hospital, St. Michael’s Hospital and Sunnybrook Health Sciences Centre, the group is working to develop a common database so that future research can utilize the city’s large patient population for collaborative research between sites.

recenT Program acTiviTiesEarlier this year, the BBDC provided close to $250,000 to support a Diabetes in Pregnancy (DIP) sub-study led by Drs. Denice Feig (Mount Sinai Hospital), Lor-raine Lipscombe (Women’s College Hospital) and Howard Berger (St. Michael’s Hospital). The sub-study is a collaboration with the Ontario Family Health Study (OFHS), which aims to create a platform for recruiting and following pregnant parents and their children from near conception through 5 years of age and beyond imbedded within Ontario’s routine healthcare system. The sub-study’s goal is to create a sub-cohort of women with diabetes in pregnancy (DIP) within the OFHS. To do this, the team will create a DIP module within the OFHS that will contain DIP-specific clinical data of women with DIP within the OFHS. To date, the team have accomplished the following: 1) Harmonization of data fields; 2) Research Ethics Board acceptance at St. Michael’s Hospital for DIP component of OFHS; and 3) Initiated the planning stage of the database with the Applied Health Re-search Centre of St. Michael’s Hospital and outlined the structure of the database. The next steps are finalization of the database with the Applied Health Research Centre, hiring of research assistants and initiation of data collection at St. Michael’s Hospital, Research Ethics Board approval at Mount Sinai Hospital, and recruitment of the Sunnybrook site into the OFHS.

VulNErablE pOpulaTiONS/pOpulaTiON hEalThThe program expands and strengthens the impact of the knowledge generated by the core group of University of Toronto-based diabetes population health scientists by bringing together front-line clinicians and public health and policy researchers to help frame research questions, and directly shape health policy. Key areas of focus are: 1) Identifying strategies to improve outcomes in socially disad-vantaged populations with diabetes or at risk for diabetes; 2) Identifying priorities and building capacity for high quality research in diabetes population health; and 3) Informing changes in clinical practice and health system policies that affect these populations in Canada.

recenT Program acTiviTies Together with her colleagues Drs. Feig and Berger of the BBDC’s Diabetes In Pregnancy Study Group program, Dr. Lipscombe is leading the Diabetes in Preg-nancy Sub-study to create a sub-cohort of women with diabetes in pregnancy (DIP) within the Ontario Family Health Study (OFHS). This cohort will include women with pre-gestational and gestational diabetes who been referred to DIP clinics within participating OFHS sites. The goal is to create a DIP module within the OFHS that will contain DIP-specific clinical data from DIP patients within the OFHS. The team is in the process of creating the DIP database and receiving ethics approvals to recruit women at participating sites and populate the DIP module of the OFHS. This will enable researchers to follow women with DIP and their offspring for long-term outcomes of diabetes in pregnancy. As a second project, the team used a novel database of primary care electronic medical records linked to health care administrative data to create and validate algorithms to identify and track patients with diabetes within population-based health care systems. They are currently preparing a manuscript for publication, which will have national and international impact on the ability to study patients with diabe-tes on a population level.

the four applied research Programs span the enormous chasm between the known evidence of what interventions positively impact diabetes, and what occurs in the domain of the practical. here we bring together incredible assets that already exist in diabetes knowledge translation and population health research in order to accelerate innovations that can markedly improve the lives of those living with diabetes. More information on these programs can be viewed on the BBDC’s website www.bbdc.org.

prOgraM lEadEr Dr. DeniCe feig

prOgraM lEadEr Dr. geOrge fantUs

prOgraM lEadEr Dr. LOrraine LiPsCOMBe

appliEd rESEarCh PrOgraMs


http://www.bbdc.org

kNOwlEdgE TraNSlaTiON aNd OpTiMiZiNg CarE MOdElSThe mandate of this program is to ensure that scientific knowledge of what we know constitutes best practice is implemented to improve the lives of people with diabetes. Our primary focus is to examine diabetes care gaps that could best be addressed by pharmacists and develop programs that sup-port and empower pharmacists in the care of patients with diabetes. There are approximately 37,000 pharmacists in Canada, most of whom work in a community setting making pharmacists highly accessible. Approximately 85% of patients with diabetes are taking at least one medication and people with diabetes will see a pharmacist more often than any other health care provider. Pharmacists are highly trained medication experts and this togeth-er with their expanded scope of practice and reimbursement for cognitive services creates an environment where patient-centred care can improve diabetes outcomes.

recenT Program acTiviTies The program launched its Guidebook for Pharmacists on Diabetes Man-agement across the country in both English and French language versions. The Guidebook incorporates recommendations from Canadian evidence-based guidelines in diabetes, blood pressure and lipid management and is supplemented with information that pharmacists need to know, includ-ing prevention and management of adverse effects, tips for assessment of adherence and medication management. Print and e-book versions of the guidebook are available at www.diabetespharmacistsnetwork.ca. To date, almost 6,000 pharmacists across the country have the Guidebook.

The program also simultaneously launched a national Diabetes Phar-macists Network which is free and open to all licensed pharmacists and pharmacy students in Canada with an interest in diabetes. The goal of the network is to bring together pharmacists from across Canada to share ideas and best practices through events, publications and networking. Currently, we have almost 600 members from across the country.

The program launched a Call to Action Video to inspire pharmacists but also challenge them to ask themselves if they are doing everything they can for their diabetes patients.

The 2nd Annual BBDC Pharmacist Networking Event was held at the Canadian Diabetes Association Annual Conference in Winnipeg in Oc-tober 2014. The panel discussed Trials and Tribulations of Implementing Patient-Centred Care in Diabetes in the Community Pharmacy Setting.

Earlier this year, Dr. MacCallum received a $200,000 Sun Life Financial Impact Challenge Grant and a $250,000 contribution from AstraZeneca to support the activities of the program.

Four Pharm D students from the Leslie Dan Faculty of Pharmacy at the University of Toronto completed a non-direct patient care or research Ad-vanced Pharmacy Practice Experience rotation at the BBDC in 2014-2015.

Dr. MacCallum presented at numerous conferences and stakeholder meetings over the past year on the role of pharmacists in diabetes care including the Ontario Pharmacy Council, the Canadian Association for Healthcare Reimbursement, the Canadian Diabetes Association, the Canadian Pharmacists Association and the Annual Health Insurance Invitational Forum.

CONTiNuiNg hEalTh EduCaTiON aNd prOfESSiONal dEVElOpMENTContinuing education is a process of lifelong learning for health professionals to expand and fulfill their potential, retain their capacity to practice safely and effectively, and to meet the healthcare priorities of the population and broader health care systems. This program provides continuing health education and op-portunities for professional development for all members of the diabetes team. In addition to building individual knowledge and skills, it will also adopt interpro-fessional education principles to improve collaborative patient-centered care. The BBDC designs its education practices using evidence-based teaching and learning principles most likely to change practice behaviour.

recenT Program acTiviTies Diabetes Update 2015 was held at the Metro Toronto Convention Centre in March 2015. This biennial continuing education event is targeted to health care providers in primary and specialty care who are involved in diabetes education and management. Over 500 health care providers from across Ontario and beyond at-tended this event centrally themed around improving the quality of diabetes care. Plenary talks, panel discussions and interactive workshops were used to highlight the patient experience in diabetes management strategies. The complete program can be viewed in the Educational Activities section of this annual report.

iNTErNaTiONal diabETES OuTrEaChThree quarters of people with diabetes are now living in low-and middle-income countries. In the next 20 years, Africa, the Middle East, and South- East Asia will shoulder the greatest increase in diabetes prevalence. The University of Toronto, in conjunction with Canadian Association of General Surgeons and Canadian Interna-tional Development Agency (CIDA), has developed a sustainable, integrated, multi-level Diabetes Education, Training, and Capacity Building model to tangibly impact the lives of those living with diabetes internationally. The Guyana Diabetic Foot Project has already resulted in a 50% reduction in diabetes related major amputations. The project uses proven U of T educational resources such as the International Inter-professional Wound Care Course to train Guyanese key opinion leaders. In partner-ship with the BBDC, the Global Diabetes Collaboration Initiative plans to attract funding in order to expand these programs into the Caribbean, Sub-Saharan Africa, and the Indian subcontinent and in addition to bring effective strategies back to our own disadvantaged populations in Ontario and in Canada.

recenT Program acTiviTies Earlier this year, the World Diabetes Foundation approved funding of $303,821 USD towards a three year Guyana Diabetes Care Project. The project, led by Drs. Julia Lowe and Brian Ostrow in Toronto and the Ministry of Health in Guyana, will: develop the capacity to diagnose and treat diabetic retinopathy in Guyana; introduce a protocol for the management of diabetes in pregnancy; train health professionals to educate the adult population in health promotion and diabetes prevention; and build research infrastructure in the Ministry of Health.

