PowerPoint Presentation

1Who we are

*RMS has been rated BB (Stable) by India Ratings and Research Fitch group*RMS financial practices are annually audited by DeloitteReach : National and InternationalInternationally, we have operations in Dubai and Srilanka

Milestones

Stem Cell BankingThe magic of regeneration has always been seen in nature. We humans are discovering its powers NOW!

Regeneration can be seen perfectly in sea cucumbers. Their bodies can grow up to three feet long and if cut into pieces, each piece can REGROW into a new sea cucumber.

The White-tailed deer can REGROW their antlers and this is the most extreme example of regeneration!Lizards have the ability to REGROW their tail within nine months.

The starfish have the ability to REGROW their arms and sometimes their whole bodies. Even if the critter is down to one arm, as long as it has its central nerve ring intact, it can grow into an entirely new starfish.The human body has so much to offer, we are exploring its capacity to the best!What are these magical cells?Basic unit of life

Stem cells are the body's raw material from which all other cells with specialized functions are generated.

How amazing is it that life begins with a single cell! Where do we find them?Umbilical Cord BloodUmbilical Cord TissueBone MarrowPeripheral BloodOther sources under researchDental PulpAdipose Tissue (Fat)Embryo

Disease statisticsWorldwide, the annual number of new cases of childhood cancer exceeds 200,000 and more than 80% of these are from the developing world.Every year around 32,000 children with Thalassemia are born in IndiaApproximately 8,000 cases (4,400 males and 3,820 females) of Hodgkin's Lymphoma are detected per year. In India, 21% of all Hodgkins disease was seen in children with a marked male female ratio of 5.5:1Each year approximately 300,000 children are born with sickle cell anaemia or one of its variants and nearly 80 per cent of these births occur in poor socio-economic countries

References: http://www.indianjcancer.com/article.asp?issn=0019-509X;year=2009;volume=46;issue=4;spage=264;epage=273;aulast=Arora2. http://jcnh.in/download/isse1/3.%20Amrita%20Panja.pdf3. http://www.lymphomainfo.net/hodgkins/incidence.html4. Piel FB, Patil AP, Howes RE, Nyangiri OA, Gething PW, Williams TN, et al. Global distribution of the sickle cell gene and geographical confirmation of the malaria hypothesis.Nat Commun.2010;1:104.[PMC free article][PubMed]

PM Narendra Modi speaking about stem cellsPM Narendra Modi visited the Stem Cell Research facility at Japan in Sep 2014.He had a conversation with Shinya Yamanaka, Japans stem cell pioneer and a 2012 Nobel Prize winnerSpoke about concerns regarding the prevalence of sickle cell anaemia among IndiansAlong with Shinya Yamanaka, Hon PM Narendra Modi discussed about remedy for sickle cell anaemia through stem cells

Indian PM Narendra Modi (R) speaking to Japanese Nobel Prize-winning stem cell researcher Shinya Yamanaka (L)Click here to read more Umbilical Cord Stem Cells and upcoming usesAcquired Hearing Loss : 63 million people in India suffer of acquired hearing lossCerebral Palsy: In India, it is estimated at around 3 cases per 1000 live births. Congenital Heart Disease : Every year 78,000 infants born with congenital heart disease in India dieJuvenile Diabetes: India is home to an estimated 97,700 children with Type 1Diabetes MellitusPediatric Stroke: Prevalence of stroke in India range from 44 to 843 per 100,000 population. Traumatic Brain Injury: 1.5 2million persons are injured and 1million die every year in India.Autism : India is home to about 10million people with autism.

In a landmark decision, approval given by U.S. FDA for the following diseases. Approvals expected for commercial use as early as 2017

Umbilical Cord BloodUmbilical Cord TissueTissue of the umbilical cord (not the blood inside it)Contains Mesenchymal Stem Cells. These have the ability to regenerate tissue, nerve cells and damaged organs.Repairs bone, cartilage and connective tissue. Future treatment may include spinal cord injuries and strokesFirst clinical trial - 1995 Is now being researched and explored with over 200 clinical trials under way (globally)Blood that flows in the umbilical cord and placentaContains Hematopoietic Stem Cells. These have the ability to regenerate all types of blood cells.Treats blood related diseases and cancers such as leukemia, anemia, thalassemia and autoimmune disorders.First case - 1988 Is now being used to treat over 80 blood related diseases with 30,000 successful transplants (globally)

