arul anandar college (autonomous), karumathur 625 … · 15uchp12 core lab –i inorganic...

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354 ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR – 625 514 DEPARTMENT OF CHEMISTRY B.Sc., CHEMISTRY CBCS STRUCTURE (from the academic year 2015-2016 onwards) I SEMESTER PART Sub. Code PAPER Hrs Cr I 15UTAL11/ 15UHNL11/ 15UFNL11/ 15USNL11 Tamil / Hindi / French / Spanish 6 4 II 15UENA11/ 15UENB11 English for Effective Communication-I (Stream-A) English for Effective Communication-I (Stream-B) 6 4 III 15UCHC11 Core -1 General Chemistry – I 5 4 15UCHP12 Core Lab –I Inorganic Qualitative Analysis 3 --- 15UCHB11 Allied Chemistry – I 15UCHR12 Allied Chemistry Lab - 1 15UCHA11 15UMAB11 Allied -1 Biochemistry/ Allied Mathematics - 1 3/ 5 3/ 4 15UCHQ12 Allied Biochemistry Lab 2 -- IV 15USBE11 Skill Based Elective – 1 (Computer Literacy) Programming in C 2 1 15USBP11 Programming in C Lab 2 1 15UFCE11 FC-Personality Development 1 1 V 15UNSS/NCC/ PED/YRC/ROT/ ACF/NCB12 Extension Activities NSS / NCC/Phy. Edn/ YRC/ROTARACT/AICUF/NATURE CLUB - - 15UBRC11 Bridge Course 1 Total 30 19/20 II SEMESTER I 15UTAL22/ 15UHNL22/ 15UFNL22/ 15USNL22 Tamil / Hindi / French/ Spanish 6 4 II 15UENA22 15UENB22 English for Effective Communication-II (Stream-A) English for Effective Communication-II (Stream-B) 6 4 III 15UCHC22 Core -2 General Chemistry -II 5 4 15UCHP12 Core Lab –I Inorganic Qualitative Analysis 3 3 15UCHB22 Allied Chemistry – 2

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Page 1: ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR 625 … · 15UCHP12 Core Lab –I Inorganic Qualitative Analysis 3 --- 15UCHB11 Allied Chemistry – I 15UCHR12 Allied Chemistry Lab

354

ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR – 625 514

DEPARTMENT OF CHEMISTRY

B.Sc., CHEMISTRY

CBCS STRUCTURE (from the academic year 2015-2016 onwards)

I SEMESTER

PART Sub. Code PAPER Hrs Cr

I 15UTAL11/ 15UHNL11/ 15UFNL11/ 15USNL11

Tamil / Hindi / French / Spanish

6 4

II 15UENA11/ 15UENB11

English for Effective Communication-I (Stream-A) English for Effective Communication-I (Stream-B)

6 4

III 15UCHC11 Core -1 General Chemistry – I 5 4

15UCHP12 Core Lab –I Inorganic Qualitative Analysis 3 ---

15UCHB11 Allied Chemistry – I

15UCHR12 Allied Chemistry Lab - 1

15UCHA11 15UMAB11

Allied -1 Biochemistry/ Allied Mathematics - 1

3/ 5

3/ 4

15UCHQ12 Allied Biochemistry Lab 2 --

IV 15USBE11 Skill Based Elective – 1 (Computer Literacy) Programming in C

2 1

15USBP11 Programming in C Lab 2 1

15UFCE11 FC-Personality Development 1 1

V 15UNSS/NCC/ PED/YRC/ROT/ ACF/NCB12

Extension Activities NSS / NCC/Phy. Edn/ YRC/ROTARACT/AICUF/NATURE CLUB

- -

15UBRC11 Bridge Course 1

Total 30 19/20

II SEMESTER

I 15UTAL22/ 15UHNL22/ 15UFNL22/ 15USNL22

Tamil / Hindi / French/ Spanish

6 4

II 15UENA22 15UENB22

English for Effective Communication-II (Stream-A) English for Effective Communication-II (Stream-B)

6 4

III 15UCHC22 Core -2 General Chemistry -II 5 4

15UCHP12 Core Lab –I Inorganic Qualitative Analysis 3 3

15UCHB22 Allied Chemistry – 2

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15UCHR22 Allied Chemistry Lab - 2

15UCHA22 15UMAB22

Allied – 2 Biochemistry/ Allied Mathematics - 2

3 5

3 4

15UCHQ22 Allied Biochemistry Lab 2 2

IV 15USBE22 Skill Based Elective – 2 (Computer Literacy) Programming in Visual Basic

2 1

15USBP22 Programming in Visual Basic Lab 2 1

15UFCE22 FC-Social Analysis and Human Rights 1 1

V 15UNSS/NCC/ PED/YRC/ROT/ACF/NCB12

Extension Activities NSS / NCC/Phy. Edn/ YRC/ROTARACT/AICUF/NATURE CLUB

--- 1

Total 30 24/23

III SEMESTER

I 15UTAL33/ 15UHNL33/ 15UFNL33/ 15USNL33

Tamil / Hindi / French / Spanish

6 4

II 15UENA33/ 15UENB33

English – Language Through Literature – I (Stream-A) English – Language Through Literature – I (Stream-B)

6 4

III 15UCHC33 Core - 3 Organic Chemistry -I 6 6

15UCHP33 Core Lab – II Volumetric Estimations 3 3

15UCHB33 Allied Chemistry - I

15UCHR33 Allied Chemistry Lab - I

15UPYB33 Allied – 3 Physics 3 3

15UPYP33 Allied Physics Lab 2 -

IV 15UCHN13 Basic Tamil/Advanced Tamil/Non-Major Elective -1 Chemistry in Your Life

3 2

15UFCE33 FC-Environmental Studies 1 1

V 15UNSS/NCC/ PED/YRC/ROT/ ACF/NCB23

Extension Activities NSS / NCC/Phy. Edn/ YRC/ROTARACT/AICUF/NATURE CLUB

- -

15UARE14 ARISE

30 23

IV SEMESTER

I 15UTAL44/ 15UHNL44/ 15UFNL44/ 15USNL44

Tamil / Hindi / French / Spanish

6 4

II 15UENA44/ 15UENB44

English – Language Through Literature – II (Stream-A) English – Language Through Literature – II

6 4

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(Stream-B)

III 15UCHC44 Core-4Inorganic Chemistry -I 4 4

15UCHC54 Core-5 Physical Chemistry - I 5 5

15UCHB44 Allied Chemistry - II

15UCHR44 Allied Chemistry Lab - II

15UPYB44 Allied – 4 Physics 3 3

15UPYR44 Allied Physics Lab 2 2

IV 15UCHN24 Basic Tamil/Advanced Tamil/Non-Major Elective -2 Chemicals for Life and Living

3 2

15UFCE44 15UFCF44

Bioethics, Religions and Peace Studies / Catechism of the Catholic Church.

1 1

V 15UNSS/NCC/ PED/YRC/ROT/ ACF/NCB24

Extension Activities NSS / NCC/Phy. Edn/ YRC/ROTARACT/AICUF/NATURE CLUB

- 1

15UARE14 ARISE 1

30 27

V SEMESTER

III 15UCHC65 Core -6 Organic Chemistry - II 6 6

15UCHC75 Core-7 Inorganic Chemistry - II 6 6

15UCHC85 Core-8 Physical Chemistry - II 6 6

15UCHP45 Core Lab –III Organic Analysis and Estimation 4 3

15UCHP55 Core Lab-IV Gravimetry and Preparation 4 --

15UCHE15 Elective 1– Medicinal Chemistry 4 3

30 24

VI SEMESTER

III 15UCHC96 Core -9 Organic Chemistry - III 6 6

15UCHD06 Core -10 Inorganic Chemistry - III 6 6

15UCHD16 Core -11 Physical Chemistry -III 6 6

15UCHP66 Core Lab –IV Gravimetry and Preparation 4 3

15UCHP76 Core Lab-V Physical Chemistry 4 3

15UCHE26 Elective – 2 Industrial Chemistry 4 3

30 27

Non-Major Elective -1: Chemistry in Your Life

Non-Major Elective-2 : Chemicals for Life and Living

Semester: I II III IV V VI TOTAL

Credits : 19/20 24/23 23 27 24 27 144*

* 144 credits from 2017-18 onwards; 142 credits upto 2016-17 batches.

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Part – I 16 credits

Part – II 16 credits

Part – III

Core 74

Allied 16

Core Electives 06

Total 96 credits

Part IV

Non-Major Electives 04

Skill Based Electives 04

Foundation Course 04

Total 10 credits

Part V 02 credits

Bridge Course 01 credit

ARISE 01 credit

-------------------------------------------------------------------

TOTAL 144 CREDITS

Self-Learning Courses

15UCHSL3 Third Semester : Forensic Chemistry

15UCHSL4 Fourth Semester : Food Chemistry

15UCHSL5 Fifth Semester : Fuel Chemistry

15UCHSL6 Sixth Semester : Chemistry for Competitive Exams

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ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR – 625 514 DEPARTMENT OF CHEMISTRY

GENERAL CHEMISTRY – I (2015-2016 onwards)

Class : I B.Sc Chemistry Part : III Core -1 Semester : I Hours : 75 Subject Code : 15UCHC11 Credits : 4 Objectives :

To understand 1. the basic concepts needed for understanding chemistry 2. the electron-displacement effects in organic compounds and to study the reactions

of various organic reaction intermediates. 3. relation between electronic configuration and periodicity in properties of elements 4. the principles and applications of adsorption and catalysis

To study the chemistry of important polymers

To learn the safety methods in the laboratory

UNIT-I Basic Concepts in Organic Chemistry (15 Hours) General Introduction.Functional groups.Structural Formulae.Isomerism- Fundamental ideas only – Structural and stereoisomerism – types and examples. Organic reactions – Types of reactions.Cleavage of bonds – Homolysis and heterolysis. Types of reagents –Electrophiles, nucleophiles and free radicals. –definition and examples Localised and delocalised bonds. Resonance- Rules of resonance. Steric inhibition of resonance.Hyperconjugation.Inductive and field effects - definition. Organic Reaction intermediates: Generation, stability, structure and reactions of carbocations, carbanions, free radicals and carbenes. UNIT-II Periodic Table and Rare Gases (15 hours) Mendeleev’s table.Merits and demerits.Long form of the periodic table and its advantages. Classification into s,p,d and f-block elements. Study of the variation of the following properties of elements in terms of their electronic configurations. Atomic radius, ionic radius, ionization potential, electron affinity, electronegativity, metallicity and their periodic variations Rare Gases: General discussion. Isolation of rare gases.Compounds of xenon.Xenon fluorides and oxides – Preparation, structure and bonding in XeF2, XeF4, XeF6, XeO3 and XeOF4. UNIT III Surface Chemistry (15 Hours) Adsorption of gases on solids.Characteristics.Chemisorption and Physisorption.Factors influencing adsorption. Different types of adsorption curves. Adsorption isotherms.Langmuir and Freundlich adsorption isotherms. Applications of adsorption. Catalysis – Definition.Characteristics.Types of catalysis - examples.Theories of catalysis.

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Autocatalysis. Catalytic poisons. Promoters. Applications of catalysis Enzyme catalysis – Lock and key mechanism and kinetics.Michelis-Menton equation.Effect of pH and temperature on enzyme action. UNIT IV Introduction to Polymers (15 Hours) Monomers and Polymers.Definition.Classification of polymers.Distinction among plastics, elastomers and fibers.Homo and heteropolymers.Copolymers.Chemistry of Polymerisation.Chain polymerisation.Free radical, ionic, coordination and step polymerisation.Polyaddition and poly condensation. Important polymers – Teflon, PMMA, polyethylene, polystyrene, PAN, polyesters, polycarbonates, polyamides, polyurethanes, PVC, epoxy resins, rubber-styrene and neoprene rubbers. Phenol-formaldehyde and urea-formaldehyde resins. UNIT V Safety in the Laboratory and Separation Techniques (15 hours) Storage and handling of chemicals.Toxic and poisonous chemicals. Waste and fume disposal. Precautions and first-aid procedure.Uses of different glassware.Hazard symbols.Laboratory safety measures. General purification techniques.Purification of solid organic compounds.Recrystallisation.Use of mixed solvents.Use of drying agents and their properties.Sublimation. Extraction – use of immiscible solvents.Solvent extraction.Soxhlet extraction. Books for Study

1. ArunBahl, B.S. Bahl., A Text Book of Organic Chemistry, S.Chand& Co (2011) 2. B.R. Puri&L.R.Sharma&M.S.Pathania, Principles of Physical Chemistry, Vishal Publishing

Co (2012) 3. B.R.Puri, L.R.Sharma, &K.C.Kalia , Principles of Inorganic Chemistry, Milestone Publishers

(2012) Books for References

1. B.K.Sharma ., Polymer Chemistry, Goel Publishing House (1989) 2. R. Gopalan, P.S. Subramanian and K. Rangarajan, Elements of Analytical Chemistry,

Sultan Chand & Sons. Chapter 1

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ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR – 625 514 DEPARTMENT OF CHEMISTRY

INORGANIC QUALITATIVE ANALYSIS (2015-2016 onwards)

Class : I B.Sc Chemistry Part : III Core Practical Semester : I & II Hours : 45 (Each Semester) Subject Code : 15UCHP12 Credits : 3

Objectives: To enable the learners to

learn principles of analysis of simple salts and mixtures

Develop analytical skills in identifying the acid and basic radicals in the given unknown mixture of salts.

Semi-Micro Qualitative analysis Analysis of a mixture containing two anions (one simple and one interfering) and two cations (of different groups) from the following Cations: Lead, bismuth, copper, cadmium, iron, aluminum, zinc, manganese, nickel, cobalt, barium, strontium, calcium, magnesium and ammonium. Anions: Halides, carbonate, nitrate, sulphate, oxalate, borate, phosphate, chromate and fluoride.

Book for Study 1. Course material provided by the Department

Book for Reference 1. V.V. Ramanujam., Inorganic Semi micro qualitative Analysis (2001)

Evaluation Continuous Internal Assessment (50 Marks)

Sl. No Components Marks

1 Observation Note book Maintained neatly and regularly

10

2 Results of the regular Practical 20

3 Internal Test 20

TOTAL 50

End-Semester Examination (50 Marks) Duration: 3 Hours (At the end of II Semester) Analysis of a mixture containing two acid and two basic radicals.

Sl. No Components Marks

1 Record Notebook. Maintained neatly 05

2 Final result 40

3 Viva voce 05

TOTAL 50

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ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR – 625 514

DEPARTMENT OF CHEMISTRY

BIOCHEMISTRY - I

(2015-2016 onwards)

Class : I B.Sc Chemistry Part : III Allied-1

Semester : I Hours : 45

Subject Code : 15UCHA11 Credits : 3

Objectives

To enable the student to understand

the basics of Biochemistry

the metabolism of carbohydrates and lipids

preparation and reactions of amino acids and proteins

Unit I Introduction and Biomolecules (9 Hours)

Definition.Branches in Biochemistry.Biomolecules and their characteristics. Characteristics of

living matter. Concept of cell.

Carbohydrates: Occurrence and classification. Properties, structure and biological importance

of monosaccharide’s, Disaccharides and polysaccharides – examples.

Lipids: Occurrence and classification. Properties, structure and biological importance of lipids:

simple lipids, compound lipids and derived lipids- definition and examples.

Aminoacids and Peptides: Classification and Properties of amino acids. Peptides, polypeptides,

Preparation and biological importance of peptides.

Unit II Carbohydrates Metabolism (9 Hours)

Metabolism of carbohydrates (a) Glycogen synthesis and breakdown. (b) Oxidation: Glycolysis,

citric acid cycle, the pentose phosphate pathway. Carbohydrate metabolism in various

tissues.Chemistry of muscle contraction. Blood sugar level. Glycosuria-Diabetes Mellitus-

Glucose tolerance Glycosylated Hemoglobin.Hormonal effects of carbohydrate metabolism.

Unit III Lipid metabolism (9 Hours)

Metabolism of lipids: (a) oxidation of fatty acids (b) Biosynthesis of Fatty acids (b) Metabolism

of cholesterol. Role of liver in Lipid metabolism.Role of adipose tissue in lipid metabolism. .

Hormonal control of lipid metabolism.

UNIT IV Amino acids and Proteins (9 Hours)

Classification of proteins.Properties of proteins. Structure of proteins: primary, secondary,

tertiary and quaternary structure. Biological importance of proteins.Catabolism of amino acids

(a) conversion of α- amino acids to -keto acid (b) Disposal of Nitrogen – urea cycle (c) disposal

of carbon skeleton (d) disposal of sulphur.Biosynthesis of amino acids.

UNIT V Integration of carbohydrate, lipids and protein metabolism (9 Hours)

Inter conversion between three different metabolisms. Regulation and control of metabolism.

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Text Book

Course material provided by the Department

Reference Books

1. GR Agarwal, KiranAgarwal and O.P Agarwal, Text book of Biochemistry, 10th Edition Goel

Publishing House, Meerut (1999)

2. J.L. Jain, Fundamentals of Biochemistry, V edition S.Chand& Company Ltd (2001)

3. Powar and Chatwal, Biochemistry, Himalaya Publishing House, 4th Edition (1999)

4. Dhaka and Singha, A Text Book of Biochemistry, Aman Publishing House (1997).

5. McKee, Biochemistry: The molecular basis of Life. 3rd Edition.McGraw Hill (2004).

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ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR – 625 514

DEPARTMENT OF CHEMISTRY

ALLIED CHEMISTRY – I

(2015-2016 onwards)

Class : I B.Sc Mathematics Part : III Allied-1

Semester : I Hours : 45 (+30)

Subject Code : 15UCHB11 Credits : 3

Objectives

To enable the student to understand

o Relation between electronic configuration and periodicity in properties of elements

o Concept of chemical bonding

o Stereoisomerism in organic chemistry and the relation between the structure of

molecules and their colour

o the safety methods in the laboratory

Unit I Periodic Table (9 hours)

Mendeleev’s table.Merits and demerits.Long form of the periodic table and its advantages.

Classification into s,p,d and f-block elements.

Study of the variation of the following properties of elements in terms of their electronic

configurations. Atomic radius, ionic radius, ionization potential, electron affinity,

electronegativity, metallicity and their periodic variations

Unit II Chemical Bonding (9 hours)

Covalent bond: orbital overlap, hybridization, geometry of organic molecules- CH4,C2H4,C2H2,

C6H6- Molecular orbital theory, bonding, antibonding and non-bonding orbitals. Molecular

orbitals. MO configuration of H2, N2, O2, F2. Bond order.

Diborane: Preparation and properties, structure, preparation and uses of NaHB4, Borazole

Unit III Optical Isomerism (9 hours)

Symmetry, elements of symmetry. Cause of optical activity, tartaric acid, Racemisation,

Resolution – definition. Geometric isomerism of maleic and fumaric acids.Distinguishing

geometrical isomers on the basis of dipole moments.

Unit IV Colour and Constitution (9 hours)

Chromophore, auxochrome, bathochromic shift, hypsochromic shift, hyperchromic effect,

hypsochromic effect.Classification of dyes.

Dyes: azo, phthalein and triphenylmethane dyes- Preparation of methyl orange,

phenolphthalein and Bismarck brown.

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Unit V Safety Methods in Lab (9 hours)

Storage and handling of chemicals.Toxic and poisonous chemicals. Waste and fume disposal.

Precautions and first-aid procedure.Uses of different glassware.Hazard symbols.Laboratory

safety measures.

Books for Study

1. ArunBahl, B.S. Bahl., A Text Book of Organic Chemistry, S.Chand& Co (2011)

2. B.R. Puri&L.R.Sharma&M.S.Pathania, Principles of Physical Chemistry, Vishal Publishing

Co (2012)

3. B.R.Puri, L.R.Sharma, &K.C.Kalia , Principles of Inorganic Chemistry, Milestone Publishers

(2012)

Book for Reference

1. R. Gopalan, P.S. Subramanian and K. Rangarajan, Elements of Analytical Chemistry,

Sultan Chand & Sons.

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ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR – 625 514 DEPARTMENT OF CHEMISTRY

ALLIED CHEMISTRY LAB (2015-2016 onwards)

Class : I B.Sc Mathematics Part : III Allied Practical Semester : I & II Hours : 30 (Each Semester) Subject Code : 15UCHP12 Credits : 1

I. VOLUMETRIC ANALYSIS: 1. Estimation of sodium hydroxide using standard sodium carbonate. 2. Estimation of hydrochloric acid- standard oxalic acid. 3. Estimation of oxalic acid- standard sulphuric acid. 4. Estimation of ferrous sulphate- standard Mohr salt solution. 5. Estimation of oxalic acid- standard ferrous sulphate. 6. Estimation of potassium permanganate- standard sodium hydroxide.

II. ORGANIC ANALYSIS: 1. Detection of Elements (N, S, Halogens). 2. To distinguish between aliphatic and Aromatic. 3. To distinguish between saturated and unsaturated. 4. Functional group tests for phenols, acids (mono), aromatic primary amine, diamide, carbohydrate, aldehyde, ketone Functional groups characterized by confirmatory test.

Course material provided by the Department

EVALUATION Continuous Internal Assessment (CIA) – 50 Marks

Sl.No Components Marks

1 Observation Notebook –Neatly and Regularly maintained 05

2 Practical Results – Regular Class work 25

3 Internal Test 20

TOTAL 50

End-Semester Examination (at the end of even semester - 3 hour duration) One Volumetric estimation and an organic compound analysis to be carried out.

Sl.No Components Marks

1 Record Note book –Neatly maintained 05

2 Volumetric Estimation -Procedure 05

3 Volumetric Estimation-Result within the prescribed error limit 20

4 Organic Analysis -Result 20

TOTAL 50

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ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR – 625 514

DEPARTMENT OF CHEMISTRY

GENERAL CHEMISTRY – II

(2015-2016 onwards)

Class : I B.Sc Chemistry Part : III Core -2

Semester : II Hours : 75

Subject Code : 15UCHC22 Credits : 4

Objectives:

To enable the learners to understand

the concept of chirality, optical activity and conformations of simple alkanes and

cyclohexane.

the basic concepts of Inorganic Chemistry

laws related to ideal and real gases, liquefaction methods, molecular velocities and

collision properties.

the principle involved in quantitative analysis.

the methods and materials required for products which are used in our daily life

UNIT I Stereochemistry and Conformational Analysis (15 Hours)

Optical activity.Chirality.Enantiomerism.Diastereomers.Racemic modification.Resolution of

racemic mixtures.Meso compounds.

