Breast cancer in Portugal: Temporal trends and

age-specific incidence by geographic regions

Gonçalo Forjaz de Lacerda, Scott P. Kelly, Joana Bastos, Clara Castro,

Alexandra Mayer, Angela B. Mariotto, William F. Anderson

Supplementary Figures

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Supplementary Fig. 1. Estimated Age Effects

APC model estimates of the longitudinal (A) and cross-sectional (B) age-specific curves for

breast cancer incidence in Portugal, by geographic regions (Azores and Madeira excluded),

1998–2011. Shaded bands represent 95% confidence limits. Incidence rates rose continuously

throughout life in the longitudinal curve, but not in the cross-sectional curve, where rates plateau

after menopause (South and North) or even decrease (Centre).

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Supplementary Fig. 2. Estimated Period and Cohort Effects

APC model estimates of the period rate ratios (A) and cohort rate ratios (B) for breast cancer

incidence in Portugal, by geographic regions (Azores and Madeira excluded), 1998–2011.

Shaded bands represent 95% confidence limits. When compared to the referent time-period

(2005), the period relative risk for being diagnosed with breast cancer overall was higher in all

three regions in more recent periods, with the North presenting the sharpest increase. Likewise,

when compared to women born before 1947 (reference cohort), younger cohorts also revealed an

increased risk of breast cancer.

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