Why should we preserve Umbilical Cord Stem Cells when other sources are available?Cell Concentration is almost 10%-20% higher than other sources.Faster differentiation and multiplication potential since they are immature cells unlike adult stem cells from other sources.Less prone to rejection as they have less developed features.Preserved only for your familys use and no queuing to find a matching donor.Requires only a 4/6 match

Case study: Stanford professor dies after long search for bone marrow donorCord Blood Transplantation Success StoryThe first successful cord blood transplant was done on Matthew farrow

Click here to read the success storyObstetrician from UK with leukemia is helped by cord blood transplantDavid Hall, 66, from UK, spent 33 years delivering babies and clamping umbilical cords, which became the source of his second chance at life.

Click here to read the success storyIn 1988, Matthew, a 6 year old then, was diagnosed of Fanconi Anaemia. Today, 26 years later, Matthew Farrow is alive and the lucky recipient of the worlds first cord blood transplant.

India's first Cord Blood transplantation was for Acute Lymphoblastic Leukemia (ALL) at Tata Memorial Hospital in 1996, followed by many more

A child from Mumbai, Thane becomes the first patient in India to be cured of thalassemia in 2008

Rishi Bhanushali, a thalassemic major child from Kutch, Gujarat, gets treated in 2009

1000 Cord blood transfusions were done in India

Hospitals performing Umbilical Cord Blood Stem Cell transplants in India

Transplant Specialist Panel Sr.no.Transplant specialistsHospital1. Dr Sandip Shah Gujarat Cancer Research Institute, Ahmedabad 2. Dr. Revathi RajApollo Hospital, Chennai3. Dr. Vijay RamananRuby Hall Clinic, PuneDr. Adwaita A Gore1. Prince Aly Khan Hospital, Mazgaon42. Kohinoor Hospital, Kurla5Dr. Niranjan RathodKokilaben Hospital, Mumbai6Dr. Tapan SaikiaKokilaben Hospital, MumbaiDr. Suparno ChakrabartiDharamshila Hospital, Delhi78Dr. Rahul NaithaniMax Super speciality Hospital, New Delhi9Dr. Neeraj SidharthanAmrita Institute of Medical Sciences, KeralaDr. Rahul Bhargava10Artemis Hospital, Gurgaon11Dr. Mahesh RajashekaraiahBGS Global Hospital, BangaloreDr.Indranil Ghosh12Apollo Hospital, KolkataDr. Gaurav Kharya13BLK Super Speciality Hospital, New DelhiDr. Suresth Advani14 Jaslok HospitalDr. Dharma ChoudharyBLK Super Speciality Hospital, New Delhi15Dr. Ashish Dixit16Manipal Hospital, BangaloreDr.Kannan Subramanian17Sahaydri Hospital, PuneDr Mammen Chandy18Tata Medical Centre, KolkataDr. Sunil Parekh19Bombay Hospital, Mumbai20Dr.Abhay A. BhaveLilavati Hospital and Research Centre

Dr. Vijay Ramanan, PuneStem cells can be used to treat 80 blood disorders and many more in near future. Babycell is an institution which you can approach for your needs for stem cell purposeDoctors SpeakPast president: Federation of Obstetric and Gynaecological Societies of India(FOGSI)

Stem cell preservation is a smart, affordable, and simple way of ensuring a good life and hope of saving your loved ones from health related problems in future. Umbilical Cord Blood Banking is the most optimum solution available to mankind today!Dr. Suchitra Pandit, MumbaiDr. Nayna Patel, Anand

Doctor speaks

Babycell services are excellent. They come on time for deliveries. Stem cell banking is very useful for your future family health.

Dr. G. Sudha Rani, Hyderabad

Best services are provided by your team and also patients are satisfied.

Dr. B. Usha Rani, Hyderabad

Meet and ReceiveFill up the health questionnaire, personal details, understand the Client Benefits and sign up!Receive Collection Kit and follow instructions mentioned on it.On the day of delivery, carry kit and call us to arrange the collection and transportation.

