azaindoles - alexanian lab | homealexanian.chem.unc.edu/img/seminars/tonyazaindoles.pdf ·...
TRANSCRIPT
![Page 1: Azaindoles - Alexanian Lab | Homealexanian.chem.unc.edu/img/Seminars/TonyAzaindoles.pdf · 2015-11-04 · What are Azaindoles? • Indole bioisostere • Not prevalent in nature •](https://reader035.vdocuments.us/reader035/viewer/2022070800/5f023b4f7e708231d4033afe/html5/thumbnails/1.jpg)
Azaindoles
Anthony CarestiaGroup Meeting Presentation
![Page 2: Azaindoles - Alexanian Lab | Homealexanian.chem.unc.edu/img/Seminars/TonyAzaindoles.pdf · 2015-11-04 · What are Azaindoles? • Indole bioisostere • Not prevalent in nature •](https://reader035.vdocuments.us/reader035/viewer/2022070800/5f023b4f7e708231d4033afe/html5/thumbnails/2.jpg)
What are Azaindoles?
• Indole bioisostere
• Not prevalent in nature
• 7-azaindole is the most common• Uses as organometallic ligand
• Interesting photophysical properties
• Kinase Inhibitors
Heterocyclic Chemistry, Fifth Edition, 2010Chem. Rev. 2009, 109, 3080–3098Molecules 2014, 19, 19935-19979
Kinase
ATP
![Page 3: Azaindoles - Alexanian Lab | Homealexanian.chem.unc.edu/img/Seminars/TonyAzaindoles.pdf · 2015-11-04 · What are Azaindoles? • Indole bioisostere • Not prevalent in nature •](https://reader035.vdocuments.us/reader035/viewer/2022070800/5f023b4f7e708231d4033afe/html5/thumbnails/3.jpg)
Retrosynthetic Analysis
![Page 4: Azaindoles - Alexanian Lab | Homealexanian.chem.unc.edu/img/Seminars/TonyAzaindoles.pdf · 2015-11-04 · What are Azaindoles? • Indole bioisostere • Not prevalent in nature •](https://reader035.vdocuments.us/reader035/viewer/2022070800/5f023b4f7e708231d4033afe/html5/thumbnails/4.jpg)
N1-C2 Bond Forming Reactions• Modified Reissert Synthesis
• Modified Batcho-Leimbgruber Synthesis
Arkivoc, 2004, v, 286-300Bioorg. Med. Chem. Lett. 2005, 15, 977-982
![Page 5: Azaindoles - Alexanian Lab | Homealexanian.chem.unc.edu/img/Seminars/TonyAzaindoles.pdf · 2015-11-04 · What are Azaindoles? • Indole bioisostere • Not prevalent in nature •](https://reader035.vdocuments.us/reader035/viewer/2022070800/5f023b4f7e708231d4033afe/html5/thumbnails/5.jpg)
Eli Lily’s Synthesis of 5-HT1 Receptor Agonists
• 5-HT1 receptor agonist
• Anti-migrane compounds
• Exhibit undesired side effects
J. Med. Chem. 2003, 46, 3060-3071
![Page 6: Azaindoles - Alexanian Lab | Homealexanian.chem.unc.edu/img/Seminars/TonyAzaindoles.pdf · 2015-11-04 · What are Azaindoles? • Indole bioisostere • Not prevalent in nature •](https://reader035.vdocuments.us/reader035/viewer/2022070800/5f023b4f7e708231d4033afe/html5/thumbnails/6.jpg)
N1-C2 Bond Forming Reactions• Lithiation of methylamino pyridines
• Lithiation to form the N1-Pyridine Bond
Chem. Soc. Rev., 2007, 36, 1120–1132
![Page 7: Azaindoles - Alexanian Lab | Homealexanian.chem.unc.edu/img/Seminars/TonyAzaindoles.pdf · 2015-11-04 · What are Azaindoles? • Indole bioisostere • Not prevalent in nature •](https://reader035.vdocuments.us/reader035/viewer/2022070800/5f023b4f7e708231d4033afe/html5/thumbnails/7.jpg)
Retrosynthetic Analysis
![Page 8: Azaindoles - Alexanian Lab | Homealexanian.chem.unc.edu/img/Seminars/TonyAzaindoles.pdf · 2015-11-04 · What are Azaindoles? • Indole bioisostere • Not prevalent in nature •](https://reader035.vdocuments.us/reader035/viewer/2022070800/5f023b4f7e708231d4033afe/html5/thumbnails/8.jpg)
N1-Pyridine Bond Forming Reactions• Modified Hemetsberger-Knittel Synthesis
• Scope of pyridyl substitution
Synthesis 2005, 16, 2751–2757
![Page 9: Azaindoles - Alexanian Lab | Homealexanian.chem.unc.edu/img/Seminars/TonyAzaindoles.pdf · 2015-11-04 · What are Azaindoles? • Indole bioisostere • Not prevalent in nature •](https://reader035.vdocuments.us/reader035/viewer/2022070800/5f023b4f7e708231d4033afe/html5/thumbnails/9.jpg)
Total Synthesis of Variolin B
Chem. Rev. 2009, 109, 3080–3098
