AUGUST 2014

GINKGO AND STROKE

The popular supplement is

showing promise in the field of

stroke recovery, as studied by

Dr. Zahoor Shah.

PG2

LEADERSHIP LESSONS

As Dr. Paul Erhardt

celebrates 20 years of leading

the CD3, he reflects on what

has made him successful.

PG3

PHARMACY CAMP

The annual event introduces

high school students to a

career path and a source of

inspiration.

PG4

INTERNATIONAL APPE

An alumnus shares his

experience of completing an

Advance Pharmacy Practice

Experience in China.

PG4

Having left the comforts of the United States

to explore graduate education abroad, Dr.

Amanda Bryant-Friedrich has firsthand

knowledge of the complex transition

awaiting graduate students who come to the

College of Pharmacy and Pharmaceutical

Sciences from around the

academically and see the

world, but these experiences were often

challenging; missing her home and

community at times compounded the

challenges. In her new role as Director of

International Pharmaceutical Sciences

globe. Completing her

doctorate in Heidelberg,

Germany and postdoctoral

training in Basel, Switzerland

allowed her to grow

The monthly

e-newsletter of the

nationally ranked

University of Toledo

College of Pharmacy

and Pharmaceutical

Sciences

i m m i g r a t i o n a n d

matriculation that originate

from a lack of knowledge

from the perspectives of both

the student and the

respective institution of

Graduate Student Recruitment and

Retention, Dr. Bryant-Friedrich is a valuable

resource to graduate students experiencing

the United States, often for the first time.

“Students who decide to pursue advanced

degrees outside their country of origin are

often faced with barriers of

higher learning,” Dr. Bryant-Friedrich said.

As the College engages new regions of the

world to attract graduate students, Dr.

Bryant-Friedrich plans to introduce

(Continued on page 4)

Refill x

Welcoming and retaining international graduate students

HOME AWAY FROM HOME : away from homeaway from homeaway from home

NEW INTERNATIONAL GRADUATE

STUDENTS IN THE COLLEGE

20 20 19 19

2011 2012 2013 2014

The Center for Drug Design and

Development celebrated 20 years under

the leadership of Distinguished

University Professor Paul W. Erhardt

with a research symposium that

welcomed prominent researchers,

professor emeriti, alumni and scholars.

The plenary lecture, by Dr. Gunda

Georg, explored “Drug Discovery in

Academia: Minnelide for Pancreatic

Cancer and Gamendazole for Male

Contraception.” Dr, Georg is head of

medicinal chemistry at University of

Minnesota and the director of the

Institute for Therapeutics Discovery &

Development.

The keynote speaker was Dr.

C h r i s t o p h e r A . L i p i n s k i , a

pha rmaceu tica l co ns ulta nt and

contractor who is best known for his

"Rule of Five," the most frequently cited

medicinal chemistry publication of the

last decade. Dr. Lipinski discussed the

direction of drug discovery.

The dinner lecture on “Fascinating

Excursions into Chiral Chemistry: An

Insider‟s Perspective” was presented by

Dr. Mukund Chorghade, Chief Scientific

Officer at THINQ Pharma. Dr.

Chorghade, an adjunct faculty member

at Cal Tech, Harvard, MIT and

Cambridge Universities, has published

hundreds of articles and has received

three “Scientist of the Year” awards.

STROKE IN AMERICA

Stroke is the fourth leading cause of

death and a major cause of long-term

disability, which inflicts substantial

economic and societal burdens. Drug

therapies aimed at post-stroke recovery

that can enhance a person‟s own ability

to replenish injured or dead brain cells

with new developing brain cells

(endogenous neurogenesis) may help

minimize the cost related to prolonged

hospital stays and rehabilitation. Ginkgo

biloba, a widely studied herbal product

for the treatment of neurological

d i s o r d e r s , o f f e r s e n d o g e n o u s

neurogenesis-enhancing properties that

hold the promise of providing recovery-

improving benefits to stroke patients.

EFFECTS OF GINKGO BILOBA

Led by Dr. Zahoor A. Shah, Dr. Shadia E.