Dr. Lowe and her colleagues also received a $90,000 Sun Life Financial Impact Challenge Grant for their 2-year Guyana and Ethiopia Diabetes Project which will expand on their work in Guyana and will bring their previously successful model to Ethiopia.

prOgraM lEadEr Dr. rene WOng

prOgraM lEadEr Dr. JULia LOWe

prOgraM lEadEr Dr. LOri MaCCaLLUM


http://www.diabetespharmacistsnetwork.ca

http://www.diabetespharmacistsnetwork.ca/watch-our-video/

CliNiCal rESEarCh plaTfOrMThis platform coordinates, expands, and enhances the impact of Toronto-based clinical trial capacity across each of the priority research areas of focus for the BBDC, with an initial focus on diabetes and heart disease. The BBDC is part-nering with the Applied Health Research Consortium (AHRC) at St. Michael’s Hospital to establish a Toronto-based cross-site clinical research collaboration.

iNfOrMaTiCS plaTfOrMOntario is uniquely advantaged for population health research due to its single population database which links multiple administrative and clinical datasets at ICES. However, we do not have a single dataset containing the appropriate clinical information to support population health research, clinical trial recruitment, knowl-edge translation research, and basic science programs. In partnership with the Ap-plied Health Research Consortium (AHRC) at St. Michael’s Hospital, the BBDC is currently developing plans for an advanced diabetes registry, to support clinical research studies and applied research on health services and policy interventions.

COrE labOraTOryThe BBDC Core Laboratory provides high quality laboratory services to diabetes researchers at the University of Toronto involved in clinical and/or basic re-search. The lab also provides services to the wider scientific community including external academic and/or industry initiated research. The BBDC has expanded its Core Laboratory services to better serve the needs of BBDC researchers and affiliates as the BBDC expands its research enterprise. A steering committee of BBDC members based at Mount Sinai Hospital, The Hospital for Sick Children, and St. Michael’s Hospital have established close collaborations across institutions in order to offer a more complete lab inventory that greatly supports diabetes researchers. Assays and services that go beyond the traditional services of the BBDC core lab are available to investigators.

TraiNiNg aNd rESEarCh EXCEllENCE plaTfOrM The BBDC is an extraordinary training ground for the diabetes researchers and in-novators of the future, offering multiple levels of support for qualified individuals in-volved in diabetes research, patient care, and education. The current core offering of the BBDC is its broad portfolio of training grants offered to students, postdoctoral fel-lows, and investigators across a diverse set of disciplines in the University of Toronto and Toronto Academic Health Sciences Network (TAHSN). As always, we welcome feedback from the our members on how to enhance the programs of the BBDC for better impact, community building, and profile-building for the Centre.

Underpinning the Discovery and applied research programs are technology and other support platforms that draw upon a broad set of assets within the University of toronto research community. these platforms enable the research programs, allowing for maximal potential for impact. More information on these platforms can be viewed on the BBDC’s website www.bbdc.org.

The BBDC membership is a network of individuals involved in diabetes research, education and care from various departments at the University of Toronto and its affiliated hospitals. Membership is free and open to individuals involved in full or part-time diabetes research, education, or patient care (i.e. scientists, physicians, nurses, dietitians, pharmacists, etc.) and whose primary university appointment or employment (i.e. more than 50% of total salary), is with the University of Toronto or one of its affiliated hospitals.

The BBDC occasionally makes membership available to non-U of T affiliated faculty and health professionals who are invited by the BBDC to play a major role in the Centre’s activities (e.g. those asked to join BBDC committees or to partici-pate in research programs).

Post-doctoral fellows, graduate students, undergraduate students, research associ-ates and assistants, and technicians are not eligible for membership; however, they are welcome to join our e-mail list.Approximately 194 members are registered with the BBDC: 121 are U of T faculty involved in diabetes research and 73 are health professionals involved in diabetes care or education. Members are profiled on our website www.bbdc.org.

bENEfiTS Of MEMbErShip Allows individuals to become eligible to apply for the BBDC’s funding pro-

grams (specific eligibility requirements are outlined for each funding program) Enables individuals to attend the BBDC’s Annual Scientific Day and other

events which may be open to members and their trainees only. Research member’s diabetes-related activities and contact information are post-

ed on our website which enables local and foreign trainees to locate potential supervisors at the University, and helps facilitate the development of collabora-tive diabetes-related activities.

fully affiliaTEd hOSpiTalS

BaycrestCentre for Addiction and Mental

HealthHolland Bloorview Kids

Rehabilitation HospitalHospital for Sick ChildrenMount Sinai HospitalSt. Michael’s Hospital Sunnybrook Health

Sciences Centre University Health Network

(includes Princess Margaret Hospital, Toronto General Hospital, Toronto Western Hospital, and Toronto Rehabilitation Institute)

Women’s College Hospital

COMMuNiTy affiliaTEd hOSpiTalS aNd SiTESBridgepoint Health Credit valley Hospital/

Trillium Health Centre George Hull Centre for Children

and Families Hincks-Dellcrest Centre Humber River Regional Hospital Lakeridge Health Network Markham-Stouffville Hospital North York General Hospital ontario Shores Centre for Mental

Health Sciences Providence Healthcare Rouge valley Health SystemThe Royal victoria Hospital Scarborough Hospital St. Joseph’s Health Centre Southlake Regional

Health Centre Surrey Place Centre Toronto East General Hospital Waypoint Centre for

Mental Health CareWest Park Healthcare Centre

bbdC MeMBershiP

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www.bbdc.org

www.bbdc.org

Endowment IncomeExpendable Contributions (from industry, hospital, and university partnerships and collaborations)other (expendable donations, unrestricted educational grants, events, miscellaneous)

842,5101,230,000

426,452

2,498,962

adminisTraTion (salaries, supplies, equipment, review expenditures, miscellaneous)

480,158

educaTional acTiviTiesDiabetes Update 20151st BBDC-Joslin Diabetes Center ConferenceBBDC Seminar Series Annual Scientific Day Knowledge Translation and optimizing Care Models Program

144,549105,17711,82033,810

212,360

Funding Programs For TraineesPost-doctoral FellowshipsGraduate Studentships1

Charles Hollenberg Summer Studentship Program 2015Trainee Travel Awards Annual Trainee Awards

240,000295,12136,00028,8041,200

Funding Programs For FaculTy & HealTH care ProFessionals

Sun Life Financial Impact Challenge Grant – Diabetes in Developing CountriesSun Life Financial Impact Challenge Grant – Education and Knowledge TranslationSun Life Financial Equipment Grants for Diabetes ResearchSun Life Financial New Investigator AwardSun Life Financial Pilot and Feasibility GrantsReuben & Helene Dennis Scholar in Diabetes ResearchArchie Sopman Diabetes Research and Education Awards 20142

BBDC-Novo Nordisk Chair in Incretin BiologyDiabetes Educator of the Year Award 2014

90,000

200,000

60,00020,000

159,39110,0007,913

145,8711,000

oTHerInternational Diabetes outreach ProgramDiabetes in Pregnancy Program

14,81096,629

2,394,613

104,349

STaTEMENT Of OpEraTiONS: Actuals for the year July 1, 2014 to June 30, 2015

hOw Our fuNdS wErE SpENT iN 2014/2015

1 Payments are made directly to the award recipients by the Faculty of Medicine, Graduate and Life Sciences Education office.

2 Payments are made directly to the award recipients by the Toronto General & Western Hospital Foundation.

EXpENdiTurESrEVENuES

$1,295,300

$507,716

$480,158

$111,439

Funding Programs

educaTional acTiviTies

adminisTraTion

oTHer

20%5%

54%21%

TOTal SpENT $2,394,613

5%

54%

21%

20%

BBDCfiNaNCES

fUnDing prOgraMS +fUnDing dECiSiONSthis past year, the BBDC provided almost $1.3 million in diabetes research and education funding for 96 applicants including faculty, health professionals, post-doctoral fellows, graduate, undergraduate and medical students. this section of our annual report provides a brief overview of the significant funding that we provide for the diabetes research, education and care communities at the University of toronto and its affiliated institutions. except where noted, the BBDC’s funding programs are mainly open to members of the BBDC. specific eligibility requirements for each program are outlined on our website www.bbdc.org.

