Polytecnique School of the University of São Paulo

Department of Mechatronics Engineering

Artificial heart & applications of ultrasound

in medicine

Chi Nan Pai

• 1999 – Medical Doctor (USP)

• 2005 – Mechatronics Engineer (USP)

• Now – Assistant professor (USP)

Ti

69.0

28.5

370 g

Implantable

maglev centrifugal

blood pump

Laboratory of Ultrasound

(Prof. Julio Adamowski & Prof. Flavio Buiochi)

Ventricular assist

device (VAD)

• 2010 – Doctor of Eng. (Tokyo Tech – Shinshi / Shimokohbe Lab)

(chinan.pai@usp.br)

Artificial heart Lungs

Heart

VAD

Pulsatile flow

Continuous flow

Aorta

Diaphragm

Battery &

controller

Mini implantable

maglev CBP

Pulsatile flow through a CBP

Brushless DC motor

Outlet

Inlet Top housing Maglev impeller

Magnetic bearing (MB)

Time

Pump flow Continuous flow (now)

Pulsatile flow (research)

(Physiological)

Artificial heart

Cardiovascular simulator

Aortic valve

Mitral valve Flow sensor

Pressure sensor

Flow

resistance

Aorta simulator Left atrium simulator

Flow

Ventricle simulator

• Tests of VADs

• Tests of intravascular devices

• Use for tissue engineering

3D printing to test the concept

Petri dish

Cells

Not physiological

VAD

Ultrasound in medicine

Flexible linear array

Array with 64 elements Ultrasound transducer

from our lab

• Better coupling with human body

• More confortable for patient Fracture imaging

Image of movement of

tongue during speech

• Financial support from

Minister of Health

• Technology to fabricate

ultrasound transducers for

medical use

No need of X-ray

Ultrasound in medicine

Bone fracture Bone callus formation Long bone calcification

Bone callus

(soft tissue)

Cortical bone

Soft tissue

Trabecular bone

Emitter

Receiver

Gel

d

Transducer with 250 KHz

• Evaluation of the bone fracture healing process

• Ultrasonic stimulation of the cell tissue

• Better and faster healing process?

Tissue regeneration