Nada and graduate student Jatin

Tulsulkar, researchers in the College of

Pharmacy and Pharmaceutical Sciences

have discovered that mice treated with

Ginkgo biloba 4 hours after inducing an

experimental stroke, and then daily for

seven days, had improved recovery and

less brain damage than the control mice.

It was also observed that Ginkgo biloba-

t r e a t e d m i c e h a d e n h a n c e d

neurogenesis, partly due to the increased

protein expression of hemeoxygenase 1,

an antioxidant gene that also has a role

in neurogenesis. Pertinently, mice

lacking the hemeoxygenase 1 gene were

observed to have reduced neurogenesis

after stroke. An important finding was

that in Ginkgo biloba-treated mice the

majority of these new cells were found

in the proximity of the stroke injury site,

suggesting their role in repairing the

injured/dead neurons.

Besides prevention, improving recovery

following a stroke should become the

USING REWARDS TO TREAT SUBSTANCE ABUSE In 2008, the National Survey on Drug Use

and Health (NSDUH) estimated that 1.9

million Americans were current cocaine

users, with the majority falling between the

ages of 18 and 25.

Ginkgo bilobaGinkgo bilobaGinkgo biloba ENHANCES STROKE RECOVERY

“Research is formalized curiosity. It is poking

and prying with a purpose.”

Zora Neale Hurston

author and anthropologist

CD3 ANNIVERSARY SYMPOSIUM

C o c a i n e ‟ s p h y s i o l o g i c a l a n d

psychological effects include cardiac

disturbances, strokes and seizures, and

psychosis, making treatment for cocaine

addiction a serious public health

concern.

Dr. Caren Steinmiller, who earned her

B.S. in „93 and her M.S. in „95 from The

LEADERSHIP LESSONS

1

2

3

4

THE EFFECTS OF TIME

“Has it really been that long? Time flies when you‟re having fun.”

AFFETTUOSO

“I have an all-encompassing fascination for the science of medicinal chemistry, a science where the intriguing relationships between its beautiful chemical structures and their biological properties are oftentimes applicable toward potentially alleviating some health issue being experienced by people less fortunate than I.”

TEAMING UP

“Addressing technical problems in a teamwork fashion, CD3‟s constituencies have always been supportive and have rallied to get the job done. Our numbers of patents, papers and graduate thesis documents provide solid testimonials to that, and we can all be very proud for such accomplishments.”

FOR AND BY THE PEOPLE

“It has been, and will always be, CD3‟s people that make the CD3 so very special in its productivity and fun. The camaraderie established when tackling this complex field has brought us together like a close-knit family, vibrant with each generation of new student members arriving as our matured graduates depart.”

On the occasion of his twentieth

anniversary of leading the Center for

Drug Design and Development,

Distinguished University Professor Paul

W. Erhardt looks back.

ASSET LIABILITY AND RESTRUCTURING

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LOREM IPSUM EUSIMOND TINCIDUNT WISI

prime focus of current stroke research.

We now know that neurogenesis is not

only an ongoing process in adults, but

can also be induced by pathological

conditions like traumatic brain injury

and ischemic stroke, and strategies that

promote endogenous neurogenesis as

part of the repair and regeneration

process should be prioritized.

Neurogenesis in the adult brain involves

not only the proliferation and migration

of precursor cells known as stem cells/

neural progenitor cells (NSCs) but also

their functional integration into the

neural network. Though ischemia is

potent in inducing the proliferation and

migration of NSCs, it does not provide

an environment conducive to their

survival, differentiation and integration,

and creating an environment with

exogenous drugs is paramount to

improving the number of NSCs that can

result in improved brain repair and

regeneration.

The study, first reported in Molecular

Neurobiology (Vol. 49, 2014) and then

reviewed in Neural Regeneration Research

(Vol. 9, 2014), confirmed that Ginkgo

biloba, in addition to its antioxidant,

neuritogenic and angiogenic properties,

provides a conducive environment for

the survival and functional integration

of NSCs into neural system.

