Supplementary Table legend:

Supplementary Table 1. A summary of some factors/pathways/genes that play a role in regulation of KLF4 and those that KLF4 plays a role in their regulation. References are included.

Supplementary Table 1.

Factors that regulate KLF4

References

Pathways/genes regulated by KLF4

References

TGF-b1

(1-4)

IL-10

(5)

IFN-g

(6,7)

TGF-b1

(8)

IL-10

(9)

IL-6

(10)

IL-17

(11)

Slurp1

(12)

IL-1b

(13,14)

NF-B pathway

(15-17)

Erk5

(18)

Notch1

(19,20)

Notch1

(21-24)

HNF-6

(25)

Shh

(26)

Apolipoprotein E

(27)

C/EBPa

(28)

Keratin 4 & 19

(29,30)

SUMOylation

(31)

Laminin a 3A

(32)

KLF4

(33,34)

Ornithine decarboxylase

(35)

KLF5

(34)

Laminin a 1

(36)

AP-2a

(37,38)

Histidine decarboxylase

(39)

Butyrate

(40)

p53

(41,42)

p53

(43-45)

Wnt signaling and -Catenin

(46-49)

Prostaglandin

(50)

PSG-5

(51)

PPAR receptor

(50,52-54)

cGMP-dependent protein kinase

(55)

Polyadenylation

(56)

Epidermal barrier trasncriptional targets

(57)

Heat stress

(58)

ABL oncogenes

(59)

Tip60

(60)

Tight junction protein CLMP

(61)

FOXO

(62)

Steroidogenic genes LDLR and CYP11A

(63)

HMGB1

(64)

Adepogenesis

(65)

All-trans retinoic acid

(66,67)

HSC70

(68)

AICAR

(69)

Zip4

(70)

Sp1

(71)

Ghrelin

(72)

ELF4

(73)

Estrogen receptor a

(74,75)

Cyclosporin

(76)

platelet-derived growth factor receptor b

(77)

Platelet factor 4

(78)

p57

(79)

HDL

(80)

GPA33

(81)

p63

(82)

Nitric oxide synthase

(83)

Estrogen

(84)

HSP90

(85)

PKC

(86)

Mitofusin 2

(87)

Trichostatin

(88,89)

p21

(33,43,86,90-92)

Acetylbritannilactone

(93)

cyclin D1

(94,95)

Lim mineralization protein 3

(96)

cyclin D2

(97)

pVHL

(98)

cyclin E

(90,99)

ZNF750

(100)

cyclin B

(101)

LIF

(102)

Thyrotropin-releasing hormone

(103)

CDX2

(104,105)

SM22a

(106,107)

Oxygen

(108)

Conjuctival forniceal gene expression

(109)

TLR9

(5)

HBG

(110)

Src

(5)

Phosphofructokinase platelet isoform

(111)

Hypermethylation

(112)

Bmi1

(113)

Change in chromatin structure

(114)

DLK2

(115)

DNA damage

(43,44,116,117)

Alkaline phosphatase

(48,118-120)

Nerve growth factor

(121)

Proton-coupled folate transporter (PCFT)

(122)

Hydrogen peroxide

(121)

E-cadherin

(123,124)

Sheer stress

(125)

DMP1

(126)

Leptin

(127)

Myocardin

(128)

Honokiol

(129)

epigenetic remodeling

(130)

Dnmt1

(131)

Tight junction proteins ZO-1, occludin and claudin-5

(132)

AGPAT9

(133)

EMT promoting factors

(134-142)

Ubiquitylation

(143)

Epidermal progenitor genes and differentiation genes

(144)

Renin-angiotensin

(145)

Pax6

(146)

APC

(104)

MET

(147,148)

p300

(120)

Elk3

(148)

CtBPs

(149)

T-cell associated genes

(150)

Contact inhibition

(151)

Keratin 13

(152)

Serum starvation

(151)

TIMP-1 and -2

(153)

cAMP

(65)