Reactions involving stereoisomers – Stereospecific and stereoselective syntheses.Asymmetric

synthesis – Partial Method.

Configuration – absolute and relative configuration. R,S notation for optical isomers with one

and two chiral centers. Erythro and threo representations.

Optical activity in compounds containing no chiral centres.- biphenyls, allenes and spiranes.

Geometrical isomerism – E,Z- notation. Methods of distinguishing geometrical isomers.

(Cyclisation, Dipole moment and Melting point methods)

Conformations- Definition.Conformations of ethane, butane and cyclohexane.Cyclohexane-

chair and boat forms. Chair inversion. Conformations of methylcyclohexane.

UNIT II Basic Concepts of Inorganic Chemistry (15 Hours)

Avogadro number .Mole concept.Mole fraction.Definition and problems.Balancing chemical

equations. Calculations based on chemical equations. Oxidation and reduction.Oxidation

number.Balancing redox equation – oxidation number and ion-electron methods. Molecular

mass and equivalent mass.- Equivalent weights of acids, bases and salts. Calculations.

UNIT III Gaseous State (15 Hours)

The kinetic theory of ideal gases. Deduction of gas laws from the kinetic gas equation. Deviation

from ideal behaviour.Van der Waals equation.Reduced equation of state.Law of corresponding

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states.Compressibility factor.Critical phenomena.Andrews experiments. Van der Waals

equation and the critical constants.

Distribution of molecular velocities. Maxwell-Boltzmann distribution.(No derivation). Types of

molecular velocities.Calculations.

Collision properties – Mean free path – collision frequency- Collision diameter. Viscosity of

gases.

UNIT IV Titrimetric methods of Analysis (15 Hours)

General principle of titrimetric methods of analysis.Requirements.

Expressing concentration – molarity, molality, normality, Wt%, ppm, milliequivalents (mEq) and

millimoles.

Primary and secondary standards.Criteria for primary standards.Preparation of standard

solution.Standardisation of solutions.Limitations of volumetric analysis. Endpoint and

equivalence point. Acid-base titrations.Indicators.Choice of indicators.

Complexometric titrations: Principle. Titrations involving EDTA- General principle. Metal ion

indicators and characteristics.

Precipitation titrations: Argentometric titrations. Indicators for precipitation titrations involving

silver.Determination of chloride by Volhard’s method.Adsorption indicators.

UNIT V Chemicals for living (15 Hours)

Preparation of Tooth powder, Tooth paste, Talcum powder, Shampoo, Perfumes, Dish washing

powder, Toilet cleaning liquids.

Wax products – Candles, Shoe polish.

Inks – Blue, Red, Printing inks, Ink for stamps

Agarbathies, Napthalene balls, Chalk crayons.

Scope of small scale industries.Agencies promoting village industries IDBI, SISI, SIPCOT etc.

Books for Study

1. ArunBahl, B.S. Bahl., A Text Book of Organic Chemistry, S.Chand& Co (2011)

2. B.R.Puri, L.R.Sharma, &K.C.Kalia , Principles of Inorganic Chemistry, Milestone Publishers

(2012)

3. B.R. Puri&L.R.Sharma&M.S.Pathania, Principles of Physical Chemistry, Vishal Publishing

Co (2012)

Books for References

1. B.S. Sekar, Small Scale Industries, Jaime Publications, Bombay (1975)

2. Malik and Agarwal, Reference Book and Directory for Small Industries, Small Industry

Research Institute, New Delhi (1975)

3. R. Gopalan, P.S. Subramanian and K. Rangarajan, Elements of Analytical Chemistry,

Sultan Chand & Sons. Chapters 5,6

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ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR – 625 514

DEPARTMENT OF CHEMISTRY

BIOCHEMISTRY - II

(2015-2016 onwards)

Class : I B.Sc Chemistry Part : III Allied-2

Semester : II Hours : 45

Subject Code : 15UCHA22 Credits : 3

Objectives

To enable the student to learn

the mechanism of enzyme action and its applications

the structure and functions of nucleic acids

the classification and functions of harmones

the metabolic functions of vitamins

UNIT I Enzymes (9 Hours)

Enzymes.Classification of enzymes.Properties of Enzymes.Factors affecting Enzyme

activity.Nomenclature and units of enzyme activity.Enzyme Kinetics.Mechanism of Enzyme

action.coenzyme and cofactors. Diagnostic applications of Enzymes.Therapeutics uses of

Enzymes.Application of Enzymes in Food industry.

UNIT II Nucleic acids (9 Hours)

Nucleic acids.Nucleosides and Nucleotides and Biological importance. Properties and structure

of Nucleic acids: (a) DNA: Primary, secondary and tertiary structure (b) RNA: Types of RNA,

structure and functions. Genetic code and Genetic code table. Biosynthesis of proteins.viruses.

Metabolism of

Nucleic acids (a) metabolism of phosphoric acid, pentoses, Purine and pyrimidine bases (b)

metabolism of free nucleotides

UNIT III Hormones (9 Hours)

Hormones. Classification of Hormones based on chemical nature and Secreting glands.

Hierarchy of Hormonal function.Mode of action of Hormones. Chemical nature and functions of

Hormones: Pituitary, Thyroid Pancreas, Adrenal, Gonadal (sex), placental, pineal body, kidney.

UNIT IV Vitamins (9 Hours)

Vitamins.Classification of vitamins. Chemical nature and metabolic functions of fat soluble

vitamins: vitamin A, D, E and K. Chemical nature and metabolic function of water soluble

vitamins: Thiamine (B), Riboflavin (B2) Pyridoxine (B6), Niacin, Pantothenic acid, Biotin, Vit. B12,

Folic acid, Para amino benzoic acid, Inositol, -Lipoicacid ,choline and vitamin C.

UNIT V Biochemical aspects of important physiological process (9 Hours)

Digestion and absorption.Detoxification.Excretion.Respiration Muscular function.Liver

function.Nervous function.Aging.

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Water balance.Electrolyte balance and its maintenance.Cerebrospinal fluid. Essential elements,

macro and micro elements and general functions. Metabolic functions of Ca, P, I, and Fe.

Text Book

Course material provided by the Department

Reference Books

1. GR Agarwal, KiranAgarwal and O.P Agarwal, Text book of Biochemistry, 10th Edition Goel

Publishing House, Meerut (1999)

2. J.L. Jain, Fundamentals of Biochemistry, V edition S.Chand& Company Ltd (2001)

3. Powar and Chatwal, Biochemistry, , Himalaya Publishing House, 4th Edition (1999)

4. Dhaka and Singha, A Text Book of Biochemistry ,Aman Publishing House (1997).

5. McKee, Biochemistry: The molecular basis of Life. 3rd Edition.McGraw Hill (2004).

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DEPARTMENT OF CHEMISTRY

ALLIED CHEMISTRY – II

(2015-2016 onwards)

Class : I B.Sc Mathematics Part : III Allied-2

Semester : II Hours : 45

Subject Code : 15UCHB22 Credits : 3

Objectives

To enable the student to understand

the principle involved in quantitative analysis

structure and bonding in coordination compounds

preparation and reactions of aminoacids and carbohydrates

the theory of photochemical processes

electrolytic conductance and electrochemical cells

Unit I Titrimetric Methods (9 hours)

General principle of titrimetric methods of analysis.Requirements.Expressing concentration –

molarity, molality, normality, Wt%, ppm, milliequivalents (mEq) and millimoles.

Standardisation of solutions.Limitations of volumetric analysis. Endpoint and equivalence point.

Acid-base titrations.Strong Acid – Strong Base, Strong Acid – Weak Base, Weak Acid –Strong

Base, Weak Acid – Weak Base.Indicators.Choice of indicators.

Unit IICoordination Chemistry (9 hours)

Nomenclature.Werner theory.Chelation- examples. Haemoglobin Chlorophyll - functions. EDTA

and its applications in analysis.

Unit III Life Chemistry (9 hours)

Amino Acids: Classification, preparation and properties of glycine and alanine. Isoelectric point

and zwitter ion.Peptide bond.

Classification of proteins by physical properties and by biological functions.

Carbohydartes: classification, preparation and properties of glucose and fructose. Conversion of

glucose to fructose and vice versa.

Unit IV Fundamentals of Photochemistry (9 hours)

Definition of Photochemical reactions, Grotthus Draper Law and Einstein’s Law, Quantum

Efficiency (High and Low).Jablonsky diagram.Comparison between thermal and photochemical

reactions.Chemiluminescence, Fluorescence, Phosphorescence.Photosensitisation. (Definitions

with suitable examples)

Unit V Electrochemistry (9 hours)

Measurement of conductance.Kohlraush’s law.pH determination. Conductometric

titrations.Salt hydrolysis. Buffer solutions and buffer action. Galvanic cells, e.m.f. standard

electrode potentials, reference electrodes. Electrochemical series and its applications.

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Books for Study

1. ArunBahl, B.S. Bahl., A Text Book of Organic Chemistry, S.Chand& Co (2011)

2. B.R. Puri&L.R.Sharma&M.S.Pathania, Principles of Physical Chemistry, Vishal Publishing

Co (2012)

3. B.R.Puri, L.R.Sharma, &K.C.Kalia , Principles of Inorganic Chemistry, Milestone Publishers

(2012)

Books for Reference

1. Elements of Analytical Chemistry, R. Gopalan, P.S. Subramanian and K. Rangarajan,

Sultan Chand & Sons.

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ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR – 625 514 DEPARTMENT OF CHEMISTRY

ALLIED BIOCHEMISTRY – PRACTICAL (2015-2016 onwards)

Class : I B.Sc Chemistry Part : III Allied Practical Semester : I & II Hours : 30 (Each Semester) Subject Code : 15UCHP12 Credits : 2

1. Qualitative tests for Protein, carbohydrate, lipids. 2. Measurement of pH. 3. Estimation of sugar – Benedict’s method 4. Estimation of calcium 5. Estimation of vitamin C 6. Estimation of Iron by colorimetry. 7. Estimation of Nickel by colorimetry 8. Separation of amino acids by paper chromatography (Demonstration Only) 9. Separation of lipids by TLC (Demonstration Only) 10. Column chromatography (Demonstration Only)

Course material provided by the Department

EVALUATION Continuous Internal Assessment (50 Marks)

Sl. No Components Marks

1 Observation Note book Maintained neatly and regularly

10

2 Results of the practical-Regular class work 20

3 Internal Test 20

TOTAL 50

End-Semester Examination (50 Marks )(Duration: 3 Hours) Examination at the end of even-semester.

Sl.No Components Marks

1 Record Notebook 10

2 Estimation - Procedure 05

3 Identification of the given sample with correct procedure 10

4 Estimation-Final Result within the prescribed error limit 20

5 Viva voce 5

TOTAL 50

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ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR – 625 514

DEPARTMENT OF CHEMISTRY

ORGANIC CHEMISTRY – I

(For students admitted from the Academic Year 2015-2016 onwards under the New CBCS Pattern)

Class : II B.Sc. Chemistry Part : III Core-3

Semester : III Hours : 90

Subject Code : 15UCHC33 Credits : 6

Objectives

1. To understand the chemistry of alkanes, cycloalkanes and predicting the stability of

cycloalkanes.

2. To study the preparation and reactions of unsaturated hydrocarbons and dienes.

3. To learn the chemistry of alcohols, phenols and ethers

4. To study and understand the chemistry of aromatic compounds and concept of

aromaticity.

5. To study the preparation and reactions of alkyl and aryl halides.

Unit I Alkanes andCycloalkanes (18 Hours)

Nomenclature of alkanes

Methods of formation of alkanes.-Reduction of alkenes and alkynes, Wurtz reaction, Kolbe

reaction, Corey-House reaction and decarboxylation reactions. Physical properties and chemical

reactions.

Cycloalkanes – Preparation-Wurtz reaction, Dieckmann’s ring closure and reduction of aromatic

hydrocarbons. Properties and reactions.Stability of Cycloalkanes.Baeyer’s strain

theory.Limitations.Heats of combustion and relative stability of Cycloalkanes.

Unit II Alkenes,Alkadienes and Alkynes (18 Hours)

Alkenes: Nomenclature. Geometrical isomerism in alkenes.

General methods of preparation. – dehydration of alcohols and dehydrohalogenation of alkyl

halides. Dehalogenation of dihalides.

Reactions of alkenes.Addition reactions – hydrogenation.Addition of halogens and hydrogen

halides.Markownikov’s rule and peroxide effect.Hydration – Hydroboration.

Alkadienes: Nomenclature and classification. Stability of conjugated dienes. Preparation and

reactions of 1, 3-butadiene – 1,2- and 1,4-addition. Diels-Alder reaction.

Alkynes: Nomenclature. Structure of acetylene.General methods of preparation.Acidity of

alkynes. Reactions of alkynes: addition of hydrogen, hydrogen halides and water.

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Unit III Alcohols, Phenols and Ethers (18 Hours)

Alcohols: Nomenclature. Classes of alcohols.General methods of preparation.Hydroboration of

alkenes.Properties.Hydrogen bonding in alcohols.Acidity.Reactions of alcohols.Distinction

between primary, secondary and tertiary alcohols.

Preparation, properties and reactions of allyl alcohol, ethylene glycol and glycerol.

Phenols: Nomenclature. Methods of preparation.Acidity.Effect of substituents on the acidity of

phenols.Reactions of Phenols- Kolbe’s reaction.Reimer-Tieman reaction, Gattermann reaction,

Lederer-Manasse reaction and Houben-Hoeschreaction.Mechanism of the above

reactions.Fries rearrangement.

Ethers and epoxides.Preparation and reactions of diethyl ether, anisole and ethylene

oxide.Estimation of methoxy group.

Unit IV Aromatic Hydrocarbons – Benzene and Alkyl benzenes (18 Hours)

Structure of benzene: Kekule structure. Stability of benzene ring with reference to heats of

hydrogenation and combustion.Resonanceenergy.Resonance picture of benzene.Bond lengths

in benzene.Orbital picture of benzene.

Aromaticity and Huckel’srule.Application of Huckel’s rule to the following systems-

cyclopentadienyl anion, cycloheptatrienylcation.

Electrophilic aromatic substitution reactions – General mechanism.Nitration, sulphonation,

halogenation and Friedel-Craft’s reactions.

Disubstitution in benzene. Directive influence – classification of substituents – o,p- and meta-

directing groups. Effect of substituents in orientation and reactivity.

Unit V Alkyl and Aryl Halides (18 Hours)

Alkyl Halides – Nomenclature and classification. Methods of formation.Properties and chemical

reactions.Mechanisms of SN1, SN2 and SNireactions.Elimination reactions E1 and E2 reactions.

Preparation, properties and reactions of CHCl3, allyl chloride, vinyl chloride, freons, DDT

Aryl Halides.Preparation, properties and reactions of chlorobenzene.Mechanism of nucleophilic

aromatic substitution.

Aralkylhalides: Preparation, properties and reactions of benzyl chloride. Distinction between

nuclear and side-chain halides.

TEXT BOOK

1. P.L.Soni and H.M.Chawla, Text Book of Organic Chemistry.28th Edition. Sultan Chand

(2006)

Reference Book

1. Morrison and Boyd, Organic Chemistry, 6thEdition. Prentice Hall (2006).

2. Bahl and Arul Bahl, Text Book of Organic Chemistry, Chand and Company (2003)

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ARUL ANANDAR COLLEGE (AUTONOMOUS),KARUMATHUR – 625 514 DEPARTMENT OF CHEMISTRY

VOLUMETRIC ESTIMATIONS (For students admitted from the Academic Year 2015-2016 onwards under the New CBCS Pattern)

Class : II B.Sc. Chemistry Part : III Core Lab-3 Semester : III Hours : 45 Subject Code :15UCHP33 Credits: 3 Objectives: To enable the learners to

- learn the principles of quantitative analysis - develop skills in handling apparatus for quantitative analysis - Understand the volumetric techniques to estimate the given solution

Volumetric Analysis Introduction to volumetric analysis.Preparation of standard solutions.Primary and secondary standards.

A double titration with preparation of standard solution.

1. Estimation of Na2CO3 (NaOH – HCl - Na2CO3) 2. Estimation of NaOH (Na2CO3 mixture – Double indicator method) 3. Estimation of FAS (Oxalic acid – KMnO4 - FAS) 4. Estimation of Fe2+ (Oxalic acid – KMnO4-Fe2+) 5. Estimation of Oxalic acid (FAS – KMnO4– Oxalic acid) 6. Estimation of Calcium – Permanganimetry 7. Estimation of Copper (K2Cr2O7 – Thio – Cu2

+) 8. Estimation of K2Cr2O7 (K2Cr2O7 – FAS -K2Cr2O7) -External indicator

Text Book Course Material supplied by the Department

Reference Book Vogel’s Text book of Quantitative Chemical Analysis, 5th Edition, ELBS/Longman England 1989.

EVALUATION Continuous Internal Assessment (CIA) – 50 Marks

S.No. Components Marks 1 Observation Notebook –Neatly and Regularly maintained 10 2 Practical Results – Regular Class work 20 3 Internal Test 20 TOTAL 50

End-Semester Examination (at the end of III semester - 3 hour duration) One double titration with preparation of standard solution

S.No. Components Marks 1 Record Note book –Neatly maintained 05 2 Volumetric Estimation -Procedure 10 3 Volumetric Estimation-Result within the prescribed error limit 35 TOTAL 50

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DEPARTMENT OF CHEMISTRY

B.Sc., Chemistry: Allied-2

ALLIED CHEMISTRY – I

(For students admitted from the Academic Year 2015-2016 onwards under the New CBCS Pattern)

Class : II B.Sc. Physics Part : III Allied-3

Semester : III Hours : 45

Subject Code : 15UCHB33 Credits: 3

Objectives

To enable the student to understand the

o relation between electronic configuration and periodicity in properties of elements

o concept of chemical bonding

o basic industrial chemical processes used in fuels and in the synthesis of petrol

o rates of chemical reactions, order and its determination and the application of Le

Chatelier’s principle in equilibrium processes

o safety methods in the laboratory

Unit I Periodic Table (9 hours)

Mendeleev’s table.Merits and demerits.Long form of the periodic table and its advantages.

Classification into s,p,d and f-block elements.

Study of the variation of the following properties of elements in terms of their electronic

configurations. Atomic radius, ionic radius, ionization potential, electron affinity,

electronegativity, metallicity and their periodic variations

Unit II Chemical Bonding (9 hours)

Covalent bond: orbital overlap, hybridization, geometry of organic molecules-

CH4,C2H4,C2H2.Molecular orbital theory, bonding, antibonding and non-bonding

orbitals.Molecular orbitals. MO diagram of H2, N2, O2, F2. Bond order and Magnetic nature.

Diborane: Preparation and properties, structure, preparation and uses of NaBH4, Borazole

Unit III Basic concepts in Organic Chemistry (9 hours)

General Introduction.Functionalgroups.StructuralFormulae.Isomerism- Fundamental ideas only

– Structural and stereoisomerism – types and examples.Types of reagents –Electrophiles,

nucleophiles and free radicals.–definition and examples.Organic reactions – Types of

reactions.Cleavage of bonds – Homolysis and heterolysis.

Unit IV Chemical Kinetics (9 hours)

Rate, order, molecularity, pseudo first order, determination of order.Measurement of reaction

rate of fast reactions (Stopped Flow method, Pressure Jump method).Derivation of rate

constant for first and second order reactions.Effect of temperature on the rate – Arrhenius

equation.Energy of activation.Types of reactions with examples.(Basic concepts)

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Unit V Safety Methods in Lab (9 hours)

Storage and handling of chemicals.Toxic and poisonous chemicals. Waste and fume disposal.

Precautions and first-aid procedure.Uses of different glassware.Hazardsymbols.Laboratory

safety measures.

Text Books

1. A Text Book of Organic Chemistry, ArunBahl, B.S. Bahl., S.Chand& Co (2011)

2. Principles of Inorganic Chemistry, B.R.Puri, L.R.Sharma, &K.C.Kalia Milestone Publishers

(2012)

3. Principles of Physical Chemistry, B.R. Puri&L.R.Sharma&M.S.Pathania, Vishal Publishing

Co (2012)

Reference Books

1. Elements of Analytical Chemistry, R. Gopalan, P.S. Subramanian and K. Rangarajan,

Sultan Chand & Sons.

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DEPARTMENT OF CHEMISTRY

NON MAJOR ELECTIVE: CHEMISTRY IN YOUR LIFE

(For students admitted from the Academic Year 2015-2016 onwards under the New CBCS Pattern)

Class : II B.A. History, Economics Part : IV NME-1

Semester : III Hours : 45

Subject Code : 15UCHN13 Credits: 2

Objective:

To introduce the basic concepts on the importance and uses of various chemical

substances around us.

Unit I Air (9 hours)

Composition of air. Role of various components present in air. Biological importance of

oxygen.Air pollution- acid rain, ozone depletion, green house gases and green house effect.

Unit II Water (9 hours)

Importance of water.Naturalwater.Sources of water. Drinking water – making water fit to drink

– chlorination. Water pollution- Chemicals causing water contamination – contamination by

fertilisers, soaps and detergents and their effect.

Unit III Nutrients& Medicines (9 hours)

Important nutrients – carbohydrates, fats, proteins – their role in human health.Role of

vitamins, minerals - iron, calcium, cobalt in human health. Medicines: Antibiotics, Analgesics,

Antipyretics, Antidepressents – definition – few examples.

Unit IV Fireworks &Cosmetics (9 hours)

Firework – Chinese invention. Basic ingredients and principle of firework. Colour of firework.

Perfumes – basic composition. Fragrances.Substances that give colour- Dyes. Hair dyes and hair

colouring. Safety of hair dyes.

Unit VPolymers (9 hours)

Definition.Classification.Applications – Teflon, Polythene, PVC, Polystyrene, Nylon.

