bacterial infections zora dubská department of dermatovenereology of 3rd faculty of medicine and...
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Bacterial infectionsBacterial infectionsZora DubskáZora Dubská
Department of Department of Dermatovenereology of 3rd Faculty of Medicine and Faculty Dermatovenereology of 3rd Faculty of Medicine and Faculty Hospital Kralovske Vinohrady in PragueHospital Kralovske Vinohrady in Prague
Head: Prof. Petr Arenberger, MD, MBAHead: Prof. Petr Arenberger, MD, MBA
Bacterial skin infections
- Pyoderma
- Skin infections caused by corynebacteria
- Mycobacteria
- Borreliosis
- Anthropozoonoses
- Actinomycosis
Pyoderma
- Bacterial infection of skin caused by pyogenic cocci
- Staphylococcus aureus
- Beta hemolytic streptococcus group A
- Pyoderma bound to follicles
- Pyoderma bound to sweat glands
- Superficial pyoderma
- Deep pyoderma
Pyoderma bound to follicles
- Purulent inflammation of hair follicles and hairballs
- Frequent infections (shaving, friction with clothing)
- Most Staphylococcus aureus - coagulase - vertical spread
Folliculitis - purulent inflammation of the follicle - 2 forms - Folliculitis simplex disseminata - Folliculitis barbae
Folliculitis - therapy
- ATB solutions (erythromycin, clindamycin)
- Disinfecting solutions containing iodine or salicylic acid
- Systemic ATB according to the sensitivity
Furunculus
- Follicular skin abscesses that arise from folliculitis
or primarily
- Neck, axilla, buttocks, groins
- Hot and humid environment, obesity, hyperhidrosis,
diabetes mellitus, malnutrition, HIV immunodeficiency
- Follicular pustule followed by erythematosus painful bump with a central yellowish pin
- Lymphadenopathy, fever
Carbunculus
- Merging several neighboring furunculi
- Extensive hump, which is emptied with several fistulas
- Neck
- Fever
- Leukocytosis
- Bacteremia
Furunculus - therapy
- Saloxyl
- Systemic antibiotics according to sensitivity
- Ev. incision
- The carbuncle surgical incision required!
Pyoderma bound to sweat glands - Hidradenitis suppurativa axillaris
- Chronic suppurative disease
- Apocrine sweat glands - axilla, perianogenital area
- Inflammatory infiltrates, abscesses, fistulas
- Total excision, systemic retinoids, antibiotics
Pyoderma bound to the nail - paronychia
- Suppurative disease of lateral nail fold
- After injury
- Disinfecting solution – potassium permanganate,
antibiotic ointment
Impetigo- Superficial pyoderma
- Streptococci ( maculovesiculous form )- Staphylococci (bullous form)
- Maculovesiculous form - red macula with vesicles, pustules followed by crust formation
- Bullous form - Bull on erythematous base
followed by red scaling leasions
- Face - nasal entrance
Impetigo - therapy
- Topical treatment with antiseptic solution and antibiotic ointment (mupirocin, a. fusidicum, bacitracin)
- In case of failure of local treatment – systemic atb according
to sensitivity
- Hygiene
- Streptococcus type A - the risk of glomerulonephritis – Urine
Deep pyoderma
- Ecthyma - ulcerative pyoderma in infected excoriations of itching dermatoses
- Erysipelas
- Phlegmona - diffuse spreading infection of the skin,
subcutaneous tissue, along fascia, tendons, muscles
- Necrotising fasciitis - inflammation of deep fascia and soft tissue + systemic response
Erysipelas- Frequent acute infection of the skin and
subcutaneous tissue
- Streptococcus pyogenes
- The spread of infection via lymphatic vessels
– entrance - injuries, interdigital mycosis ..
- Fever up to 40 C, chills- Within few hours in the affected area (mostly legs or face) - sharply bordered erythema
- Skin is warm, painful, edema, lymph nodes swollen
Erysipelas - therapy
- Applied parenteral penicillin (usually procaine benzylpenicillin 10 x 1.5 mil.j.i.m. finished by benzathine benzylpenicillin 1.5 mil.j.i.m.)