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http://www.bbdc.org

aNNual TraiNEE awardS The Annual Trainee Awards program is intended to showcase the best innovative and novel diabetes research being conducted by trainees at the University of Toronto and to provide an incentive for BBDC trainees to share their very best work with their colleagues and the BBDC membership. Each year graduate, undergraduate, and medical students, post-doctoral and clinical fellows and medical residents are invited to submit an abstract for this competition. The top ten abstracts are selected for poster presentation at the BBDC’s Annual Scientific Day where they are judged by internationally renowned diabetes researchers. This year’s posters were co-judged by Dr. Jeffrey E. Pessin (Associate Editor, Journal of Biological Chemistry; Senior Associate Editor, Diabetes) and Dr. Jonathan Rocheleau (Institute of Biomaterials and Biomedical Engineering, University of Toronto). The win-ners receive a gift card for the University of Toronto Bookstore. The 2014/2015 prize winners are:

award rECipiENT SupErViSOr(S) abSTraCT TiTlE

1st Prize $400 gift card

Ying LiuDr. Michael Wheeler

Discovery and characterization of zinc transporters in pancreatic beta cells

2nd Prize $300 gift card

Melika Zadeh-Tahmasebi

Dr. Tony LamIleal short chain fatty acids lower glucose production via an ileal GPR43 neuronal signaling axis

3rd Prize $200 gift card

Kenny ChanDr. Amira Klip andDr. Dana Philpott

Palmitoleate reverses high fat-induced pro-inflammatory macrophage polarization

Honourable Mention $100 gift card

Frank Duca Dr. Tony LamMetformin activates a duodenal AMPK-dependent pathway to lower hepatic glucose production in rats


Dinushan Nesan

Dr. Dominic NgCellular cholesterol modulates the differentiation of satellite cells to brown fat in LCAT-deficient LDLR-null mice


Anthony Scalia

Dr. Maria Rozakis Epigenetic regulation of hepatic gluconeogenesis

CharlES hOllENbErg SuMMEr STudENTShip prOgraM 2015This program is designed to introduce undergraduate and medical students to the field of diabetes research by providing an opportunity to perform a summer research studentship in the laboratory of a BBDC member. Each year the BBDC awards up to 15 studentships valued at $4,800 each. Students are required to participate in the program’s weekly Seminar Series and to present their work at the end of the summer at the Mini-conference (see the Educational Activities section of this report for the mini-conference program). The following are the 2015 summer studentship recipients:

rECipiENT SupErViSOr(S) TiTlE Of rESEarCh

Zaid AttoDr. Jonathan Rocheleau

Developing a microfluidic platform to ensure oxygen consumption in ex vivo pancreatic islets

Emma Butcher

Dr. Jayne Danska

Immune Responses to Gut Microbiome in Children at Risk for Type 1 Diabetes

Felix ChanDr. Robert Bandsma

Early post-natal malnutrition programs long-term metabolic effects: ß-cell-dysfunction and the role of epigenetic modifications.

Lauren Chan

Dr. Darren YuenPathological Angiogenesis in Diabetes is Regulated by Slit2 and its Robo Receptors

Melissa GeDr. I. George Fantus

The Role of TxNIP in the Development of Diabetic Nephropathy

Rida GullDr. Michael Wheeler

Investigating the role of UCP2 in mediating CMPF-induced beta cell dysfunction

Stephen Hale

Dr. Patricia Brubaker

Role of syntaxin-1a in the secretion of glucagon-like peptide-1 by the murine intestinal L cell in vivo

Maya Jacobson

Dr. Amira KlipInflammatory pathways induced by fatty acids in human monocytes

Dana Kablawi

Dr. Derek van der Kooy

Characterization pancreatic stem cells and their progeny cell type in pancreas and gut-derived tissue explants

Alexandra Majerski

Dr. Minna Woo Investigating the role of DJ-1 in atherosclerosis

Inga MuserDr. Daniel Mueller

The role of CREB-regulated transcription coactivator 1 (CRTC1) and phosphoenolpyruvate carboxykinase (PCK-1) gene variants in weight gain and glucose changes induced by antipsychotic drug treatment

Ernesto Hernandez Ramos

Dr. Denise Belsham

The saturated fatty acid palmitate induces hypothalamic inflammation and insulin resistance in AgRP/NPY expressing neurons: Reversal with anti-inflammatory agents

Ka Wun (Wendy) Siu

Dr. Carolyn Cummins

Identification of selective LXRß antagonists for the treatment of glucocorticoid-induced diabetes

victoria Tokarz

Dr. Maria Rozakis-Adcock

PHIP1 epigenetic regulation of IL1ß/IFNß proinflammatory signaling in pancreatic ß-cells

Tong WuDr. Bruce Perkins

Knowledge Translation of Corneal Confocal Microscopy for Diabetic Neuropathy Screening in Clinical Practice: Establishment of an Automated Image Analysis and Interpretation Tool

15 stUDentshiPs eaCh vaLUeD at $4,800

fUnDing PrOgraMs fOr TraiNEES

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bbdC-uNiVErSiTy hEalTh NETwOrk graduaTE awardSThese graduate awards were made possible by the 10-year partnership between the BBDC and the University Health Net-work. To be eligible for this award, students must be full-time graduate students in the Faculty of Medicine. The student’s supervisor must hold a full-time UHN appointment as an active staff physician, or if he/she holds an associate staff position or staff scientist position the supervisor’s principal laboratory or clinical research space must be physically located at the UHN. Awards are valued at up to $21,000 each. The following are the 2014/2015 award recipients:

rECipiENT SupErViSOr TiTlE Of rESEarCh

Amina AllalouDr. Michael Wheeler and Dr. Lucy osborne

Identification of Metabolite Biomarkers for the Transition from Gestational Diabetes to Type 2 Diabetes

William Cameron

Dr. Jonathan RocheleauUse of a novel NADPH sensor to investigate NADPH production and regulation in pancreatic beta-calls

Harsh DesaiDr. Minna Woo and Dr. Daniel Winer

Elucidating the role of macrophage JAK2 in the pathogenesis of diabetes

Sophie Hamr Dr. Tony LamDissecting duodenal fatty acid-sensing mechanisms in the neuronal control of hepatic triglyceride-rich vLDL

Pamuditha Silva

Dr. Jonathan Rocheleau and Dr. Dawn Kilkenny

Investigating the mechanisms and dynamics of fibroblast growth factor receptor like 1 (FGFRL1) in pancreatic ß-cells through quantitative fluorescence microscopy

Melika Zadeh Tahmasebi

Dr. Tony Lam Fatty Acid Sensing in the Ileum Regulates Glucose Homeostasis

bbdC-NOVO NOrdiSk STudENTShipSA collaboration with Novo Nordisk Canada Inc. was established in 1996 to provide long-term endowment in support of graduate students who are pursu-ing a career in diabetes research. As part of the Ontario Student Opportunity Trust Fund program (OSOTF), the support obtained from Novo Nordisk was matched by equal contributions from the University of Toronto and the Government of Ontario for a total endowment of 4.2 million dollars. To be eligible for this award, students must be full-time graduate students in the Faculty of Medicine and must demonstrate financial need. Studentships are valued at up to $21,000 each. The fol-lowing are the 2014/2015 award recipients:

rECipiENT SupErViSOr(S) TiTlE Of rESEarCh

Ji Dong BaiDr. Xiao-Yan Wen

Identification and mechanistic studies of novel gluconeogenesis regulators for anti-diabetic drug repurposing using transgenic zebrafish Pck1 reporters

Tina Binesh Marvasti

Dr. Alan MoodyIdentification of Biomarkers of vascular Intraplaque Hemorrhage in Patients with Type-2 Diabetes Mellitus

Kenny ChanDr. Amira Klip and Dr. Dana Philpott

Metabolic inflammation: NoD receptors in lipid-induced macrophage polarization

Sha (Lucy) Guan

Dr. Warren Lee and Dr. Amira Klip

Investigating the regulation and perturbation of insulin transcytosis across the microvascular endothelium – implications for the pathogenesis of insulin resistance

victoria Higgins

Dr. Khosrow Adeli

Closing the Gaps in Pediatric Reference Intervals for Biomarkers of Metabolic Disease

Luke Johnston

Dr. Anthony Hanley

Serum composition of non-esterified fatty acids (NEFA) in the progression of metabolic abnormalities underlying type 2 diabetes

Evan LewisDr. Thomas Wolever

The Effects of omega-3 Supplementation on Nerve Structure and Function in Type 1 Diabetes Mellitus – A Clinical Pilot Study

Marcel LinoDr. Michelle Bendeck

The role of Discoidin Domain Receptor 1 in vascular calcification and type 2 diabetes

Ingrid Dominique Santaren

Dr. Anthony Hanley

Understanding the Link Between Dairy Foods and Type 2 Diabetes Etiology: A Novel Approach Using Dairy Fatty Acid Biomarkers