![Page 10: Azaindoles - Alexanian Lab | Homealexanian.chem.unc.edu/img/Seminars/TonyAzaindoles.pdf · 2015-11-04 · What are Azaindoles? • Indole bioisostere • Not prevalent in nature •](https://reader035.vdocuments.us/reader035/viewer/2022070800/5f023b4f7e708231d4033afe/html5/thumbnails/10.jpg)
Retrosynthetic Analysis
![Page 11: Azaindoles - Alexanian Lab | Homealexanian.chem.unc.edu/img/Seminars/TonyAzaindoles.pdf · 2015-11-04 · What are Azaindoles? • Indole bioisostere • Not prevalent in nature •](https://reader035.vdocuments.us/reader035/viewer/2022070800/5f023b4f7e708231d4033afe/html5/thumbnails/11.jpg)
Building the Pyridine Ring• Ruthenium cycloisomerization
• Combinatorial approach
J. Am. Chem. Soc. 2006, 128, 4592-4593ACS Comb. Sci. 2012, 14, 434−441
![Page 12: Azaindoles - Alexanian Lab | Homealexanian.chem.unc.edu/img/Seminars/TonyAzaindoles.pdf · 2015-11-04 · What are Azaindoles? • Indole bioisostere • Not prevalent in nature •](https://reader035.vdocuments.us/reader035/viewer/2022070800/5f023b4f7e708231d4033afe/html5/thumbnails/12.jpg)
Building the Pyridine Ring• Ruthenium cycloisomerization
• Combinatorial approach
• 22 aldehyde• 4 aminopyrroles• Yields range from 22-97%• 65 different examples
J. Am. Chem. Soc. 2006, 128, 4592-4593ACS Comb. Sci. 2012, 14, 434−441
![Page 13: Azaindoles - Alexanian Lab | Homealexanian.chem.unc.edu/img/Seminars/TonyAzaindoles.pdf · 2015-11-04 · What are Azaindoles? • Indole bioisostere • Not prevalent in nature •](https://reader035.vdocuments.us/reader035/viewer/2022070800/5f023b4f7e708231d4033afe/html5/thumbnails/13.jpg)
Retrosynthetic Analysis
![Page 14: Azaindoles - Alexanian Lab | Homealexanian.chem.unc.edu/img/Seminars/TonyAzaindoles.pdf · 2015-11-04 · What are Azaindoles? • Indole bioisostere • Not prevalent in nature •](https://reader035.vdocuments.us/reader035/viewer/2022070800/5f023b4f7e708231d4033afe/html5/thumbnails/14.jpg)
Azaindoles from Alkynes
• Tandem Sonogashira-Cyclization
Chem. Soc. Rev., 2007, 36, 1120–1132
![Page 15: Azaindoles - Alexanian Lab | Homealexanian.chem.unc.edu/img/Seminars/TonyAzaindoles.pdf · 2015-11-04 · What are Azaindoles? • Indole bioisostere • Not prevalent in nature •](https://reader035.vdocuments.us/reader035/viewer/2022070800/5f023b4f7e708231d4033afe/html5/thumbnails/15.jpg)
Alkyne Cyclization to Form Azaindoles• Base mediated cyclization
• Electrophile mediated cyclization
• Amino-palladation cyclization
Synlett, 2005, 20, 3121Tetrahedron Lett., 2004, 45, 539J. Comb. Chem., 2005, 7, 510
![Page 16: Azaindoles - Alexanian Lab | Homealexanian.chem.unc.edu/img/Seminars/TonyAzaindoles.pdf · 2015-11-04 · What are Azaindoles? • Indole bioisostere • Not prevalent in nature •](https://reader035.vdocuments.us/reader035/viewer/2022070800/5f023b4f7e708231d4033afe/html5/thumbnails/16.jpg)
Larock Heteroannulations• Larock Heteroannulation Mechanism
• First heteroannulation to form azaindoles
• Higher yields are attained with LiCl additives
Tetrahedron Lett., 1993, 34, 2823Tetrahedron Lett., 1998, 39, 627
![Page 17: Azaindoles - Alexanian Lab | Homealexanian.chem.unc.edu/img/Seminars/TonyAzaindoles.pdf · 2015-11-04 · What are Azaindoles? • Indole bioisostere • Not prevalent in nature •](https://reader035.vdocuments.us/reader035/viewer/2022070800/5f023b4f7e708231d4033afe/html5/thumbnails/17.jpg)
Merck’s Synthesis of GnRH Antagonists• 7-azaindole GnRH antagonist
• 6-azaindole GnRH antagonist
Tetrahedron Lett., 2001, 42, 6441-6445
![Page 18: Azaindoles - Alexanian Lab | Homealexanian.chem.unc.edu/img/Seminars/TonyAzaindoles.pdf · 2015-11-04 · What are Azaindoles? • Indole bioisostere • Not prevalent in nature •](https://reader035.vdocuments.us/reader035/viewer/2022070800/5f023b4f7e708231d4033afe/html5/thumbnails/18.jpg)
Conclusions• Azaindole cores are interesting motifs found in man-made biologically active compounds
• There’s not one best method for making azaindoles
• Reissert and Batcho-Leimgruber are the most common
• Larock Heteroannulation seems the most versatile
• Building off pyrrole core is very underrepresented