artificial sweetener gets fda approval
TRANSCRIPT
Japanese plan first European fiber plant Japan's first move into synthetic fiber making in Europe has come in Ireland's County Mayo. Asahi Chemical Industries is the leading shareholder in two joint ventures to produce acrylic fiber and yarn at Ballina. Hong Kong's Textile Alliance, Ltd., is Asahi's major partner.
With approvals by both the Japanese and Irish governments in hand and a site purchased, one venture will put an 18,000 metric-ton-per-year fiber unit on stream about June 1976. The other will bring an adjacent spinning plant capable of making 2500 tons a year of acrylic yarn into operation at the same time.
Technology will come from Asahi Chemical, Japan's number one acrylic fiber maker. At home, the company produces all three major synthetic fibers, but acrylic is its largest profit maker. Asahi has sold equipment and technology abroad in the past, but has been slower to invest overseas than have such other leading Japanese fiber firms as Teijin and Toray Industries. Last year, however, it set up Asahi Chemical International as a subsidiary to evaluate and organize foreign ventures.
The company holds a 45% interest in Asahi Synthetic Fibres (Ireland); Textile Alliance owns 35% and Japan's Toray Industries 10%. Toray's interest stems from its position as the main shareholder (about 30%) in Textile Alliance.
Textile Alliance, whose sales currently are about $160 million a year, markets textile products and also is engaged in dyeing and finishing, weaving and knitting, and garment production. It's now bent on integrating backward into fiber production as well.
Asahi owns 60% of Asahi Spinning (Ireland), Ltd., the second Irish venture, with Textile Alliance and C. Itoh & Co., a Japanese trading firm, owning 15% each. The remaining 10% in both Irish firms is held by the Irish government's Industrial Development Authority.
Dumping okay called dangerous precedent Russell W. Peterson, chairman of the White House Council on Environmental Quality, has blasted the U.S. Eighth Circuit Court's decision to allow Reserve Mining Co. to
continue dumping 67,000 tons a day of taconite tailings, which contain asbestos fibers, into Lake Superior. He warns that if the language of the opinion is allowed to stand, virtually the only way the Government could prove a case involving health hazards is by "counting dead bodies through an after-the-fact epidemiology study."
In a letter to Wallace H. Johnson, an assistant attorney general in the Justice Department s land and natural resources division, Mr. Peterson further alleges that the court "in essence abandoned the traditional legal test applicable in a civil case, i.e., more probable than
Peterson: unreasonable to expect proof
not, and has imposed a test requiring scientific certainty."
In its ruling the court said that "plaintiffs have failed to prove that a demonstrable health hazard exists." The court added that "given the current state of medical and scientific knowledge, plaintiffs' case is based only on medical hypothesis and is simply beyond proof.'
In Mr. Peterson's view it is unreasonable to expect such proof, especially for cancer, since the full causes of the disease remain unknown "after the most intensive research campaign in medical history." Also, the court's approach to a possible health hazard is entirely wrong in Mr. Peterson's view. He says that lack of knowledge about a potential hazard should not be misread as proof that the hazard is slight or does not exist, and points out that "because of the latent effects of carcinogens it will be more than 10 years before the magnitude of the health risk to the people of Duluth and Silver Bay will be fully realized, and unfortunately it will be based upon the fate of over 200,000 people."
Artificial sweetener gets FDA approval With one artificial sweetener off the market for five years and another under scrutiny by the Food and Drug Administration, a new entry into the sweetener market has just been approved by FDA.
The sweetener, aspartame, a product of G. D. Searle & Co., is about 180 times as sweet as sugar. And although the caloric value of aspartame is similar to that of sugars and proteins, the caloric intake of consumers using the product will be greatly reduced, since much smaller amounts are needed to produce the same sweetening effect. Aspartame is, in fact, the condensation product of two amino acids, aspartic acid and phenylalanine.
To be sold under the trademark Equa, the sweetener's chemical name is L-aspartyl-L-phenylalanine methyl ester, and it is claimed not to produce the bitter aftertaste associated with other artificial sweeteners. Searle predicts that the individual daily consumption of 0.8 gram of aspartame will provide about 5% of the normal daily intake of aspartic acid and about 10% of that of phenylalanine.
Aspartame is metabolized into its individual components in humans, and here some concern arises. FDA is requiring labeling of the compound to warn persons afflicted with phenylketonuria (PKU)—an inborn metabolic defect characterized by intolerance for normal levels of phenylalanine—to avoid the product. However, Dr. Frank L. Lyman, of White Plains, N.Y., a physician and author of a book on the disease, says that because of dietary requirements, PKU sufferers "would never use a product like this [artificial sweetener] in the first place."
The new sweetener will be filling the void, partially at least, created by FDA's removal of cyclamates from the market in 1969. At that time cyclamates were suspected of being carcinogens, but new studies in the U.S. and overseas seem to disprove this, and Abbott Laboratories, the leading producer, filed a new food additive petition with FDA in November 1973. But this review is moving slowly and probably will drag on into 1975 (C&EN, Feb. 25, page 8). Meanwhile, saccharin is also suspect as a carcinogen, and FDA and the National Academy of Sciences currently are reviewing safety data on the widely used artificial sweetener to determine its fate.
August 5, 1974 C&EN 5