Hepatocyte nuclear factor-6

(25)

Gastrin

(60)

Histone acetylation

(42,120)

Dextran sulfate sodium

(16)

mTOR pathway

(42,117)

Oxidative stress

(91,154)

DNA repair mechanisms

(42,155)

Matrix stiffness in ex vivo cultures of mouse proximal tubular epithelial cells

(156)

Ephrin-B/EphB signaling

(48)

Anaphase promoting complex

(4)

Autophagy markers LC3II and Atg7

(117)

Bone morphogenetic protein (BMP)-2, -4 and -6

(1)

C/EBPb

(65)

SLUG

(135)

p27

(157)

miRNA

(126,158-184)

Apoptosis

(41,89,116,117,185-196)

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90.Hagos EG, Ghaleb AM, Dalton WB, Bialkowska AB, Yang VW. Mouse embryonic fibroblasts null for the Kruppel-like factor 4 gene are genetically unstable. Oncogene 2009;28(9):1197-205.

91.Nickenig G, Baudler S, Muller C, Werner C, Werner N, Welzel H, et al. Redox-sensitive vascular smooth muscle cell proliferation is mediated by GKLF and Id3 in vitro and in vivo. Faseb J 2002;16(9):1077-86.

92.Mori K, Hamanaka H, Oshima Y, Araki Y, Ishikawa F, Nose K, et al. A HIC-5- and KLF4-dependent mechanism transactivates p21(Cip1) in response to anchorage loss. J Biol Chem 2012;287(46):38854-65.

93.Fang XM, Liu B, Liu YB, Wang JJ, Wen JK, Li BH, et al. Acetylbritannilactone suppresses growth via upregulation of kruppel-like transcription factor 4 expression in HT-29 colorectal cancer cells. Oncol Rep 2011;26(5):1181-7.

94.Shie JL, Chen ZY, Fu M, Pestell RG, Tseng CC. Gut-enriched Kruppel-like factor represses cyclin D1 promoter activity through Sp1 motif. Nucleic Acids Res 2000;28(15):2969-76.

95.Shie JL, Chen ZY, O'Brien MJ, Pestell RG, Lee ME, Tseng CC. Role of gut-enriched Kruppel-like factor in colonic cell growth and differentiation. Am J Physiol Gastrointest Liver Physiol 2000;279(4):G806-14.

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97.Klaewsongkram J, Yang Y, Golech S, Katz J, Kaestner KH, Weng NP. Kruppel-like factor 4 regulates B cell number and activation-induced B cell proliferation. J Immunol 2007;179(7):4679-84.

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100.Sen GL, Boxer LD, Webster DE, Bussat RT, Qu K, Zarnegar BJ, et al. ZNF750 is a p63 target gene that induces KLF4 to drive terminal epidermal differentiation. Dev Cell 2012;22(3):669-77.

101.Yoon HS, Yang VW. Requirement of Kruppel-like factor 4 in preventing entry into mitosis following DNA damage. J Biol Chem 2004;279(6):5035-41.

102.Li X, Song Y, Wang D, Fu C, Zhu Z, Han Y, et al. LIF maintains progenitor phenotype of endothelial progenitor cells via Kruppel-like factor 4. Microvasc Res 2012;84(3):270-7.

103.Perez-Monter C, Martinez-Armenta M, Miquelajauregui A, Furlan-Magaril M, Varela-Echavarria A, Recillas-Targa F, et al. The Kruppel-like factor 4 controls biosynthesis of thyrotropin-releasing hormone during hypothalamus development. Mol Cell Endocrinol 2011;333(2):127-33.

104.Dang DT, Mahatan CS, Dang LH, Agboola IA, Yang VW. Expression of the gut-enriched Kruppel-like factor (Kruppel-like factor 4) gene in the human colon cancer cell line RKO is dependent on CDX2. Oncogene 2001;20(35):4884-90.