Julie Anh Dung van

Dr. James Scholey

Urine Peptidomics in Early Type 1 Diabetes Mellitus: A Discovery-Based Approach

Christopher villa

Dr. Elena Comelli and Dr. Wendy Ward

Role of supplemental vitamin D given from conception to adulthood may have a role in preventing bone abnormalities and metabolic syndrome symptoms in C57BL/6J mice consuming a Western diet

TaMaraCk graduaTE award iN diabETES rESEarChThis graduate scholarship was made possible by a generous private endowment which was matched by equal funding from the University of Toronto and the Government of Ontario under the Ontario Student Opportunity Trust Fund program (OSOTF). To be eligible for this award, students must be full-time graduate students in the Faculty of Medicine and must demonstrate financial need. Preference is given to those students whose primary area of study is vascular problems of diabetes. The award is valued at up to $21,000. The 2014/2015 award recipients are:


Alan Poon Dr. Carol Westall Spatial distribution of early retinal changes in adolescents with Type 1 diabetes

Anthony Scalia Dr. Maria Rozakis-Adcock Characterization of novel mediators of hepatic gluconeogenesis

yOw kaM-yuEN graduaTE SChOlarShip iN diabETES rESEarChThis graduate scholarship was made possible by a generous private endowment which was matched by equal funding from the University of Toronto and the Government of Ontario under the Ontario Student Opportunity Trust Fund program (OSOTF). To be eligible for this award, students must be full-time graduate students in the Faculty of Medicine and must demonstrate fi-nancial need. The value of the award varies depending on endowment income and is normally between $10,000 and $15,000. The 2014/2015 award recipient is:


Effie viguilioukDr. David Jenkins and Dr. John Sievenpiper

The effect of replacing animal protein for vegetable protein on glycemic control in individuals with diabetes: A cross-sectional study, systematic review and meta-analysis of randomized controlled trials

4.2 MilliON dOllar

enDOWMent Was estaBLisheD By nOvO nOrDisK,

the University Of tOrOntO,

anD the gOvernMent

Of OntariO


pOST-dOCTOral fEllOwShipS The support of research fellows has been a major priority of the BBDC since the Centre’s inception. Each year, the BBDC endeavours to provide as many fellow-ships as possible to enable individuals holding an MD or PhD to carry out full-time diabetes research at the University of Toronto or one of its affiliated institutions. The objective of these awards is to attract and foster young investigators to initiate and/or continue research training in the field of diabetes. Fellowship stipends are normally $40,000 or $50,000 depending on the degree held.

bbdC pOST-dOCTOral fEllOwShipS aNd hugh SEllErS pOST-dOCTOral fEllOwShip The following are the 2014/2015 recipients:

award rECipiENT SupErViSOr TiTlE Of rESEarCh

Hugh Sellers Post-doctoral Fellowship

Sri Nagarjun Batchu

Dr. Andrew Advani

JAK2 in diabetic nephropathy

BBDC Post-doctoral Fellowship

Dafna Greitzer-Antes

Dr. Herbert Gaisano

Characterization of the Syn-1A/Kv2.1 and the new Syn-3/Kv2.1 ex-citosomes in mediating exocytosis of predocked and newcomer granules in pancreatic islet beta cells

BBDC Post-doctoral Fellowship

Xavier Revelo

Dr. Daniel Winer

The Role of Neutrophil Extracellular Traps and Their Targeted Toll-Like Receptors in Insulin

bbdC fEllOwShipS iN diabETES CarE (fuNdEd by Eli lilly/bOEhriNgEr iNgElhEiM diabETES alliaNCE)The BBDC Fellowships in Diabetes Care have been made possible by a generous contribution of $120,000 annually from Eli Lilly/Boehringer Ingelheim Diabetes Alliance. Eli Lilly first established this program in 2009 and has been generously providing annual support since then. The following are the 2014/2015 recipients:


Ying Liu Dr. Michael WheelerDiscovery and characterization of zinc transporters in pancreatic beta cells

Mohammad Massumi

Dr. Michael Wheeler and Dr. Andras Nagy

Production of mouse ß-cells derived from iPS cells

Dinushan Nesan Dr. Dominic Ng

The role of cellular cholesterol and endoplasmic reticulum stress in the ontogeny of diabetes and insulin resistance.

TraiNEE TraVEl awardSAttendance at scientific meetings provide all researchers, trainees and established researchers alike, with an opportunity to hear about cutting edge research in their field, often well before those results are published in scientific journals. Scientific meetings provide an opportunity for trainees to present their research findings to an international audience of their peers and promote networking and the establishment of research collaborations. The Trainee Travel Awards are available to U of T graduate students, undergraduate students, medical students, post-doctoral fellows, medical residents and clinical fellows conducting diabetes research. Trainees receive reimbursement of up to $1,000 (CAD) to attend a national or international meeting. To be eligible, the trainee must be presenting a first-author abstract directly related to diabetes research which has been accepted for poster or oral presentation at the meeting. The 2014/2015 award recipients are:

Period 1 reciPienTs (For travel occurring between July 1 and December 31, 2014)

rECipiENT SupErViSOr(S) abSTraCT TiTlE

Kenny Chan Dr. Amira KlipPalmitoleate reverses palmitate-induced pro-inflammatory macrophage polarization

Sarah Farr Dr. Khosrow AdeliGlucagon-like peptide-1 reduces intestinal chylomicron production by peripheral and central pathways

S. Mohsen Hosseini Dr. Andrew PatersonPolymorphism upstream of cryopyrin gene (NLRP3) is associated with severe retinopathy in type 1 diabetes

Lilia MagomedovaDr. Carolyn L. Cummins

Arginine and glutamate rich 1 is a glucocorticoid receptor coactivator critical for adipogenesis

Dinushan Nesan Dr. Dominic Ng Cellular lipids modulate satellite cell to brown fat conversion in LCAT deficient mice

Nicolas Pillon Dr. Amira KlipPalmitate challenged muscle cells attract monocytes through TLR4-dependent release of ATP

Brittany Rasmussen

Dr. Tony LamDuodenal linoleic acid sensing lowers glucose production in rats and mic via a CCK-independent neuronal network

Jennifer Taher Dr. Khosrow AdeliIntestinally-derived GLP modulates hepatic lipoprotein metabolism via a potential brain-gut-liver axis

Period 2 reciPienTs (For travel occurring between January 1 and June 30, 2015)


Moustafa AbdallaDr. Andrew Advani and Dr. Claudia dos Santos

Edge-Shift Analysis Reveals RAS Inhibitor Unaffected Therapeutic Targets in Rodents and Humans with Diabetic Nephropathy

Paymon AziziDr. Amira Klip and Dr. Warren L. Lee

A Novel Assay for Insulin Transcytosis Reveals an Unexpected Role for Clathrin

Wei Bai Dr. Bruce PerkinsStatin Use in Primary Prevention of Cardiovascular Disease in Longstanding T1DM: Results from the Canadian Study of Longevity in Diabetes

Sri Nagarjun Batchu Dr. Andrew AdvaniIP Receptor Agonism Augments Insulin Release and Attenuated Almbuminuria through Nephrin-Dependent Mechanisms

Genevieve Boulet Dr. Bruce PerkinsPrevalence of Insulin Pump Therapy and its Association with Glycemic Control in Longstanding T1DM: Results from the Canadian Study of Longevity in Diabetes Cohort

victoria Higgins Dr. Khosrow AdeliA Comprehensive Database of Pediatric and Adult Reference Intervals for Biochemical Markers Based on the Canadian Health Measures Survey (CHMS)

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CON'T NEXT pagE pEriOd 2 rECipiENTS (For travel occurring between January 1 and June 30, 2015)


CON'T pEriOd 2 rECipiENTS (For travel occurring between January 1 and June 30, 2015)


Linda Hiraki Dr. Andrew PatersonGenetic Signal for Renal Function Decline in Type 1 Diabetes (T1D) Identified by Analysis of Repeated Longitudinal Measures

Alexander Ivovic Dr. Adria Giacca The Roles of NoD Receptors in Fat-induced Beta-cell Dysfunction

Joseph Jamnik Dr. Ahmed El-Sohemy Effect of Gluten on the Plasma Proteome in Humans

Luke W. JohnstonDr. Anthony Hanley and Dr. Richard Bazinet

Serum Non-Esterified Fatty Acid (NEFA) Concentration is Associated with Longitudinal Progression of ß-Cell Dysfunction: Prospective Metabolism and Islet cell Evaluation (PRoMISE) Cohort

Cynthia Luk Dr. Minna Woo FAK Signaling Controls Insulin Sensitivity through Adipocyte Survival

Yuliya LytvynDr. David Cherney and Dr. Paul Dorian

Plasma Uric Acid Effects on Glomerular Hemodynamic Profile of Patients with Uncomplicated Type 1 Diabetes

