avian influenza (highly pathogenic) - universitas...
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Avian Influenza (Highly Pathogenic)
Fowl plague, Fowl pest, Brunswick bird plague,Fowl disease, Fowl or bird grippe
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Center for Food Security and Public Health
Iowa State University - Oct 2005
Overview
• Organism
• Economic Impact
• Epidemiology
• Transmission
• Clinical Signs
• Diagnosis and Treatment
• Prevention and Control
• Actions to take
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The Organism
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Center for Food Security and Public Health
Iowa State University - Oct 2005
Influenza Virus
• Family Orthomyxoviridae
• Three main types
−Type A
Multiple species
−Type B Humans
−Type C Humans and swine
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Center for Food Security and Public Health
Iowa State University - Oct 2005
Influenza A
• Multiple species
−Humans
−Avian Influenza
• Most virulent group
• Classification by surface antigensinto subtypes
−Hemagglutinin (H or HA)
−Neuraminidase (N or NA)
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Center for Food Security and Public Health
Iowa State University - Oct 2005
Surface Antigens and Subtypes
• 15 HA and 9 NA for influenza A
−All in aquatic birds
• Hemagglutinin (HA)
−Function: Sites for attachment to infect host cells
• Neuraminidase (NA)
−Function: Remove neuraminic acid from mucin and release from cell
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Center for Food Security and Public Health
Iowa State University - Oct 2005
Influenza A
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Center for Food Security and Public Health
Iowa State University - Oct 2005
Influenza B
• Mostly humans
• Common
• Less severe than A
• Epidemics occur less often than A
• Human seasonal vaccine
−Two strains of type A
−One strain of type B
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Center for Food Security and Public Health
Iowa State University - Oct 2005
Influenza C
• Humans and swine
• Different pattern of surface proteins
• Rare
−Mild to no symptoms
• By age 15, most have antibodies
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Center for Food Security and Public Health
Iowa State University - Oct 2005
Avian Influenza
• Pathogenicity based on genetic features and/or severity of disease in poultry
−Low pathogenic AI (LPAI) H1 to H15 subtypes
−Highly pathogenic AI (HPAI)
Some H5 or H7 subtypes
LPAI H5 or H7 subtypes can mutate into HPAI
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Importance
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Center for Food Security and Public Health
Iowa State University - Oct 2005
History
• 1878: First identified case in Italy
• 1924-25: First U.S. cases
• Low pathogenic avian influenza first identified mid-twentieth century
• 1970’s: Migratory waterfowl carriers
• Outbreaks in mink, seals and whales
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Center for Food Security and Public Health
Iowa State University - Oct 2005
Economic Impact
• Direct losses:
− Depopulation and disposal
− High morbidity and mortality
− Quarantine and surveillance
− Indemnities
• 1978-2003: Seasonaloutbreaks of LPAI inMinnesota cost growers $22 million
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Center for Food Security and Public Health
Iowa State University - Oct 2005
Economic Impact
• 1983: U.S. outbreak (H5N2)
−$65 million in losses
−Destruction of 17 million birds
−30% increase in egg prices
• 1999-2000: Italy outbreak (H7N1)
−$100 million in compensation to farmers
−18 million birds destroyed
− Indirect losses of $500 million
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Center for Food Security and Public Health
Iowa State University - Oct 2005
Economic Impact
• 1997: Hong Kong outbreak (H5N1)
−$13 million for depopulation and indemnities
−1.4 million birds
• 2001: Hong Kong
outbreak (H5N1)
−1.2 million birds
−$3.8 million
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Center for Food Security and Public Health
Iowa State University - Oct 2005
Economic Impact
• 2003: European outbreak (H7N7)− Over 33 million birds destroyed
− ¼ of Netherlands’ poultry stock
− Cost?
• 2003-2004: SE Asia (H5N1)− 8 countries
− >100 million birds destroyed
− Cost?