Plastics- Definition.Thermo and thermosetting plastics. Bakelite and its uses

Textbook

1. Study material given by the course teacher.

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DEPARTMENT OF CHEMISTRY

SELF LEARNING COURSE: FORENSIC CHEMISTRY

(For students admitted from the Academic Year 2015-2016 onwards under the New CBCS Pattern)

Class : Chemistry Part : SLC

Semester : III Hours :

Subject Code : 15UCHSL3 Credits : 03

Unit I . Chemical Toxicology

Poisons.Types and classification.Diagnosis of poisons in the living and the

dead.Clinicalsymptoms.Heavy metal contamination of sea foods.Use of neutron activation

analysis in detecting arsenic in human hair.

Unit II. Crime Detection

Explosives.Bombdetection.Metal detectors and other security devices. Composition of bullets

and detecting powder burns.

Unit III. Forgery and Counterfeiting

Documents. Different types of forged signatures. Use of UV rays.Comparison of type written

letters.Checking silver line and water mark in currency notes. Alloy analysis using AAS to detect

counterfeit coins. Detection of gold purity.Diamond checking.

Unit IV. Tracks and Traces

Tracks and traces. Casting of foot prints. Residue prints. Tyre patterns.Glass fracture. Tool

marks. Paints.Fibres.Analysis of biological substances.

Unit V. Medical Aspects

Misuse of scheduled drugs.Burns and their treatment by plastic

surgery.Metaboliteanalysis.Detecting steroid consumption among athletes.

REFERENCES

1. T.H. James, Forensic Sciences. Stanley Thames Ltd. (2000)

2. Richard, An Introduction to Forensic Science. 8thEdition.Prentice Hall.(2004)

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ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR – 625 514

DEPARTMENT OF CHEMISTRY

B.Sc. Chemistry: Core – 4

INORGANIC CHEMISTRY–I

(For students admitted from the Academic Year 2015-2016 onwards under the New CBCS Pattern)

Class : II B.Sc. Chemistry Part : III Core-4

Semester : IV Hours : 60

Subject Code : 15UCHC44 Credits: 4

Objectives

To enable the learners to understand

the structure of the atom

the different approaches in explaining the chemical bond.

the structure of atomic nucleus, nuclear reactions, fission, fusion, radioactivity and its

applications.

Unit – IAtomic Structure (12 Hours)

Introduction.Applications and limitations of Bohr’s theory and the line

spectra.Sommerfieldtheory.Atomic spectra of hydrogen atom.

Quantum numbers.Heisenberg’s uncertainty principle, Pauli’s exclusion principle,

Aufbauprinciple.Hund’s rule of maximum multiplicity.

Unit – II Chemical Bonding–I (12 Hours)

Introduction.Properties of ionic compounds.Lattice energy – Born-Haber cycle – Determination

to NaCl crystal. Factors affecting lattice energy.

Properties of covalent compounds.Partialcovalencyin ionic compounds – Fajans’ rules.

Electronegativity scales – Pauling, Mulliken.

Weak forces – Hydrogen bonding – Nature and types of hydrogen bonding –Applications.van

der Waal’s forces.

Unit – III Chemical Bonding–II (12 Hours)

Theories of covalent bond –Sidgwick – Powell theory, VSEPR theory.Structure of BeCl2, BF3, CH4,

NH3, H2O, PCl5, SF6.

Valence bond theory. Hybridisation – sp, sp2, sp3, sp3d, sp3d2 hybridisations.

Molecular orbital theory – Construction of MO diagrams. MO diagram for simple homo

diatomic (H2, He2, B2, C2, N2, O2 and F2) and hetero diatomic (CO and NO) molecules.Bond order

and magnetic properties.

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Unit – IV Nuclear Chemistry (12 Hours)

Introduction.Radioactivity.Stable and unstable nuclei and their relationship to n-p

ratio.Magicnumbers.Mass defect and binding energy.Packingfraction.Mass-energy

relationships.

Theories of radioactivity.Soddy’s group displacement law.Half-life

period.Averagelife.Radioactive disintegration series.

Nuclear Reactors and Nuclear energy.Nuclear fission – atomic bomb.Nuclear fusion – stellar

energy, hydrogen bomb.

Applications of radioactivity in medicine, agriculture and industry.Radiocarbon dating.

Unit – V Chemistry of Acids, Bases and Non-aqueous Solvents (12 Hours)

Definition, applications and limitations: Arrhenius concept, Bronsted-Lowry concept, Lewis

concept.

Pearson’s classification as Hard and Soft Acids and Bases (HSAB) – Applications and

limitations.Non-aqueous solvents – Ammonia.

Textbook

1. B. R. Puri, L. R. Sharma and K. C. Kalia, “Principles of Inorganic Chemistry”, 31st Edition,

Milestone Publishers and Distributors, New Delhi, India, 2008

Reference Books

1. James E. Huheey, Ellen A. Keiter, Richard L. Keiter&Okhil K. Medhi, “Inorganic Chemistry

– Principles of Structure and Reactivity”, 4thEdition,Pearson Education, New Delhi, 2006

2. SathyaPrakash, G. D.Tuli, S. K. Basu& R. D. Madan,“Advanced Inorganic Chemistry”,

S.Chand& Company, New Delhi,2007

3. John D. Lee, “Concise Inorganic Chemistry”, 5thEdition, Blackwell Science, New Delhi,

2006

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ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR – 625 514 DEPARTMENT OF CHEMISTRY

B.Sc. Chemistry: Core – 5 PHYSICAL CHEMISTRY–I

(For students admitted from the Academic Year 2015-2016 onwards under the New CBCS Pattern)

Class : II B.Sc. Chemistry Part : III Core -5 Semester : IV Hours : 75 Subject Code : 15UCHC54 Credits: 5

Objectives To enable the learners to understand

the structure of crystals

the importance of first law of thermodynamic and its application to the determination of thermodynamic parameters

To understand the importance of energy and entropy changes in predicting the feasibility of reactions

Enabling the learner to understand the energy changes in physical and chemical processes.

Unit – I Solid State (15 Hours) Crystal lattice – Face and edge of the crystal.Interfacialangles.Symmetry in crystals.Unitcell.Law of constancy of interfacial angle.Law of rationality of indices.Spacegroup.Millerindices.Spacelattices.Number of atoms per unit cell in a cubic lattice. Close packing of spheres (HCP,CCP). Diffraction of X-rays by crystals.Bragg’s equation. Experimental methods of crystal analysis.- Single crystal and powder techniques Analysis of the structure of NaCl , CsCl and KCl. Radius ratio. Molecular crystals - Applications. Crystal imperfections. Stoichiometric defects - Frenkel and Schottky effects. Non-stoichiometric defects – metal-excess and deficiency defects.

Unit – II Thermodynamics-I (15 Hours) Importance of Thermodynamics.Thermodynamic terms. – system, surroundings, processes. State variables. First law of thermodynamics.Exact differentials. Applications of the law to ideal gases: Heat capacity. Relation between Cp and Cv. Isothermal processes: Change in internal energy – work done in reversible isothermal expansion and compression. Adiabatic expansion – Joule-Thomson effect.Joule-Thomson coefficient and its significance. Application of the law to real gases: Isothermal processes: Work done, change in internal energy.

Unit – III Thermodynamics –II (15 Hours) Limitations of first law and the need for the second law.Formulation of second law of thermodynamics on the basis of Carnot cycle.Work function.

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Spontaneous processes. Criteria of spontaneity. Entropy(S), Internal Energy (E), Enthalpy (H), Gibbs Free Energy (G), Helmholtz Free Energy (A). Change in entropy for reversible and irreversible processes. Maxwell relation.

Evaluation of S for mixing.Expansion under isothermal and adiabatic conditions.Gibbs-Helmholtz equation.Partial molar free energy - Gibbs-Duhemequation, Clapeyron-Clausius equation.

Unit – IV Chemical Equilibrium and III Law of Thermodynamics (15 Hours) Law of mass action.Kp and Kc. Relationships between Kp and Kc. Properties of equilibrium constants. Van’t Hoff isotherm. Derivation of thermodynamic equilibrium constant and its relationship with free energy changes under standard conditions. Van’t Hoff isochore.Le-Chatelierprinciple.Formation of ammonia – Haber’s process. Third law of thermodynamics: Nernst heat theorem. Formulation of third law.Determination of absolute entropy of solids, liquids and gases.

Unit – V Thermochemistry (15 Hours) Thermochemistry – Types of enthalpy of reaction. Measurements of enthalpy of reaction.Thermochemicalequations.Standard enthalpy changes.Thermochemical law – Hess’s law.Calculation of standard heats of formation and combustion. Heat of neutralization, heat of hydration, heat of transition.Bond energy and heat of reaction. Variation of enthalpy change of the reaction with temperature (Kirchoff equation).

Text Book 1. Text Book of Physical Chemistry. M.V.Sankaranarayanan and V.Mahadevan, Universities

Press (India). 2011.

Reference Book 1. Principles of Physical Chemistry.Puri, Sharma and Pathania. Vishal Publishing (2003)

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ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR – 625 514 DEPARTMENT OF CHEMISTRY

B.Sc. Chemistry Allied–2 ALLIED CHEMISTRY – II

(For students admitted from the Academic Year 2015-2016 onwards under the New CBCS Pattern)

Class : II B.Sc. Physics Part : III Allied-4 Semester : IV Hours : 45 Subject Code : 15UCHB44 Credits: 3

Objectives To enable the student to understand

the theory of photochemical processes

structure and bonding in coordination compounds

preparation and reactions of aminoacids and carbohydrates

principles of chemical energetics, relation between heat and work and the concept of free energy

electrolytic conductance and electrochemical cells

Unit I Fundamentals of Photochemistry (9 hours) Definition of Photochemical reactions, Grotthus Draper Law and Einstein’s Law, Quantum Efficiency (High and Low).Jablonskydiagram.Comparison between thermal and photochemical reactions.Chemiluminescence, Fluorescence, Phosphorescence.Photosensitisation. (Definitions with suitable examples) Unit II Coordination Chemistry (9 hours) Introduction.Types of ligands.Terminology. IUPAC Nomenclature.Wernertheory.Chelation- examples. Valence Bond Theory and its applications.(Tetrahedral and Octahedral). Haemoglobin Chlorophyll - functions. EDTA and its applications in analysis. Unit III Life Chemistry (9 hours) Amino Acids: Classification, preparation and properties of glycine and alanine. Isoelectric point and zwitterion.Peptide bond. Classification of proteins by physical properties and by biological functions. Carbohydartes: classification, preparation and properties of glucose and fructose. Conversion of glucose to fructose and vice versa. Unit IV Energetics (9 hours) Energetics- Definition of first law thermodynamics. Types of systems.Reversible, irreversible.Isothermal and adiabatic processes.Joule-Thomson effect.Enthalpy, bond energy. Need for the second law. Entropy and its significance.Free energy change in a chemical reaction. Spontaneous processes – Criteria of spontaneity of chemical reaction. Unit V Electrochemistry (9 hours) Faradays Laws, Specific conductance, Equivalent conductance, Variation of conductance with dilution.Kohlraush’slaw.pH determination. Conductometric titrations. Buffer solutions and

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buffer action. Daniel cells, e.m.f. standard electrode potentials, reference electrodes. Electrochemical series and its applications. Text Books

1. A Text Book of Organic Chemistry, ArunBahl, B.S. Bahl., S.Chand& Co (2011) 2. Principles of Inorganic Chemistry, B.R.Puri, L.R.Sharma, &K.C.Kalia. Milestone Publishers

(2012) 3. Principles of Physical Chemistry, B.R. Puri&L.R.Sharma&M.S.Pathania. Vishal Publishing

Co (2012)

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ARUL ANANDAR COLLEGE (AUTON’OMOUS),KARUMATHUR – 625 514 DEPARTMENT OF CHEMISTRY

B.Sc. Chemistry: Allied Practical–2 ORGANIC ANALYSIS & VOLUMETRIC ESTIMATIONS

(For students admitted from the Academic Year 2015-2016 onwards under the New CBCS Pattern)

Class : II B.Sc.Physics Part : III Allied Practical Semester : III/IV Hours : 30 Subject Code : 15UCHR44 Credits : 2

I. VOLUMETRIC ANALYSIS: 1. Estimation of sodium hydroxide using standard sodium carbonate. 2. Estimation of hydrochloric acid- standard oxalic acid. 3. Estimation of oxalic acid- standard sulphuric acid. 4. Estimation of ferrous sulphate- standard Mohr salt solution. 5. Estimation of oxalic acid- standard ferrous sulphate. 6. Estimation of potassium permanganate- standard sodium hydroxide.

II. ORGANIC ANALYSIS: 1. Detection of Elements (N, S, Halogens). 2. To distinguish between aliphatic and Aromatic. 3. To distinguish between saturated and unsaturated.

4. Functional group tests for phenols, acids (mono), aromatic primary amine, diamide, carbohydrate, aldehyde, ketone

Functional groups characterized by confirmatory test.

Course material provided by the Department

EVALUATION Continuous Internal Assessment (CIA) – 50 Marks

Sl.No Components Marks

1 Observation Notebook –Neatly and Regularly maintained 05

2 Practical Results – Regular Class work 25

3 Internal Test 20

TOTAL 50

End-Semester Examination (at the end of IV semester - 3 hour duration) One Volumetric estimation and an organic compound analysis to be carried out.

Sl.No Components Marks

1 Record Note book –Neatly maintained 05

2 Volumetric Estimation -Procedure 05

3 Volumetric Estimation-Result within the prescribed error limit 20

4 Organic Analysis -Result 20

TOTAL 50

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ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR – 625 514 DEPARTMENT OF CHEMISTRY

NON MAJOR ELECTIVE: CHEMICALS FOR LIFE AND LIVING

(For students admitted from the Academic Year 2015-2016 onwards under the New CBCS Pattern)

Class : II B.Sc., Physics, Maths and RDS Part : IV NME-2 Semester : IV Hours : 45 Subject Code :15UCHN24 Credits : 2 Objective:

To introduce basic concepts on the importance and uses of various chemical substances in our life.

Unit 1 Energy resources (9 hours) Hydrocarbons and fossil fuels – Cooking gas, CNG, coal and petroleum -Basic discussion. Nuclear energy: Principle. Nuclear reactors in India Solar Energy: Principle of solar energy conversion to electricity. Environmental issues related to fossil fuels and nuclear energy.

Unit 2 Nutrients & Medicines (9 hours) Important nutrients – carbohydrates, fats, proteins – their role in human health.Role of vitamins, minerals - iron, calcium, cobalt in human health. Medicines: Antibiotics, Analgesics, Antipyretics, Antidepressents – definition – few examples.

Unit 3 Fireworks& Perfumes (9 hours) Firework – Chinese invention. Basic ingredients and principle of firework. Colour of firework. Perfumes – basic composition. Fragrances. Substances that give colour- Dyes. Hair dyes and hair colouring. Safety of hair dyes.

Unit 4 Polymers (9 hours) Definition.Classification.Applications – Teflon, Polythene, PVC, Polystyrene, Nylon. Plastics- Definition.Thermo and thermosetting plastics. Bakelite and its uses

Unit 5 Nucleic acids (9 hours) Nucleic acids – Elementary idea on the structure of DNA and RNA – their role.Hormones in our body.Their functions and deficiency symptoms.

Textbook 1. Study material given by the course teacher.

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ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR – 625 514 DEPARTMENT OF CHEMISTRY

SELF LEARNING COURSE: FOOD CHEMISTRY (For students admitted from the Academic Year 2015-2016 onwards under the New CBCS Pattern)

Class : Chemistry Part : SLC Semester : IV Hours : Subject Code : 15UCHSL4 Credits: 03 Objectives To understand

The importance of nutrition and balanced diet

Various additives used in food products

Nature and identification of food adulterants

Food preservation and quality norms of food products

Current developments in food science Unit-I Nutrition and Balanced Diet: Nutrition – calorific value of food stuff. Energy requirements of individuals – diet and its components – the protein requirements – biological value of proteins, supplementary value of proteins. Diseases associated with protein malnutrition. Nutritional value of carbohydrates. – Fibers in the diet, dietary sugars – nutritional aspects of lipids. Unit-II Food additives: Artificial sweeteners – saccharin, cyclomate, asparatame – food flavours – esters, aldehydes and heterocyclic compounds. Antioxidants.Food colours – changes in cooking. Restricted use. Baking powder –Yeast. Taste enhancers – MSG-vinegar Beverages: Soft drinks, soda, fruit juices and alcoholic beverages (Types and content of alcohol). Composition of soft drinks. Excessive use leading to urinary bladder stones. Unit-III Food adulteration – Types of adulterants- intentional, incidental and metallic. Common adulterants in different foods – milk and milk products, vegetable oils, and fats, spices and condiments, cereals, pulses, sweetening agents and beverages. Unit-IV Food Preservation- Methods – preservation by low temperature, high temperature. Preservatives. Quality control: Specifications and standards: PFA, FPO, FDA, drug license, WHO standards, ISI specifications. – Basic concepts. Unit V Introduction to food technology and future foods – Biotechnology in food.Nutraceuticals.Organic foods. Low cost nutrient supplements. Space foods. Text Books 1. M. Swaninathan, Food Science- Chemistry and Experimental Foods. The Bangalore Printing

and Publishing Co. (1993) 2. B.Srilakshmi, Food Science. New Age International Publishers(India). 2005

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ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR – 625 514

DEPARTMENT OF CHEMISTRY

B.Sc. CHEMISTRY MAJOR

(For students admitted from the academic year 2015-2016 onwards under the New CBCS)

ORGANIC CHEMISTRY – II

Class : III B.Sc. Chemistry Part : III Core-6

Semester : V Hours : 90

Subject Code : 15UCHC65 Credits : 6

Objectives

1. To study the synthetic methods and reactions of aldehydes and ketones.

2. To study the preparation, reactions and properties of carboxylic acids and the

derivatives.

3. To study the chemistry of polycyclic hydrocarbons

4. To learn the chemistry of amines, nitro compounds and diazonium compounds.

5. To understand the principles of organic synthesis and to study the synthetic

applications of EAA, Malonic Ester and Organometallics.

Unit I Carbonyl Compounds (18 Hours)

Nomenclature. Structure of carbonyl group. General methods of preparation of aliphatic

aldehydes and ketones. Physical properties. Acidity of -hydrogen. Chemical reactions-

Haloform reaction. Nucleophilic addition reactions. Addition of ammonia derivatives.

Condensation reactions- Mechanism of Aldol, Cannizarro,Tischenko reactions. Oxidation –

Reaction with Tollen’s, Fehling’s reagents. Baeyer-Villiger oxidation of ketones. Reduction by

MPV,Clemmensen, Wolff-Kishner and Complex Metal Hydrides.

Aromatic Aldehydes: Benzaldehyde. General methods of formation. Reactions, Claisen, Perkin,

Benzoin, Knoevenagel reactions.

Acetophenone and Benzophenone. Preparation and reactions.

p-Benzoquinone – Preparation and reactions.

Unit II Carboxylic acids and their Derivatives (18 Hours)

Preparation and reactions. Acidity of carboxylic acid. Effect of substituents on the acidity.

Conversion to functional derivatives. Reduction. HVZ reaction.

Preparation and reactions of Acrylic acid, Benzoic acid and Cinnamic acid.

Substituted acids: Preparation and reactions of Glycolic acid, Lactic acid, Salicylic acid,

Anthranilic acid, Glyoxalic acid and Pyruvic acid. Action of heat on , - and - hydroxy- and

amino acids.

Saturated dicarboxylic acids: Preparation and reactions of Oxalic, Malonic, and Succinic acids.

Action of heat on dicarboxylic acids. Phthalic acid, Phthalic anhydride and Phthalimide.

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Unsaturated dicarboxylic acids: Maleic and Fumaric acids. Preparation and reactions.

Unit III Polycyclic Hydrocarbons (18 Hours)

Isolated Systems: Diphenyl and Diphenylmethane. Preparation and reactions

Fused ring systems: Preparation and reactions of Naphthalene, Anthracene and Phenanthrene.

Structural elucidation of Naphthalene and Anthracene.

Preparation and reactions of Naphthols, Naphthylamines and Anthraquinone.

Carcinogenic hydrocarbons.

Unit IV Nitrogen Compounds (18 Hours)

Aromatic Nitro compounds – Nitrobenzene. Preparation and reactions. Reduction products of

Nitrobenzene.

Amines: Classification. Preparation and reactions. Basicity of amines. Separation of a mixture of

primary, secondary and tertiary amines. Basicity of aliphatic amines. Effect of substituents on

the basicity of aromatic amines.

Aliphatic diazo compounds: Diazomethane, Diazoacetic ester. Preparation and reactions.

Benzenediazonium chloride: Preparation structure and reactions.

Unit V Principles of Organic Synthesis (18 Hours)

Carbon-Carbon bond forming reactions: alkylation of active methylene compounds-Ethyl

acetoacetate and Malonic ester. Synthetic applications of Ethylacetoacetate and Malonic ester.

Fittig reaction, Claisen reaction, Claisen-Schmidt and Michael addition. Diels-Alder reactions-

synthesis of cyclic compounds.

Synthesis using organometallic compounds.

Organomagnesium compounds: Grignard reagents. Preparation, structure and chemical

reactions.Organozinc compounds – Preparation and reactions. Reformatsky reaction.

Organolithium compounds – Preparation and reactions of Phenyllithium.

Text Books

ArunBahl& B. S. Bahl, Advanced Organic Chemistry, 6th edition. S. Chand (2010)

Reference Books

1. Morrison and Boyd, Organic Chemistry, 6th edition. Prentice Hall (2006)

2. P. L. Soni and H. M. Chawla, Text Book of Organic Chemistry. 28th Edition. S. Chand (2006)

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ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR – 625 514 DEPARTMENT OF CHEMISTRY

B.Sc. CHEMISTRY MAJOR (For students admitted from the academic year 2015-2016 onwards under the New CBCS)

INORGANIC CHEMISTRY – II

Class : III B.Sc. Chemistry Part : III Core-7 Semester : V Hours : 90 Subject Code : 15UCHC75 Credits : 6

Objectives: To enable the learners to understand

the structure of atomic nucleus, nuclear reactions, fission, fusion, Radioactivity and its applications.

the different approaches in explaining the chemical bond.

the principles and applications of adsorption and catalysis

the general methods for extracting elements from their ores and their refining methods.

the trends in physical and chemical properties of s-block elements. UNIT I General Methods of Extraction of metals (18 Hours) Occurrence of metals- ore and mineral. Metallurgy – definition. Ore dressing – froth floatation, gravity, magnetic and chemical separation. Conversion of concentrated ore into metallic oxide – calcination and roasting. Isolation of the metal – electrolytic, chemical and auto reduction. Metal displacement. Complex formation followed by metal displacement. Refining of metals – physical and chemical methods. Electrolysis. van Arkel process and zone refining.