Daiva Nielsen Dr. Ahmed El-SohemyChanges in Food Group and Nutrient Intakes Following a DNA-based Dietary Advice Intervention for Sodium Intake

Alan Poon Dr. Carol WestallSpatial distribution of early thickness changes in the inner retinal layer in adolescents with Type 1 Diabetes

Kacey Prentice Dr. Michael Wheeler CMPF Induces Persistent Metabolic Inflexibility and Impaired Insulin Secretion

Ingrid Dominique Santaren

Dr. Anthony Hanley and Dr. Richard Bazinet

Individual Serum Saturated Fatty Acids and Markers of Chronic Subclinical Inflammation: The Insulin Resistance Atherosclerosis Study (IRAS)

Pamuditha SilvaDr. Jonathan Rocheleau and Dr. Dawn Kilkenny

Towards a Microfluidic Device for Highly Efficient Adenoviral Transduction of Pancreatic Islets

Tharini Sivasubramaniyam

Dr. Minna Woo Dissecting Molecular Mechanisms of Fatty Liver Disease that Promotes Atherogenesis

Holly Stacey Dr. Patricia BrubakerThe Role of Syntaxin-1a in Glucagon-like Peptide-1 Secretion from Adult Mouse Intestinal L-Cells

Christopher R. villaDr. Elena M. Comelli and Dr. Wendy E. Ward

Improvement of Metabolic Parameters in Mice Supplemented with vitamin D Throughout Life

Alanna Weisman Dr. Bruce PerkinsNeuropathy Prevalence Compared with other Complications in LongstandingT1DM: Preliminary Analysis of the Canadian Study of Longevity in Diabetes Cohort

arChiE SOpMaN diabETES rESEarCh aNd EduCaTiON awardS 2014This program is intended to promote continuing diabetes education for health professionals who do not normally have access to funds to travel to diabetes conferences or bring seminar speakers to Toronto. Award recipients who attend conferences are encouraged to share their learnings from the conference with their colleagues. The awards are open to University Health Net-work employees who are dietitians, nurses, social workers, pharmacists, staff physicians or scientists who are primarily involved in diabetes education, clinical care or research. Funding can be used for travel to a national or international diabetes meet-ing, or to support a visiting lecturer in diabetes or metabolic disorders. Funding for this program is provided by the Toronto General and Western Hospital Foundation Archie Sopman endowment fund. The endowment is held at the University Health Network (UHN) and award payments are made directly to the recipients by the UHN. The funding recipients for the 2014 calendar year are:

rECipiENT pOSiTiON aNd uhN SiTE purpOSE award

Kathryn Camelon

Practice Leader, Clincial Nutrition, Allied Health, Toronto General Hospital

Travel to diabetes meeting

Up to $1,000

Lucia ChanRegistered Nurse, Diabetes Clinic, Toronto Western Hospital


Up to $1,000

Kathy Cohen

Registered Dietician, Allied Health, Toronto Western Hospital


Up to $1,000

Doreen Klaar

Registered Dietician, Allied Healh & Family Health Team, Toronto Western Hospital


Up to $1,000

Kitty MakNurse Clinician, Endocrinology, Toronto General Hospital


Up to $1,000

M. Cecilia Palma

Registered Nurse, Endocrinology, Toronto General Hospital


Up to $1,000

Mary T. Weiland

Clinical Dietician, Bariatrics, Toronto Western Hospital


Up to $1,000

Elaine WylieDiabetes CNS, Diabetes Clinic, Toronto General Hospital


Up to $1,000

fUnDing PrOgraMs fOr faCulTy + hEalTh prOfESSiONalS

DiaBetes ManageMent is a teaM aPPrOaCh. We enCOUrage ONgOiNg prOfESSiONal dEVElOpMENT Of OUr aLLieD heaLth teaM MeMBers.

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aSTraZENECa iMpaCT ChallENgE graNT: CardiOVaSCular/diabETESIn 2013, the BBDC and the Heart & Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research in conjunction with the Vice-Dean, Research and International Relations, Faculty of Medicine established this funding program to support research initiatives focusing on diabetes and heart disease. The purpose of this funding program is to establish the University of Toronto as an international leader in the study of diabetes and heart disease and to foster bench to bedside translational research with a focus on innovation and first-in man clinical trials. Applicants must be members of either the BBDC and/or the Heart & Stroke/Richard Lewar Centre of Excellence to be eligible to apply. This funding program is administered by and payments are made to the award recipients by the Heart & Stroke/Richard Lewar Centre of Excellence. In 2015, the program received a generous $750,000 contribution from AstraZeneca which will provide three $250,000 grants over the next three years. The next grant will be awarded in July 2015.

bbdC - NOVO NOrdiSk Chair iN iNCrETiN biOlOgyIn 2010, the BBDC-Novo Nordisk Chair in Incretin Biology was established at the Banting & Best Diabetes Centre, University of Toronto. The research Chair was made possible through a $3 million gift from Novo Nordisk in apprecia-tion of the innovative diabetes research undertaken by the Centre. Both Novo Nordisk and the University of Toronto, Faculty of Medicine have a long-standing tradition of diabetes research originally dating back to the discovery of insulin, and most recently focused on the science of incretin biology which holds the potential to have the kind of transformative impact that insulin had in improving the lives of people with diabetes. This Chair will position the University of Toronto as a leader in this area of research. Dr. Daniel J. Drucker is the inaugural BBDC-Novo Nordisk Chair in Incretin Biology from May 2010 to April 2015. Dr. Drucker is a clinician-scientist world-renowned for his ability to translate scientific breakthroughs into clinical treatments for patients.

diabETES EduCaTOr Of ThE yEar award 2014Each year one award is presented to recognize a diabetes educator who has demonstrated outstanding efforts and achieve-ments in his/her role as a diabetes educator. This award is meant to recognize achievements above and beyond their clinical job descriptions, and exceptional individuals who contribute to initiatives across teams within their organization and more broadly to the diabetes community. To be eligible, the candidate must be a full or part-time diabetes health care professional employed within the boundaries of one of the following Local Health Integration Networks (LHINs): Central LHIN, Cen-tral East LHIN, Central West LHIN, Mississauga Halton LHIN, or Toronto Central LHIN. Candidates are not required to be members of the BBDC. The 2014 award recipient is:

rECipiENT prOfESSiON aNd hOSpiTal affiliaTiON award

Dana Whitham, MSc, RD, CDE, CPTCase Manager, Diabetes Comprehensive Care Program St. Michael’s Hospital

$1,000

rEubEN & hElENE dENNiS SChOlar iN diabETES rESEarCh (biENNial prOgraM)This award was established to support new clinician-scientists and basic scientists in the early stages of their careers. Faculty are eligible for this funding within five years of their first faculty appointment. The following is the 2014-2016 award recipient:

rECipiENT TiTlE Of rESEarCh award

Dr. Margaret HahnHypothalamic-insulin resistance as a mechanism for antipsychotic-induced glucose dysregulation

$10,000 for 2014/2015 $10,000 for 2015/2016

SuN lifE fiNaNCial EQuipMENT graNTS fOr diabETES rESEarChThere are limited opportunities for researchers to obtain funding for new research equipment, which is essential for conduct-ing state-of-the-art experiments. Funding for equipment is made possible by a generous contribution from Sun Life Financial. A minimum amount of $5,000 and a maximum amount of $30,000 is made available for the one-time purchase of laboratory equipment for diabetes research. The 2014/2015 equipment grant recipients are:

rECipiENT 1) TiTlE Of rESEarCh 2) EQuipMENT award

Herbert Gaisano (Principal Applicant) Michael Wheeler Patricia Brubaker Minna Woo

Superhigh resolution SToRM/PALM microscopy to examine signaling in pancreatic islet cells and intestinal L-cellsSToRM (Stochastic optical reconstruction microscopy) module

$30,000

Minna Woo (Principal Applicant) Daniel Winer

Temperature and Light Control in Assessment of Energy HomeostasisCLAMS-ENC temperature and light controlled enclosure

$30,000

SuN lifE fiNaNCial iMpaCT ChallENgE graNT: diabETES iN dEVElOpiNg COuNTriESThis grant is made possible by a generous contribution from Sun Life Financial. In socially disadvantaged communities throughout the world effective, timely, and accurate diagnosis and treatment plans are critical for the successful treatment of diabetes. This pro-gram provides one-time funding of up to $90,000 to assist researchers and/or diabetes care providers in developing innovative strate-gies to improve outcomes in populations with diabetes or at risk of diabetes in developing countries. The 2015 grant recipient is:


Dr. Julia Lowe (Principal Applicant) Dr. Brian ostrow Dr. Nashwah Taha Dr. R. Gary SibbaldDr. Reeta Gobin Dr. Ahmed Reja

Guyana and Ethiopia Diabetes Project $90,000


SuN lifE fiNaNCial iMpaCT ChallENgE graNT – EduCaTiON aNd kNOwlEdgE TraNSlaTiON: EMphaSiS ON ThE COMMuNiTy pharMaCiSTThis grant is made possible by a generous contribution from Sun Life Financial. This program provides funding of up to $200,000 to enable applicants to explore new initiatives or to build upon ongoing work in the area of knowledge transla-tion and education, with a focus on the community pharmacist. The purpose of this grant is to invite new proposals to empower the community pharmacist with the resources he/she needs to better care for the patient with diabetes. The 2015 grant recipient is:


Dr. Lori MacCallum (Principal Applicant) Dr. Rene Wong

Bridging Gaps in Knowledge and Capacity Building $200,000

SuN lifE fiNaNCial NEw iNVESTigaTOr awardThis award is made possible by a generous contribution from Sun Life Financial. The award was established to support new clinician-scientists and basic scientists in the early stages of their career, which is a particularly challenging and vulnerable time as the researcher transitions from trainee to independent investigator. Faculty are eligible for this funding within five years of their first faculty appointment. The following is the 2014-2016 award recipient:


Dr. Daniel WinerDefining the Role of Intestinal Immunity in obesity Related Insulin Resistance

$20,000 for 2014/2015 $20,000 for 2015/2016

SuN lifE fiNaNCial pilOT aNd fEaSibiliTy graNTSNew ideas and directions for research involve risk-taking by scientists and funding agencies. Most established funding agencies require considerable evidence of feasibility before they consider funding an application for a new project. Further-more, researchers who are new to the diabetes field, who may wish to adapt their non-diabetes research techniques to a diabetes-related topic of interest, are disadvantaged in most funding competitions. The BBDC, therefore, prioritizes pilot and feasibility funding to attract researchers without a pre-existing track record of diabetes research or established diabe-tes researchers who wish to pilot an innovative research idea or project. Thanks to a generous contribution from Sun Life Financial, the BBDC is once again able to offer pilot and feasibility grants. The program provides one year of funding of up to $40,000 per applicant, to enable investigators to explore completely new initiatives in the area of biomedical research/basic science research in diabetes. Applicants are not required to be members of the BBDC at the time of application sub-mission. The following are the 2014/2015 recipients:


Dr. Adria GiaccaThe role of nucleotide-oligomerization domain (NoD) receptors in type 1 diabetes

$40,000

Dr. Jonathan RocheleauDr. Warren Chan

optimizing nanoparticle delivery to beta cell mass using an islet-on-a-chip microfluidic device

$40,000

Dr. Derek van der KooyA novel source of pancreatic stem cells in intestinal muscular layer in adult mice and its potential in generating ß-cells

$40,000

Dr. Michael Wheeler Discovery of novel targets to enhance ß cell function and insulin secretion $39,391

EduCaTiONal aCtivities

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The BBDC together with the Joslin Diabetes Center co-hosted the first collaborative BBDC-Joslin Diabetes Center Conference on October 17-18, 2014 in Toronto. The one and a half day event focused on nutrients, the digestive tract and diabetes. The goal of the conference is to bring together the two leading diabetes research cen-tres in Canada and the United States to promote the exchange of innovative research ideas and collaboration.

This event was so well-received that the University of Copenhagen joined the BBDC and the Joslin Diabetes Center to host the 2nd annual confer-ence in Copenhagen in October 2015. The 2016 conference will be held in Boston. These three organizations have long been at the heart of global diabetes research, and the annual meetings seek to build on that long tradition to bring together prominent researchers from across the globe.

We are grateful to Eli Lilly, Novo Nordisk and the Canadian Institutes of Health Research for their generous support of this event. The program is as follows:

1ST bbdC-JOSliN diabETES CENTEr CONfErENCE OCTObEr 17-18, 2014 MarS CENTrE, TOrONTO, CaNada

friday, OCTObEr 17, 2014

8:00 AM Registration and Continental Breakfast

guT pEpTidES/hOrMONE phySiOlOgy MOdEraTOr: dr. khOSrOw adEli

9:35 inTroducTion and Welcome: Drs. George King and Gary Lewis

9:45 Novel Approaches to the Prevention and Treatment of Type 2 Diabetes Matthias Tschöp, MD

10:25 Hormonal Signaling in the Gut Tony Lam, PhD

10:55 Break

11:10 Hypoglycemia and the Control of Metabolism after Gastrointestinal Surgery Mary-Elizabeth Patti, MD

11:40 GLP-1 Relevance Beyond Glucoregulation Daniel Drucker, MD, FRCPC

12:10 PM Gut Insulin Signaling and Tumor Susceptibility Christian Rask-Madsen, MD

12:40 Lunch

MiCrObiOME MOdEraTOr: dr. gEOrgE kiNg

2:00 Pathways in Microbe Induced obesity Martin Blaser, MD

2:40 The Influence of the Microbiota and Innate Immunity of Gut Inflammation Dana Philpott, PhD

3:10 Interaction Between Host Genetics, Diet and the Gut Microbiome in Generation of the Metabolic SyndromeC. Ronald Kahn, MD

3:40 Break

4:00 The Causal Web of Autoimmunity: Sex, Genes and the Microbiome in Type 1 Diabetes Jayne Danska, PhD

4:30 Dietary Drivers of Host-Microbe Dynamics in the GI Tract Suzanne Devkota, PhD

EVENiNg rECEpTiON

5:00 Trainee Poster Session / Wine and Cheese Reception

SaTurday, OCTObEr 18, 2014

8:00 AM Continental Breakfast

guT aS iT rElaTES TO whOlE bOdy phySiOlOgy MOdEraTOr: dr. TONy laM

9:00 Gut-Brain Communication in Glucose Homeostasis: Implications for Diabetes Pathogenesis and Treatment Michael W. Schwartz, MD

9:40GLP-1 Regulation of Intestinal Lipid and Lipoprotein Metabolism via a Gut-Brain Axis Khosrow Adeli, PhD, FCACB, DABCC, FACB

10:10 Role of Bile Acids in Human Diabetes and Metabolism Allison Goldfine, MD

10:40 Break

11:00 Glucagon-Like Peptide-1: The Missing Link in the Metabolic Clock? Patricia Brubaker, PhD

11:30 Growth Factor and GLP-1 Signaling Pathways in the Regulation of the Endocrine Pancreas Rohit Kulkarni, MD, PhD

12:00 PMclosing sTaTemenTs: Drs. George King and Gary Lewis Lunch

1ST bbdC-JOSliN diabETES CENTEr COnferenCe NuTriENTS, ThE digESTiVE TraCT aNd diabETES


26Th aNNual SCiENTifiC dayfriday, May 8, 2015 ThE Old Mill iNN, 21 Old Mill rOad, TOrONTO

8:00 AM Continental breakfast and poster set-up

SESSiON 1 Chair: dr. fraNk duCa

8:40 Welcome and inTroducTion: Dr. Tony Lam

8:45The Role of Insulin in GLP-1 in the Cause and Treatment of Depression and Cognitive Disorders Roger McIntyre, MD, FRCPC

9:15Antipsychotic Medications and Glucose Dysregulation: From Mice to Men Margaret Hahn, MD, PhD, FRCPC

9:45Nucleic Acid Targeting Pathways Promote Inflammation in obesity Related Insulin ResistanceXavier Revelo, PhD

10:00Refreshments, Poster Presentations, and BBDC Annual Trainee Awards Competition poster judging by Drs. Jeffrey Pessin and Jonathan Rocheleau. Moderator: Dr. Herbert Gaisano

SESSiON 2 Chair: dr. JONaThaN rOChElEau

11:15Novel Approaches to Diabetes Related Complications Requires a Team Approach: Cell Based Strategies, Imaging Advances and Cardio-Renal Interactions. Kim Connelly, MBBS, PhD

11:45 Metabolomics as an Investigative Tool to Understand Diabetes Michael Wheeler, PhD

12:15 PM BBdc direcTor’s rePorT: Dr. Gary Lewis, Professor, Department of Medicine, Division of Endocrinology & Metabolism, University of Toronto

12:30 Lunch

CharlES hOllENbErg MEMOrial lECTurEShip Chair: dr. TONy laM

1:30 The New Biology of Diabetes Domenico Accili, MD

2:30 BBDC Annual Trainee Awards Presentation 2014/2015 Drs. Jeffrey E. Pessin, Jonathan Rocheleau, and Tony Lam

2:40 Evaluation and adjournment

This annual event which is organized by the BBDC’s Training and Research Excel-lence Committee provides an opportunity for BBDC members to exchange scien-tific information and ideas, and assists in the development of collaborative diabetes-related research activities. It also provides a valuable opportunity for BBDC trainees to network and present their research. BBDC post-doctoral fellowship recipients, graduate studentship recipients and select Annual Trainee Awards abstract submitters present posters of their work. This year Dr. Jeffrey Pessin (Associate Editor, Journal of Biological Chemistry and Senior Associate Editor, Diabetes) and Dr. Jonathan Rocheleau (University of Toronto) co-judged ten pre-selected posters for the Annual Trainee Awards competition. The event focuses on the latest diabetes research topics with both clinical and laboratory applications. This year’s Charles Hollenberg Memo-rial Lectureship was delivered by Dr. Domenico Accili, Director of the Columbia Diabetes Research Center, Columbia University. Registration is free for all BBDC members, their trainees and U of T endocrine residents.