• 2004-2005: SE Asia and Eurasia
− Spread to Eurasia by migratory birds
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Epidemiology
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Center for Food Security and Public Health
Iowa State University - Oct 2005
Geographic Distribution
• Worldwide distribution
• Reservoir− Free flying aquatic birds:
Ducks, geese, shorebirds, gulls, terns, auks
• Recent outbreaks− The Netherlands, Australia, Mexico,
U.S., SE Asia, Eurasia
• Similarity to Newcastle Disease makes actual distribution difficult to define
• Altered avian ecosystems have created new niche for AI viruses
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Center for Food Security and Public Health
Iowa State University - Oct 2005
Morbidity/Mortality
• Approaches 100%in commercialpoultry flocks
• Deaths within 2 to 12 days after first signs of illness
• Survivors inpoor condition
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Transmission
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Center for Food Security and Public Health
Iowa State University - Oct 2005
Animal Transmission
• Initial source of infection
−Other poultry, migratory waterfowl, pet birds
• Spread by aerosol, shared drinking water, fomites
• Virus in respiratory secretions and feces
• Virus present in eggs but eggs unlikely to survive and hatch
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Center for Food Security and Public Health
Iowa State University - Oct 2005
Human Transmission
• Previously considered non-pathogenic for humans
• 1997, Hong Kong
−18 humans infected, 6 died
−H5N1 virus linked to outbreak in live bird market and area farms
• 2003, the Netherlands
−83 confirmed cases in humans, 1 death
−H7N7 strain
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Center for Food Security and Public Health
Iowa State University - Oct 2005
Human Transmission
• 2004-2005, SE Asia
−118 cases, 61 deaths Indonesia, Viet Nam, Thailand, Cambodia
−H5N1 strain
−Within the vicinity of poultry outbreaks
−Evidence for human-to-human transmission
• Role of swine−Proposed “mixing vessel”
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Animals and Highly Pathogenic Avian Influenza
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Center for Food Security and Public Health
Iowa State University - Oct 2005
Clinical Signs
• Incubation period: 3-14 days
• Birds found dead
• Drop in egg production
• Neurological signs
• Depression, anorexia, ruffled feathers
• Combs swollen, cyanotic
• Conjunctivitis and respiratory signs
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Center for Food Security and Public Health
Iowa State University - Oct 2005
Post Mortem Lesions
• Lesions may be absent with sudden death
• Severe congestion of the musculature
• Dehydration
• Subcutaneous edema of head and neck area
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Center for Food Security and Public Health
Iowa State University - Oct 2005
Post Mortem Lesions
• Nasal and oral cavity discharge
• Petechiae on serosal surfaces
• Kidneys severely congested
• Severe congestion of the conjunctivae
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Center for Food Security and Public Health
Iowa State University - Oct 2005
Sampling
• Before collecting or sending any samples, the proper authorities should be contacted
• Samples should only be sent under secure conditions and to authorized laboratories to prevent the spread of the disease
• HPAI samples may be zoonotic
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Center for Food Security and Public Health
Iowa State University - Oct 2005
Diagnosis
• Clinically indistinguishable from virulent Newcastle Disease
• Suspect with:−Sudden death
−Drop in egg production
−Facial edema, cyanotic combs and wattles
−Petechial hemorrhages
• Virology and serology necessary for definitive diagnoses
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Center for Food Security and Public Health
Iowa State University - Oct 2005
Differential Diagnosis
• Virulent Newcastle disease
• Avian pneumovirus
• Infectious laryngotracheitis
• Infectious bronchitis
• Chlamydia
• Mycoplasma
• Acute bacterial diseases
−Fowl cholera, E. coli infection
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Center for Food Security and Public Health
Iowa State University - Oct 2005
Diagnosis
• Laboratory Tests
−HP AI is usually diagnosed by virus isolation
• Presence of virus confirmed by
−AGID
−ELISA
−RT-PCR
• Serology may be helpful
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Center for Food Security and Public Health
Iowa State University - Oct 2005
Treatment
• No specific treatment
• Supportive care and antibiotics for secondary infections
• Antivirals (amantadine) effective in reducing mortality
−Not approved in food animals
−Results in resistant viruses
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Avian Influenza in Humans
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Center for Food Security and Public Health
Iowa State University - Oct 2005
Clinical Signs in Humans
• 1997: Hong Kong (H5N1)
