Available and Available and Ongoing Ongoing

Clinical TrialsClinical Trialsfor Parkinson’s for Parkinson’s

Disease PatientsDisease Patients

EARLY PDEARLY PD

STRIDE and FIRST STEP – evaluate STRIDE and FIRST STEP – evaluate Stalevo vs. Sinemet with regard to:Stalevo vs. Sinemet with regard to: Does Stalevo improve PD more than Sinemet?Does Stalevo improve PD more than Sinemet? Does Stalevo cause less dyskinesia?Does Stalevo cause less dyskinesia? Does Stalevo lower homocysteine? Elevations Does Stalevo lower homocysteine? Elevations

of homocysteine may cause strokes and be of homocysteine may cause strokes and be associated with dementiaassociated with dementia

CoQ10 CoQ10 May slow progression of diseaseMay slow progression of disease Stabilizes energy production in cellsStabilizes energy production in cells

MODERATE PDMODERATE PD

Glutathione – antioxidantGlutathione – antioxidantMay improve symptomsMay improve symptomsMay slow progressionMay slow progression

Eye Safety StudyEye Safety StudyTests eyesight while taking Tests eyesight while taking Parkinson Disease medicationsParkinson Disease medications

ADVANCED PDADVANCED PD

Istradefylline – for patients with Istradefylline – for patients with fluctuationsfluctuations

Spheramine – transplantation of Spheramine – transplantation of retinal cellsretinal cells These cells make levodopa and serve as These cells make levodopa and serve as

levodopa pumps in the brainlevodopa pumps in the brain for pts with moderate – severe symptoms for pts with moderate – severe symptoms

in the morning before taking medicationin the morning before taking medication Sarizotan – for dyskinesiaSarizotan – for dyskinesia

OTHEROTHER

Fatigue StudyFatigue Study Try to understand and treat potential Try to understand and treat potential

causes of fatigue in PDcauses of fatigue in PD Psychosis StudyPsychosis Study

Evaluating the use of Melperone (an Evaluating the use of Melperone (an antipsychotic) in PD patients with antipsychotic) in PD patients with psychosispsychosis

SPECT scan studiesSPECT scan studies Develop a scan as a diagnostic tool to Develop a scan as a diagnostic tool to

discern between Parkinsonian and non-discern between Parkinsonian and non-Parkinsonian tremorParkinsonian tremor

If interested in If interested in clinical trials, clinical trials,

please call:please call:813-844-4455813-844-4455

oror

813-974-5909813-974-5909