We gratefully acknowledge partial support of this year’s event by: AstraZeneca, Eli Lilly/Boehringer-Ingelheim Diabetes Alliance, GlaxoSmithKline, Janssen Inc., Merck Canada Inc., Novo Nordisk, Sanofi Diabetes, and the University Health Network. We are also grateful to Sun Life Financial, a major supporter of the BBDC. The program is as follows:

Annual Trainee Awards poster judges Drs. Jonathan Rocheleau (left) and Jeffrey Pessin (centre) evaluate Anthony Scalia’s poster.

guEST SpEakEr Dr. DOMeniCO aCCiLi

annUaLSCiENTifiC day


wEEkly SEMiNar SEriES aNd MiNi-CONfErENCE 2015Summer studentship recipients and their supervisors are required to participate in the Charles Hollenberg Summer Student-ship Program which consists of a weekly Seminar Series and a half-day Mini-conference. The weekly seminars are held every Tuesday from 4 to 5 p.m. throughout June and July. Each seminar includes two 20-minute presentations prepared by two supervisors, followed by two 5-minute presentations by their summer students describing how their projects fit into the overall goals of their labs. All students present the results of their work at the end of the summer in a workshop format at the half-day Mini-conference. The BBDC would like to thank Dr. Cristina Nostro for coordinating the 2015 Summer Studentship Pro-gram. The 2015 Mini-Conference program is as follows:

2015 CharlES hOllENbErg SuMMEr STudENT MiNi-CONfErENCETuESday, auguST 4, 2015 12:55 – 5:00 p.M. TOrONTO MEdiCal diSCOVEry TOwEr, 4Th flOOr SEMiNar rOOM 4-204

12:55 inTroducTion: Dr. M. Cristina Nostro, Program Coordinator

1:00The Role of Syntaxin-1A in the Secretion of Glucagon-like Peptide-1 from the Adult Mouse L-Cell In Vivo Stephen Hale

1:15 Palmitate’s Effect in the mHypoE-46 Neuronal Cell Line Ernesto Ramos

1:30Comprehensive Metabolic Screening of Pancreatic Islets Using a Multi-Parametric Microfluidic Platform Zaid Atto

1:45 Palmitate-induced Caspases Trigger Pyroptosis in Human Monocytes Maya Jacobson

2:00validity of In Vivo Corneal Confocal Microscopy Automated Image Analysis in Identifying and Predicting Neuropathy in Type 1 Diabetes Tong Wu

2:15The Role of PHIP1 in the Epigenetic Regulation of IL-1ß and IFNγ Pro-Inflammatory Signalling in Pancreatic ß-Cells Victoria Tokarz

2:30 Immune Responses to Gut Microbiome in Children at Risk for Type 1 Diabetes Emma Butcher

2:45 Break

3:00 The Effect of Malnutrition on High-Fat Diet-Induced ß-cell Dysfunction and Insulin Resistance Felix Chan

3:15 Robo4 Knockout Enhances Glomerular Angiogenesis in the Diabetic Kidney Lauren Chan

3:30The Role of CRTCI variant rs3746266 in Antipsychotic Induced Weight Gain in a Sample of Patients Treated for Schizophrenia and Schizoaffective Disorder Inga Muser

3:45Characterization of Pancreatic Stem Cells and their Progeny Cell Type in Pancreas and Gut-Derived Tissue Explants Dana Kablawi

4:00 Role of Src Kinase in the Pathogenesis of Diabetic Nephropathy Melissa Ge

4:15 Identification of Selective LXRß Antagonists for the Treatment of Glucocorticoid-Induced Diabetes Wendy Siu

4:30 Investigating the Role of DJ-1 in Atherosclerosis Alexandra Majerski

4:45Using Metabolomics as a Tool to Investigate Novel Diabetes Biomarkers and their Role in Pancreatic Beta Cell Dysfunction Rida Gull

CharlES hOllENbErg sUMMer stUDentshiP PrOgraM


Diabetes Update is a biennial continuing education event organized by the BBDC’s Continuing Health Education and Professional Development Commit-tee. This one-day event is targeted to health care providers involved in diabetes education and management such as, but not limited to, physicians, nurses, dietitians and pharmacists from across Ontario and beyond. Diabetes Update 2015 was held on Friday, March 6, 2015 and was attended by over 500 health care providers.

The BBDC would like to thank the following for supporting Diabetes Update 2015: Gold Level Sponsors: Boehringer Ingelhim, Eli Lilly, and Merck. Silver Level Sponsors: Abbott, AstraZeneca, GlaxoSmithKline, LifeScan, Medtronic, Novo Nordisk, Roche, and Sanofi Diabetes. We are also grateful to Sun Life Financial, a major supporter of the BBDC. The program is as follows:

diabETES updaTE 2015friday, MarCh 6, 2015 METrO TOrONTO CONVENTiON CENTrE, SOuTh buildiNg

7:45 AM Registration and Continental Breakfast

8:30 Welcome, opening Remarks and Introduction: Dr. Rene Wong

plENary SESSiONS

8:40 Patient-Centered Diabetes Care - The Next Frontier Victor M. Montori, MD, MSc

9:40The Top Papers of the Year: Should they change our practices? Alice Cheng, MD, Heidi Lazar-Meyn, and Ross Upshur, BA, MA, MD, MSc

10:40 Health and Networking Break

MOrNiNg CONCurrENT SESSiONS

11:10

session 1: Pragmatic Advice to Help Patients Engage in Physical Activity Paul Oh, MD, MSC

session 2: Managing Type 2 Diabetes in Multimorbid older Adults Ross Upshur, BA, MA, MD, MSc

session 3 (offered during morning session only): How Can We Improve Postpartum Care and Diabetes Prevention in Women with Past Gestational Diabetes? Lorraine Lipscombe, MD, MSc

session 4: The Intersection of Food Insecurity and Diabetes Enza Gucciardi, MHSc, PhD and Sandra Fitzpatrick, RD, CDE

session 5: Bridging Gaps in Diabetic Foot Care Mariam Botros, CDE, DCH, IIWCC

session 6: Strategies for Implementing Diabetes Medication Reviews in a Busy Community Practice John Papastergiou, BSc, BScPhm

session 7: Managing Inpatient Glycemic Control: Insulin order Sets and other Lessons LearnedHenry Halapy, RPh and Catherine Yu, MD, MHSc

12:25 PM Lunch break

plENary SESSiON

1:40 Adverse Effects of Drugs for Diabetes David Juurlink, MD, PhD

2:40 BBDC Diabetes Educator of the Year 2014 Award Presentation

2:50 Health and Networking Break

afTErNOON CONCurrENT SESSiONS

3:05 Repeat of morning concurrent sessions (except for session 3)

4:20 Evaluation and adjournment

diabETES updaTE 2015

guEST SpEakEr Dr. viCtOr M. MOntOri


Each year the BBDC invites internationally renowned diabetes researchers to present their work on diabetes research at our Seminar Series and to interact with BBDC faculty. To ensure a broad audience, seminars have been incorporated into the University of Toronto City-wide Endocrine Rounds which are held every Friday morning at the Mount Sinai Hospital. This year’s presentations are as follows:

bbdC SEMiNar SEriES 2014/2015 (iN CONJuNCTiON wiTh CiTy-widE ENdOCriNE rOuNdS)8:00 – 9:00 a.M. MOuNT SiNai hOSpiTal, lEbOViC buildiNg, 3rd flOOr CONfErENCE rOOM

September 12, 2014The Anterior Chamber of the Eye: A Natural Body Window to Study Pancreatic Islet Biology In vivoAlejandro Caicedo, PhDUniversity of Miami Miller School of Medicine

