a/prof kerrie mcdonald [email protected] - pathfinders · dynamic biobanking never stand still...
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A/Prof Kerrie McDonald
Cure Brain Cancer – Neuro-Oncology Group
Personalising treatment for
Glioblastoma patients
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Glioblastoma
Never Stand Still Medicine Personalised treatment
Affects all ages
Affects both men and women
No preventative screening measures
No effective treatment strategy
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Personalised Treatment
Never Stand Still Medicine Personalised treatment
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Dynamic Biobanking
Never Stand Still Medicine Pipeline
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Biobanking: Pre-clinical Models
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Never Stand Still Medicine Case Study
Case Study 1
• Headaches and nausea for a week
• MRI revealed cystic mass in the temporal lobe
• Gross total resection April 2015
• Ki67 >30%
• Negative for amplification of EGFR, PDGFRA
• Negative for PTEN loss
• INI preserved
• IDH1 wildtype
• MGMT unmethylated
• Chromosomal CGH/ SNP Microarray
• Amplification 2p in 3 discrete sites including MYCN
• Copy Number gains of 1q and 7q
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MP Rage before surgery
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Whole Genome Sequencing
Never Stand Still Medicine Case Study
• TSC 1
• TP53
• CIC
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T1 saggittal with gadolinium 3/9/15
at relapse
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Treatment
Never Stand Still Medicine Case Study
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Treatment
Never Stand Still Medicine Case Study
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Treatment
Never Stand Still Medicine Case Study
• Treated with sirolimus
• Stable tumour response for 4-6 weeks
• Excellent quality of life
• Passed away after a 9 month battle
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We need new treatments: Immunotherapy
Never Stand Still Medicine Case Study
(1) Tetanus-diphtheria vaccine
CMV
(2) CMV-PEPTIDE
CMV CMV Peptide + GM-CSF
Toxin released
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Thank you!!
Never Stand Still Medicine Acknowledgements
Prof Charlie Teo Dr Mustafa Khasraw All of the patients and their families
Dr Jacob Fairhall Dr Raj Reddy
Dr Liz Hovey