UNIT II Representative Elements – I(s-Block elements) (18 Hours) Alkali metals – Comparative study. Diagonal relationship of lithium with magnesium. Extraction of lithium. Uses. Compounds of alkali metals – sodium borohydride – preparation and uses. Alkaline earths – Group discussion. Beryllium- extraction and uses. Diagonal relationship with aluminum. Comparison with Mg.

Unit-III Representative Elements – II (p-Block elements) (18 Hours) Chemistry of boron. Boron hydrides – diborane –preparation and structure. Boric acid and borates. Borazole – preparation and structure. Group 14 elements: General properties. Carbon-catenation, allotropes. Silicon-hydrides, silicates and silicones. Group 15 elements: General properties.Nitrogen-oxides, oxoacids.Phosphorus-allotropes, oxoacids. Group 16 elements: General properties,Oxygen-anomalous behaviour, hydrogen bonding. Sulphur-allotropes, oxoacids.

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Group 17 elements: General properties.Oxoacids of halogens. Inter-halogen compounds – XYand XY3 types.Pseudohalogens

Unit-IV Transition Elements (18 Hours) First, second and third transition series. General characteristics. Occurrence, extraction, properties and uses of Titanium, Chromium, Cobalt, Nickel, Tungsten and Platinum

Unit V Inner Transition Elements (18 Hours) Lanthanides - Electronic Structure & Oxidation States. Magnetic Properties. Spectral Properties. Lanthanide contraction. Separation – Solvent Extraction, Valency Exchange, Ion Exchange methods. Actinides - Electronic Structure & Oxidation States. Magnetic Properties. Actinide contraction. Comparison of Lanthanides and Actinides.

Text Book

Modern Inorganic Chemistry. R.D.Madan. S.Chand (2004).

Reference Books Advanced Inorganic Chemistry. SatyaPrakash, G.D.Tuli, S.K.Basu, R.D.Madan. S.Chand (2008). Concise Inorganic Chemistry. John D. Lee. Wiley Publications (2010) Principles of Inorganic Chemistry. Puri, Sharma, Kalia. Milestone Publishers & Distributers. (2016)

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ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR – 625 514 DEPARTMENT OF CHEMISTRY

B.Sc. CHEMISTRY MAJOR (For students admitted from the academic year 2015-2016 onwards under the New CBCS)

PHYSICAL CHEMISTRY – II

Class : III B.Sc. Chemistry Part : III Core-8 Semester : V Hours : 90 Subject Code : 15UCHC85 Credits : 6

Objectives:

1. To understand the importance of phase rule and its application to one- and two-component systems.

2. To understand the kinetics and the order of chemical reactions. 3. To study the theory of separation of liquid mixtures and to study the distribution law

and its applications. 4. To understand the description of structure of atom in terms of Schrodinger

equation. 5. To study the laws, processes and reactions of photochemistry

Unit I Phase Rule (18 Hours) Phase rule. Concepts of phase, component and degrees of freedom. Gibbs phase rule- derivation. Clapeyron and Clausius-Clapeyron equation and their applications to equilibria in phase transitions (solid-liquid, liquid-vapour, soild-vapour). One component system: Water and Sulphur systems. Two component systems: i) Simple eutectic- Lead-Silver system ii) Formation of compound with congruent and incongruent melting point FeCl3-H2O and Na2SO4-H2O systems

Unit II Chemical Kinetics (18 Hours) Introduction. Rate of reaction. Rate law and rate constants. Order and molecularity of reactions. Derivation of rate constant and half life period for first and second order reactions. Examples for first and second order reactions. Third order reactions. (No Derivation). Methods of determining the order of a reaction. Complex reactions- consecutive, parallel and reversible reactions-Elementary idea. Influence of temperature on the rate of a reaction. Arrhenius rate equation and its significance. Bimolecular collision theory. Theory of absolute reaction rates. Lindemann’s hypothesis.

Unit III Solutions of Non-Electrolytes (18 Hours) Ideal solutions. Vapour pressure-composition diagram of solution. Raoult’s law. Positive and negative deviations from the law. Principle of fractional distillation. Steam distillation. Binary systems. Azeotropic distillation. Partially miscible binary liquid systems. Critical Solution Temperature. –UCST, LCST, both UCST and LCST. Effect of addition of solute on CST. Solubility of gases in liquids. Henry’s law.

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Distribution law: Thermodynamic derivation. Limitation of the law. Application of studying association, dissociation and solvation. Study of formation of complex ions. Solvent extraction. Efficiency of extraction.

Unit IV Quantum Chemistry (18 Hours) Dual nature of electrons -De Brogliesparticle-waveduality. Davisson-Germer experiment -Heisenberg’s uncertainty principle. Probability concept of electron. Schrodinger wave equation. Interpretation of wave function. Eigen Equation, Eigen values and Eigen function. Operator-Commuting,Hermitian. Solution of wave equation for particle in a one dimensional. Schrodinger equation for hydrogen atom. Probability densities of orbitals.

Unit V Photochemistry (18 Hours) Comparison of thermal and photochemical reactions. Laws of Photochemistry. Beer-Lambert law. Grothus-Draper law. Stark-Einstein law. Quantum efficiency and its determination, reason for low and high efficiency. Consequences of light absorption by atoms and molecules. Jablonski energy level diagram. Primary and secondary photo physical processes- Radiationless transition-internal conversion and intersystem crossing. Fluorescence and Phosphorescence – Applications. Experimental study of photochemical reactions. Qualitative aspect of photochemical H2-Cl2 and H2-Br2 reactions. Basic concepts of photosensitized reactions. Flash photolysis and Chemiluminescence. Bioluminescence. Text Book Principles of Physical Chemistry. B. R. Puri, Sharma and L. R. Pathania. Vishal Publishing (2003) Reference Book Text Book of Physical Chemistry. M.V.Sankaranarayanan and V. Mahadevan. Universities Press (2011)

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ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR – 625 514

DEPARTMENT OF CHEMISTRY

B.Sc. CHEMISTRY MAJOR

(For students admitted from the academic year 2015-2016 onwards under the New CBCS)

ORGANIC ANALYSIS AND ESTIMATION

Class : III B.Sc. Chemistry Part : III (Core Lab III)

Semester : V Hours : 60

Subject Code : 15UCHP45 Credits : 3

Objectives:

To enable the learners to

learn the principles of Organic analysis.

Develop the skills in analyzing the given organic compound, finding the functional

group and to prepare a suitable derivative.

1. Identification of acidic, basic, phenolic and neutral organic substances.

2. Detection of N,S and halogens

3. Test for aliphatic and aromatic nature of compounds

4. Test for saturation and unsaturation

5. Identification of functional groups

Carboxylic acids, Phenols, aldehydes, ketones, reducing sugars, primary amines,

amides.

6. Estimation of Phenol

7. Estimation of aniline.

Text Book

Course material to be supplied by the Department

Reference Book

Vogel’s Text Book of Practical Organic Chemistry. 4th edition. ELBS, 1984.

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Evaluation

Continuous Internal Assessment (50 Marks)

Sl. No Components Marks

1 Regular practical observation 10

2 Results of the practical 25

3 Internal Test 15

TOTAL 50

End-Semester Examination (50 Marks). (At the end of odd-semester)

Sl. No Components Marks

1 Record Notebook. Maintained neatly 05

2 Procedure- volumetric estimation 05

3 Identification of the organic compound 15

4 Estimation- within the prescribed limit 20

5 Viva voce 05

TOTAL 50

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ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR – 625 514

DEPARTMENT OF CHEMISTRY

B.Sc. CHEMISTRY MAJOR

(For students admitted from the academic year 2015-2016 onwards under the New CBCS)

GRAVIMETRY AND PREPARATION

Class : III B.Sc. Chemistry Part : III (Core Lab IV)

Semester : V & VI Hours : 60 (30+30)

Subject Code : 15UCHP55/15UCHP66 Credits : 3

Gravimetric Estimations

1. Estimation of lead as lead chromate

2. Estimation of barium as barium chromate

3. Estimation of calcium as calcium oxalate monohydrate

4. Estimation of copper as CuSCN

Organic preparations

1. Hydrolysis - Acid from an ester/amide

2. Acetylation - Acetanilide from aniline

3. Oxidation - Benzoic acid from benzaldehyde

Inorganic preparations

1. Potash alum (or) Chrome alum

2. Prussian blue

3. Tetraamminecopper(II)sulphate

Text Book

Course material to be provided by the department.

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Continuous Internal Assessment (50 Marks)

Sl. No Components Marks

1. Observation Note book

Maintained neatly and regularly

10

2. Results of the practical

25

3. Internal Test 15

TOTAL 50

End-Semester Examination (50 Marks)

Sl.No Components Marks

1. Record Notebook 5

2. Gravimetric Estimation –Procedure 5

3. Estimation-Final Result within the prescribed error limit 20

4. Preparation – Final result 15

5. Viva voce 5

TOTAL 50

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ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR – 625 514 DEPARTMENT OF CHEMISTRY

B.Sc. CHEMISTRY MAJOR (For students admitted from the academic year 2015-2016 onwards under the New CBCS)

MEDICINAL CHEMISTRY Class : III B.Sc. Chemistry Part : III Core Elective-1 Semester : V Hours : 60 Subject Code : 15UCHE15 Credits : 3

Objectives 1) To impart fundamental knowledge about the nature of drugs, drug activity,

structure-activity relationship, and drug synthesis. 2) To introduce a basic idea of drugs used for treating various diseases. 3) To motivate the student to pursue a career in pharmaceutical industries.

Unit I (12 hours) Introduction to the different systems of medicine-ayurveda, Siddha, homeopathy and allopathy. History of medicinal chemistry. Discovery of drugs-an introduction. Terminology. Sources of drugs. Drug classification. Mechanism of drug action and metabolism of drugs. Unit II (12 hours) Principles of drug discovery and synthesis. The concept of lead compounds. Synthetic considerations.Use of computers in drug design. Relationship between chemical structure and pharmacological activity. Unit III (12 hours) Analgesics, antipyretics and anti-inflammatory Agents: Classification based on structure. Salicylates. Paracetamol. Opioid analgesics- morphine and its analogues. NSAIDS.- Important drugs. Antidepressant Drugs- Definition . Anxiety. Classification. Benzodiazepines and barbiturates. Unit IV (12 hours) Chemotherapy-Basic principles of chemotherapy. The molecular basis of chemotherapy. Antibacterials- sulphonamides. Antibiotics- beta-lactam antibiotics, tetracyclins, chloramphenicol, aminoglycosides, macrolides and flouroquinolones.Antimalarials. Unit V (12 hours) Blood- Composition-grouping-Rh factor- buffers in blood. Functions of plasma proteins – clotting mechanism – blood pressure.Coagulants and anticoagulants- definition and examples. Antianemic drugs. Cardiovascular drugs- definition and names of drugs used for each of the following –antiarrythmic agents, antihypertensives – antianginals, vasodilators – lipid lowering agents. Drug abuse and dependence- The nature of drug dependence- nicotine, ethanol and cannabis Text Book

Jayashree Ghosh.A Textbook of Pharmaceutical Chemistry. S.Chand (1997) Reference Books

1. Rang, Ale and Ritter.Pharmacology. Churchill Livingstone (1995) 2. S.Lakshmi. Pharmaceutical Chemistry.Sultan Chand & Sons. 2nd edition (1998) 3. AshutoshKar.Medicinal Chemistry. New Age International (1992)

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ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR – 625 514 DEPARTMENT OF CHEMISTRY

B.Sc. CHEMISTRY MAJOR (For students admitted from the academic year 2015-2016 onwards under the New CBCS)

ORGANIC CHEMISTRY – III

Class : III B.Sc. Chemistry Part : III Core-9 Semester : VI Hours : 90 Subject Code : 15UCHC96 Credits : 6

Objectives 1. To study the chemistry of heterocyclic compounds and dyes. 2. To understand the structure and reactions of carbohydrates. 3. To study the structural elucidation and synthesis of alkaloids and terpenes. 4. To study the mechanism of important molecular rearrangements and tautomerism. 5. To study and apply spectrometric techniques in studying the structure of organic compounds.

Unit I Heterocyclic Compounds and Dyes (18 Hours) Nomenclature. Preparation, properties and reactions of Pyrrole, Furan, Thiophen, Pyridine, Indole, Quinoline and Isoquinoline. Dyes- Theories of colour and constitution. Classification according to structure and applications. Preparation and uses of Methyl orange, Bismarck brown, Malachite green, Phenolphthalein, Fluorescein, Indigo and Alizarin

Unit II Carbohydrates (18 Hours) Carbohydrates: Classification. Monosaccharides -Properties and reactions. Structural elucidation of Glucose and Fructose. Epimerisation and Mutarotation. Ring structure and conformation. Descending, Ascending and inter-conversions of monosaccharides. Determination of ring size. Disaccharides – Sucrose, maltose and lactose – Structure and properties. (No structural elucidation). Polysaccharides- Starch and Cellulose. Properties and Uses.

Unit III Alkaloids and Terpenes (18 Hours) Alkaloids:General methods of isolation. General structure determination. Structural elucidation of Coniine, Piperine and Nicotine. Terpenes: Classification. Occurrence. Isolation. General properties. Isoprene rule. Structural

elucidation of Citral and Geraniol. Preparation and properties of Menthol and -pinene.

Unit IV Molecular Rearrangements (18 Hours) Molecular rearrangements: Anionotropic and Cationotropic rearrangements. Intramolecular and intermolecular rearrangements. Mechanism of the following reactions – Pinacol-Pinacolone, Beckmann, Benzidine, Hoffman, Curtius, Benzilic acid, Claisen, Fries and Wagner-Meerwein rearrangements.

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Unit V Spectrometric Identification of Organic Compounds (18 Hours) UV-Visible Spectroscopy: Types of electronic transition. Chromophore, Auxochrome. Bathochromic, Hypsochromic, Hyperchromic and Hypochromic shifts. UV spectrum of conjugated dienes. Carbonyl compounds. Woodward-Fieser rules applied to conjugated dienes

and ,-unsaturated carbonyl compounds. Simple examples. IR Spectroscopy: Molecular Vibrations. Fingerprint region. Characteristic absorption of functional groups. Interpretation of IR spectra of simple molecules. NMR Spectrum: Fundamental concepts. Chemical shift. Shielding and de-shielding. Area of signals. Spin-Spin splitting. Coupling constants. Interpretation of PMR spectra of Ethyl bromide, Ethanol, Acetaldehyde.

Text Book B. S. Bahl&ArunBahl.Advanced Organic Chemistry. S. Chand. Revised Edition (2010) Reference Book Morrison Boyd &Bhattacharjee.Organic Chemistry. Pearson Education. 7th Edition(2010)

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ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR DEPARTMENT OF CHEMISTRY

B.Sc. CHEMISTRY MAJOR (For students admitted from the Academic Year 2015-2016 onwards under the New CBCS Pattern)

INORGANIC CHEMISTRY-III Class : III B.Sc. Chemistry Part : III Core-10 Semester : VI Hours : 90 Subject Code : 15UCHD06 Credits : 6

Objectives 1. To acquire a thorough understanding of classification, bonding and properties of

coordinationcompounds. 2. To study the chemistry of metal carbonyls and nitrosyls. 3. To study the chemistry of organo-transition metal complexes and their applications

in industrial processes. 4. To study the role of metal complexes in biological systems.

Unit I Coordination Compounds (18 Hours) Introduction. Nomenclature. Types of ligands. Coordination number – examples for C.N. 2, 3, 4, 5 and 6. Isomerism in coordination compounds: Structural Isomerism - ionization, hydration, linkage, coordination, ligand, polymerization. Stereo Isomerism - geometrical and optical isomerism. Stability of Complexes. Thermodynamic and kinetic stability (no derivation). Chelation - chelate effect. Factors affecting Chelation. Structure of EDTA and DMG.

Unit II Bonding in Coordination Compounds (18 Hours) Theories: Werner’s theory. Valence Bond Theory (VBT) – High and low spin states. Hybridisation – sp3, dsp2, dsp3, sp3d2 and d2sp3. Applications of VBT to octahedral, tetrahedral and square planar complexes. Magnetic properties of complexes. Crystal Field Theory (CFT) – postulates – crystal field splitting in Octahedral, Tetrahedral and Square planar complexes. High and low spin octahedral complexes. Factors influencing Crystal Field splitting. Calculation of CFSE. Uses and limitations of CFT. Jahn-Teller distortion in octahedral complexes. Magnetic properties. Spectrochemical series.

Unit III Metal Carbonyls and Nitrosyls (18 Hours) Metal Carbonyls. EAN rule and its application to the carbonyls of Cr, Mn, Fe, Co and Ni. Bonding in metal carbonyls – molecular orbitals of CO. General methods of preparation of carbonyls – direct combination and reductive carbonylation. Structure determination of Ni(CO)4, Fe(CO)5, and Mn2(CO)10. Metal Nitrosyls – Preparation and structure of sodium nitroprusside. EAN rule applied to [Co(CO)3(NO)]

Unit IV Reaction Mechanism in Coordination Compounds (18 Hours) Substitution reactions of octahedral complexes – SN1, SN2. Acid and Base hydrolysis of Octahedral complexes. Substitution reactions of square-planar complexes – Trans effect

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(theories included). Mechanism of Electron Transfer Reactions in Solution Phase – Outer Sphere and Inner Sphere Mechanisms. Two-electron Transfer Reactions.

Unit V Bioinorganic Chemistry (18 Hours) Introduction. Metal complexes in biological systems – chlorophyll, cyanocobalamine. Iron containing oxygen carriers – Introduction. Myoglobin and hemoglobin. Structure of the prosthetic group. Mechanism of binding of oxygen and CO to myoglobin and hemoglobin. Copper containing enzyme – Structure and functions of superoxide dismutase (SOD). Zinc containing enzyme – Structure and functions of carbonic anhydrase.

Text Book J. E. Huheey, E. A. Keiter, R. L. Keiter, O. K. Medhi. Inorganic Chemistry – Principles of Structure and Reactivity. 4th Edition. Pearson Education (2008).

Reference Books 1. R. Gopalan, V. Ramalingam. Concise Coordination Chemistry. 1st Edition.Vikas Publishing

House (2001). 2. D. Banerjea. Coordination Chemistry. 3rd Edition. Asian Books (2009). 3. B. R. Puri, L. R. Sharma, K. C. Kalia. Principles of Inorganic Chemistry. 33rd Edition.

Milestone Publishers & Distributors (2016). 4. R. M.Roat-Malone.Bioinorganic Chemistry – A Short Course. John Wiley & Sons (2013).

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ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR DEPARTMENT OF CHEMISTRY

B.Sc. CHEMISTRY MAJOR (For students admitted from the Academic Year 2015-2016 onwards under the New CBCS Pattern)

PHYSICAL CHEMISTRY-III

Class : III B.Sc. Chemistry Part : III Core-11 Semester : VI Hours : 90 Subject Code : 15UCHD16 Credits : 6

Objectives

1. To study the behaviour of ions in solution. 2. To study the principles of pH, buffer solutions and salt hydrolysis. 3. To understand the basics of electrodes, electrode potential and electrochemical cells. 4. To study the theory of spectroscopic techniques- Microwave, IR, Raman, NMR and ESR. 5. To study the basic concepts of Group Theory.

Unit I Solutions of Electrolytes –Conduction (18 Hours) Electrolytic conduction. Faradays laws of electrolysis. Specific, equivalent and molar conductance. Variation of conductance with dilution. Strong and weak electrolytes. Ionic mobility. Determination of ionic mobilities. Transport number. Determination of transport number by Hittorf and moving boundary method. Kohlrausch’s law. Applications of Kohlrausch’s law. Applications of conductance measurements- conductometric titrations. Ostwald’s dilution law. Theory of strong electrolytes – Debye-Huckel theory. Onsager equation and its significance. Unit II Ionic Equilibria (18 Hours) Ionic product of water. pH of acids and bases. Common ion effect. solubility product of sparingly soluble salts. Derivation of Hendersen equation. Hydrolysis of salts, Degree of hydrolysis, Hydrolysis constant- Salt of weak acid and strong base, salt of strong acid and weak base, salt of weak acid and weak base. Relationship between Kh,Ka,Kb and Kw Unit III Electrochemical Cells (18 Hours) Galvanic cells. Reversible and irreversible cells. Emf and its measurements. Standard cells. Electrode reactions. Measurement of electrode potentials. Standard electrode potentials. Sign convention. Reference electrodes – Standard hydrogen, Calomel and Quinhydrone electrodes. Electrochemical series and its significance. Concentration cells with and without transference. Liquid junction potentials. Derivation of Nernst equation for emf of cells. Applications of emf measurements. Determination of pH using Hydrogen, Quinhydrone and Glass electrodes. Potentiometric titrations. Applications of concentration cells. Overvoltage.

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Unit IV Spectroscopy (18 Hours) Introduction. Molecular Spectroscopy: Introduction. Regions of the electromagnetic spectrum. Microwave spectroscopy: Rotation of molecules. Rotational spectrum of simple diatomic molecules. IR Spectroscopy: Vibration of diatomic molecules. Simple harmonic and anharmonic vibrations. Characteristic group vibrations. Raman Spectroscopy: Introduction. Molecular polarisability. Selection rules. Mutual exclusion principle. Magnetic resonance: Theory of PMR spectroscopy. Instrumentation. Chemical shift and Spin-Spin coupling. CMR - Introduction EPR Spectroscopy: Basic Idea. Hyperfine splitting. Applications-hydrogen atom, methyl radical Unit V Group Theory (18 Hours) Molecular symmetry elements and symmetry operations. Illustrations. Products of symmetry operations. Properties of group-classes and subgroups. Group multiplication table. Point groups. Group Theory of NH3 and water molecules. Text Book Puri, Sharma and Pathania. “Principles of Physical Chemistry”. Vishal Publishing. Revised Edition (2013) Chapters 17,18,19,22.

