automated animal board for positioning in ocular photography and imaging

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Automated Animal Board for Positioning in Ocular Photography and Imaging Dhaval Desai Nathan Kleinhans Holly Liske Laura Piechura Kellen Sheedy Client: B’Ann Gabelt Department of Ophthalmology Advisor: Wally Block, PhD Department of Biomedical Engineering

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Automated Animal Board for Positioning in Ocular Photography and Imaging. Dhaval Desai Nathan Kleinhans Holly Liske Laura Piechura Kellen Sheedy Client: B’Ann Gabelt Department of Ophthalmology Advisor: Wally Block, PhD Department of Biomedical Engineering. Glaucoma. - PowerPoint PPT Presentation

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Page 1: Automated Animal Board for Positioning in Ocular Photography and Imaging

Automated Animal Board for Positioning in Ocular

Photography and Imaging

Dhaval DesaiNathan Kleinhans

Holly LiskeLaura PiechuraKellen Sheedy

Client: B’Ann GabeltDepartment of Ophthalmology

Advisor: Wally Block, PhDDepartment of Biomedical Engineering

Page 2: Automated Animal Board for Positioning in Ocular Photography and Imaging

Glaucoma• High intraocular

pressure

• Damage of the nerve fibers and the optic disc

• Result: Vision loss

• Current cure: None

• Second leading cause of blindness in the world

Page 3: Automated Animal Board for Positioning in Ocular Photography and Imaging

Normal Vision

National Eye Institute

Page 4: Automated Animal Board for Positioning in Ocular Photography and Imaging

Vision with Glaucoma

National Eye Institute

Page 5: Automated Animal Board for Positioning in Ocular Photography and Imaging

Motivation

• Aim 1: Early diagnosis of glaucoma– Nerve fiber layer thickness– Normal vs. glaucoma

• Aim 2: Explore treatment options– Chemotherapeutics and gene therapy– Animal model: Monkey– Monitor nerve fiber layer parameters at

several time points

Page 6: Automated Animal Board for Positioning in Ocular Photography and Imaging

Problem Statement

Fine adjustments in the positioning of the eye are necessary to obtain quality images of the retina and nerve for glaucoma research. The goal of this project is to construct an automated positioning device that provides accurate alignment of the animal for successive scans.

Page 7: Automated Animal Board for Positioning in Ocular Photography and Imaging

Design Specification

• Automated or require minimal manual labor

• Support weights up to 50 lbs

• Rotate 30 degrees from horizontal in pitch and roll directions

Page 8: Automated Animal Board for Positioning in Ocular Photography and Imaging

Rotary Actuator Model

•Independent rotary actuators–Control pitch and roll

•Automated rotation

•Inclinometer to measure angular displacement

Page 9: Automated Animal Board for Positioning in Ocular Photography and Imaging

Rotary Actuator Model

Pros:• No center support of

plate required• Low center of gravity• Direct correlation to

handheld control

Cons:• Precision• Torque on actuators• Actuator cost

Page 10: Automated Animal Board for Positioning in Ocular Photography and Imaging

• Mechanical approach

• Tape runs through platform in both directions

• Relies on system of internal pulleys

• Small motor retrieves tape (normalizes)

Ticker-Tape Model

Page 11: Automated Animal Board for Positioning in Ocular Photography and Imaging

Ticker-Tape Model

Cons:• Manual• Normalizing may

decrease life in service

Pros:• Simple design• Easy to record

displacement• Inexpensive design

Page 12: Automated Animal Board for Positioning in Ocular Photography and Imaging

Linear Actuator Model• Employs two

electric linear actuators

• Ball and socket heads are mounted to actuators

• Central ball and socket column

• Inclinometer to measure angular displacement

Page 13: Automated Animal Board for Positioning in Ocular Photography and Imaging

Linear Actuator ModelPros: • Automated design• Continuous motion

and fine adjustment capabilities

Cons:• Complicated design• Actuators and

inclinometers are expensive

Page 14: Automated Animal Board for Positioning in Ocular Photography and Imaging

Design Matrix

Criteria Rotator Ticker Tape

Linear Actuator

Accuracy 4 7 7

Maximum loads 6 4 9

Cost 2 8 5

Ease of Manufacturing

6 4 6

Prototype Life 7 4 8

Total 25 27 35

Page 15: Automated Animal Board for Positioning in Ocular Photography and Imaging

Future Work

• Final Design modifications

• Choose and order materials

• Build prototype

• Test

Page 16: Automated Animal Board for Positioning in Ocular Photography and Imaging

References

• Glaucoma Research Foundation. www.glaucoma.org

• National Glaucoma Research. American Health Assistance Foundation. www.ahaf.org

• Glaucoma Resource Guide. National Eye Institute. www.nei.nih.gov/health

Page 17: Automated Animal Board for Positioning in Ocular Photography and Imaging

Questions?