“Controversies and other ethical issues

related to stem cell therapies make drug

induced, enhanced neurogenesis a

promising treatment strategy,” stressed

senior author Zahoor A. Shah. “Besides

one docu me nte d c l in ical tr ia l

recommending the use of Ginkgo biloba

after ischemic stroke, further high

quality and large-scale randomized

controlled trials are warranted to test

its efficacy in stroke recovery” he said.

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LOREM DOLORE

SIT ALIQUAM

23%

9%

68%

University of Toledo College of

Pharmacy and Pharmaceutical Sciences,

co-authored a paper on cocaine

addiction management that appeared in

Drug and Alcohol Dependence, one of the

leading journals for substance abuse

research.

Dr. Steinmiller, a lecturer in the

Department of Pharmacology, studied

the effectiveness of contingency

management treatment, a way of

rewarding substance abusers, often

monetarily, for adhering to their

treatment plans. Read the study and

results online.

Ginkgo bilobaGinkgo bilobaGinkgo biloba ENHANCES STROKE RECOVERY

ABOUT GINKGO BILOBA

One of the world‟s oldest living species of trees, the ginkgo tree can grow up to 120 feet tall and live for up to 1,000 years. Ginkgo biloba has been used for medicinal purposes for thousands of years to treat a broad range of disorders, from memory loss to circulatory disorders. The research on Ginkgo biloba‟s use for the treatment of Alzheimer‟s disease and stroke is a budding area of excitement among researchers. People who take Ginkgo biloba supplements should take note of the potential drug interactions and safety recommendations.

C o c a i n e ‟ s p h y s i o l o g i c a l a n d

psychological effects include cardiac

disturbances, strokes and seizures, and

psychosis, making treatment for cocaine

addiction a serious public health

concern.

Dr. Caren Steinmiller, who earned her

B.S. in „93 and her M.S. in „95 from The

Each summer, the college welcomes two

cohorts of 40 rising high school seniors

to Pharmacy Camp, a four-day

experience sponsored by Walgreens,

that introduces prospective students to

pharmacy in a hands-on format.

Campers shadowed Toledo pharmacists,

visited the Toledo Zoo where they

learned about veterinary pharmacy from

alumnus Matt Buderer, and made some

great friendships with other campers.

Proudly sporting their “future Rocket

scientist” gear, many of this summer‟s

pharmacy campers hope to be part of

next fall‟s freshman class.

Galvanizing students to explore careers

as pharmacists and pharmaceutical

scientists is the primary goal of

Pharmacy Camp.

One camper said, “I can't thank The

University of Toledo enough for giving

me such an amazing opportunity and

experience of a lifetime. I've never been

more positive and sure about anything

like I now am about attending this

school and pursuing pharmacy as my

future career.”

HOME AWAY FROM HOME continued from page 1

members of the college community to

the educational systems, culture and

research enterprise in each region. Her

new role also requires a heightened

sense of awareness of the political and

economic conditions of the countries

from which international learners

originate to make sure that students

receive counseling and support to help

them maintain an exceptional level of

academic performance, even when

thoughts of home are a distraction.

A n o t h e r a s p e c t o f r e t a i n i n g

international students is ensuring their

sense of community upon their arrival.

“ I inte nd to ma inta in s tro ng

relationships with community-based

organizations that have ties and services

important to the needs of our

international students. This will include

working with the UT Center for

International Students and Programs as

w e l l a s T o le d o S is t e r C i t i e s

International and other organizations

with a common interest in international

relationships,” Dr. Bryant-Friedrich said.

The college is continually increasing the

population of graduate students who are

well prepared academically for

coursework and research. Dr. Bryant-

Friedrich sees this as an opportunity to

create recruitment pipelines from

prestigious institutions abroad.

Dr. Bryant-Friedrich, who has mentored

17 graduate students from 11 countries,

feels fortunate for the opportunity to

ease the transition for graduate students

in the College of Pharmacy and

Pharmaceutical Sciences.

“The global scientific community relies

on the establishment of productive

collaborations based on mutual trust

and understanding,” Dr. Bryant-

Friedrich said. “What better way to

improve the human condition than to

bring brilliant students from around the

world together to improve what really

matters.”