105.Faber K, Bullinger L, Ragu C, Garding A, Mertens D, Miller C, et al. CDX2-driven leukemogenesis involves KLF4 repression and deregulated PPARgamma signaling. J Clin Invest 2013;123(1):299-314.

106.Salmon M, Gomez D, Greene E, Shankman L, Owens GK. Cooperative binding of KLF4, pELK-1, and HDAC2 to a G/C repressor element in the SM22alpha promoter mediates transcriptional silencing during SMC phenotypic switching in vivo. Circ Res 2012;111(6):685-96.

107.Yu K, Zheng B, Han M, Wen JK. ATRA activates and PDGF-BB represses the SM22alpha promoter through KLF4 binding to, or dissociating from, its cis-DNA elements. Cardiovasc Res 2011;90(3):464-74.

108.Jean JC, George E, Kaestner KH, Brown LA, Spira A, Joyce-Brady M. Transcription factor Klf4, induced in the lung by oxygen at birth, regulates perinatal fibroblast and myofibroblast differentiation. PLoS One 2013;8(1):e54806.

109.Gupta D, Harvey SA, Kenchegowda D, Swamynathan S, Swamynathan SK. Regulation of mouse lens maturation and gene expression by Kruppel-like factor 4. Exp Eye Res 2013;116:205-18.

110.Kalra IS, Alam MM, Choudhary PK, Pace BS. Kruppel-like Factor 4 activates HBG gene expression in primary erythroid cells. Br J Haematol 2011;154(2):248-59.

111.Moon JS, Kim HE, Koh E, Park SH, Jin WJ, Park BW, et al. Kruppel-like factor 4 (KLF4) activates the transcription of the gene for the platelet isoform of phosphofructokinase (PFKP) in breast cancer. J Biol Chem 2011;286(27):23808-16.

112.Yang WT, Zheng PS. Promoter hypermethylation of KLF4 inactivates its tumor suppressor function in cervical carcinogenesis. PLoS One 2014;9(2):e88827.

113.Yu T, Chen X, Zhang W, Colon D, Shi J, Napier D, et al. Regulation of the potential marker for intestinal cells, Bmi1, by beta-catenin and the zinc finger protein KLF4: implications for colon cancer. J Biol Chem 2012;287(6):3760-8.

114.Maejima T, Inoue T, Kanki Y, Kohro T, Li G, Ohta Y, et al. Direct evidence for pitavastatin induced chromatin structure change in the KLF4 gene in endothelial cells. PLoS One 2014;9(5):e96005.

115.Rivero S, Diaz-Guerra MJ, Monsalve EM, Laborda J, Garcia-Ramirez JJ. DLK2 is a transcriptional target of KLF4 in the early stages of adipogenesis. J Mol Biol 2012;417(1-2):36-50.

116.Talmasov D, Xinjun Z, Yu B, Nandan MO, Bialkowska AB, Elkarim E, et al. Kruppel-like factor 4 is a radioprotective factor for the intestine following gamma-radiation-induced gut injury in mice. Am J Physiol Gastrointest Liver Physiol 2015;308(2):G121-38.

117.Liu C, DeRoo EP, Stecyk C, Wolsey M, Szuchnicki M, Hagos EG. Impaired autophagy in mouse embryonic fibroblasts null for Kruppel-like Factor 4 promotes DNA damage and increases apoptosis upon serum starvation. Mol Cancer 2015;14:101.

118.Chen X, Whitney EM, Gao SY, Yang VW. Transcriptional profiling of Kruppel-like factor 4 reveals a function in cell cycle regulation and epithelial differentiation. J Mol Biol 2003;326(3):665-77.

119.Hinnebusch BF, Siddique A, Henderson JW, Malo MS, Zhang W, Athaide CP, et al. Enterocyte differentiation marker intestinal alkaline phosphatase is a target gene of the gut-enriched Kruppel-like factor. Am J Physiol Gastrointest Liver Physiol 2004;286(1):G23-30.

