EJOCFK (9) 1477–1640 (2008) · ISSN 1434-193X · No. 9/2008

[09]Eur. J. O

rg. Chem. 22000088, 1477–1640

Cover PictureKurt Faber et al.Asymmetric Bioreduction of Activated C=C Bonds

MicroreviewChristophe Mathe and Christian PerigaudSynthesis of Conformationally Restricted Nucleoside Analogues

EurJOCEuropean Journal ofOrganic Chemistry

9/20083rd March Issue

D 6093

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EWG = electron withdrawing group

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The EUChemSoc Societieshave taken the cant step into the future by merg-ing their traditional journals, to form two leading chemistry journals, the European Jour-nal of Inorganic Chemistry and the European Journal of Or-ganic Chemistry. Three further EUChemSoc Societies (Austria, Czech Republic and Sweden) are Associates of the two journals.

COVER PICTURE

The cover picture shows a culture of yeast cells,whose flavin-dependent reductases � their three-dimensional structure is depicted in the magnify-ing glass � catalyse the asymmetric bioreductionof C�C bonds. Although these enzymes havebeen identified already in 1932, their true physio-logical role remains largely a mystery. Thanks toadvances in genetic engineering, these biocata-lysts are now becoming available in sufficientamounts to allow their application for prepara-tive-scale biotransformations: Although their“natural” substrates are still unknown, thestudy of K. Faber et al. on p. 1511ff. shows thatthey accept an astonishing variety of alkenesbearing an electron-withdrawing group � suchas enals, enones, α,β-unsaturated imides, ornitroalkenes � to furnish the correspondingalkanes with excellent stereoselectivities.S. Kohlwein and G. Oberdorfer are thankedfor their contribution in the design of thegraphic.

Eur. J. Org. Chem. 2008, 1479�1484 www.eurjoc.org 2008 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim 1479