Reference Book Dogra S K & Dogra, S. “Physical Chemistry Through Problems” 2ndEdition. New Age International (2015).

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ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR – 625 514

DEPARTMENT OF CHEMISTRY

B.Sc. CHEMISTRY MAJOR

(For students admitted from the academic year 2015-2016 onwards under the New CBCS)

PHYSICAL CHEMISTRY

Class : III B.Sc. Chemistry Part : III (Core Lab V)

Semester : V Hours : 60

Subject Code : 15UCHP76 Credits : 3

Objectives:

To enable the learners to carry out experiments in physical chemistry.

1. Determination of Molecular weights

Transition temperature method – Using sodium thiosulphatepentahydrate as the

solvent.

Cryoscopic method – Rast’s method using Naphthalene as the solvent.

2. Phase equilibria

Determination of CST of phenol-water system

Estimation of NaCl by studying the CST of phenol-water system

Construction of phase diagrams – Two component systems

a) Simple eutectic

b) compound formation

3. Chemical kinetics

Determination of rate constant of hydrolysis of methyl acetate by an acid.

Determination of relative strengths of two acids by studying the kinetics of hydrolysis of

ester.

4. Electrochemistry

Conductometric titrations: HClvsNaOH and CH3COOH vsNaOH

Potentiometric titrations: Fe2+vs K2Cr2O7

5. Partition experiments

Determination of association of benzoic acid in benzene.

6. Adsorption Isotherm. Adsorption of benzoic acid over activated carbon.

Text Book

Course material to be supplied by the department

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EVALUATION

Continuous Internal Assessment (50 Marks)

Sl. No Components Marks

1. Regular practical Observation 10

2. Results of the regular practical 25

3. Internal Test 15

TOTAL 50

End-Semester Examination (50 Marks)

Sl.No Components Marks

1. Record Notebook 5

2. Procedure 5

3. Experiment -Final Result within the prescribed error limit 35

4. Viva voce 5

TOTAL 50

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ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR – 625 514 DEPARTMENT OF CHEMISTRY

B.Sc. CHEMISTRY MAJOR (For students admitted from the academic year 2015-2016 onwards under the New CBCS)

INDUSTRIAL CHEMISTRY

Class : III B.Sc. Chemistry Part : III Core Elective-2 Semester : V Hours : 60 Subject Code : 15UCHE26 Credits : 3

Objectives

1. To study the applications of chemical principles in various industrial manufacturing processes like petrochemicals, sugar, fertilizers, pesticides and paper industry.

2. The study the principles and importance of green chemistry concepts.

Unit I Petrochemicals (12 Hours) Crude oil. Constitution and distillation. Composition of different distillates. Ignition point, flash point and octane number. Cracking. Catalysts used in petroleum industries – structure, selectivity and applications. Manufacture of synthetic petrol. Dergius and Fischer-Tropsch processes/ Manufacture of petrochemicals – acetaldehyde, acetic acid, phenol, cumene, linear alkyl benzenes. Unit II Sugar Industry (12 Hours) Sugar Industry in India. Sugar cane and sugar beet – manufacture of cane sugar. Extraction of juice – concentration – separation of crystals – sulphitation and carbonation – testing and estimation of sugar. Bagasse – use of Bagasse for the manufacture of paper and electricity. Unit III Fertilisers and Pesticides (12 Hours) Classification of fertlisers – urea, super phosphate and potassium nitrate. Mixed fertliser – fertliser industry in India Insecticides and pesticides – Definition. Classification. Inorganic pesticides. Lead arsenate, Paris Green, Lime, sulphur, hydrocyanic acid. Organic pesticides – Natural and synthetic. Fungicuides – Repellants. Unit IV Paper and Pulp industry (12 Hours) Introduction. Manufacture of pulp – sulphite pulp, soda pulp and rag pulp. Beating, refining, filling, sizing and coloring. Manufacture of paper, calendaring. Unit V Principles of Green Chemistry (12 Hours) Definition. Need for Green chemistry. Difference between Green Chemistry and Environmental Chemistry. Waste minimization techniques. 12 principles of green chemistry. One example illustrating each principle.

Visit to the above industries and submission of report

Reference Books 1. Chemical Process Industries. Schreve. McGraw Hill 2. Industrial Chemistry. B.K.Sharma. Goel Publishing House (2003) 3. Green Chemistry. An Introductory Text. Royal society of Chemistry (UK) (2002)

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ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR – 625 514 DEPARTMENT OF CHEMISTRY

B.Sc., CHEMISTRY MAJOR (For students admitted from the academic year 2015-2016 onwards under the New CBCS)

FUEL CHEMISTRY

Class : III B.Sc. Chemistry Part : Self Learning-III Semester : V Hours : Subject Code : 15UCHSL5 Credits : 3

Objectives Elaborate study of Fuels: Introduction - classification - preparation - properties - their sources of energy - storage - alternate fuels - applications

UNIT-I Fuels And Combustion - Introduction - Classification of Fuels – Calorific Value – Theoretical Calculation of Calorific Value of a Fuel Gross calorific value and net calorific value – Characteristics of a Good Fuel - Solid fuels - Wood. Coal - Classification of Coal by Rank - Selection of Coal - Analysis of Coal and its significance

UNIT-II Types of cooking - Types of Carbonization of Coal - Role of Sulphur in Coal - Role of Ash in Coal. Gaseous fuels - Producer Gas - Water Gas - Natural Gas – Oil Gas - Biogas - Components - composition - preparation – advantages - disadvantages and applications of Coal gas - Gobar gas - LPG UNIT-III Liquid fuels -Petroleum- Cracking- Advantages of catalytic cracking over thermal cracking - Synthetic Petrol. Refining of Gasoline – Reforming - Knocking - Octane number of Gasoline - Diesel Engine Fuels - Diesel - Octane number of Diesel Oil - Diesel index. UNIT-IV Residual fuel oils - Asphalt - Aviation fuel- advantages -Kerosene as a fuel. Analysis and testing of liquid and gaseous fuels - Utilization of fuels - Solar power.

UNIT-V Other sources of energy – Electricity Power - Modern Concept of Fuel - Fuels for Metallurgy. Power Alcohol - Recent Advances In Fuel Technology. Alternative Fuels – Alcohols – Promising Biofuel : An Alternative Source to Diesel and Gasoline - Control of Pollution in Refineries.

Reference Books 1. B.K. Sharma.Industrial Chemistry.GoelPublishing House(2016) 2. JayashreeGhosh.Fundamental Concepts of Applied Chemistry. S.Chand(2010) 3. K.BagavathiSundari.Applied chemistry. MJP Publishers (2006)

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ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR – 625 514 DEPARTMENT OF CHEMISTRY

B.Sc. CHEMISTRY MAJOR (For students admitted from the academic year 2015-2016 onwards under the New CBCS)

CHEMISTRY FOR COMPETITIVE EXAMS

Class : III B.Sc. Chemistry Part : Self Learning-IV Semester : VI Hours : Subject Code : 15UCHSL6 Credits : 3

Objective: To train the students face any competitive examinations for jobs or entrance examination for higher studies To develop the skills to answer multiple choice questions Unit -I Multiple choice questions in Stereochemistry, Reaction Mechanisms, Spectroscopy Unit -II Multiple choice questions in Chemical Bonding, Main group of elements, Lanthanides Coordination Chemistry Unit -III Multiple choice questions in Thermodynamics, Chemical Kinetics, Electrochemistry Unit -IV Multiple choice questions in Separation techniques, Purification Techniques, Data Analysis & Reporting Unit - V Multiple choice questions Polymer Chemistry, Industrial Chemistry Reference Books 1. Unique Quintessence of Chemistry-Unique Publishers, New Delhi. (For UPSC/State Civil Services and Competitive Exam)Editor R.S. Arora 2. Chemistry for Competitive Exams – T.S.Rao&T.Sampurna – CBS Publishers & Distributors,

New Delhi 3. IIT Objective Chemistry-Arul Syamal – Atlantic Publishers & Distributors Pvt (Ltd) 4. Objective Question Bank in Chemistry – B.K.Sharma 5. Objective Chemistry- K.L.Chugh – Kalyani Publishers, New Delhi.

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DEPARTMENT OF CHEMISTRY ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR

M.Sc. Chemistry – Course Structure under CBCS (Applicable to the students admitted from the academic year 2017-2018 onwards)

S.No Course Code Title of the Paper Hours/Week Credit

SEMESTER-I

1 Core 17PCHC11 Organic Reaction Mechanism & Stereochemistry

5 4

2 17PCHC21 Group Theory & Solid State Chemistry 4 4

3 17PCHC31 Quantum Chemistry and Chemical Bonding

5 4

4 17PCHC41 Research Methodology 3 2

5 Elective-1 17PCHE11 Chemistry of Materials 5 4

6 Practical 17PCHP11 Organic Chemistry Practical 8 5

TOTAL 30 23

SEMESTER-II

7 Core 17PCHC52 Conformational Analysis, Reagents and Organic Synthesis

4 4

8 17PCHC62 Coordination, Organometallics and Bioinorganic Chemistry

4 4

9 17PCHC72 Principles of Molecular Spectroscopy 4 4

10 Elective-2 17PCHE22 Medicinal Chemistry 4 4

11 NME 17PCHN12 Green &Environmental Chemistry 6 4

12 Practical 17PCHP22 Inorganic Chemistry Practical 8 5

TOTAL 30 25

SEMESTER-III

13 Core 17PCHC83 Applications of Spectroscopy 6 4

14 17PCHC93 Analytical Chemistry 5 4

15 17PCHD03 Chemical Thermodynamics, Equilibria and Electrochemistry

6 4

16 Elective-3 17PCHE33 Biochemistry 5 4

17 Practical 17PCHP33 Physical Chemistry Practical 8 5

TOTAL 30 21

SEMESTER-IV

18 Core 17PCHD14 Natural Products 4 4

19 17PCHD24 Nuclear Chemistry and Photochemistry

4 4

20 17PCHD34 Chemical Kinetics, Surface Chemistry & Computational Chemistry

5 4

21 17PCHD44 Project Work 12 5

22 Elective-4 17PCHE44 Molecular Dynamics 5 4

TOTAL 30 21

Semester I II III IV Total

Credit 23 25 21 21 90

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DEPARTMENT OF CHEMISTRY ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR

ORGANIC REACTION MECHANISM AND STEREOCHEMISTRY

(Applicable to the students admitted from the academic year 2017-2018 onwards under CBCS) Class : I M.Sc. Chemistry Part : Core-1 Semester : I Hours : 75 Code : 17PCHC11 Credits : 4 To enable the learners

1. to know the mechanism and stereochemistry of organic reactions.

2. to understand the aliphatic and aromatic substitution reactions.

3. to know the mechanism of elimination and addition reactions.

UNIT–I: Introduction to Reaction Mechanism (15 Hours)

Bronsted and Lewis concepts of acids and bases – Hard and Soft Acids and Bases theory. Energy

changes. Intermediates Vs transition states. Hammond postulate. Principle of microscopic

reversibility. Methods of determining reaction mechanism. Non kinetic methods – isotopic

labelling, isolation of intermediates and effects due to structural changes. Kinetic methods –

kinetic isotope effect, substituent effect and field effect of substituents.

UNIT–II: Introduction to Stereochemistry (15 Hours)

Projection formulas of stereoisomers – Interconversion of Flying Wedge, Fischer, Sawhorse and

Newman projections. Molecular Symmetry. Chirality. Optical activity, ORD and CD – Cotton

effect. Stereoisomerism. Absolute Configuration. Cahn Ingold and Prelog or R,S designation of

compounds having chiral centres. Absolute configuration of compounds having chiral axis –

Allenes, Spiranes, Biphenyls and ANSA compounds. E-Z nomenclature. Erythro and Threo

nomenclature. Prostereoisomerism and Topicity.

UNIT–III: Aliphatic Nucleophilic Substitution Reactions (15 Hours)

SN2Mechanism. SN1Mechanism. Ion pair mechanism for SN1 reaction. Energetics,

stereochemistry and distinction of SN2 and SN1reactions. Factors influencing nucleophilic

substitution reactions - effect of substrate, nature of nucleophile, solvent polarity, leaving

group ability on the course of the reaction. SNi Mechanism. Neighboring group participation.

Nonclassical carbocations. Allylic and Vinylic substitution. Electrophilic substitution reactions in

aliphatic system– SE1, SE2 and SEi reactions.

UNIT–IV: Aromatic Substitution Reactions (15 Hours)

Aromatic Electrophilic Substitutions. General Mechanism. Characteristics – reactivity and

orientation, relative rates of substitutions, partial rate factor. Reactions with carbon

electrophiles - Friedel Crafts Alkylation and Acylation. Vilsmeier-Haack reaction. Reimer

Tiemann reaction. Aromatic electrophilic rearrangement of hydrazobenzene. Aromatic

Nucleophilic Substitution reactions – ArSN2, ArSN1 mechanisms. Linear free energy relationship

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– Hammett equation – significance of sigma and rho – Limitations and deviations of Hammett

equation. Taft equation.

UNIT–V: Elimination and Addition reactions (15 Hours)

E1, E2 and E1CB mechanisms. Regioselectivity in β Elimination reactions. Bredt’s rule. Hofmann

elimination. Competition between elimination and substitution. Electrophilic addition of

halogens to carbon carbon multiple bonds. Hydroboration. Nucleophilic addition to carbonyl

bond – Aldol, Dieckmann and Stobbe condensations. Reformatsky, Perkin, Knoevenagel and

Mannich reactions.Micheal addition.

References

1. Jerry March, “Advanced Organic Chemistry: Reactions, Mechanisms and Structure”, 5th Edition, Wiley, 2000.

2. D. Nasipuri, “Stereochemistry of Organic Compounds-Principles and Applications”, 2nd Edition, New Age International, 2002.

3. P. S. Kalsi, “Organic Reactions Stereochemistry and mechanism”, New Age International Publishers, 2012.

4. N. Tewari, “Advanced Organic Stereochemistry” Books and Allied (P) Ltd, 2012. 5. E. L. Eliel and S. H. Wilen, “Stereochemistry of Organic Compounds”, John Wiley, 2003. 6. T. H. Lowry and K. S. Richardson, “Mechanism and Theory in Organic Chemistry”, 2nd

Edition, Harper and Row, 1981. 7. P.Sykes, A Guide book to Mechanisms in Organic Chemistry, 6th Edn., Longmans

Scientific and Technical, Essex, 1986. 8. F.S.Gould, Mechanism and Structure in Organic Chemistry, Holt, New York, 1959. 9. F.A.Carey and R.J.Sundberg, Advanced Organic Chemistry, Part A and Part B, 3rd

Edn., Plenum press, New York, 1990.

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DEPARTMENT OF CHEMISTRY

ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR

GROUP THEORY AND SOLID STATE CHEMISTRY

(Applicable to the students admitted from the academic year 2017-2018 onwards under CBCS)

Class : I M.Sc. Chemistry Part : Core-2

Semester : I Hours : 60

Code : 17PCHC21 Credits: 4

Objectives

To enable the learners

1. to understand the principles and applications of group theory.

2. to learn the solid state structure and diffraction methods.

3. to study the polymeric inorganic compounds.

UNIT–I: Principles of Group Theory (12 Hours)

Introduction - groups, subgroups, classes, Group multiplication table; Molecular symmetry,

symmetry elements and operations– products of symmetry operations; classes of symmetry

operations and classification of molecules as point groups Cnv, Cnh, Dnh and Dnd.

Representations of groups: matrix representation of symmetry operations, reducible and

irreducible representations; Statement of Great Orthogonality theorem; character tables and

their construction for C2v and C3v point groups.

UNIT–II: Applications of Group Theory (12 Hours)

Symmetry and chemical bonding - Formulating SALC’s with projection operators, LCAO -

Molecular Orbital theory for inorganic compounds; tetrahedral and octahedral compounds -

Molecular vibrations - symmetry of vibrations in non-linear molecules – selection rules for IR

and Raman vibrations in CO2, H2O and CH4.

UNIT–III: Solid State Structure (12 Hours)

Close packing of atoms and ions – HCP and BCC types of packing – voids, radius ratio derivation

and its influence on structures. Representative structures of AB and AB2 types of compounds:

rock salt, caesium chloride, wurtzite, zinc blende, rutile, fluorite. Structure of graphite and

diamond.

UNIT – IV: Diffraction Methods (12 Hours)

Introduction, Characterisation of solids, Laws of Crystallography – space groups – screw axis

and glide plane – seven crystal systems and Bravais lattice –Miller indices- interplanar distances

in orthogonal crystal systems – X-ray diffraction studies – powder and rotating crystal methods

– systematic absences and lattice types – electron diffraction by gases – principles and

measurements – determination of structures – comparison between electron, neutron and X-

ray diffractions.

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UNIT–V: Polymeric Inorganic Compounds (12 Hours)

Isopoly and heteropoly acids – Bonding of 6- and 12 – isopoly and heteropoly anions. Structure

of silicates - applications of Pauling’s rule of electrovalence –one-, two- and three- dimensional

silicates. Synthesis and structure of ring and cage compounds: borazine, phosphazine,

carboranes. Cages – P2O3, Boron compound, Clusters.

REFERENCE BOOKS

1. J. E. Huheey, E. A. Keiter and R. L. Keiter, “Inorganic Chemistry – Principles of Structure

and Reactivity”, Harper Collins College Publishers, 4th Edition, 1993.

2. F. A. Cotton and G. Wilkinson, “Advanced Inorganic Chemistry” 5th Edition, Wiley-

Interscience Publication, New York, 1988.

3. K.V.Raman, Group Theory and its Applications to Chemistry, Tata McGraw-Hill,1990.

4. V.Ramakrishnan and M.S.Gopinathan, Group Theory in Chemistry, Vishal, 1988.

5. L. W. Azaroff, “Introduction to Solids”, Mc-Graw Hill.

6. N. B. Hannay, “Solid State Chemistry”, Prentice Hall, New Delhi, 1976.

7. F. C. Philips, “An Introduction to Crystallography”, Longman.

8. K. F. Purcel and J. C. Kotz, Inorganic Chemistry”, W. G. Saunder’s Company, Philadelphia.

9. Shriver, Atkins and Langford, “Inorganic Chemistry”, ELBS.

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DEPARTMENT OF CHEMISTRY

ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR

QUANTUM CHEMISTRY AND CHEMICAL BONDING

(Applicable to the students admitted from the academic year 2017-2018 onwards under CBCS)

Class : I M.Sc. Chemistry Part : Core-3

Semester : I Hours : 75

Code : 17PCHC31 Credits: 4

To enable the learners

1. to learn the fundamentals of quantum chemistry.

2. to study the quantum mechanics of simple systems and the applications.

3. to understand the bonding in simple molecules and metals.

UNIT–I: Fundamentals of Quantum Chemistry (15 Hours)

Introduction to quantum mechanics – Blackbody radiation, photoelectric effect, de Broglie

equation and its verification, Interpretation of Bohr’s first postulate in terms of wave nature of

electron, Heisenberg Uncertainty principle; Setting up the Schrodinger equation, operators,

algebra of operators, linear operators, setting up operators of linear momentum, angular

momentum, kinetic energy and total energy of systems.

UNIT–II: Quantum Mechanics of Simple Systems (15 Hours)

Writing the Hamiltonian for H and He atoms- eigen functions and eigen values, proving that

linear momentum and angular momentum operators are linear, Hermitian operator and its

properties, commutator theorem and its converse, Expansion theorem; Postulates of quantum

mechanics. The Schrödinger wave equation- particles in 1D and 3D boxes, harmonic oscillator,

rigid rotator, Hydrogen atom, Hydrogen orbital - Time dependent Schrödinger wave equation-

Approximation methods - Pertubation Theory (first order and non-degenerate), The Variation

method.

UNIT–III: Applications of Quantum Chemistry (15 Hours)

Chemical bonding- VB & MO theory as applied to H2+, Conjugated hydrocarbons and Aromatic

hydrocarbons, Huckel MO theory - Molecular Spectroscopy and quantum mechanics-Born

Oppenheimer approximation, Schrodinger equation for rotational, vibrational and electronic

components and their selection rules.

UNIT–IV: Chemical Bonding (15 Hours)

VB approach to bonding – Concept of hybridisation and structure of molecules. VSEPR theory

shapes of molecules. MO approach to covalent bonding – symmetry and overlap of atomic

orbitals – symmetry of molecular orbitals – sigma, pi and delta bonding – energy levels in homo

and hetero nuclear diatomic systems – bond length, bond order and bond energy – ionic

character in a covalent bond. Dipolemoment – Determination and applications.

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UNIT–V: Metallic Bonding (15 Hours)

Drude Lorentz theorem, merits and demerits – Sommerfeld theroem – band theorem –

formation of Brillouin zones – conductors and insulators – semiconductors - Hall effect –

photoconductivity - superconductors,. Point-, line- and plane defects in solids – Stoichiometric

and non-stoichiometic defects – Frenkel and Schotky defects. Effect of imperfections on

physical properties like electrical conductivity, thermal, optical and magnetic phenomena.

REFERENCE BOOKS

1. P.W.Atkins, Physical Chemistry, 5thEdition, International Student Edition, Oxford, (1994)

2. J. Moore, Physical Chemistry, Orient Longman, 5thEdition(1972)

3. A.K.Chandra, Introductory Quantum Chemistry, Tata McGraw-Hill, 4thEdition (2001)

4. Quantum Chemistry, McQuarrie A. D., Viva Books, India, 1stIndian Edition (2003)

5. Quantum Chemistry & Spectroscopy, Engel T. and Reid P., Pearson, 3rdedition(2006)

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DEPARTMENT OF CHEMISTRY

ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR

RESEARCH METHODOLOGY

(Applicable to the students admitted from the academic year 2017-2018 onwards under CBCS)

Class : I M.Sc. Chemistry Part : Core - 4

Semester : I Hours : 45

Code : 17PCHC41 Credits: 2

To enable the learners

1. to know the chemical literature of research.

