AR-INBRE &

Lyon College

Institutional Profile

• Batesville, AR; population ~10,000• 42 Full Time Faculty• 8 Bio/Chem Faculty• 4.5 INBRE Eligible Faculty• ~600 Undergraduates• Bio/Chem/Biochem grads/year: ~20• Placement in graduate school/year: ~6

Curriculum Development

• INBRE Faculty Recruitment; Fall, 2003• Biochemistry Major added Fall, 2007• First three graduates, May, 2010– med school– pharm school– Teach for America

• Courses Added to Support the Major– Biochemistry (regular rotation)– Advanced Biochemistry

INBRE Supported PublicationsBook Chapters

B.D. Gehm & A. Levenson, "Resveratrol as a Phytoestrogen," chapter 17 (pp. 439 - 464) in Resveratrol in Health and Disease, ed. by B.B. Aggarwal & S, Shishodia; 679 pp; CRC Press, 2005.

Book ReviewsGregerson, RG and Lindblom, TH (2008) A Unique Textbook for Teaching Courses in Bioinformatics [review of Discovering

Genomics, Proteomics, and Bioinformatics, 2nd ed. (Cummings, B.; 2006)]. Computing in Science and Engineering 10(1), pg. 7-8.

Research PapersF.A. Beckford, “Reaction of the anticancer organometallic ruthenium compound, [(6-p-cymene)Ru(ATSC)Cl]PF6, with human

serum albumin”. International Journal of Inorganic Chemistry, Volume 2101, (2010).F.A. Beckford, M. Shaloski, Jr., G. Leblanc, J. Thessing, L. C. Lewis-Alleyne, A.A. Holder, L. Li and N.P. Seeram. Microwave synthesis

of mixed ligand diimine-thiosemicarbazone complexes of ruthenium(II): biophysical reactivity and cytotoxicity. Dalton Trans., 2009, 10757-10764.

Beckford, F.A., Harness, R. and Robertson, C. Thiosemicarbazone complexes of group 12 elements. 1. An investigation of the thiosemicarbazone from p-dimethylaminobenzaldehyde. Journal of Undergraduate Chemistry Research (2008), 7(3), 92.

Wang YY, Charlesworth A, Byrd SM, Gregerson RG, MacNicol MC, andMacNicol AM (2008) A novel mRNA 3 untranslated region ′translationalcontrol sequence regulates Xenopus Wee1 mRNA translation. DevelopmentalBiology 317:454–46

Beckford, F.A., and Holt, A. “Coordination Chemistry of Polycyclic Thiosemicarbazones. I. Reactions of the thiosemicarbazone from 9-Anthraldehyde.” Journal of Undergraduate Chemistry Research (2007), 6, 173.

Ghedin E, Wang S, Spiro D, Caler E, Zhao Q, Crabtree J, Allen JE, Delcher AL, Guiliano DB, Miranda-Saavedra D, Angiuoli SV, Creasy T, Amedeo P, Haas B, El-Sayed NM, Wortman JR, Feldblyum T, Tallon L, Schatz M, Shumway M, Koo H, Salzberg SL, Schobel S, Pertea M, Pop M, White O, Barton GJ, Carlow CK, Crawford MJ, Daub J, Dimmic MW, Estes CF, Foster JM, Ganatra M, Gregory WF, Johnson NM, Jin J, Komuniecki R, Korf I, Kumar S, Laney S, Li BW, Li W, Lindblom TH, Lustigman S, Ma D, Maina CV, Martin DM, McCarter JP, McReynolds L, Mitreva M, Nutman TB, Parkinson J, Peregrín-Alvarez JM, Poole C, Ren Q, Saunders L, Sluder AE, Smith K, Stanke M, Unnasch TR, Ware J, Wei AD, Weil G, Williams DJ, Zhang Y, Williams SA, Fraser-Liggett C, Slatko B, Blaxter ML, Scott AL (2007) Draft genome of the filarial nematode parasite Brugia malayi. Science 317(5845), pg. 1756-60.

Lindblom, T. and Dodd, A. (2006) Xenobiotic Detoxification in the Nematode Caenorhabditis elegans. Journal of Experimental Zoology 305A, pg. 720-730.

Lu Y, Heydel JM, Li X, Bratton S, Lindblom T., Radominska-Pandya A. (2005) Lithocholic acid decreases expression of UGT2B7 in Caco-2 cells: a potential role for a negative farnesoid X receptor response element. Drug Metab Dispos. 33(7): 937-46.

Extramural Funding Independent Support

National Institutes of Health, National Institute of Environmental Health SciencesAcademic Research Enhancement Award 2 R15 ES0131128-02Combinatorial Control of Toxin Induced Gene Expression in C. elegansJan. 29, 2010 – Dec. 31, 2013Lindblom, Tim H. (P.I.)

INBRE SupportSummer Research Fellowship; June 1 – August 31, 2009.

Lindblom, Tim H. (P.I.) and Lehmann, Michael (Mentor)Combinatorial Control of Toxin Induced Gene Expression in C. elegans

INBRE InvestigatorsRobert Gregerson; Translation Control in Xenopus Oocytes

June, 2005 – May, 2007Floyd Beckford; Anticancer thiosemicarbazone complexes of ruthenium and copper – synthesis,

biochemistry, and cellular mechanisms targeting nucleic acids.August, 2008 - Current

Barry Gehm; Signaling by Non-Classical Ligands of Estrogen ReceptorAugust, 2005 – May, 2010

Biomedical Science Faculty

Current• Floyd Beckford; Chemistry; Associate Professor• Barry Gehm; Biochemistry; Assistant Professor

with TenurePotential

• Tim Lindblom; Biology; Associate Professor• Han Ong; Biology; Assistant Professor• Patrick Mulick; Clinical Psychology; Assistant

Professor