120.Evans PM, Zhang W, Chen X, Yang J, Bhakat KK, Liu C. Kruppel-like factor 4 is acetylated by p300 and regulates gene transcription via modulation of histone acetylation. J Biol Chem 2007;282(47):33994-4002.

121.Su C, Sun F, Cunningham RL, Rybalchenko N, Singh M. ERK5/KLF4 signaling as a common mediator of the neuroprotective effects of both nerve growth factor and hydrogen peroxide preconditioning. Age (Dordr) 2014;36(4):9685.

122.Furumiya M, Inoue K, Ohta K, Hayashi Y, Yuasa H. Transcriptional regulation of PCFT by KLF4, HNF4alpha, CDX2 and C/EBPalpha: implication in its site-specific expression in the small intestine. Biochem Biophys Res Commun 2013;431(2):158-63.

123.Cowan CE, Kohler EE, Dugan TA, Mirza MK, Malik AB, Wary KK. Kruppel-like factor-4 transcriptionally regulates VE-cadherin expression and endothelial barrier function. Circ Res 2010;107(8):959-66.

124.Koopmansch B, Berx G, Foidart JM, Gilles C, Winkler R. Interplay between KLF4 and ZEB2/SIP1 in the regulation of E-cadherin expression. Biochem Biophys Res Commun 2013;431(4):652-7.

125.Jiang YZ, Jimenez JM, Ou K, McCormick ME, Zhang LD, Davies PF. Hemodynamic disturbed flow induces differential DNA methylation of endothelial Kruppel-Like Factor 4 promoter in vitro and in vivo. Circ Res 2014;115(1):32-43.

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127.Imbernon M, Sanchez-Rebordelo E, Gallego R, Gandara M, Lear P, Lopez M, et al. Hypothalamic KLF4 mediates leptin's effects on food intake via AgRP. Mol Metab 2014;3(4):441-51.

128.Turner EC, Huang CL, Govindarajan K, Caplice NM. Identification of a Klf4-dependent upstream repressor region mediating transcriptional regulation of the myocardin gene in human smooth muscle cells. Biochim Biophys Acta 2013;1829(11):1191-201.

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131.Xiao X, Tang W, Yuan Q, Peng L, Yu P. Epigenetic repression of Kruppel-like factor 4 through Dnmt1 contributes to EMT in renal fibrosis. Int J Mol Med 2015;35(6):1596-602.

132.Ma J, Wang P, Liu Y, Zhao L, Li Z, Xue Y. Kruppel-like factor 4 regulates blood-tumor barrier permeability via ZO-1, occludin and claudin-5. J Cell Physiol 2014;229(7):916-26.

133.Fan SH, Wang YY, Wu ZY, Zhang ZF, Lu J, Li MQ, et al. AGPAT9 suppresses cell growth, invasion and metastasis by counteracting acidic tumor microenvironment through KLF4/LASS2/V-ATPase signaling pathway in breast cancer. Oncotarget 2015;6(21):18406-17.

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139.Lin ZS, Chu HC, Yen YC, Lewis BC, Chen YW. Kruppel-like factor 4, a tumor suppressor in hepatocellular carcinoma cells reverts epithelial mesenchymal transition by suppressing slug expression. PLoS One 2012;7(8):e43593.

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142.Yao S, Tian C, Ding Y, Ye Q, Gao Y, Yang N, et al. Down-reguation of Kruppel-like factor-4 by microRNA-135a-5p promotes proliferation and metastasis in hepatocellular carcinoma by transforming growth factor-beta1. Oncotarget 2016.

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144.Boxer LD, Barajas B, Tao S, Zhang J, Khavari PA. ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes. Genes Dev 2014;28(18):2013-26.

145.Hayashi K, Sasamura H, Nakamura M, Sakamaki Y, Azegami T, Oguchi H, et al. Renin-angiotensin blockade resets podocyte epigenome through Kruppel-like Factor 4 and attenuates proteinuria. Kidney Int 2015;88(4):745-53.