2. to know about the chemical abstracts.

3. to acquire knowledge about scientific writings.

UNIT - 1 : Research Methodology: An Introduction (9 Hours)

Meaning. Objectives. Motivation in research. Types of research - fundamental research,

applied research, action research, historical research, experimental research. Research

Approches. Research Methods versus Methodology. Research and Scientific Method. Research

Process. Criteria for Good research. Problems encountered by Researchers.

UNIT - 2 : Chemical Literature (9 Hours)

Sources of chemical information: primary, secondary and tertiary sources.

Indexes and abstracts in science and technology: applied science and technology index,

biological abstracts, chemical abstracts, chemical titles, current chemical reactions, current

contents, engineering index, index chemicus, index medicus, physics abstracts, science citation

index.

Classical and comprehensive reference works in chemistry. Beilstein, compilations of data,

synthetic methods and techniques, treatises, reviews.

UNIT - 3 : Chemical Abstracts (9 Hours)

Current awareness searching: CA weekly issues, CA issue indexes. Retrospective searching: CA

volume indexes-general subject index, chemical substance index, formula index, index of ring

systems, author index, patent index.

CA Collective indexes: Collective index (CI), decennial index (DI).Access points for searching CA

indexes: index guide, general subject terms, chemical substance names, molecular formulas,

ring systems, author names, patent numbers. Locating the reference: finding the abstract ,

finding the original document, chemical abstract service source index.

UNIT - 4 :Report Writing (9 Hours)

Characteristics of a good report. Format and contents of a research report. Preliminary Section

– Title page, Researcher’s declaration, Certificate of the Research Supervisor,

Acknowledgements. Table of contents. List of tables. List of figures and illustrations. Abstract.

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Text or Body of the Report – Introduction, Research process, Results and discussion, Summary,

conclusion and recommendations. Reference Material – Bibliography. Footnotes.

UNIT - 5: Computer Searches of Literature (9 Hours)

Additional Skill Acquisition Programme (ASAP) Alerts, Chemical Abstract Alerts, SciFinder,

ChemPort, Science Direct , STN International. Journal home pages.

REFERENCE BOOKS

1. R. L. Dominoswki, Research Methods, Prentice Hall, 1981.

2. H. F. Ebel, C. Bliefert and W. E. Russey, The Art of Scientific Writing, VCH, Weinheim,

1988.

3. C.R. Kothari, “Research Methodology Methods and Techniques” New Age International

Publishers, 2010.

4. G. Vijayalakshmi, C. Sivapragasam, “Research Methods Tips and Techniques” MJP

Publishers, 2009.

5. H. M. Kanare, Writing the Laboratory Notebook; American Chemical Society: Washington,

DC, 1985.

6. Gibaldi, J. Achtert, W. S. Handbook for writers of Research Papers; 2nd ed.; Wiley Eastern,

1987.

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DEPARTMENT OF CHEMISTRY

ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR

CHEMISTRY OF MATERIALS

(Applicable to the students admitted from the academic year 2017-2018 onwards under CBCS)

Class : I M.Sc. Chemistry Part : Elective-1

Semester : I Hours : 75

Code : 17PCHE11 Credits: 4

To enable the learners

1. to learn about the materials and the systems under technological importance.

2. to understand the materials synthesis.

3. to acquire knowledge in modern characterization of materials.

UNIT I Introduction to Materials (15 Hours)

Inorganic Materials - Organic materials – Nanotechnology. Composites and Nanomaterials.

Mechanical properties. Refractories, characterization, properties and applications. Bulk to nano

transition - physical phenomena– Metals, semiconductors, Carbon nanotubes, fullerenes,

Quantum dots.

UNIT II Systems under Technological Importance (15 Hours)

Naturally occurring materials. Optical and magnetic systems based on Metals. Inorganic

semiconductors - optical materials, magnetic materials. Organic semiconductors –

Optoelectronic materials. Nano systems – catalysis, surface coating technology, high

temperature superconductivity.

UNIT III Chemical and non – chemical approach to Materials synthesis (15 Hours)

Solution based material synthesis – Precipitation methods, hydrothermal, Micro – emulsion, Sol

– gel, Phase transfer reactions. Synthesis and properties of monolayer capped metal

nanoparticles. Material synthesis using microwave radiation and ultra-sonic waves. Solid state

synthesis. Hybrid methods for materials synthesis.

UNIT IV Tc Materials (15 Hours)

High Tc Materials. Normal state properties, anisotropy, temperature dependence of electrical

resistance. Superconducting state; heat capacity; coherence length, elastic constants,

microwave absorption-pairing and multigap structure in high Tc materials. Applications of high

Tc materials.

UNIT V Modern Characterization of Materials (15 Hours)

Routine characterization tools – UV–Visible spectrophotometer, Fluorimeter, NMR, IR, Particle

size analyzer, Powder X – ray microscopy, Scanning electron microscopy, Transmission electron

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microscopy, X – ray photoelectron spectroscopy, Atomic force microscopy – Scanning probe

microscopy.

REFERENCE BOOKS

1. Materials Science, J.C. Anderson, K.D. Leaver, J.M. Alexander and R.D. Rawlings, ELBS.1990

2. Principles of the Solid State, H.V. Keer, Wiley Eastern.1993

3. Charles P. Poole Jr. Frank J. Owens, Introduction to Nanotechnology, John Wiley & Sons,Inc.

2003.

4. Nan Yao, Zong Lin Wang, Handbook of Microscopy for Nanotechnology, Kluwer academic

publishers, London, 2005.

5. J. D. Lee, Concise Inorganic Chemistry, , Fifth edition, Blackwell publishing, 2008.

6. Robert T. Morrison, Robert N. Boyd, and Robert K. Boyd, Organic Chemistry, 6thedition

Benjamin Cummings, 1992.

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DEPARTMENT OF CHEMISTRY ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR

ORGANIC CHEMISTRY PRACTICAL

(Applicable to the students admitted from the academic year 2017-2018 onwards under CBCS) Class : I M.Sc. Chemistry Part : Core Lab-1 Semester : I Hours : 120 Code : 17PCHP11 Credits : 5 I Organic Analysis

Separation of two component mixture and identification of components (about 4 – 5

mixtures)

II Preparation of Organic Compounds (Double Stage)

1. p-bromo acetanilide from aniline (acetylation and bromination) 2. acetyl salicylic acid from methyl salicylate (hydrolysis and acetylation) 3. p-bromoaniline from acetanilide (bromination and hydrolysis) 4. m-nitroaniline from nitrobenzene (nitration and reduction)

III Separation of Organic Compounds (Demonstration only)

1. Isolation of caffeine from tea leaves

2. Isolation of casein from milk

IV Estimation of Organic Compounds

1. Ketone

2. Glucose

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DEPARTMENT OF CHEMISTRY

ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR

CONFORMATIONAL ANALYSIS, REAGENTS AND ORGANIC SYNTHESIS

(Applicable to the students admitted from the academic year 2017-2018 onwards under CBCS)

Class : I M.Sc. Chemistry Part : Core-5

Semester : II Hours : 60

Code : 17PCHC52 Credits: 4

To enable the learners

1. to learn conformational analysis and dynamic stereochemistry.

2. to study the reagents in organic synthesis and molecular rearrangements.

3. to acquire knowledge in organic synthesis.

UNIT–I: Conformational analysis (12 Hours)

Conformational isomerism. Atropisomerism. Conformations of acyclic compounds - Ethane,

propane and n-Butane. Conformations of cyclic molecules – cyclopropane, cyclobutane and

cyclopentane. Conformations of cyclohexane – chair conformation, boat conformation,

interconversion of chair conformations. Conformations of substituted cyclohexanes – mono and

disubstituted cyclohxanes. Conformation of decalins, perhydrophenanthrene and

perhydroanthracene.

UNIT–II: Dynamic Stereochemistry (12 Hours)

Conformation and reactivity in – Weinstein Eliel equation, Curtin-Hammett principle, steric

assisted and steric hindered reactions-steroelectronic effects – cis elimination, Cyclohexyl

systems - esterification – oxidation - Substitution reaction - E2 elimination -intramolecular

rearrangements – neighbouring group participation – formation and cleavage of epoxide.

Reactions of enols and enolates.

UNIT–III: Reagents in Organic Synthesis (12 Hours)

Use of the following reagents in organic synthesis and functional group transformations:

Complex Metal Hydrides, Organocuparates - Gilman reagents, Wilkinsons Catalyst, Lithium

diisopropylamide (LDA), dicyclohexylcarbodiimide (DCC), Trimethylsilyl Halides, Tri-n-Butyltin

Hydride (Bu3SnH), Osmium Tetroxide, 2,3-Dichloro-5,6-Dicyano-1,4-Benzoquinone (DDQ),

Bakers Yeast. Woodward and Prevost Hydroxylation, Peterson Synthesis.

UNIT–IV: Molecular Rearrangements (12 Hours)

Nucleophilic Rearrangements to Electron Deficient Carbon – Wagner Meerwein, Favorski,

Benzilic Acid rearrangements.

Nucleophilic Rearrangements to Electron Deficient Nitrogen - Hoffmann, Curtius, Beckmann

and Neber rearrangements.

Electrophilic Rearrangements - Stevens and Sommelet-Hauser rearrangements.

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UNIT–V: Organic Synthesis (12 Hours)

Importance of synthesis – carbon-carbon bond making reactions – functional group

modifications – reterosynthetic analysis – synthons and synthetic equivalents – nucleophilic,

electrophilic, electroneutral and free radical synthons – umpolung – protection and

deprotection – Trimethylsilyl ether, Ethoxyethylactal, tert-Butoxycarbamate and 1,3—

dithiolane. Diels Alder reactions – C-X, C-C disconnections. Robinson annulation method – 1,2

and 1,3 disconnections.

REFERENCE BOOKS

1. J. March, Advanced Organic Chemistry, 4thEdn. John Wiley, New York, 1992.

2. P. Sykes, A Guide book to Mechanisms in Organic Chemistry, 6th Edn., Longmans

Scientific and Technical, Essex, 1986.

3. F. S. Gould, Mechanism and Structure in Organic Chemistry, Holt, NewYork, 1959.

4. P. S. Kalsi, “Organic Reactions Stereochemistry and Mechanism”, New Age International

Publishers, 2012.

5. T. H. Lowry and K. S. Richardson, Mechanism and theory in Organic Chemistry, Harper

and Row, New York, 1976.

6. F. A. Carey and R. J. Sundberg, Advanced Organic Chemistry, Part A and Part B, 3rdEdn.,

Plenum press, New York, 1990.

7. E. L. Eliel, Stereochemistry of Carbon Compounds, McGraw Hill, 1962.

8. D. Nasipuri, Stereochemistry of Organic compounds, 2nd Edn, New Age

International, New Delhi, 1972.

9. E. L. Eliel ,N.C.Allinger, S.J.Angyal and G.A.Morrision, Conformational analysis,

Interscience, New York, 1965.

10. R. E. Ireland, Organic Synthesis, Prentice Hall, 1969.

11. S. Turner, Design of Organic Synthesis, Elsevier, 1976

12. S. Warren, Designing Organic Synthesis – A programmed introduction to synthon

approach, Wiley, New York, 1978.

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DEPARTMENT OF CHEMISTRY ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR

COORDINATION, ORGANOMETALLICS AND BIO-INORGANIC CHEMISTRY

(Applicable to the students admitted from the academic year 2017-2018 onwards under CBCS)

Class : I M.Sc. Chemistry Part : Core-6 Semester : II Hours : 60 Code : 17PCHC62 Credits: 4

To enable the learners 1. to know the reaction mechanism of coordination compounds.

2. to study the pi-acceptor complexes. 3. to acquire knowledge in bio-inorganic chemistry and organometallics.

UNIT–I: Chemistry of Coordination Compounds (12 Hours) Werner’s coordination theory – Isomerism in coordination compounds – types of ligands and chelate effect – stability constant determination. Job’s method.VB theory and CFT - Splitting of d orbitals under different geometries – octahedral, tetrahedral and square planar. CFSE – evidence for CFSE – structure of spinels – factors affecting CFSE – spectrochemical series – Jahn-Teller distortion – M.O. theory of bonding –sigma and p-bonding in coordination compounds.

UNIT–II: Inorganic Reaction Mechanism (12 Hours) Electron transfer reactions: Outer-sphere and inner sphere electron transfer reactions –The Marcus theory – non-complementary reactions – synthesis of coordination compounds by electron transfer reactions. Substitution reactions : substitution reactions of square planar complexes of Pt(II) and other d8metal complexes – significance of trans-effect – substitution reactions of octahedral complexes – acid and base hydrolysis reactions – anation reactions – synthesis of coordination compounds by substitution reactions. Molecular rearrangements and reactions of coordinated ligands – the template effect and macrocyclic ligands.

UNIT–III: Pi-acceptor Complexes (12 Hours) Pi acceptor ligands. synthesis, properties, structure and bonding of mono nuclear and poly-nuclear carbonyls – nitrosyl complexes – dinitrogen complexes – metal carbonylato complexes, carbonyl hydrides and complex metal cyanides.

UNIT–IV: Bioinorganic Chemistry (12 Hours) Metalloporphyrins – chlorophyll, hemoglobin and myoglobin – structure and function of hemoglobin cytochromes. Metalloenzymes enzyme action inhibition and restoration –carboxypeptidase-A and carbonic anhydrase – Vitamin B12 and B12 coenzymes. Metalloproteins – non-heme iron proteins – rubredoxin and ferrodoxin – copper proteins and their classification – nitrogenases, their structure and function. Metal ions in biology -–sodium ion pump – metal poisons and chelating agents in medicine

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UNIT–V: Organometallics (12 Hours) Metal alkyl and aryls – 18 electron rule – olefin and acetylene complexes – Zeise’s salt –Dewar-Chatt approach to bonding in ethylene and acetylene complexes – cyclopentadiene, benzene and cyclobutadiene complexes of transition metals – their preparations, bonding and reactions. Homogeneous catalysis involving organometallics – oxidative addition and reductive elimination reactions – hydrogenation, isomerization and hydroformylation of olefins –carbonylation of methanol, oxidation of olefins (Wacker’s process) - heterogeneous catalysis –Ziegler-Natta polymerization of propylene.

REFERENCE BOOKS 1. F.A.Cotton and G.Wilkinson, “A Text book of Advanced Inorganic Chemistry”3rdEdn.Wiley,

1972. 2. R.S.Drago, “Physical Methods in Inorganic Chemistry”, Van Nostrand Reinhold, 2ndEdn. 1968. 3. B.N.Figgis and J.Lewis, “The Magneto Chemistry of Complex Compounds” in “Modern

Coordination Chemistry”, Edn Lewis & Wilkins PP-400-454, Interscience,N.Y. 1967. 4. J.C.BalorEdts. “Comprehensive Inorganic Chemistry, Vol. IV & V, Academic Press,1979. 5. K.F.Purcell and J.C.Kotz, “Inorganic Chemistry, Holt Saunders, 1977. 6. J.E.Huhey, Inorganic Chemistry, Haarper and Rao 3rd Edition Edn. 1983. 7. C. E. Coates. M L H Green, P Powell K Wade Principles of Organometallic Compounds.

Chapman and Hall, 1977. 8. W. Kaim and B. Schewederski, “Bioinorganic Chemistry: Inorganic Elements in the Chemistry

of Life”, John-Wiley and sons, New York. 9. S. J. Lippard and J. M. Berg, “Principle of Bioinorganic Chemistry”, Parima Publishing

Company, New Delhi.

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DEPARTMENT OF CHEMISTRY

ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR

PRINCIPLES OF MOLECULAR SPECTROSCOPY

(Applicable to the students admitted from the academic year 2017-2018 onwards under CBCS)

Class : I M.Sc. Chemistry Part : Core-7

Semester : II Hours : 60

Code : 17PCHC72 Credits: 4

To enable the learners

1. to acquire knowledge in microwave and infrared spectroscopy.

2. to know Raman, Electronic and Fluorescence spectroscopy.

3. to learn in detail about the NMR and ESR spectroscopy.

UNIT–I: Introduction, Microwave Spectroscopy and Infrared Spectroscopy (12 Hours)

Microwave Spectroscopy - Rotation of molecules - rotational spectra of rigid rotator, intensities

of rotational lines, effect of isotopic substitution - rotational spectrum of non-rigid rotator -

linear & symmetric top molecules - Stark effect. Applications - determination of bond length,

bond angle dipolemoment and atomic mass from microwave spectra.

Infrared Spectroscopy: vibrating diatomic molecule - harmonic and anharmonic oscillators -

diatomic vibrating rotator - vibrations of polyatomic molecules - molecular vibrations, types of

molecular vibrations, rotational vibrational spectra of linear and symmetric top molecules. FTIR

spectroscopy.

UNIT–II: Raman, Electronic and Fluorescence Spectroscopy (12 Hours)

Raman spectroscopy- classical and quantum theory of Raman effect- rotational Raman spectra-

linear, symmetric top molecules-vibrational Raman spectra- Raman activity of vibrations, rule of

mutual exclusion, polarizability ellipsoids- rotational Fine structures-Resonance Raman and

Laser Raman spectroscopy.

Electronic Spectra of diatomic molecules-The Born-Oppenheimer approximation, vibrational

coarse structure: progressions, intensity of vibrational-electronic spectra: Franck-Condon

principle, dissociation energy and dissociation products, rotational fine structure ofelectronic-

vibration transitions, Fortrat diagram – predissociation. Fluorescence and phosphorescence –

Jablonski diagram – Fluorescence spectroscopy – FRET.

UNIT–III: Nuclear Magnetic Resonance Spectroscopy-I (12 Hours)

Nuclear spin states and NMR active nuclei, nuclear magnetic moments- mechanism of

resonance absorption- population of nuclear spin states, proton NMR- interaction of spin

magnetic moment of a proton with external magnetic moment, chemical shift and shielding.

Nuclear spins in a magnetic field - Zeeman effect -Larmor precession -resonance phenomenon -

spin - lattice and spin-spin relaxation times -nuclear shielding and chemical shift -spin-spin

coupling – basic principles of FT NMR.

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UNIT–IV: Nuclear Magnetic Resonance Spectroscopy-II (12 Hours)

Analysis of complex NMR spectra -chemical equivalence, chemical environment, spin-spin

splitting, coupling constant, geminal, vicinal, long-range, trans, aromatic, allylic coupling, factors

influencing coupling constant, splitting of nmr signals- AB, AX and AMX types -Overhauser

effect - NMR of paramagnetic compounds -relaxation by paramagnetic ions in solution - 2

Dimensional NMR - Pulse sequences - NMR in solids –magic angle spinning -chemical shift

anisotropy - NMR Imaging - MRI.

UNIT–V: Electron Spin/Paramaganetic Resonance Spectroscopy (12 Hours)

Electron spin - Electronic Zeeman effect - EPR spectrum of hydrogen atom (first order

treatment) - g factors - Hyperfine splitting: nuclear spin (I = 1/2, 1, 3/2, 5/2) interaction with

electron spin - hyperfine coupling constants - EPR spectra of organic radicals (AA and AB type)-

EPR spectra of heteronuclear compounds - McConnell’s relation – Introduction to multi

electron systems: zero field splitting - Kramer’s degeneracy - S = 1/2 , 3/2, 5/2 in the transition

metal complexes - anisotropy in the hyperfine coupling constant – EPR instrumentation.

REFERENCE BOOKS

1. Fundamentals of Molecular Spectroscopy, C.N.Banwell, Tata McGraw-Hill, 3rdEdn.

2. R.Chang, Basic Principles of Spectroscopy, McGraw Hill.

3. G. N. Barrow, Introduction to Molecular Spectroscopy, International Mc.Graw Hill Edition

(1993)

4. B. P. Straughan and S. Walker, Spectroscopy, Vol.I to III, Chapman Hall, London (1976),

5. Quantum Chemistry and Spectroscopy, Engel T. and Reid P., Pearson, Third edition(2006).

6. J. D. Roberts, “High Resolution Nuclear Magnatic Resonance”, McGraw-Hill, New York.

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DEPARTMENT OF CHEMISTRY

ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR

MEDICINAL CHEMISTRY

(Applicable to the students admitted from the academic year 2017-2018 onwards under CBCS)

Class : I M.Sc. Chemistry Part : Elective-2

Semester : II Hours : 60

Code : 17PCHE22 Credits : 4

To enable the learners

1. to know the physical principles and drug action.

2. to acquire knowledge in antibiotics, antibacterials, antifungal and antimalarials.

2. to study non-steroidal drugs.

Unit I Physical Principles (12 Hours)

Structure and activity. Relationship between chemical structure and biological activity

(SAR).Receptor Site Theory. Approaches to drug design. Introduction to combinatorial synthesis

in drug discovery. Factors affecting bioactivity. Relationship between Free-Wilson analysis and

Hansch analysis.

Unit II Drug Action (12 Hours)

Pharmacodynamics. Introduction, elementary treatment of enzymes stimulation, enzyme

inhibition, sulfonamides, membrane active drugs, drug metabolism, xenobiotics,

biotransformation, significance of drug metabolism in medicinal chemistry.

Unit III Antibiotics and Antibacterials (12 Hours)

Introduction, Antibiotic β-Lactam type - Penicillins, Cephalosporins, Antitubercular

.Streptomycin, Ciprofloxacin, Norfloxacin. Broad spectrum antibiotics .Tetracyclines, Anticancer

– Dactinomycin (Actinomycin D) – Synthesis & drug action, antibacterial drug.

Unit IV Antifungal and Antimalarials (12 Hours)

Antifungal polyenes, Antineoplastics. Antiviral. Antimalarials. Chemotherapy of malaria.

Chloroquine, Chloroguanide and Mefloquine

Unit V Non-steroidal Drugs (12 Hours)

Non-steroidal Anti-inflammatory Drugs. Analgesics - Diclofenac Sodium, Ibuprofen and

Netopam. Antipyretic Drugs – Paracetamol, Calpol. Antihistaminic and antiasthmatic agents –

Classification - Terfenadine, Cinnarizine, Salbutamol and Beclomethasonedipropionate. Oral

contraceptives.

