Auxiliary in the treatment of nausea and vomi�ng induced by chemotherapy

SUBLINGUAL TABLETS PHARMACEUTICAL FORM AND FORMULA: Each 300 mg tablet contains equal amounts of: Colchicum autumnale 4D, Colchicum autumnale 6D (nausea at the smell of food), Conium maculatum 2D, Conium maculatum 4D (ver�go and nausea a�er chemotherapy), Ipecacuanha 4D, Ipecacuanha 30D, Ipecacuanha 200D (persistent nausea and vomi�ng a�er chemotherapy), Nux vomica 4D (pain in stomach very sensi�ve with nausea and vomi�ng a�er chemotherapy , Veratrum album 3D, Veratrum album 30D, Veratrum album 200D (Copius vomi�ng and nausea a�er chemotherapy ). 3mg each lactose base; Magnesium stearate.

THERAPEUTIC INDICATIONS: Auxiliary in the treatment of discomfort caused by conmmon chemotherapy side effects (cytotoxic pharma) such as nausea and vomit on early and late stages, post chemotherapy.PHARMACOCYNETIC AND PHARMACODYNAMICS The ac�on of a homeopathic remedy in its ac�ve mechanism lies in two essen�al principles:1. THE SIMILARITY BETWEEN THE TOXIC POWER OF A SUBSTANCE AND ITS THERAPEUTIC POWER

Certain substances u�lized in ponderable doses provoke symptoms in a healty person while when u�lized in very small or infinitesimal doses, they can cure a sick person. The ac�ve principle is the similarity principle. “Similla Similibus Curantur”-what is similar should be cured whit the similar.

2. INDIVIDUALIZATION OF TREATMENT By u�lizing infinitesimal doses as applied in classic homeopathy, where is necessary to know all the pa�ent`s symptoms, the ones directly related to his/her illness as well as the ones that indicate his/her individual reac�on to the same illness. Therfore, the Arndt-Schultz principle (Law of Inverse Effect) explains the pharmacology dilu�on principles which indicates the exis�ng rela�onship between the different dilu�on levels and the ac�on at body level; thus, we can have a great range of deep-ac�ng chronic medicine. Low dilu�ons s�mulate, medium doses modulate and high dilu�ons inhibit without suppressing the organ’s func�ons. Thus, homeopathy makes this possible based on this two essen�al principles: treat illness whit diluted and dynamized remedies in an integral way; which means, ac�ng upon the physical, func�onal, emo�onal and mental areas of the body.

CONTRAINDICATIONS: Pregnancy, breast feeding and sensi�vity towards the medica�on and its components.ADVERSE REACTIONS: UnknownSECONDARY AND ADVERSE REACTIONS: UnknownALTERATIONS IN LABORATORY TESTS: There have been no altera�ons in laboratory tests.PRECAUTIONS RELATED TO CARCINOGENESIS, MUTAGENESIS, TERATOGENESIS REACTIONS AND ABOUT FERTILITY: UnknownDOSES AND ADMINISTRATION: Dissolve 2 tablets under the tongue every 15 minutes for two hours prior to chemotherapy and a�er chemotherapy dissolve 2 tablets every 15 minutes twince. Con�nue whith 2 tablets every 4 hours for 7 to 10 days.RESCUE DOSES: In the event of nausea and/or vomit, dissolve 2 tablets under the tongue every 15 minutes un�l the symptoms disappear for a maximum of 2 hours, a�er that, con�nue with the previous method of 2 tablets every 4 hours.MANIFESTATIONS AND HANDLING OF OVERDOSE OR ACCIDENTAL INGESTION: Unknown overdosing effects.PRESENTATION: Bo�le with 100 sublingual tablets. STORING RECOMMENDATIONS: Keep away from heat and moinsture. LEGENDS OF PROTECTION: Exclusive literature for physicians. Keep out the reach of children. FEDERAL DRUG ADMINISTRATION: NDC: 62630-001-17.

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European Journal of Cancer 2004. 40: 2041-46.2-Joel G. Anderson, Ann Gill Taylor. Use of Complemenatary Therapies for Cancer.

J. Altern Complemen Med. 2012 March; 18(3): 235-241.3-Mc Ewen B.S. Physiology and Neurobiology of Stress and Adap�on: Central Role of

the Brain. Physiology Rev. 2007; 87(3): 873-904.4-Grider JR, Kuemmerle JF, Jim JG. 5-HT Released by Mucosal S�muli Ini�ates

Peristalsis by Ac�va�ng 5HT4/5-HT1p Receptors on Sensory C GRP Neurons. Am. J. Physiol. 1996;270 (5pt 1): 778-782.

5-Gershon M.D. The Enteric Nervous System: A Second Brain. Hosp. Pract. 1999;34(7):31-32, 35-38, 41-42 passim.

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