146.Zhang P, Ha T, Larouche M, Swanson D, Goldowitz D. Kruppel-Like Factor 4 Regulates Granule Cell Pax6 Expression and Cell Proliferation in Early Cerebellar Development. PLoS One 2015;10(7):e0134390.

147.Chen Z, Wang Y, Liu W, Zhao G, Lee S, Balogh A, et al. Doxycycline inducible Kruppel-like factor 4 lentiviral vector mediates mesenchymal to epithelial transition in ovarian cancer cells. PLoS One 2014;9(8):e105331.

148.Tsoyi K, Geldart AM, Christou H, Liu X, Chung SW, Perrella MA. Elk-3 is a KLF4-regulated gene that modulates the phagocytosis of bacteria by macrophages. J Leukoc Biol 2015;97(1):171-80.

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151.Garrett-Sinha LA, Eberspaecher H, Seldin MF, de Crombrugghe B. A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells. J Biol Chem 1996;271(49):31384-90.

152.He H, Li S, Hong Y, Zou H, Chen H, Ding F, et al. Kruppel-like Factor 4 Promotes Esophageal Squamous Cell Carcinoma Differentiation by Up-regulating Keratin 13 Expression. J Biol Chem 2015;290(21):13567-77.

153.Sung MT, Hsu HT, Lee CC, Lee HC, Kuo YJ, Hua K, et al. Kruppel-like factor 4 modulates the migration and invasion of hepatoma cells by suppressing TIMP-1 and TIMP-2. Oncol Rep 2015;34(1):439-46.

154.Cullingford TE, Butler MJ, Marshall AK, Tham el L, Sugden PH, Clerk A. Differential regulation of Kruppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelin-1, oxidative stress and cytokines. Biochim Biophys Acta 2008;1783(6):1229-36.

155.El-Karim EA, Hagos EG, Ghaleb AM, Yu B, Yang VW. Kruppel-like factor 4 regulates genetic stability in mouse embryonic fibroblasts. Mol Cancer 2013;12:89.

156.Chen WC, Lin HH, Tang MJ. Matrix-Stiffness-Regulated Inverse Expression of Kruppel-Like Factor 5 and Kruppel-Like Factor 4 in the Pathogenesis of Renal Fibrosis. Am J Pathol 2015;185(9):2468-81.

157.Wei D, Kanai M, Jia Z, Le X, Xie K. Kruppel-like factor 4 induces p27Kip1 expression in and suppresses the growth and metastasis of human pancreatic cancer cells. Cancer Res 2008;68(12):4631-9.

158.Xu N, Papagiannakopoulos T, Pan G, Thomson JA, Kosik KS. MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell 2009;137(4):647-58.

159.Davis-Dusenbery BN, Chan MC, Reno KE, Weisman AS, Layne MD, Lagna G, et al. down-regulation of Kruppel-like factor-4 (KLF4) by microRNA-143/145 is critical for modulation of vascular smooth muscle cell phenotype by transforming growth factor-beta and bone morphogenetic protein 4. J Biol Chem 2011;286(32):28097-110.

160.Chen Q, Li L, Tu Y, Zheng LL, Liu W, Zuo XY, et al. MiR-34a regulates apoptosis in liver cells by targeting the KLF4 gene. Cell Mol Biol Lett 2014;19(1):52-64.

161.Cittelly DM, Finlay-Schultz J, Howe EN, Spoelstra NS, Axlund SD, Hendricks P, et al. Progestin suppression of miR-29 potentiates dedifferentiation of breast cancer cells via KLF4. Oncogene 2013;32(20):2555-64.

162.Eggers JC, Martino V, Reinbold R, Schafer SD, Kiesel L, Starzinski-Powitz A, et al. microRNA miR-200b affects proliferation, invasiveness and stemness of endometriotic cells by targeting ZEB1, ZEB2 and KLF4. Reprod Biomed Online 2016;32(4):434-45.