REFERENCE BOOKS

1. John M. Beale, Jr., John H. Block. Wilson and Gisvold's Textbook of Organic Medicinal and

Pharmaceutical Chemistry, 12th Revised Edition. 2010

2. S.S. Pandeya & J.R. Dimmock.An Introduction to Drug Design, New Age International. 1997

3. R.B. Silverman.The Organic Chemistry of Drug Design and Drug Action, Academic Press. 2nd

Edition, 2004

4. D. Lednicer.Strategies for Organic Drug Synthesis and design, John Wiley, 2nd Edition, 2008.

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DEPARTMENT OF CHEMISTRY ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR

GREEN AND ENVIRONMENTAL CHEMISTRY

(Applicable to the students admitted from the academic year 2017-2018 onwards under CBCS) Class : I M.Sc. Chemistry Part : Non Major Elective Semester : II Hours : 90 Code : 17PCHN12 Credits: 4 To enable the learners 1. to learn the principles of green chemistry.

2. to study the green solvents in green synthesis. 3. to acquire knowledge in radioactive pollution and pollution from agriculture.

UNIT I: Introduction to Green Chemistry (18 Hours) Green chemistry - Introduction - need for green chemistry - goals of green chemistry - Anastas' twelve principles of green chemistry –Limitations and the progress of green chemistry. Atom economy. Designing a green synthesis - choice of starting materials, solvents, catalysts, reagents, processes with suitable examples. UNIT II: Microwave and Ultrasound Assisted Organic Synthesis and Biocatalysts

(18 Hours) Microwave activation - advantages of microwave exposure –Difference between conventional heating and microwave heating. Microwave assisted reactions, condensation reactions - oxidation, reduction reactions, multicomponent reactions. Sonochemistry– uses, acoustic cavitation - saponification - substitution, addition, oxidation reactions, reductions by sonochemical method. Solid supported synthesis - use of biocatalysts in green chemistry - advantages - biochemical (microbial) oxidation and reduction reactions UNIT III: Ionic liquids - Phase Transfer Catalyst and Supercritical CO2 in Green Synthesis

(18 Hours) Ionic liquids - synthesis, physical properties of ionic liquids - applications in alkylation, epoxidation, Friedal-Crafts reaction - Diels-Alder reactions – Knoevengal condensations and Wittig reactions.PTC –Crown ethers, Quaternary ammonium salt. Definition - advantages, types of PTC reactions - synthesis of PTC, applications of PTC in organic synthesis - Michael reaction - alkylation of aldehydes and ketones. Wittig, generation of dihalocarbene, elimination reaction. Supercritical CO2- uses in extracting natural products, dry cleaning, bromination, Kolbe-Schmidt synthesis - Friedel-crafts reaction. Dimethyl carbonate as a methylating agent in green synthesis. UNIT IV: Pollution from Agriculture (18 Hours) Pesticides – classification. Mode of action of insecticides. Bio-accumulation and biomagnification of pesticides - Major disasters with pesticides and herbicides - Toxicity of DDT, gammexene and malathion - comparison of organochlorine, organophosphate and carbamate insecticides – Detoxification of pesticides and allied chemicals - Safer pesticides - Minimisation of environmental problems caused by fertilisers.

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UNIT V: Radioactive Pollution (18 Hours) Nature of radioactive emission - units - Radiation from natural sources and Manmade activities - Effects of radiation on human health - Permissible radiation dose - Comparative risk analysis of fossil fuel based power generation versus nuclear power generation - Radioactive fall out - Nuclear winter: atmospheric turbidity and effects - Radioactive pollution in land, atmosphere and water - Nuclear waste disposal: Nature, general principles and strategies - Causes and prevention of nuclear reactor accidents - Chernobyl disaster - Three Mile Island disaster. REFERENCE BOOKS

1. Paul T. Anastas and John C. Warner, “Green Chemistry”, Oxford University Press, Indian Edition, 2008.

2. V. K. Ahluwalia and M. Kidwai, “New Trends in Chemistry”, Anamaya Publishers,2ndEdition, 2007.

3. V. Kumar, “An Introduction to Green Chemistry”, Vishal Publishers, 1stEdition, 2007. 4. V. K. Ahluwalia and R. S. Varma, “Green Solvents”, Narosa Publishing, 1stEdition, 2009. 5. V.K.Ahluwalia and Renu Aggarwal, “Organic Synthetic Special Techniques”, Narosa, 2nd

Edition, 2009. 6. V. K. Ahluwalia, “Green Chemistry - Environmentally Benign Reactions”, Ane books,

2006. 7. Rashmi Sanghi and N. M. Srivastava, “Environment Friendly Alternatives”, Narosa

Publishing House, 2003. 8. D. K. Asthana and Meera Asthana, “Environment - Problems and Solutions”, S.Chand.

2006. 9. Benny Joseph, “Environmental Studies”, Tata McGraw Hill Publishing Company Ltd, New

Delhi.2005

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DEPARTMENT OF CHEMISTRY ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR

INORGANIC CHEMISTRY PRACTICAL

(Applicable to the students admitted from the academic year 2017-2018 onwards under CBCS) Class : I M.Sc. Chemistry Part : Core Lab-2 Semester : II Hours : 120 Code : 17PCHP22 Credits: 5 Practical – A :Qualitative Analysis

Less common metal ions – Tl, Se, Te, Ce, W, Ti, Zr, Th, V, U, Li, Mo (Two metal ions in Cationic

and Anionic forms)

Practical – B :Quantitative Analysis

a) EDTA Titrations : Zn(II), Mg(II), Cu(II) and Ni(II)

b) Redox Titrations : Fe(II) vs. Ce(IV) , Fe(II) vs. dichromate NO2- Vs. Ce(IV)

Practical – C :Estimation of Copper, Ferric, Nickel, Chromium and Manganese using photo electric colorimeter. (Demo only)

Practical – D: Inorganic preparations

(a) Tetrammine Copper (II) sulphate

(b) Hexammine Chromium (III) nitrate

(c) Potassium tris (oxalato) cuprate (II)

REFERENCE BOOKS

1. A. I. Vogel, “Quantitative Inorganic Analysis”, ELBS, 3rdEdition, 1971. 2. V. V. Ramanujam, “Inorganic Semimicro Qualitative Analysis”, The National

Publishing Company, Madras, 1974.

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DEPARTMENT OF CHEMISTRY

ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR

APPLICATIONS OF ORGANIC & INORGANIC SPECTROSCOPY

(Applicable to the students admitted from the academic year 2017-2018 onwards under CBCS)

Class : II M.Sc. Chemistry Part : Core-8

Semester : III Hours : 90

Code : 17PCHC83 Credits: 4

To enable the learners

1. to know the UV-Vis spectra of organic compounds and metal complexes.

2. to study the IR and Raman spectroscopy.

3. to acquire knowledge in NMR, Mass, NQR and Mossbauer spectroscopy.

UNIT–I: UV-Vis Spectra of Organic Compounds and Metal Complexes (18 Hours)

Characterization of organic compounds: application of Woodward-Fieser rules to conjugated

dienes, , -unsaturated carbonyl compounds; benzene and its substituted derivatives;

polycyclic aromatic hydrocarbons; polyenes; polyenes, and heterocyclic compounds.

Term symbols for atoms and ions – splitting of orbitals and terms in crystal fields –

characteristics of d-d transitions – energy levels – Orgel and Tanabe – Sugano diagram – effect

of Jahn – Teller distortion and spin-orbit coupling on absorption spectra – crystal field spectra

of transition metal complexes – calculation of 10Dq and B for Co(II) (Oh) and Ni(II) (Oh)

complexes. Spectral properties of lanthanide complexes. Charge transfer spectra of halide,

cyanide and bipyridine complexes (octahedral, square planar and tetrahedral complexes).

UNIT–II: IR and Raman Spectroscopy (18 Hours)

Quantitative studies: calculation of force constants of IR vibrations, hydrogen bonding- intra-

and intermolecular hydrogen bonding. Conformational studies: cyclic 1,2-diols and 1,3-diols,

cyclohexanes. Characteristic group absorptions of organic compounds: carbon skeleton

vibrations, alcohols, phenols, ethers, peroxides, ketones, aldehydes, carboxylic acids, esters,

lactones, amines, amino acids; groups absorbing in the fingerprinting region, aromatic over

tones and combination bands. Effect of inductive and mesomeric effects on carbonyl frequency

– effect ring strain on carbonyl stretching frequency.

Combined application of IR and Raman spectra for structural elucidation of N2O, ClF3,ClO4-and

NO3-.Group theoretical approach to find the IR and Raman active vibrations of simple

compounds.Effect of coordination upon ligand vibrations of H2O, CNS-, NO3-, CN-& SO4

2-.

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UNIT–III: NMR Spectroscopy (18 Hours)

Chemical shifts: region of proton chemical shift in organic molecules; chemical shift

equivalence- interchange through symmetry operations, tagging, restricted rotations, magnetic

equivalence.NMR spectra of protons bonded to O, N, S: chemical exchange, hydrogen bonding.

Factors influencing coupling constant – Karplus equation, simplification of complex spectra.13C

NMR spectroscopy– off resonance decoupling, effect of alkyl and halogen substitution,

hybridisation effects. Basic principle of 2D NMR spectroscopy, COSY, NOESY. 31P NMR spectra of P4S3, H3PO3and H3PO2.

19F NMR spectra of CIF3, BrF5 and equimolar mixture

of TiF62- and TiF4 in ethanol.

UNIT–IV: MassSpectrometry (18 Hours)

Mass spectrometry – basic principles – molecular ion peak – parent peak – fragments –meta

stable ion – isotope peaks – determination of molecular weight and molecular formula –

fragmentation pattern of simple organic molecules – McLafferty rearrangement – retro Diels

Alder reaction. Combined spectroscopic problems involving simple organic molecules.

UNIT–V: NQR and MossbauserSpectroscopy (18 Hours)

Applications of NQR spectroscopy: the quadrupole coupling constant e2qQ and the asymmetry

parameter interpretation of NQR spectra, structural information from NQRspectra, NQR spectra

of haloorganic compounds and complexes.

Applications of Mossbauer spectroscopy: Doppler effect, isomer shift, quadrupole splitting,

magnetic interactions; magnetic and quadrupole splitting in ferromagnetic compounds,

Mossbauer spectra of high- and low-spin Fe(II) and Fe(I II) compounds; site symmetry of metal

centers in iron complexes; differentiation of non-equivalent metal centers in polynuclear

complexes; discovering oxidation states-Sn, Sn(II) , Sn(IV) compounds.

REFERENCE BOOKS

1. P.S.Kalsi, Spectroscopy of Organic Compounds, 3rdEdn., New Age International,

New Delhi, 1998.

2. William Kemp Organic Spectroscopy, ELBS, 2ndEdn., 1987.

3. Y.R.Sharma, Elementary Organic Absorption Spectroscopy, Chand & Co, 1986

4. Atta-ur-Rahman, Nuclear Magnetic Resonance, Springer Verlag, New York,1986.

5. R.M.Silverstein, G.C.Bassler and T.C.Morrill, Spectrometric Identification of Organic

Compounds, 4thEdn.John Wiley, 1981.

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DEPARTMENT OF CHEMISTRY

ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR

ANALYTICAL CHEMISTRY

(Applicable to the students admitted from the academic year 2017-2018 onwards under CBCS)

Class : II M.Sc. Chemistry Part : Core - 9

Semester : III Hours : 75

Code : 17PCHC93 Credits : 4

To enable the learners

1. to know the errors in chemical analysis.

2. to study the spectral and thermal techniques.

3. to acquire knowledge in chromatographic and electroanalytical techniques.

UNIT–I: Errors in Chemical Analysis (15 Hours)

Systematic and random errors. Distribution of experimental results. Statistical treatment,

standard deviation, variance, confidence limits, application of statistics to data treatment and

evaluation, student-t and f tests, detection of gross errors, rejection of a result-Q test,

estimation of detection limits. Least square method, correlation coefficient and its

determination.

UNIT–II: Spectral and Thermal Techniques (15 Hours)

Instrumentation of AAS and AES. Types of optical instruments, components of optical

instruments-sources, monochromators, detectors. Sample preparations. Applications in

quantitative analyses.

Principles, instrumentation and applications of Thermogravimetry (TG), Differential Thermal

Analysis (DTA) and Differential Scanning Calorimetry (DSC).

UNIT – III: Chromatographic Techniques (15 Hours)

Principles of chromatography: Partition and Adsorption chromatography. Types - TLC, Column

chromatography, Paper chromatography, Super critical fluid chromatography and Reversed

phase chromatography. Principles and Instrumentation of HPLC,GC. Ion –exchange and Gel

permeation chromatography.

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UNIT–IV: Electroanalytical Techniques (15 Hours)

Instrumentation - different types of electrodes - two electrode and three electrode cell set up,

importance of supporting electrolyte, mass transport processes - General classification of

electroanalytical techniques.

Potentiometry - ion selective electrodes and measurement of open circuit potential.

Coulometry- Controlled potential coulometry, constant current coulometry, Determination of

number of transferred electrons.

Voltammetry techniques – Polorography - Cyclic voltammetry – Rotating disc electrode- Pulse

techniques (Normal pulse, Differential pulse and square wave)-stripping voltammetry: Anodic,

cathodic and adsorptive. Chronopotentiometry and chronoamperometry.

UNIT–V: Advanced Chemical Analysis (15 Hours)

Principle, instrumentation and applications of PES (UPS and XPS), Aüger electronspectroscopy,

EDAX, Electron microscopy (SEM, TEM) and SPM (STM and AFM).

REFERENCE BOOKS

1. R. Stock and C. B. F. Rice, Chromatographic Methods, Chapman and Hall,New York. 1985

2. V. K. Srivastava and K. K. Srivastava, Introduction to Chromatography, S. Chand & Co.,

New Delhi, 2nded, 1981.

3. Willard, Merrit, Dean and Settle, Instrumental methods of Analysis CBS Publishers and

Distributors, 6th ed., 1986.

4. Skoog, D. A. West, D. M. Holler. P. J. Fundamentals of Analytical Chemistry, 7th edition,

Harcourt College Publishers, Singapore. 1988

5. A. Sharma, S. G. Schulman, Introduction to Fluorescence Spectroscopy. Wiley-Interscience,

New York, 1999.

6. C. N. Banwell and E. M. McCash, Fundamentals of Molecular Spectroscopy, 4th ed. Tata

Mc.Graw –Hill, New Delhi,1994.

7. Vogel, A.I. A Textbook of Quantitative Inorganic Analysis, ELBS. 1989

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DEPARTMENT OF CHEMISTRY

ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR

CHEMICAL THERMODYNAMICS, EQULIBRIA AND ELECTROCHEMISTRY

(Applicable to the students admitted from the academic year 2017-2018 onwards under CBCS)

Class : II M.Sc. Chemistry Part : Core-10

Semester : III Hours : 90

Code : 17PCHD03 Credits : 4

To enable the learners

1. to acquire knowledge in equilibrium and non-equilibrium thermodynamics.

2. to learn chemical and phase equilibria.

3. to acquire knowledge in statistical thermodynamics and electrochemistry.

UNIT–I: Equilibrium Thermodynamics and Non-equilibrium Thermodynamics (18 Hours)

General review of enthalpy, entropy and free energy concepts - second law of thermodynamics

- concept of entropy - Gibbs function- Gibbs- Helmholtz equation- Maxwell relations - Third law

and its limitations-thermodynamics of systems of variable compositions-partial molar quantities

and their determination - chemical potential - Gibbs-Duhem equation - Gibbs-Duhem-Margules

equation - fugacity and its determination - choice of state.

Non-equilibrium thermodynamics - conservation of mass and energy-entropy production-

entropy production in chemical reactions-entropy production and entropy flow in open

systems- Onsager’s theory - validity and its verification.

UNIT–II: Statistical Thermodynamics (18 Hours)

Combinatory rule - probability theorem - permutations and combinations - energy states and

energy levels - macro-states and micro-states - Maxwell-Boltzmann statistics - thermodynamic

probability, Sterling’s approximation, Legrange’s undetermined multiplier, distribution

functions.

Partition function and thermodynamic functions- molar partition function- entropy and third

law - separation of partition function- translational, rotational, vibrational and electronic

partition functions, combined partition function- equilibrium constant and partition function.

Quantum statistics - Bose-Einstein and Fermi-Dirac statistics - photon gas -degeneracy and

Bose-Einstein condensation, application to liquid He - negative Kelvin temperature.

UNIT–III: Chemical and Phase Equilibria (18 Hours)

Reaction free energy/ reaction potential - reaction isotherm and direction of spontaneity -

Standard reaction free energy - its calculation from thermochemical, electrochemical and

equilibrium data - Temperature coefficient of reaction free energy and equilibrium constant.

Gibbs phase rule - its thermodynamic derivation - application of phase rule to three component

systems - Formation of one pair, two pairs and three pairs of partially miscible liquids - Systems

composed of two solids and a liquid - Common ion effect – Salting out.

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UNIT–IV: Electrochemistry-I (18 Hours)

Mean ion activity and activity coefficient of electrolytes in solution - ion association -ionic

strength - Debye-Hückel theory and Debye-Hückel limiting law - its validity and limitations -

strong and weak electrolytes - Debye theory of electrolytic conductance - Debye-Hückel-

Onsager equation - verification and limitations - electrochemical cells and applications of

standard potentials.

UNIT–V: Electrochemistry-II (18 Hours)

The electrical double layer - polarizable and non-polarizable interfaces - structure of electrical

double layer - double layer models - Helmholtz, Guoy-Chapman and Sternmodels. Kinetics of

electrode processes - current-potential curve - Butler-Volmer relation and its approximations -

symmetry factor and transfer coefficient - Tafel equation – charge transfer resistance - Nernst

equation from Butler-Volmer equation - primary and secondary batteries - fuel cells - corrosion

and its prevention methods.

REFERENCE BOOKS

1. S. Glasstone, Thermodynamics for Chemists, East-west Affiliated Pvt Ltd, New Delhi

(1969)

2. R. P. Rastogi and R. R. Misra, An Introduction to Chemical Thermodynamics Vikas Publishing

House Pvt Ltd., (1992)

3. Kloz and P. M. Rosenberg, Chemical Thermodynamics: Basics Theory and Methods, 3rd ed.,

W. A. Benjamin, NY (1974)

4. P. W. Atkins, Advanced Physical Chemistry, 7th ed., Clarendon (2002)

5. S. Glasstone, Introduction to Electrochemistry, Affiliated East-West Press, (2005).

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DEPARTMENT OF CHEMISTRY ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR

BIOCHEMISTRY (Applicable to the students admitted from the academic year 2017-2018 onwards under CBCS)

Class : II M.Sc. Chemistry Part : Elective-3 Semester : III Hours : 75 Code : 17PCHE33 Credits : 4

To enable the learners 1. to learn about the metal ions in biological systems.

2. to develop knowledge in the structure and reactions of enzymes and coenzymes. 3. to study the biological constituents and their functions.

Unit I (15 Hours) Metal ions in Biological Systems. Bulk and trace metals with special reference to Na, K, Mg, Ca, Fe, Cu, Zn, and Co. Bioenergetics and ATP Cycle. DNA polymerisation, glucose storage, metal complexes in transmission of energy; Haem proteins and oxygen uptake structure and function of haemoglobin, mygolobin, and hemerythrin. Unit II (15 Hours) Electron Transfer in Biology. Structure and function of metal of proteins in electron transport processes cytochromes and ion-sulphur proteins, synthetic models. Nitrogen fixation. Biological nitrogen fixation, and its mechanism, nitrogenase, Chemical nitrogen fixation. Unit III (15 Hours) Enzymes - properties like catalytic power, specificity and regulation. Nomenclature and classification, extraction and purification. Fischer’s lock and key and Koshalnd’s induced fit hypothesis. Enzyme kinetics, Michael’s-Menten and Lineweaver Burk plots, reversible and irreversible inhibition. Mechanism of Enzyme Action. Transition state theory, orientation and steric effect, acid-base catalysis, covalent catalysis, strain or distortion. Kinds of Reactions catalysed by Enzymes - addition and elimination reactions, β-Cleavage and condensation, isomerization and rearrangement reactions. Unit IV (15 Hours) Co-Enzyme Chemistry. Cofactors as derived from vitamins, coenzymes, prosthetic groups, apoenzymes. Structure and biological functions of coenzyme A, thiamine pyrophosphate, pyridoxal phosphate, NAD+, NADP+, FMN, FAD, lipoic acid, vitamin B12. Enzyme Models. Host-guest chemistry, chiral recognition and catalysis, molecular recognition, molecular asymmetry and prochirality Biotechnological Applications of Enzymes. Use of enzymes in food and drink industry-brewing and cheese making. Enzymes as targets for drug design. Clinical uses of enzymes, enzyme therapy. Unit V (15 Hours) Biological Cell and its Constituents. Biological cell, structure and functions of proteins, enzymes, DNA and RNA in living systems. Helix coils transition. Forces involved in biopolymer interactions. Electrostatic charges and molecular expansion, hydrophobic forces, dispersion force interactions. Multiple equilibrium and various types of binding processes in biological

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systems. Hydrogen ion titration curves. Cell membrane and transport of ions. Structure and functions of cell membrane, ion transport through cell membrane. REFERENCE BOOKS 1. Principles of Biochemistry, Donald Voet, Judith G. Voet &Charlotte W. Pratt, John Wiley&

Sons.3rd Edition, 2004 2. Principles of Biochemistry, A.L. Lehninger, D.L. Nelson and M.M. Cox, CBS Publishers, Delhi. 4th Edition, 2004 3. Principles of Bioinorganic Chemistry, S.J. Lippard and J.M. Berg, University Science Books.

1994 4. Inorganic biochemistry vol. I & II ed. G.L. Eichhorn, Elsevier. 1982 5. Progress in Inorganic Chemistry, Vol 18, 38 ed.J.J. Lippard, Wiley. 1973 6. Bioorganic Chemistry: A Chemical Approach to Enzyme Action. Hermann Dugas. Springer.