Collect and TransportIn case you have opted for our phlebotomist, they will collect the sample and hand over to our logistics partner.A special cold chain arrangement with TNT is available 24 x 7 x 365 which handles our biological samplesTemperature validated kits for 72 hoursNo X-Ray Certificate

Data logger report

Data logger

Preserve and RetrieveStrategically located CPC in non-seismic, flood-proof and non-polluting environmentOn-site engineering team monitors sample to ensure temperature, humidity and pressure maintenance 24 x 7 x 365Adherence to strict guidelines as per GMP, GCP, GLP, FDA, DCGI and ISO; entry permissible only to authorized personnel Stainless steel construction, fire proof storage area, systems designed to sustain power cutGlobal shipment to any doctor centre using cryoshipper

Take a tour of our Cell Processing CentreTM right now!

View certificates

Cord Blood Processing

Babycell uses Double sedimentation spin (DSS) technologyCord Tissue Processing

Cord Collection KitUmbilical Cord is processed and segmented into small pieces.Cells obtained from enzymatic digestion of Umbilical Cord Tissue are transferred into several cryovials

The cells are frozen in the controlled-rate freezer, where the temperature is lowered gradually to optimize preservation of stem cells.After the controlled-rate freezing process, the cryovials are transferred for long term cryopreservation at -196C.Isolation of UCT to give Whole Cell Population (WCP) including MSCs, Epithelial cells and fibroblasts

Exclusive TestsTotal nucleated cell countTotal mononuclear cell countTotal CD 34+ stem cell countCD 34+ Stem cell viabilitySterility testingColony forming unit (CFU) test for stem cellsBlood groupingInfectious disease testing (HIV 1&2, HBsAg, Anti HBC, HCV, HTLV 1&2, CMVIgG, CMVIgM, Syphilis and malaria)Maternal Blood TestTests for Cord Tissue Cell count, cell viability, sterility testing and quality visual check(Babycell is the only cord blood bank that performs this test at the time of preservation. All accreditation authorities endorse CFU and strongly recommend it at the time of preservation and not retrieval)

Colony Forming Unit Assay (CFU)Standardized Milk - 4.5% Fat ContentWhole Milk - 3.25% Fat ContentReduced Fat Milk - 2% Fat ContentLow Fat Milk - 1% Fat ContentSkimmed Milk - 0.5% Fat Content

CFU VideoPower of 10

A to Z Services

Babycell Processing Technology is superior to any other banks & the value added services like CFU, HLA Typing, and personalized ANC/PNC sessions are second to none. Thanks Babycell!! Speaking about CFU and HLASpeaking about their visit to Babycell CPCTMSpeaking about LogisticsSpeaking about New born screening

Mr. and Mrs. Bhanushali (Mumbai)

Mr. and Mrs. Mulchandani (Mumbai) One of the most important factors to choose Babycell was that their storage facility is close to our city and they had the confidence to invite us to visit the lab to see their operations if we wished. We availed of their services for both our children and have been extremely satisfied till date!

Mr. and Mrs. Saini (Kota) The experience that we had with Babycell, at every phase was superior, like the presentation, coordination done at the time of collection and post sales services. They have worked extremely hard to help us to know the minutest details of the concept.

Mr. and Mrs. Anand One of the best things about Babycell is their post sales services like the New born screening test that they had provided for our new born babies, Aamya and Avin. The online post-natal sessions for mothers were helpful too. We can completely rely on Babycell for any advice in the future!! Thank you Babycell.Client testimonialsIn our case the delivery happened 5 weeks prior to the predicted date! Babycell exceeded our expectations, with the staff (Rajeshwari) immediately arriving at the hospital and staying all night waiting for the delivery. She left only after she had completed the collection of the cord. We are extremely happy and grateful to Babycell.Speaking about on time collectionSpeaking about easy plansSpeaking about entire processDuring the birth of my first child, I wasnt very sure about the benefits of stem cell banking, but during my second childs birth, I had enough wisdom and the awareness of the benefits of the banking. When I bought this from Babycell, in my view at that point in time, the offer from Babycell was best in comparison to the other companies.Babycell is reputed and professional and most important part for middle class people like us. It was affordable and the instalment scheme helped us preserve the babys stem cells as per our needs.Staying away from India and delivering baby was not an easy decision, whereas collecting stem cell and storing back in India was only in our dreams. With the Babycell overall service from the case owner, supervisor, logistics shipment, delivery, storing and testing cell the entire process were Just in time (JIT) process 100%.Client testimonials