−Fever, respiratory, vomiting, diarrhea, pain
−Fatal cases: severe bilateral pneumonia, liver dysfunction, renal failure, septic shock
• 1979: MP AI in harbor seals (H7N7)
−Conjunctivitis in humans in contact
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Center for Food Security and Public Health
Iowa State University - Oct 2005
Clinical Signs in Humans
• 2003: Netherlands (H7N7)
−Conjunctivitis
−Mild influenza or respiratory symptoms
−Fatal case: acute respiratory distress syndrome
• 2004-2005: S.E. Asia, EurAsia
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Center for Food Security and Public Health
Iowa State University - Oct 2005
Public Health Significance
• Risk is low
• Strains vary in ability to infect humans
• High occupational exposure may increase risk
• 2003: 83 cases
−Human infections from non-compliance with personal biosafety measures
−Evidence of human-to-human transmission
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Prevention and Control
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Center for Food Security and Public Health
Iowa State University - Oct 2005
Recommended Actions
• Notification of Authorities
−Federal Area Veterinarian in Charge (AVIC) www.aphis.usda.gov/vs/area_offices.htm
−State Veterinarian www.aphis.usda.gov/vs/sregs/official.htm
• Quarantine
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Center for Food Security and Public Health
Iowa State University - Oct 2005
Recommended Actions
• Confirmatory diagnosis
• Depopulation may occur
− Infected premises
−Contact-exposed premises
−Contiguous premises
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Center for Food Security and Public Health
Iowa State University - Oct 2005
Control and Eradication
• Eliminate insects and mice
• Depopulate flock and destroy carcasses
• Remove manure down to bare concrete
• High pressure spray to clean equipment and surfaces
• Spray with residual disinfectant
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Center for Food Security and Public Health
Iowa State University - Oct 2005
Prevention
• Import restrictions
• Surveillance
• Appropriate biosecurity−Control human traffic
− Introduction of new birds into flock
−Avoid open range rearing in waterfowl prevalent areas
• Education of the poultry industry
• Prompt response to MP AI outbreaks
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Influenza Vaccine Development
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Center for Food Security and Public Health
Iowa State University - Oct 2005
Avian Influenza Vaccine
• Traditional killed vaccines are effective
• Vaccines will protect only against other avian influenza viruses withthe same hemagglutinin (H) type.
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Center for Food Security and Public Health
Iowa State University - Oct 2005
Influenza A Viruses
• Mutate frequently
−Antigenic drift Point mutations accumulated during
virus replication
−Antigenic shift Hybrid virus emerges when cell infected
with two different influenza viruses
• Human, avian, swine, equine
Transfer of influenza virus to adifferent species
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Center for Food Security and Public Health
Iowa State University - Oct 2005
Influenza A Viruses
Human influenza vaccines
• Antigenic drift−Requires new strains to be used in
vaccines each year
• Antigenic shift−Caused pandemics in 1918, 1957,
1968, and ?
• Current human influenza vaccines have no efficacy against avian influenza
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Center for Food Security and Public Health
Iowa State University - Oct 2005
Vaccination
• Drawbacks to vaccination
−Expensive
−No cross protection between 15 H subtypes
−Possible creation of reassortant virus
• Inactivated H5 and recombinant vaccine licensed in the U.S. for emergency in HPAI outbreaks
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Additional Resources
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Center for Food Security and Public Health
Iowa State University - Oct 2005
Internet Resources
• World Organization for Animal Health (OIE)
−www.oie.int
• USAHA Foreign Animal Diseases –“The Gray Book”
−www.vet.uga.edu/vpp/gray_book/index
• World Health Organization
−www.who.int
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Center for Food Security and Public Health
Iowa State University - Oct 2005
Additional Resources
• CDC – Centers for Disease Control and Prevention−Avian influenza (bird flu) home page
www.cdc.gov/flu/avian
• U.S. Department of Agriculture−Biosecurity for the birds
www.aphis.usda.gov/vs/birdbiosecurity
−Avian influenza www.aphis.usda.gov/vs/birdbiosecurity/hpai
.html
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Acknowledgments
Development of this presentation was funded by a grant from the Centers for Disease Control and Prevention to the Center for Food Security and Public Health at Iowa State University.
Author: Katie Steneroden, DVMCo-authors: James Roth, DVM, PhD; Anna Rovid
Spickler, DVM, PhD; Alex Ramirez, DVM, MPH;
Glenda Dvorak, DVM, MPH