163.Fang Y, Davies PF. Site-specific microRNA-92a regulation of Kruppel-like factors 4 and 2 in atherosusceptible endothelium. Arterioscler Thromb Vasc Biol 2012;32(4):979-87.

164.Hartmann P, Zhou Z, Natarelli L, Wei Y, Nazari-Jahantigh M, Zhu M, et al. Corrigendum: Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4. Nature communications 2016;7:11907.

165.Hartmann P, Zhou Z, Natarelli L, Wei Y, Nazari-Jahantigh M, Zhu M, et al. Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4. Nature communications 2016;7:10521.

166.Jiang K, Ren C, Nair VD. MicroRNA-137 represses Klf4 and Tbx3 during differentiation of mouse embryonic stem cells. Stem Cell Res 2013;11(3):1299-313.

167.Li J, Dong J, Zhang ZH, Zhang DC, You XY, Zhong Y, et al. miR-10a restores human mesenchymal stem cell differentiation by repressing KLF4. J Cell Physiol 2013;228(12):2324-36.

168.Liang WC, Wang Y, Liang PP, Pan XQ, Fu WM, Yeung VS, et al. MiR-25 suppresses 3T3-L1 adipogenesis by directly targeting KLF4 and C/EBPalpha. J Cell Biochem 2015;116(11):2658-66.

169.Lv H, Zhang Z, Wang Y, Li C, Gong W, Wang X. MicroRNA-92a Promotes Colorectal Cancer Cell Growth and Migration by Inhibiting KLF4. Oncol Res 2016;23(6):283-90.

170.Ma J, Yao Y, Wang P, Liu Y, Zhao L, Li Z, et al. MiR-152 functions as a tumor suppressor in glioblastoma stem cells by targeting Kruppel-like factor 4. Cancer Lett 2014;355(1):85-95.

171.Ma Z, Chen Y, Min L, Li L, Huang H, Li J, et al. Augmented miR-10b expression associated with depressed expression of its target gene KLF4 involved in gastric carcinoma. Int J Clin Exp Pathol 2015;8(5):5071-9.

172.Malik D, Kaul D, Chauhan N, Marwaha RK. miR-2909-mediated regulation of KLF4: a novel molecular mechanism for differentiating between B-cell and T-cell pediatric acute lymphoblastic leukemias. Mol Cancer 2014;13:175.

173.Mao L, Zhang Y, Deng X, Mo W, Yu Y, Lu H. Transcription factor KLF4 regulates microRNA-544 that targets YWHAZ in cervical cancer. Am J Cancer Res 2015;5(6):1939-53.

174.Okuda H, Xing F, Pandey PR, Sharma S, Watabe M, Pai SK, et al. miR-7 suppresses brain metastasis of breast cancer stem-like cells by modulating KLF4. Cancer Res 2013;73(4):1434-44.

175.Shyu KG, Cheng WP, Wang BW. Angiotensin II Downregulates MicroRNA-145 to Regulate Kruppel-like Factor 4 and Myocardin Expression in Human Coronary Arterial Smooth Muscle Cells under High Glucose Conditions. Mol Med 2015;21:616-25.

176.Sun SG, Zheng B, Han M, Fang XM, Li HX, Miao SB, et al. miR-146a and Kruppel-like factor 4 form a feedback loop to participate in vascular smooth muscle cell proliferation. EMBO Rep 2011;12(1):56-62.

177.Tang W, Zhu Y, Gao J, Fu J, Liu C, Liu Y, et al. MicroRNA-29a promotes colorectal cancer metastasis by regulating matrix metalloproteinase 2 and E-cadherin via KLF4. Br J Cancer 2014;110(2):450-8.

178.Tian Y, Luo A, Cai Y, Su Q, Ding F, Chen H, et al. MicroRNA-10b promotes migration and invasion through KLF4 in human esophageal cancer cell lines. J Biol Chem 2010;285(11):7986-94.

179.Wang GC, He QY, Tong DK, Wang CF, Liu K, Ding C, et al. MiR-367 negatively regulates apoptosis induced by adriamycin in osteosarcoma cells by targeting KLF4. J Bone Oncol 2016;5(2):51-6.

