autonomic nervous system - gmch.gov.in lectures/physiology/ans 2008.pdf · autonomic pathways...
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Autonomic Nervous System
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12 Cranial Nerves
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Somatic vs. Autonomic Voluntary Skeletal muscle Single efferent neuron Axon terminals release
acetylcholine Always excitatory Controlled by the
cerebrum
Involuntary Smooth, cardiac muscle;
glands Multiple efferent neurons Axon terminals release
acetylcholine or norepinephrine
Can be excitatory or inhibitory
Controlled by the homeostatic centers in the brain – pons, hypothalamus, medulla oblongata
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Motor Pathways of the SNS and ANS
Which is the post-ganglionic fiber?
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Anatomy of the Motor Output in Sympathetic and Parasympathetic nerves
Describe the following comparisons:
•location of pre-ganglionic neuron cell body
•location of ganglia•neurotransmitter released at effectors
What neurotransmitter is released at all Autonomic ganglia?
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Autonomic Nervous System
2 divisions: Sympathetic
“Fight or flight” “E” division Exercise, excitement,
emergency, and embarrassment
Parasympathetic “Rest and digest” “D” division Digestion, defecation, and
diuresis
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These 2 systems are antagonistic.Typically, we balance these 2 to keep ourselves in a
state of dynamic balance.
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ANS StructureBoth ANS divisions share same
general structureAutonomic pathways always
consist of 2 neurons in series
They synapse in an autonomic ganglion
1st neuron in the autonomic pathway is the preganglionic neuronCell body in CNS, myelinated, and projects to the autonomic ganglion
2nd neuron is the postganglionic neuron.Cell body in autonomic ganglion, unmyelinated, and projects to the effector.
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Cholinergic and Adrenergic fibers
All preganglionic neurons are cholinergic both symp & parasymp
Ach / ach like substance --- will excite both symp & parasymp
All postgang parasymp are cholinergic Most of postgang symp are adrenergic Posgang symp to sweat gland, piloerector
muscle, skeletal muscle blood vessels are cholinergic
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Receptors
Adrenergic Rα & β
Cholinergic R Nicotinic and Muscrinic
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Antagonistic Control
A great example is heart rate. An increase in sympathetic stimulation causes HR to increase whereas an increase in parasympathetic stimulation causes HR to decrease
Most internal organs areinnervated by both branchesof the ANS which exhibitantagonistic control
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Dual Innervation of the Iris
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Exception to the dual innervation rule
Sweat glands and blood vessel smooth muscle are only innervated by sympathetic and rely strictly on up-down control
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Sympathetic and Vasomotor Tone
Sympathetic division prioritizes blood vessels to skeletal muscles and heart in times of emergency.
Blood vessels to skin vasoconstrict to minimize bleeding if injury occurs during stress or exercise.
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Exception to the antagonism rule
Symp and parasymp work cooperatively to achieve male sexual function. Parasympathetic is responsible for erection while sympathetic is responsible to ejaculationThere’s similar ANS cooperation in the female sexual response.
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Adrenal medulla special - Certain splanchnic nerves synapse on hormone-producing cells of adrenal medulla
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How does this contribute to the “diffuseness” of sympathetic activity?
Mass Sympathetic Response
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Integration of the Nervous & Endocrine Systems during Stress
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Target Organ Parasympathetic Effects
Sympathetic Effects
Eye (Iris) Stimulates constrictor muscles. Pupil constriction.
Stimulates dilator muscles. Pupil dilates.
Eye (Ciliary muscle)
Stimulates. Lens accommodates – allows for close vision.
No innervation.
Salivary Glands Watery secretion. Mucous secretion.
Sweat Glands No innervation. Stimulates sweating in large amounts. (Cholinergic)
Gallbladder Stimulates smooth muscle to contract and expel bile.
Inhibits gallbladder smooth muscle.
Arrector Pili No innervation Stimulates contraction. Piloerection (Goosebumps)
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Target Organ Parasympathetic Effects
Sympathetic Effects
Kidney No innervation. Releases the enzyme renin which acts to increase BP.
Penis Vasodilates penile arteries. Erection.
Smooth muscle contraction. Ejaculation.
Vagina; Clitoris Vasodilation. Erection. Vaginal reverse peristalsis.
Blood Coagulation No effect. Increases coagulation rate.
Cellular Metabolism
No effect. Increases metabolic rate.
Adipose Tissue No effect. Stimulates fat breakdown.
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Target Organ Parasympathetic Effects
Sympathetic Effects
Cardiac Muscle Decreases HR. Increases HR and force of contraction.
Coronary Blood Vessels
Constricts. Dilates
Urinary Bladder; Urethra
Contracts bladder smooth muscle; relaxes urethral sphincter.
Relaxes bladder smooth muscle; contracts urethral sphincter.
Lungs Contracts bronchiole (small air passage) smooth muscle.
Dilates bronchioles.
Digestive Organs Increases peristalsis and enzyme/mucus secretion.
Decreases glandular and muscular activity.
Liver No innervation No innervation (indirect effect).
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Target Organ Parasympathetic Effects
Sympathetic Effects
Mental Activity No innervation. Increases alertness.
Blood Vessels Little effect. Constricts most blood vessels and increases BP. Exception – dilates blood vessels serving skeletal muscle fibers (cholinergic).
Uterus Depends on stage of the cycle.
Depends on stage of the cycle.
Endocrine Pancreas
Stimulates insulin secretion.
Inhibits insulin secretion.
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Levels of ANS Control
Figure 14.9
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