Lecture 8

Section B (Week 2): Environmental and Chemical Triggers of Immune System Function and Dysfunction

6. How does the environment affect our immune system function?7. Effects of Diet on the immune system?8. What can we do to boost the function of our immune system – clinically proven and homeopathic approaches?9. Plagues, epidemics, pandemics – how have these events influenced our knowledge of the immune system? Examples will be the Black Plague, Cholera, Leprosy, Spanish Flu, H1N1, SARS10. Treating immune disorders - the joys and pitfalls of the Pharmaceutical Industry.

Vitamins

Vitamins

Commercial Products…

Clinical suggestions…gene therapy

http://www.majordifferences.com/2013/10/gene-augmentation-vs-corrective-gene.html#.Vy__v4SDGko

Clinical suggestions…isolation

The disorder -- severe combined immunodeficiency (SCID) -- compromises the immune system so severely that children can't fight off normally innocuous infection

http://www.cosmostv.org/2011/08/bubble-boy-kids-living-normally-after.html

Clinical suggestions…bone marrow transplantation

http://www.slideshare.net/safehealthtrip/bone-marrow-transplant-39916801

Clinical suggestions…bone marrow transplantation

http://www.drugs.com/health-guide/bone-marrow-transplant.html

Clinical suggestions…use of biologics

https://en.wikipedia.org/wiki/Infliximab

Beinke S. et al, Biochem J. 382, 393, 2004

Signaling or Cellular Communication Sequence in Innate Immunity

IKK

IKK, IB kinase

InhibitorKinase activator

Transcription Factor

TLR ligand (eg, LPS) or TNFReceptor Outside

Inside

Clinical suggestions…use of biologics

http://www.nature.com/nrrheum/journal/v7/n11/full/nrrheum.2011.145.html

Anti-TNF antibodies to “soap” TNF cytokine that is causing activeNFB activation and active inflammation

Clinical suggestion…biologics for cancer

http://www.molecularonc.com/mor/mor010106.html

Dr. Dennis SlamonPublic Lecture on May 24 at 7 pmAt Bernard Snell Hall

Movie, Living Proof atGarneau at 730 on May 17th

Q&A to follow

Type in on google“crina ualberta”

Clinical suggestion…small molecule inhibitors

http://www.bloodjournal.org/content/124/20/3040?sso-checked=true

Homeopath or alternative medicine…

Homeopathy, or homeopathic medicine, is a medical philosophy and practice based on the idea that the body has the ability to heal itself. Dates back to Hippocrates in 400 BC to treat mental illness with mandrake root

Homeopathy believes that instead of trying to attack a specific problem, another strategy to re-establish health is to attempt to stimulate a person's own immune and defense system

Homeopath suggestions…

http://www.healthyfoodadvice.net/home-remedies-that-boost-immunity/

Vitamins

http://www.celestialhealing.net/internalhealth/10_Herbs_That_Heal.htm

10 ways to boost the immune system in kids

Almonds are packed with vitamin E and manganese, a strong immune-boosting duo that both enhance natural killer cell activity

Berries are full of antioxidants, which help your body fight oxidative stress caused by free radicals

Yogurt - low sugar ones with probiotics can stimulate your immune system

Salmon is rich in omega 3 fats. Not only are these fats essential for developing brains, they also reduce inflammation, which increases airflow and protects the lungs from colds and respiratory infections

Eggs - have naturally occurring vitamin D and other immune-boosting nutrients, such as B vitamins and selenium

Broccoli is a nutritional powerhouse with a number of immune system boosters, including vitamins C, A, and E and a number of antioxidants

10 ways to boost the immune system in kids

Spinach is full of many of the vitamins and minerals that boost our immune systems including vitamin A, E, C, and K, folate, manganese, zinc, selenium, and iron.

Sweet potatoes are high in beta-carotene that can increase the number of white blood cells and the activity of killer cells. Sweet potatoes are also a great source of vitamin C, which is another immune system enhancer.

Pumpkin, sunflower, and flax seeds can boost their immune systems, a source of vitamin E, zinc, and omega 3 fatty acids, all of which help your immune system.

Oats contain beta glucans, a component of fiber that activates killer cells. These are the cells that fight bacteria, viruses, and other intruders in our bodies.

Homeopath suggestions…targets for

Omega-3 Fatty Acids - Fish oils, seafood, walnuts, flax seeds and most nuts

Folic Acid - in vitamin B9, broccoli, spinach, beans, lentils

Uric acid (Arthritis, bone metastasis) – Ginger helps reduce uric acid build up

NFB - Curcumin/turmeric in indian curries & resveratrol [in grapes, plums and wine)

NFB – Green tea contains an active polyphenol that inhibits the activities of IL-1

http://www.searchhomeremedy.com/herbal-remedies-for-arthritis-pain/

Homeopath suggestions…vitamins

http://blog.naturalhealthyconcepts.com/2013/07/23/the-immune-boosting-power-of-vitamin-c/

Homeopath suggestions…vitamins

http://www.nature.com/bonekey/knowledgeenvironment/2011/1104/bonekey20110505/full/bonekey20110505.html

Vitamin D

Vitamin A supports by retaining moisture in mucous linings of mouth, throat, nose and other body parts.

Vitamin E (IL-2 production)

Vitamin B9 (Folic Acid)

A balanced immune system…