Mr. and Mrs. Rajaram Kannan (Hyderabad)

Mrs. Sejal Bhavesh Malde, Thane

Mr & Mrs. Sajid Golandaz, Mumbai

Mr. & Mrs. BilwaSpeaking about Babycell vis a vis competition CSR ACTIVITIESSibling ProgramBabycells Sibling Program caters to expecting parentswho have a child that is diagnosed with a treatablehaematological condition. If assessed to be curable withhaematopoietic stem cell transplant, then Babycell willprovide cord blood collection, processing and storagecompletely free of cost for 5 years for the upcoming babyalong with financial support up to 5Lacs

So far we have registered 15+ clients under our Sibling Program

Donation to CARFBabycell has extended a helping hand to the cancerpatients by contributing towards the cancer aidand research foundation through every enrolment.

Go Green initiativeThis was an initiative with Mumbai Obstetric and Gynecology Society to make a positive contribution to the environment starting at our facility in Lonavla.

Spreading a smileThe objective of this program is to restore the normal development and active life of children born with cleft lip & palate. The CSR wing of RMS started to treat children with our innovative Tissue Engineered Collagen product free of cost.

https://www.youtube.com/watch?v=74s35emlwRU

In the News!Click to view published articles ofBabycell Regrow

Indications:TraumaDisease ConditionInjury

Caused to the Cartilage in JointsKneeAnkleShoulderPrevents the progress to Osteoarthritis

Defected CartilageCHONDRONImplantation Complete Regeneration of Natural CartilageRegrow Your Cells. Rebuild Your Life.Cell Therapy Cartilage Implantation

Click here to view Chondron videoCase 1 (30/M, OCD)

Case 2 (25/M, OCD)Case 3 (41/F, Osteochondral Injury)

Relook ArthroscopyIntra-op DefectPre-op MRIIntra-op DefectChondron Implant setRelook ArthroscopyPost op recoveryChondron Implant setCartilage Defect

Case study: Indications:Avascular NecrosisNon-union FracturesFibrous DisplasiaBone Cyst/ CavityFacial/ Oral Bone Gaps and Defects

Natural Alternate to Total Hip Replacement and Total Knee ReplacementBone Gap OSSRONImplantation Complete Regeneration of Natural BoneRegrow Your Cells. Rebuild Your Life.

Cell Therapy Bone Implantation

Click here to view the Ossron videoCase 1 (58/F, Non-union)Case 2 (37/M, AVN)Post-op MRIIntra-op DefectPre-op MRI

Pre-op MRIPost-op MRI

Case 3 (48/M, Maxillofacial)Case 4 (38/M, Mandibular primordial cyst)Post-op MRIOssron ImplantationPre-op MRIIntra-op defectPre-op MRIPost-op MRI

Cell Therapy Skin Regeneration

Regrow Your Cells. Rebuild Your Life.Burns THERAFORMApplication Complete Regeneration of Natural SkinDiabetic Foot UlcersMaxillofacial Cleft palate (roof of mouth)- Birth defect

ServicesCord Blood CollectionCord Tissue CollectionColony unit forming assay (CFU)HLA testingTesting, Processing, Preservation and Retrieval for 21 yearsGlobal ShipmentTransplant SpecialistNew Born ScreeningFathers Wellness Check Up Mummy & Tummy (Pre and Post Natal Care Sessions)

Babycells Additional SupportRegrow Health Cover (clause 8.1)Loyalty Privilege (clause 8.2)Quality Assurance (clause 8.3)Philanthropy Programme (clause 8.4)Life Cover (clause 8.10)Right of Money Back (clause 8.11)Sibling Program (clause 8.5)Stem cell expansion as prescribed by transplant physician (clause 8.8)Collect and transport assist (clause 8.6)Stem cell xpert programme (clause 8.9)Tailor-made Package

For those who want more!Babycell BiocordHaemoglobinopathy testHLA typingHLA cross matchingFull body screeningNew Born ScreeningColony Forming UnitGift hamperData Logger facilityMaternity photo shootHome session for ante-natal careHome session for post natal careQuality Assurance upto 30 LacsPhilanthropy program upto 30 LacsOne Treatment Free under Regrow Health Cover

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