INTERNATIONAL APPE: A STUDENT’S JOURNEY

As a P4 student pharmacist, I began my

Advance Pharmacy Practice Experiences

(APPEs) in a unique way. My first APPE

INSPIRES FUTURE ROCKET SCIENTISTS

pharmacy camp

rotation was at the Affiliated Hospital of

North Sichuan Medical College located

in Nanchong, the second most

populated city of Sichuan Province,

China.

Over the course of a month, I worked

with my preceptors to learn about

traditional Chinese medicine (TCM),

including acupuncture and herbal

By CHUN WONG, PharmD ‘14

SMOOTH SAILING

THROUGH STRATEGIC

BUSINESS DECISIONS

AROUND THE WORLD AND BACK AGAIN

DR. AMANDA BRYANT-FRIEDRICH IN 1997 ON THE DAY

SHE COMPLETED HER DOCTORATE FROM RUPRECHT

KARLS UNIVERSITÄT IN HEIDELBERG, GERMANY

“I have been impressed with the urgency of doing. Knowing is not enough; we must apply.

Being willing is not enough; we must do.”

Leonardo da Vinci

artist, inventor, original Renaissance man

COMMUNITY EDUCATION

KUDOS:

STUDENT RESEARCH

AND AWARDS

1

2

P4 student Elias Bassil, an officer in the UT chapter of Student

National Pharmaceutical Association, spoke at the Career

Pathways Center of the Norman and Louise Jones Foundation to

educate young adults about the adverse effects of illegal drugs.

Because of the success of his presentation, the foundation‟s

executive director invited Elias begin a weekly series of

presentations to discuss topics in pharmacy, careers, and

education for young adults and their families.

WALMART SCHOLARS AT AACP

Pharmacy students Kimberly Zitko and Philip King were selected to participate in the 2014 Wal-Mart Scholars program with their respective faculty mentors, Dr. Michelle Serres and Dr. Michael Peeters. Their $1000 scholarships funded their attendance at the American Association of Colleges of Pharmacy (AACP) Annual Meeting and Teachers‟ Seminar.

GRADUATE RESEARCH AWARD

Kush Patel, a graduate student mentored by Pharmaceutics Associate Professor Dr. Jerry Nesamony, earned a Graduate Student Award from the College of Graduate Studies for the Graduate Student Association (GSA). The award of $1893 will fund his research on “An Insulin Oral Drug Delivery via Calcium Alginate Nanoparticles”.

Save the date: 09.06.14 at 10 a.m. ROCKETS V. MISSOURI TAILGATE Network with alumni, faculty, students and

friends of the College of Pharmacy and

Pharmaceutical Sciences at the Pillbox tailgate

tent, sponsored by Giant Eagle. Bring your

business cards!

ABRINDO AS PORTAS

OPENING OUR DOORS

This fall, the College of Pharmacy and

Pharmaceutical Sciences welcomes

eight learners from Brazil to take

bachelor‟s level pharmaceutical science

courses at The University of Toledo as

part of the Brazil Scientific Mobility

Program (BSMP).

The one-year, non-degree program

allows Brazilian students to study in

some of the world‟s most prominent

institutions. The students, who are

nominated and supported by their home

universities, will take courses and

conduct research in cosmetic science

and formulation, pharmaceutics,

medicinal chemistry and pharmacology.

The BSMP program is sponsored by the

Brazilian Ministry of Education and the

Brazilian Ministry of Science and

Technology.

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medicine, and the role TCM can play in

improving patient health.

I was able to converse and exchange

ideas about pharmacy practice in

institutional and community settings

with local clinical pharmacists,

pharmacy faculty and pharmacy

students at North Sichuan Medical

College.

I experienced the rich Chinese culture,

including celebrating the annual Dragon

Boat Festival. Overall, this experience

w as u ndo u bte dly f ru it f u l a nd

unforgettable for me. It has certainly

given me insights on the important roles

pharmacists play in improving the

health and wellness of patients around

the world.

rotation was at the Affiliated Hospital of

North Sichuan Medical College located

in Nanchong, the second most

populated city of Sichuan Province,

China.