- Hypersensitivity to PNC - macrolides (erythromycin) - Lincosamides (clindamycin) - Cephalosporins
- The risk of recurrence and lymphedema
- Prevention of relapse - long-term application of benzathinpenicilin every 2-4 weeks
Staphylococcal scalded skin syndrome - Lyell's syndrome
- A life-threatening disease – systemic response
- Staphylococcus aureus produces exotoxins
- Separation of the upper parts of epidermis - large areas
- Infants and children under 5 years of age - the risk of sepsis,
pneumonia
- Fever, generalized erythematous, macular rash, bullas, leasions, scales, without scarring
- Nikolsky phenomenon of the unafflicted skin- Acantholytic intraepidermal blister of stratum granulosum- Systemic anti- staphylococcal ATB - ad integrum in 2 weeks
Toxic shock syndromes
- Rare shock states with skin symptoms and multiorgan involvement caused by staphylococci and beta-hemolytic streptococci group A ( producing toxins )
- Toxins act as superantigens
- Source - soft tissue infections (streptoc. syndrome)
- Alteration of the general condition, generalized macular rash followed by desquamation of palms and soles after 1-2 weeks, raspberry tongue, erythema, mucosal erosion
- Anti-shock therapy, antibiotics i.v. (antistaphylococcal) streptococcal etiology - PNC, clindamycin, cephalosporins, i.v. immunoglobulins, surgery
Scarlatina - scarlet fever- A streptococcal tonsillitis accompanied by rash
- Children between 3 to 10 years of age - Streptococcus pyogenes group A - beta hemolytic - Pyrogenic exotoxin A
- Entrance – nasopharynx - Within 1-6 days tonsillitis with fever
- Maculopapular rash – goose skin – bending areas of limbs- Face with perioral fading- Petechial enanthema on the palate, raspberry tongue- After 1-2 weeks lamellar scaling of palms, soles
dg.: clinical state, cultivation, leukocytosis in KO
Therapy of scarlatina:
- Isolation
- Parenteral application of Procaine Penicilin G i.m. 3-5 days, finished by application of Benzatinpenicilin i.m., ev. erythromycin, cephalosporins, clindamycin
- Complications - Secondary infection - Rheumatic fever - Glomerulonephritis
Skin infections caused by corynebacteria
- Erythrasma - axilla, groins - Reddish areas with satellite maculas
- Wood's lamp - red fluorescence
- Trichomycosis axillaris - Yellowish deposits on axillary, pubic hair
- Keratoma sulcatum - Pitting of the soles
Mycobacteriosis - cutaneous tuberculosis
- Specific chronic granulomatous inflammation of the skin
- Mycobacterium tuberculosis (BK)
- Histology – caseificating specific granulomas
- Dying with Ziehl - Neelsen method - cultivation
- Tuberculin (Mantoux) test - I.d. application of tuberculin - + induration over 6 mm/72h
Clinical forms of skin tuberculosis
- Primary inoculative tuberculosis - Primary complex - ulcer + regional lymphadenitis
- Tuberculosis verrucosa cutis
- Lupus vulgaris - the most common - vitropression: yellowish brown
colour - Scrophuloderma
- Tuberculosis cutis ulcerosa
- Tuberculosis cutis miliaris
- Tuberculous gumma
Tuberkulidy - Id - reaction - late allergic response to microbial antigens - Recurrent disseminated symmetric
non- infectious rashes as response to hematogenous spread of
mycobacterial antigens to the skin
- Lichen scrophulosorum - Papulonekrotical tuberculid - Erythema induratum (Bazin)
Therapy of cutaneous tuberculosis
- The condition of the patient
- A combination of drugs is needed
- Never less than 6 months of therapy
- Short-term treatment 6-9 months, long 18-24 months
- Main drugs - isoniazid, rifampicin
- Ancillary drugs - streptomycin, pyrazinamide, ethambutol
Atypical mycobacteriosis
- Ulcerative and granulomatous processes (ev. lymphadenitis) caused by other mycobacteria than M. tuberculosis and M. leprae - Granuloma of swimming pools - Mycobacterium marinum - bumps in the area of trauma for 2-3 weeks - lymphadenitis - excision - cryotherapy - ATB
Leprosy
- Chronic granulomatous intracellular infection caused by bacteria Mycobacterium leprae
- The transfer by air from the nasal secretions of persons with
leprosy lepromatosa to the mucous tissue of breathing vessels of susceptible host
- Long incubation period ( from months till 30 years)
- The most common manifestation of the skin and peripheral nerves
- Early stage - leprosy indeterminata- Border forms - tuberculoid leprosy and leprosy lepromatosa- Transient forms - bordeline (dimorphic) leprosy
Diagnostic criteria of leprosy:- Hypopigmented or erythematous leasions with loss
of sensitivity
- Enlarged peripheral nerves
- Acid - resistant rods in skin swabs or biopsy (Ziehl-Neelsen dying ) - cultivation is not possible
+ History, stay in endemic areas
- Therapy - a combination of: - Rifampicin with dapsone or klofazimin - 6 months in TT, BT - 24 months in LL, BL
Borreliosis
- Infection caused by Borrelia burgdorferi sensu lato
- The most common carrier – tick Ixodes ricinus
- Affects the skin, nervous system, joints, heart
- Acute manifestation occurs in the area of the bite after
7-10 days and is sometimes accompanied by non-specific
systemic symptoms
- Erythema chronicum migrans – specific sign
Acrodermatitis chronica atrophicans
- Appears from few years to decades after infection
- Affects skin acral extensor parts of arms and legs
around the joints
- Slight swelling of livid coloured skin
- After regression of edema - skin atrophy
Borreliosis
- Diagnostics - serology (ELISA, Western blot)
- IgM antibodies reach peak between 3rd to 6th week after infection (in ECM often negative)
- Correlation with the clinical state necessary
- Therapy - antibiotics - Doxycycline - Amoxicillin - Cefuroxime axetil - Azithromycin - Ceftriaxone i.v.
Anthropozoonoses
- Diseases caused by microorganisms transferred from animals to humans
- Anthrax - Bacillus anthracis - cattle
- Tularemia - Francisella tularensis - rodents
- Erysipeloid - Erysipelothrix rhusiopathie
- Maleus - Pseudomonas mallei – toed ungulated animals
Erysipeloid
- Acute inflammation of skin of hand fingers
- After injury in people who are in contact with fish,
poultry
- Non-ulcerative painful red-livid hot bearing
in the area of injury after 2-7 days
- Penicilin p.o. 7-10 days, ev. erythromycin
Cat scratch disease
- A rare chronic infection with significant regional lymphadenopathy
- Bartonella henselae
- Papule or vesicle in the area of the scratch after 10 days
- Systemic symptoms
- Regional lymphadenopathy persists 2-6 months
- In most cases benign
Actinomycosis - Chronic granulomatous disease
- Abscesses, fistulas, scars - men
- Fibrous facultative anaerobic bacteria - Actinomyces – G+ - A. Israel - commensals of oropharynx, intestines,
genital - mucosal injury
- Tough inflammatory infiltrates with elevated edges, fistulas, ulcers
- Cervicofacial, thoracic, abdominal form
- Microscope - yellow granular bacterial conglomerates
- Therapy - Penicillin G i.v. weeks, surgery