180.Xiao H, Li H, Yu G, Xiao W, Hu J, Tang K, et al. MicroRNA-10b promotes migration and invasion through KLF4 and HOXD10 in human bladder cancer. Oncol Rep 2014;31(4):1832-8.

181.Xie C, Huang H, Sun X, Guo Y, Hamblin M, Ritchie RP, et al. MicroRNA-1 regulates smooth muscle cell differentiation by repressing Kruppel-like factor 4. Stem Cells Dev 2011;20(2):205-10.

182.Yan C, Yu J, Liu Y, Kang W, Ma Z, Zhou L. MiR-32 promotes gastric carcinoma tumorigenesis by targeting Kruppel-like factor 4. Biochem Biophys Res Commun 2015;467(4):913-20.

183.Zheng B, Bernier M, Zhang XH, Suzuki T, Nie CQ, Li YH, et al. miR-200c-SUMOylated KLF4 feedback loop acts as a switch in transcriptional programs that control VSMC proliferation. J Mol Cell Cardiol 2015;82:201-12.

184.Zheng X, Li A, Zhao L, Zhou T, Shen Q, Cui Q, et al. Key role of microRNA-15a in the KLF4 suppressions of proliferation and angiogenesis in endothelial and vascular smooth muscle cells. Biochem Biophys Res Commun 2013;437(4):625-31.

185.Yang Y, Goldstein BG, Chao HH, Katz JP. KLF4 and KLF5 regulate proliferation, apoptosis and invasion in esophageal cancer cells. Cancer Biol Ther 2005;4(11):1216-21.

186.Ghaleb AM, Katz JP, Kaestner KH, Du JX, Yang VW. Kruppel-like factor 4 exhibits antiapoptotic activity following gamma-radiation-induced DNA damage. Oncogene 2007;26(16):2365-73.

187.Kuruvilla JG, Kim CK, Ghaleb AM, Bialkowska AB, Kuo CJ, Yang VW. Kruppel-like Factor 4 Modulates Development of BMI1(+) Intestinal Stem Cell-Derived Lineage Following gamma-Radiation-Induced Gut Injury in Mice. Stem Cell Reports 2016;6(6):815-24.

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189.Zhou Q, Hong Y, Zhan Q, Shen Y, Liu Z. Role for Kruppel-like factor 4 in determining the outcome of p53 response to DNA damage. Cancer Res 2009;69(21):8284-92.

190.Li Z, Zhao J, Li Q, Yang W, Song Q, Li W, et al. KLF4 promotes hydrogen-peroxide-induced apoptosis of chronic myeloid leukemia cells involving the bcl-2/bax pathway. Cell Stress Chaperones 2010.

191.Whitlock NC, Bahn JH, Lee SH, Eling TE, Baek SJ. Resveratrol-induced apoptosis is mediated by early growth response-1, Kruppel-like factor 4, and activating transcription factor 3. Cancer Prev Res (Phila) 2011;4(1):116-27.

192.Park CS, Lee PH, Yamada T, Burns A, Shen Y, Puppi M, et al. Kruppel-like factor 4 (KLF4) promotes the survival of natural killer cells and maintains the number of conventional dendritic cells in the spleen. J Leukoc Biol 2012;91(5):739-50.

193.Wang B, Zhao MZ, Cui NP, Lin DD, Zhang AY, Qin Y, et al. Kruppel-like factor 4 induces apoptosis and inhibits tumorigenic progression in SK-BR-3 breast cancer cells. FEBS Open Bio 2015;5:147-54.

194.Farrugia MK, Sharma SB, Lin CC, McLaughlin SL, Vanderbilt DB, Ammer AG, et al. Regulation of anti-apoptotic signaling by Kruppel-like factors 4 and 5 mediates lapatinib resistance in breast cancer. Cell death & disease 2015;6:e1699.

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