Over the course of a month, I worked

with my preceptors to learn about

traditional Chinese medicine (TCM),

including acupuncture and herbal

3 OFFICIAL RECOGNITION

UT‟s chapter of the Student Society of Health-system Pharmacists has been officially recognized by the national parent organization, the American Society of Health-System Pharmacists.

08.15.14 Beginning of smoke-free campuses at UT 08.22.14 Professional Advancement Ceremony, Nitschke Auditorium, 4pm 08.25.14 Fall 2014 classes begin. 09.04.14 Dean‟s Commission on Pharmacy Education, two-day semiannual meeting 09.06.14 Pill Box tailgate tent sponsored by Giant Eagle for Rockets v. Missouri, 10am. 09.10.14 Infectious Disease Update Registration due by 09.04.14 Download printable brochure

10.04.14 Annual Wal-Mart Student Leadership Retreat 10.24.14 Pre-gala reception in Student Union room 2592, class reunion, Homecoming Gala in the Student Union Auditorium, and post-Gala gathering in Student Union room 2592 10.25.14 Homecoming parade 10am, alumni tailgate 12pm, Rockets v. UMass at 2pm

11.12.2014 Pharmaceutical Sciences Board, two-day annual meeting

get the picture Click the links for photos of recent college events.

CD3 Symposium

Mid-Atlantic Graduate Student Symposium in Medicinal Chemistry

CALENDAR OF EVENTS TRADITION, ETHICS and the PROFESSIONAL

ADVANCEMENT CEREMONY

White Coat Ceremonies occur at

medical and pharmacy schools

across the nation, but what do

they really symbolize, and how is

our ceremony different from many

others?

The Professional Advancement

Ceremony held by the college each

year to welcome P1 students into the

professional division has its roots in

the tradition of White Coat

Cere mo nies , r i tua l “ robing”

ceremonies for physicians and other

health care professionals.

Traditionally, such ceremonies

include oaths of commitment to the

ethical and professional standards

for the profession. The white coat

symbolizes the honor bestowed by

society upon health care and

laboratory professionals, and the

ceremony welcomes initiates in

these professions to the early stages

of their professional development.

At The University of Toledo, the

P r o f e s s i o n a l A d v a n c e m e n t

Ceremony has evolved uniquely to

include the “robing” of both students

in the Doctor of Pharmacy program

a nd tho se in th e B .S . in

Pharmaceutical Sciences program‟s

cosmetic science and formulation

design, medicinal and biological

chemistry, pharmaceutics, and

pharmacology/toxicology majors.

Students who major in pharmacy

administration are honored with a

professional portfolio, symbolic of

their use of data and management in

pharmacy.

All students touch the lives of others,

either through patient care,

management or research, thus the

emphasis on standards of behavior

and professionalism benefits the new

P1 students. Their understanding of

the rewards and responsibilities of

their chosen careers is an essential

brick in the foundation of

professionalism.

www.utoledo.edu/pharmacy/alumni Jeff Barton, 419-530-5413 or Jeffrey.barton@utoledo.edu

Ashleigh Sonnenberg, 419-530-5359

Join The University of Toledo College of Pharmacy and Pharmaceutical Sciences as

we celebrate Homecoming and the 110th anniversary of the college.

Class Reunions Pre-Gala Reception Homecoming Gala Post-Gala Gathering Homecoming Parade Alumni Tailgate Rockets vs. UMass

Annual Edward C. Schmakel Homecoming Parade Bancroft Street

Pre-game tailgate Koester Alumni Pavilion

Rockets vs. UMass ($25) Glass Bowl Stadium

Pre-Gala Reception, reunion Student Union Room 2592 Cash bar, hors d'oeuvres

Gala banquet ($30) Pharmacy honoree is Jerry Wisler, ‘79. Student Union Auditorium

Post-Gala Gathering Student Union Room 2592

This year’s Homecoming theme is Blast from the Past. Do you remember when Rocky looked like this?

Homecoming 2014