1999

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DEPARTMENT OF CHEMISTRY ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR

PHYSICAL CHEMISTRY PRACTICAL

(Applicable to the students admitted from the academic year 2017-2018 onwards under CBCS) Class : II M.Sc. Chemistry Part : Core Lab -3 Semester : III Hours : 120 Code : 17PCHP33 Credits: 5

1. General Experiments:

1.1 Kinetics of acid-catalysed hydrolysis of an ester

1.2 Determination of partition coefficient of I2 between CCl4 and H2O, formation constant of

the KI3 complex, and determination of unknown KI concentration

1.3 Study of adsorption isotherms and determination of unknown concentration

2. Electrochemistry Experiments:

Conductometry Experiments

2.1 Determination of strength of a NaOH and CH3COONa

2.2 Determination of strengths of CH3COOH and CH3COONa

2.3 Determination of solubility product of a sparingly soluble salt (BaSO4)

2.4 Determination of hydrolysis constant of C6H5NH2.HCl

Potentiometry Experiments

3.1Determination of strength of Fe2+ using K2Cr2O7 as link

3.2 Determination of dissociation constant by pH metric method

3.3 Determination of solubility product of AgX

3.4 Phase diagram - three component system

REFERENCE BOOKS 1. J. B. Yadav, “Advanced Practical Physical chemistry”, 20th edn. GOEL publishing House,

Krishna Pakashan Media Ltd., (2001). 2. Findlay’s “Practical Physical Chemistry” Revised and edited by B. P. Levitt

9thed.,Longman, London, (1985). 3. J. N. Gurtur and R. Kapoor, “Advanced Experimental chemistry”, Vol. I. Chand & Co.,

Ltd, New Delhi, 1987

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DEPARTMENT OF CHEMISTRY

ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR

NATURAL PRODUCTS

(Applicable to the students admitted from the academic year 2017-2018 onwards under CBCS)

Class : II M.Sc. Chemistry Part : Core -11

Semester : IV Hours : 60

Code : 17PCHD14 Credits: 4

To enable the learners

1. to learn heterocycles and carbohydrates.

2. to acquire knowledge about terpenoids, alkaloids and steroids.

3. to acquire knowledge about vitamins, nucleic acids and proteins.

UNIT–I: Heterocycles and Carbohydrates (12 Hours)

Methods of preparation and important reactions of indole, pyrimidine, uracil and uric acid.

Structure elucidation of caffeine.

A general study of flavones and anthocyanins – Structure and synthesis of quercetin and

cyanidin chloride. Effect of pH on cyanidin chloride. Colour reactions of flavonoids.

Structure and synthesis of maltose and cellobiose – A brief study of starch and cellulose

UNIT–II:Terpenoids and Alkaloids (12 Hours)

Classification of terpenoids with examples – isoprene rules – General methods of structural

determination of terpenes – structure and synthesis of alpha-pinene, cadinene and abietic acid.

General methods of structure analysis of alkaloids – Hoffmann, Emde and von Braundeg

radations – Structure and synthesis of quinine, atropine, reserpine andmorphine (synthesis

excluded)

UNIT–III: Steroids (12 Hours)

Types of steroids – structure, stereochemistry of cholesterol (synthesis excluded) – Structural

features of bile acids – Sex harmones – androsterone, testerosterone, estrone, progesterone.

UNIT–IV: Vitamins and Nucleic acids (12 Hours)

Chemistry and physiological action of ascorbic acid, thiamin and riboflavin. Chemistry of nucleic

acids, nucleosides and nucleotides – RNA and DNA – functions of nucleic acids

UNIT–V: Amino acids and Proteins (12 Hours)

Sequence analysis of peptides by chemical, enzymatic and mass spectral methods -synthesis of

polypeptides – peptidisation methods like activated ester method – mixed anhydride- using

reagents like DCC, Woodward reagent K –solid phase peptide synthesis – Classification of

proteins – primary, secondary and tertiary structures of proteins.

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REFERENCE BOOKS

1. K.W.Bently, Alkaloids, Vol.I, Interscience, 1957.

2. Heftmann, Chromatography, Reinhold, 2ndedition, 1969.

3. K.Nakanishi, Natural Products Chemistry, Vol. I & II, Academic Press, 1975.

4. L.F.Fieser and M.Fieser, Steroids, Reinhold.L.Zechmeister (ed), Progress in the Chemistry

of Natural Products, Vols. 1 to 27,Springer-Verlag. 1968

5. P.S.Kalsi, Chemistry of Natural Products, Kalyani Publishers, New Delhi, 1983.

6. F.M.Dean, Naturally occurring oxygen ring compounds, Butterworths, London,1963.

7. J.L.Simonsen, The Terpenes, Vols 1-4, Academic Press, N.Y., 1957.

8. Paul de Mayo, Chemistry of Terpenoids, Vols. I & II, Academic Press, 1963

9. J.R.Holum, Introduction to organic and biological chemistry, John Wiley, N.Y.1969.

10. W.Klyne, The Chemistry of Steriods, Methuen and co., N.Y. 1965.

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DEPARTMENT OF CHEMISTRY

ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR

NUCLEAR CHEMISTRY AND PHOTOCHEMISTRY

(Applicable to the students admitted from the academic year 2017-2018 onwards under CBCS)

Class : II M.Sc. Chemistry Part : Core-12

Semester : IV Hours : 60

Code : 17PCHD24 Credits : 4

To enable the learners

1. to develop knowledge in nuclear chemistry.

2. to study principles of photochemistry.

3. to acquire knowledge in pericyclic reactions.

UNIT–I: Nuclear Chemistry (12 Hours)

Properties of nucleus – different types of nuclear forces – liquid drop model, shell model of

nucleus – nuclear reactions induced by charged particles – Q-value – nuclear reaction cross

section, significance and determination – theory of nuclear fission – reactor and its

components– production of feed materials for nuclear reactors – disposal of radioactive wastes

– nuclear fusion, stellar energy. Application of radioisotopes in agriculture, industry and

medicine –neutron activation analysis – hot atom chemistry.

UNIT–II: Photochemistry: Principles (12 Hours)

Absorption of light by molecules – Reaction paths of electronically excited molecules -

Fluorescence and phosphorescence – Jablonski diagram – Physical properties of the

electronically excited molecules: Excited state dipole moments, Excited state pKa and redox

potentials – Stern-Volmer equation and its application – Photosensitization –

Chemiluminescence– Quantum yield and actinometry.

UNIT–III: Inorganic Photochemistry (12 Hours)

Photochemistry of Cr(III), Co(III) andRu(II) - coordination compounds – photoaquation –

photoanation – photoisomerisation – photoredox reactions – charge transfer photo chemistry –

photosensitisation – solar energy conversiuon – photogalvanic cell – splitting of water to evolve

hydrogen and oxygen –photochemistry of Pt(II) and Pt(IV) complexes.

UNIT–IV: Organic Photochemistry (12 Hours)

Thermal vs photochemical reactions – energy transfer reactions -sensitized reactions –

Photochemical reactions of ketones and enones – Norrish type I and type II reactions – Paterno-

Buchi reaction - isomerisation of olefins – di-pi-methane rearrangement –photochemical

reduction and photochemical oxidations –oxidative couplings. Barton reaction.

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UNIT–V: Pericyclic Reactions (12 Hours)

Definition – electrocyclic, cycloaddition and sigmatropic reactions – Orbital correlation diagram,

state correlation diagram, frontier orbital theory and aromatic transition state approach–

endoselectivity and regiochemistry in Diels-Alder reactions- Cope and Claisen rearrangements.

REFERENCE BOOKS

1. K. K. Rohatgi and Mukerjee, Fundamentals of Photo Chemistry, Wiley Eastern Ltd (1986).

2. Photochemistry and Pericyclic reactions. Jagdamba Singh & Jaya Singh – New

AgeInternational, (2005).

3. G. Hughes, Radiation Chemistry, Oxford University Press(1973).

4. P.W.Atkins, Physical Chemistry, 5thEdn., Oxford, International Student Edition, (1994).

5. J. Moore, Physical Chemistry, 5thEdn., Orient Longman, (1963).

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DEPARTMENT OF CHEMISTRY

ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR

CHEMICAL KINETICS, SURFACE CHEMISTRY & COMPUTATIONAL CHEMISTRY

(Applicable to the students admitted from the academic year 2017-2018 onwards under CBCS)

Class : II M.Sc. Chemistry Part : Core-13

Semester : IV Hours : 75

Code : 17PCHD34 Credits: 4

To enable the learners

1. to acquire knowledge in chemical kinetics, catalysis and surface chemistry.

2. to study the kinetics of polymerization.

3. to acquire knowledge in cheminformatics and computational chemistry.

UNIT–I: Chemical Kinetics (15 Hours)

Basic kinetic concepts - Theories of reaction rates-collision theory - Transition State theory - salt

effect - temperature effects, Arrhenius equation, chemical interpretation of activation

parameters, microscopic reversibility - Lindemann, Hinshel wood, RRK, RRKM and Slater

treatments - fast reaction kinetics - survey of methods for very fast reactions – stopped flow

methods - chemical relaxation methods - flash photolysis.

UNIT–II: Catalysis and Surface Chemistry (15 Hours)

Homogenous catalysis - activation barrier - Hammett acid-base catalysis - rate of acid and base

catalysis - acidity function. Enzyme catalysis: Brief introduction on enzymes - advantages -

Michaelis-Menten kinetics -Lineweaver Burk plot - enzymatic inhibitor.

Heterogenous catalysis: Adsorption, physisorption and chemisorptions, Langmuir and BET

adsorption, Gibbs adsorption isotherm, insoluble surface films, electro-kinetic phenomena,

zetapotential.

Surface active agents - classification, micellization, hydrophobic interaction, CMC and factors

affecting CMC, counter-ion binding to micelles - thermodynamics of micellization–

reversemicelles.

UNIT–III: Macromolecules and Kinetics of Polymerization (15 Hours)

Overview of polymers - structure and classification of polymers - kinetics and mechanism of

free radical and ionic polymerizations - degree of polymerization – condensation and

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coordination polymerizations - Zeigler-Natta catalysis - copolymerization - molecular weight of

polymers - number and weight average molecular weights - determination of molecular weight

- light scattering and viscosity methods - gel permeation chromatography.

UNIT–IV: Introduction to Cheminformatics (15 Hours)

Introduction to cheminformatics - history and evolution of cheminformatics - use of

cheminformatics, prospects of cheminformatics - database management, cheminformatics

database - introduction to molecular modeling and drug design.

UNIT–V: Computational Chemistry (15 Hours)

Concepts of computational chemistry - molecular mechanics: general features, bond stretching,

angle bending, improper torsions, out of plane bending, non-bonded interactions, point

charges, calculation of atomic charges, polarization, van der Waals interactions, hydrogen bond

interactions, water models. Determination of pH, polarity, normality by C-programing.

Chemdraw.

REFERENCE BOOKS

1. K. J. Laidler, Chemical Kinetics,2nded, Tata McGraw Hill (1975)

2. A. A. Frost and R. G. Pearson, Kinetics and Mechanisms, John Wiley & Sons (1953)

3. J. C. Kuriacose and J. Rajaram, Kinetics and Mechanisms Transformations, Macmillan &Co.,

(1993)

4. P. W. Atkins, Advanced Physical Chemistry, 7thed., Clarendon (2002)

5. S. K. Basandra, “Local Area Networking”.Galgotia, New Delhi, (1999).

6. A. S. Tanenbaum, “Computer Networks”. Prentice Hall of India, (1996).

7. S. M. Bachrach, “ Internet for Chemists”. ACS Publications. Washington, DC, (1996).

8. A. R. Leach, “ Molecular Modelling Principles & Applications”, 2nded., Prentice Hall,(2001).

9. Tim Clark, “A Handbook of Computational Chemistry”, John Wiley, New York, (1985).

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DEPARTMENT OF CHEMISTRY

ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR

PROJECT WORK

(Applicable to the students admitted from the academic year 2017-2018 onwards under CBCS)

Class : II M.Sc. Chemistry Part : Core - 14

Semester : IV Hours : 180

Code : 17PCHD44 Credits: 5

Objective

To make the student understand and present a research finding on a topic in the subject

related to Chemistry.

Upon submission of the project report to the office of the Controller of Examinations, the viva-

voce examination will be conducted by the supervisor and the external expert suggested by the

supervisor. The Project report and the viva-voce will be evaluated for 100 marks.

Project Report 60 marks

Standard of subject and plan

Preparation

Originality

Summary and References

Viva-Voce 40 marks

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DEPARTMENT OF CHEMISTRY

ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR

MOLECULAR DYNAMICS

(Applicable to the students admitted from the academic year 2017-2018 onwards under CBCS)

Class : II M.Sc. Chemistry Part : Elective-4

Semester : IV Hours : 75

Code : 17PCHE44 Credits: 4

To enable the learners

1. to learn the principles and reactivity of molecular dynamics.

2. to understand kinetic isotopic effect, structural and solvation effects on reactivity.

3. to acquire knowledge in pharmacokinetics and pharmacodynamics.

UNIT I (15 Hours)

Principles of Reactivity. Mechanistic significance of entropy, enthalpy and Gibb’s free energy.

Arrhenius equation. Transition state theory. Uses of activation parameters, Hammond’s

postulate. Bell Evans-Polanyi principle. Potential energy surface model. Marcus theory of

electron transfer. Reactivity and selectivity principles.

UNIT II (15 Hours)

Kinetic Isotope Effect. Theory of isotope effects. Primary and secondary kinetic isotope effects.

Heavy atom isotope effects. Tunneling effect. Solvent effects.

UNIT III (15 Hours)

Structural Effects on Reactivity. Linear free energy relationships (LFER).The Hammett equation,

substituent constants, theories of substituent effects. Interpretation of σ-values. Reaction

constant ρ. Deviations from Hammett equation. Dual-parameter correlations, inductive

substituent constant. The Taft model, σl- and σR-scales.

UNIT IV (15 Hours)

Solvation and Solvent Effects. Quantitative understanding of solvent-solute effects on

reactivity. Thermodynamic measure of solvation. Effects of solvation on reaction rates and

equilibria. Various empirical indices of solvation based on physical properties, solvent-sensitive

reaction rates, spectroscopic properties and scales for specific solvation. Use of solvation scales

in mechanistic studies. Solvent effects from the curve-crossing model.

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UNIT V (15 Hours)

(a) Pharmacokinetics. Introduction to drug absorption, disposition, elimination using

pharmacokinetics, important pharmacokinetic parameters in defining drug disposition and in

therapeutics. Mention of uses of pharmacokinetics in drug development process.

(b) Pharmacodynamics. Introduction, elementary treatment of enzyme stimulation, enzyme

inhibition, sulphonamides, membrane active drugs, drug metabolism, xenobiotics,

biotransformation, significance of drug metabolism in medicinal chemistry.

REFERENCE BOOKS

1. Physical Organic Chemistry, Jack Hine, McGraw-Hill. 1962

2. Mechanism-An introduction to the study of organic reactions, R.A. Jackson, Oxford Chemistry

Series.1974

3. Medicinal Chemistry, P. Paramoo, CBS, India. 1971

4. Medicinal Chemistry: An Introduction.2ndEdition. Wiley, 2007

5. Chemical Kinetics, K.J.Laidler, Tata McGraw-Hill, 2nd Edition, New Delhi, 1991

6. Chemical Kinetics, E.S. Espenson, Tata McGraw-Hill, 4th Edition, New Delhi, 1996

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DEPARTMENT OF CHEMISTRY ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR

ELECTIVES & NONMAJOR ELECTIVE (Applicable to the students admitted from the academic year 2017-2018 onwards under CBCS)

LIST OF ELECTIVES

1. Chemistry of Materials

2. Medicinal Chemistry

3. Biochemistry

4. Molecular Dynamics

5. Nano materials and Synthetic Organic Chemistry

NON MAJOR ELECTIVE (FOR OTHER STUDENTS)

Green and Environmental Chemistry

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DEPARTMENT OF CHEMISTRY

ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR

NANOMATERIALS AND SYNTHETIC ORGANIC CHEMISTRY

(Applicable to the students admitted from the academic year 2017-2018 onwards under CBCS)

Class : M.Sc. Chemistry Part : Elective-5

Semester : Hours : 75

Code: Credits : 4

To enable the learners

1. to learn the techniques, properties and applications of nanomaterials.

2. to study the nanostructures and the synthesis of nanomaterials.

3. to acquire knowledge about the reagents for reduction and oxidation reactions.

UNIT I: Nanomaterials - An Introduction and Synthetic Methods

Definition of nanodimensional materials - Historical milestones - unique properties due to

nanosize, Quantum dots, Classification of nanomaterials. General methods of synthesis of

nanomaterials: Physical approaches- Chemical vapour deposition, Electro deposition and High

energy ball milling. Chemical approaches - Microwave irradiation, sol-gel, precipitation

technology - Reverse micelle synthesis, Synthesis of nanomaterials using microorganisms,

Sonochemical synthesis.Applications of nanomaterials: nanomaterials in medicine, in energy

sector and in ceramics industries. Inorganic nanomaterials - typical examples - nano TiO2/ZnO.

Organic nanomaterials - examples - Rotoxanes and Catenanes.

UNIT II: Techniques, Properties and Applications

Techniques for characterization of nanoscale materials. Principles of atomic force microscopy

(AFM), Transmission Electron Microscopy (TEM) - Resolution and Scanning Transition Electron

Microscopy (STEM), Scanning Tunneling Microscopy (STM), Scanning Nearfield Optical

Microscopy (SNOM). Nanocapsules - cavitands - cucurbiturils, nanocatalysis.

UNIT III: Nanostructures

Carbon clusters: Discovery of C60 - alkali doped C60 - superconductivity in C60 -larger and

smaller fullerenes. Carbon nanotubes: Synthesis- single walled carbon nanotubes – structure

and

characterization - Mechanism of formation - chemically modified carbon nanotubes – doping-

Functionalizing nanotubes - Application of carbon nanotubes. Nanowires: Synthetic strategies -

Gas phase and solution phase growth – Growth control - Properties.

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UNIT IV: Disconnection Approach and Synthetic Strategies

Introduction to retrosynthetic analysis and disconnection approach - relay and convergent

synthesis. Introduction to synthons, synthetic equivalents - target molecule -Umpolung -

designing synthesis by disconnection approach. Functional group interconversions - the

importance of the order of events in organic synthesis - protecting group - principle,

preparation and properties of alcohol, amine, carboxylic acids. One group C-C disconnections in

alcohols, olefins, ketones. Two group disconnections - 1,2 and 1,3 difunctional compounds. C-X

disconnection –chemoselectivity (guidelines) - Robinson annulation.

UNIT V: Reagents for Reduction and Oxidation Reactions (with mechanism)

Reduction: Catalytic hydrogenation - Wilkinson catalyst - dehydrogenation, reduction with LAH,

NaBH4, tertiary - butoxyaluminium hydride, NaCNBH3, tributyltinhydride, hydrazines - Wolff-

Kishner reduction, LDA, Gilman’s reagent. Oxidation: oxidation of hydrocarbons, Oxidation of

alcohols- Chromic acid, oxidation of carbon-carbon double bond- KMnO4 , OsO4, sharpless

asymmetric epoxidation, Ozone, DDQ, dioxiranes, Pb(OAc)4, SeO2,peracids, Platinum - catalysed

oxidation of alkenes.

References

1. C. N. R. Rao, A. Muller, A. K. Cheetam (Eds), The Chemistry of Nanomaterials, Vol. 1,2Wiley-

VCH, Weinheim, 2004

2. C. P. Poole, Jr., F. J. Owens, Introduction to Nanotechnology, Wiley Interscience, NewJersey,

2003.

4. Kenneth J. Klabunde (Ed), Nanoscale Materials in Chemistry, Wiley- Interscience, NewYork,

2001.

5. T. Pradeep, Nano: The Essentials in Understanding Nanoscience and Nanotechnology,

Tata McGraw Hill, New Delhi, 2007.

6. H. Fujita (Ed), Micromachines as tools in nanotechnology, Springer-Verlag, Berlin, 2003.

7. BengtNolting, Methods in modern biophysics, Springer-Verlag, Berlin, First Indian

Reprint,2004.

9. T. Tang and P. Sheng (Eds): Nano Science and Technology Novel Structures and

Phenomena, Taylor & Francis, New York, 2004

10. A. Nabok, Organic and Inorganic Nanostructures, Artech House, Boston, 2005.

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DEPARTMENT OF CHEMISTRY ARUL ANANDAR COLLEGE (AUTONOMOUS), KARUMATHUR

M.Sc. Chemistry – Course Structure under CBCS (Applicable to the students admitted from the academic year 2017-2018 onwards)

S.No Course Code Title of the Paper Hours/Week Credit

SEMESTER-I

1 Core Organic Reaction Mechanism & Stereochemistry

5 4

2 Core Group Theory & Solid State Chemistry 4 4

3 Core Quantum Chemistry and Chemical Bonding

5 4

4 Core Organic Chemistry Practical 8 5

5 Core Research Methodology 3 2

6 Elective-1 From among the five electives 5 4

TOTAL 30 23

SEMESTER-II

7 Core Conformational Analysis, Reagents and Organic Synthesis

4 4

8 Core Coordination, Organometallics and Bioinorganic Chemistry

4 4

9 Core Principles of Molecular Spectroscopy 4 4

10 Core Inorganic Chemistry Practical 8 5

11 Elective-2 From among the five electives 4 4

12 NME Green &Environmental Chemistry 6 4

TOTAL 30 25

SEMESTER-III

13 Core Applications of Spectroscopy 6 4

14 Core Analytical Chemistry 5 4

15 Core Chemical Thermodynamics, Equilibria and Electrochemistry

6 4

16 Core Physical Chemistry Practical 8 5

17 Elective-3 From among the five electives 5 4

TOTAL 30 21

SEMESTER-IV

18 Core Natural Products 4 4

19 Core Nuclear Chemistry and Photochemistry

4 4

20 Core Chemical Kinetics, Surface Chemistry & Computational Chemistry

5 4

21 Elective-4 From among the five electives 5 4

22 Core Project Work 12 5

TOTAL 30 21

Semester I II III IV Total

Credit 23 25 21 21 90