Associations Between Characteristics and RP in ≥Grade

2 and ≥3 in the whole set by univariate analysis Factors Radiation

technique

IMRT

3DCRT

MLD,Gy

≤ 19

> 19

V20,%

≤ 32

> 32

≥Grade 2 RP

P value

Hazard Ratio

(95% CI)

0.083

1.43

0.95-2.14

< 0.0001 2.25

1.47-3.45

0.004 1.86

1.22-2.82

≥Grade 3 RP P value

Hazard Ratio

(95% CI)

0.009

2.67

1.28-5.5

< 0.0001 5.77 2.55-13.03

< 0.00013.96

1.88-8.33

Associations Between Heat Shock Proteins B1 Genotypes and RP in ≥Grade 2 and ≥3

The incidences and ≥ 3 RP as a function of time from the start of radia

tion therapy of HSPB1 rs 2868371 polymorphisms CC versus CG/GG in test set , validation set and pool set

The incidences and ≥ 3 RP as a function of time from the start of radiation therapy of HSPB1 rs 2868371 polymorphisms CC versus CG/GG in pool set divided by MLD and V20

Acknowledgement

Zhongxing Liao, MD

Ritsuko Komaki , MD

Wei, Qingyi , MD, PhD

Yuan, Xianglin , MD. PhD

José L. López Guerra, MD

Yan Zhuang ,MD

Xiong Wei,MD

James D. Cox, MD