November 14, 2014Diabetes, obesity and the Central Role of the Adipocyte in Maintaining Systemic HomeostasisPhilipp E. Scherer, PhDThe University of Texas Southwestern Medical Center, Dallas

January 30, 2015The Gut Microbial Endocrine organ: A New Therapeutic Target for Cardiometabolic Diseases Stanley Hazen, MD, PhDCenter for Cardiovascular Diagnostics & Prevention, Cleveland Clinic

April 10, 2015

The NAD World Revisited: The Importance of the Intertissue Communication Mediated by NAMPT/NAD/SIRT1 in Mammalian Aging/Longevity ControlShin-Ichiro Imai, MD, PhDWashington University School of Medicine

BBDC SEMiNar SEriES (aT CiTy-widE ENdOCriNE rOuNdS)

The BBDC Core Laboratory provides high quality laboratory services to diabetes researchers at the University of Toronto involved in clinical and/or basic research. The lab also provides services to the wider scientific commu-nity including external academic and/or industry initiated research. The BBDC is expanding its Core Laboratory services to better serve the needs of BBDC researchers and affiliates as the BBDC expands its research enterprise. A steer-ing committee of BBDC members based at Mount Sinai Hospital, The Hospital for Sick Children, and St. Michael’s Hospital have established close collabora-tions across institutions in order to offer a more complete lab inventory that will greatly support diabetes researchers. A list of current services and assays provided by the Core Lab is available on the BBDC’s web site at www.bbdc.org or by contacting the Core Lab directly:

COrE LaBOratOry

dirECTOr: Dr. geOrge fantUs Phone: (416) 586-8665 E-mail: [email protected]

CO-dirECTOr: Dr. azar azaD Phone: (416) 586-8545 E-mail: [email protected]

addrESS: MOUnt sinai hOsPitaL 600 University Avenue, 6th Floor, Room 600 Toronto, ontario, M5G 1X5P

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http://www.bbdc.org

mailto:[email protected]

mailto:[email protected]

guidEbOOk fOr pharMaCiSTS ON diabETES MaNagEMENTIn the fall of 2014, the BBDC launched its Guidebook for Pharmacists on Diabetes Management across the country (a French version of the guide-book was launched in June 2015). The purpose of the book is to support pharmacists in the management of diabetes patients, particularly during scheduled medication reviews. The Guidebook incorporates recommenda-tions from Canadian evidence-based guidelines in diabetes, blood pressure and lipid management and is supplemented with information that phar-macists need to know, including prevention and management of adverse effects, tips for assessment of adherence and medication management. Print and e-book versions of the 116-page guidebook are available at www.diabetespharmacistsnetwork.ca.

COMMuNiCaTiONS + PUBLiCatiOn

SOCial MEdia

COnneCt With Us On

faCeBOOK

fOLLOW Us On

tWitter

WatCh Us On yOUtUBe

diabETES pharMaCiSTS NETwOrkThe Diabetes Pharmacists Network was created by the BBDC as a way to bring together pharmacists from across Canada who are interested in the care of patients with diabetes. At the BBDC, we are com-mitted to finding ways to improve the lives of people with diabetes and those at

risk of diabetes. We recognize the value of pharmacists in improving outcomes for patients and want to empower and support pharmacists who exemplify best practices through networking, education, and knowledge translation initiatives. The goal is to bring together pharma-cists to share ideas and best practices through events, publications and networking. The Diabetes Pharmacists Network is free and open to all licensed pharmacists in Canada with an interest in diabetes. Visit www.diabetespharmacistsnetwork.ca for more information.

www.bbdC.OrgVisitors to our web site can view detailed information on all of the BBDC’s discovery and applied research programs, funding programs and funding decisions, educational activities, current diabetes research activities being conducted by our members, links to local and international diabetes meetings, and much more.

E-Mail liSTOur members and others who join our e-mail list receive notifications regarding BBDC funding programs, seminars, educational events, the BBDC newsletter and other notifications which may be of interest to the University of Toronto diabetes research, care or education communities.

NEwSlETTErS

BBdc neWs is distributed by e-mail to our members and those who have joined our e-mail list. Issues are distributed three times per year in September, January, and June to over 465 diabetes researchers, health professionals, fellows and students, most of whom are affiliated with the University of Toronto. The newsletter highlights upcoming BBDC events, funding opportunities, award results, seminars and more. Current and past issues are available on the BBDC’s website.

BBdc PHarmacy neWsleTTer was launched in 2013 to pharmacists across Canada. The newsletter is a new initiative to update pharmacists and other stakeholders on the latest pharmacy-related knowledge translation and optimizing care efforts ongoing in the Banting & Best Diabetes Centre. Current and past issues are available on the Diabetes Pharmacists Network website.

CONTaCT uS200 Elizabeth Street Eaton Building, 12E248 Toronto, ontario M5G 2C4Canada

Phone: (416) 978-4656E-mail: [email protected] Web: www.bbdc.org

CanaDa’s LeaDing Centre Of exCeLLenCe fOr innOvatiOn in

diabETES rESEarCh, EduCaTiON, aNd CliNiCal CarE


http://www.diabetespharmacistsnetwork.ca/

https://www.facebook.com/pages/Banting-Best-Diabetes-Centre/252936551499941

https://twitter.com/bbdc_uoft

http://www.youtube.com/channel/UCmep4wsch_7a4wtn9K8lTeQ


http://www.bbdc.org


www.bbdc.org

ThE baNTiNg & bEST diabETES CENTrE graTEfully aCkNOwlEdgES ENdOwEd fiNaNCial SuppOrT frOM ThE fOllOwiNg CONTribuTOrSC. H. Best Memorial FundThe Estate of Reuben &

Helene DennisThe Estate of Marion HamiltonThe Estate of Miriam NeverenThe Estate of Dr. & Mrs.

Edward A. Sellers

The Estate of Mary E. SharpThe Estate of Archie Sopman

(Toronto General & Western Hospital Foundation)

The Estate of Arthur SpoerriNovo NordiskMr. Stephen Yow Mok Shing

ThE CENTrE iS alSO graTEful TO ThE fOllOwiNg fOr CONTribuTiONS MadE bETwEEN July 2014 aNd JuNE 2015AbbottAstraZeneca CanadaCanadian Institutes of Health ResearchEli Lilly/ Boehringer-Ingelheim

Diabetes AllianceGlaxoSmithKlineJanssen Inc.LifeScanMedtronicMerck Canada Inc.Novo Nordisk

RocheSanofi DiabetesSun Life FinancialToronto General & Western

Hospital FoundationUnited Way of Greater TorontoUniversity Health Network

Individuals who have donated to the Banting & Best Diabetes Centre this past year.

ThE bbdC graTEfully aCkNOwlEdgES ThE SuppOrT Of Our MaJOr CONTribuTOrS

BBDCSuppOrTErS

" nO singLe event in the histOry Of MeDiCine haD

ChaNgEd ThE liVES Of SO MaNy PeOPLe, sO sUDDenLy." – Stephen Hume

We Would like To exPress our graTiTude and aPPreciaTion To THe FolloWing

our Training and Research Excel-lence Committee and our Continuing Health Education & Professional De-velopment Committee who volunteer their time to review applications and organize educational events on behalf of the BBDC.

The members of our Executive Committee, Discovery Research Steer-ing Committee, and Applied Research Steering Committee.

Dr. Cristina Nostro for coordinating our 2015 Charles Hollenberg Summer Studentship Program.

Drs. Khosrow Adeli, Richard Bazinet, Alan Bocking, Arun Chocka-lingam, Elena Comelli, Michael Domanski, George Fantus, Tianru Jin, Armand Keating, Ren-ke Li, Lorraine Lipscombe, Peter Liu, Muhammad Mamdani, Justin Nodwell, Rémi Rabasa-Lhoret, Paula Rochon, Robert Rosenson, Michael Sefton, and Minna Woo, for providing scientific reviews for various BBDC funding programs this past year.

Dr. Alison Buchan and the Faculty of Medicine Research office for coordina-tor the $1M Transformational Team Grant letters of intent review process.

Everyone who participated in the 1st BBDC-Joslin Diabetes Center Confer-ence, the 26th Annual Scientific Day, and Diabetes Update 2015.

Everyone who contributed to the production of the English and French versions of the Guidebook for Pharma-cists on Diabetes Management.

our fundraisers: Shauna Seabrook (Toronto General & Western Hospital Foundation), and Christopher Adamson (University of Toronto Advancement)

aCkNOwlEdgEMENTS

Banting & Best DiaBetes Centre42

BBDCBanting & Best DiaBetes Centre

Banting & Best Diabetes CentreUNIVERSITY OF TORONTO

banting & best diabetes centre · 6 banting & best diabetes centre 2014-2015 annual report...

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