WHAT YOU’LL FIND

S P E C I A L C O L L A G E N I S S U EWNEWSApril 2011

ealth &

beautyYour body’s “health and beauty” protein

The Collagen Connection

HealtH and Beauty Staffyou want to be healthier and look younger. Who doesn’t? Fortunately, you now have advantages your mother and grandmother could not even imagine.

Molecular biologists have pinpointed the keystructural protein integrally involved in creating smooth skin, thick and strong hair, strong flexible bones, and bone mineral density. Its name? Collagen.

Surprised? You’re not alone. Say the word collagen to most people, and you conjure up images of Goldie Hawn’s lips in the movie “The First Wives Club.” Collagen and plastic surgeons seem to go together like ham and eggs. But the medical effects of generating your body’s own collagen are quite profound.

In fact, scientists call collagen the most important building block in the human body. It makes up 70% of your skin and 30% of your bone. Collagen prevents wrinkles from forming. It is integrally involved in vital skin elasticity. Collagen, along with keratin helps create thick, strong hair. Inside your bones, collagen acts as the “binding sites” for calcium. In fact, clinical trials now show that one specific collagen-generating compound, known as ch-OSA, increases bone mineral density by 2.00% compared to placebo. This was an actual increase in bone formation, not just a reduction in loss.

New research has even related the condition of youth and beauty to your body’s collagen content. But in humans, collagenproduction begins to diminish by age 21. By age 30 the signs of aging become visible.

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health & beautyomen’s

Your body’s “health and beauty” proteinThe Collagen Connection Find out collagen’s overwhelmingly positive effects on skin, hair, nails and bones – and learn how you can generate lost collagen naturally.

The truth about collagen supplements Generate collagen – don’t eat it! Know the facts about collagen and you’ll certainly benefit from its multitude of health, beauty, and rejuvenating properties.

Increase your body’s “hair bulking” protein Grow thicker, stronger hair – from the inside out Discover how to increase the diameter of each hair shaft, and create stronger, more break-resistant hair.

Create the medically “ideal condition” of bone Add bone flexibility to bone strength Increase your bones’ calcium “binding sites” Learn how collagen creates calcium “binding sites” inside your bone – increasing BMD by 200% over the clinical threshold. Plus you’ll see how collagen gives your bones both the strength and flexibility they need to withstand impact. Re-build your skin’s “structural support”Reduce wrinkles – add moisture Learn how generating new collagen “plumps out” skin and smoothes out wrinkles.

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Lookatthestaggeringstatisticsoncollagenloss.

u Collagen production decreases 1% per year, starting at age 21u A woman’s skin decreases in thickness (created by collagen) by 7% every ten years

Following Menopause…u Skin thickness declines as much as 1.13% annually.u In the first 5 years, women lose as much as 30% of their skin collagen.u The decrease in skin collagen correlates with decreases in bone mineral density.u Skin elasticity declines 0.55% per year.

Astounding statistics, for sure. Yet few Americans can recite even one of them. But clinical trials now prove that ch-OSA, can indeed generate collagen. ch-OSA

produced genuine “end point” benefits such as reducing existing fine lines and wrinkles, thickening and strengthening hair, increasing bone mineral density, and promoting stronger more flexible (impact resistant) bones.

I have been researching collagen for years. I’m happy to tell you that there’s one company that makes a collagen-generating product with the clinically-proven ingredient ch-OSA. It’s called BioSil. You can find it at your local health food store.

Generate collagen, don’t eat it! The truth about collagen supplements

What they may not want you to know

Cosmetic companies instruct you to “rub it on.” Plastic surgeons simply say

“inject it.” It’s easy to understand how neither of these choices helps your

body generate the collagen it needs to support genuine health and beauty.

But there’s a third option floating in the market now. That is, “eating” collagen

in the form of powders and pills. The story is that if you ingest collagen,

you’ll increase collagen. But the truth is, your body breaks the collagen

down and uses it as food. By contrast, BioSil’s clinically-proven patented

ch-OSA complex, helps your body to generate its own collagen. Through

the natural collagen-generating pathways.

Yours from the marketplace,

Jeff KobNOTE: If you feel this type of product could benefit you, be sure to look for products containing ch-OSA not plain OSA. All the clinical trials I have seen were with ch-OSA.

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ch-OSACOLLAGENGENERATOR

Clinical Results:

Clinicallyprovento…

u Reduce fine lines and wrinkles

u Increase skin elasticity

u Create smoother skin

u Increase the diameter of hair shafts

u Strengthen hair

u Increase bone mineral density

DID you

KNOW…• Skin is comprised of 70% collagen

• Bone is made up of 30% collagen

• Joints contain 70% collagen

collagen, it increases blood flow – delivering a greater amount of healthy nutrients to your hair. I know from personal experience. I found that styling becomes a breeze. But unlike the “spray on” thickeners you purchase at the cosmetic counter, this thickness will not shampoo out.

But there’s even better news about your hair…

Strongerhair–clinicallyproven

You’ve seen it in your sink. On the shower floor. Tangled up in your brush. It’s hair that was not strong enough to withstand simple brushing or sham-pooing. Sure, some of that lost hair is part of the natural growth cycle. But some was prematurely removed for your head. And ladies, I can absolutely tell you this is where BioSil products really help.

A “tug of war” with hair? Yes. That’s exactly what the researchers did in the BioSil clinical trial on hair. They were testing for what they call “break load.” In other words, how many pounds of pressure does it take to “snap” the hair in two. It’s the scientific measure of the hair’s tensile strength. What did they find? The hair on the women taking BioSil’s ch-OSA was significantly stronger – making it virtually break-resistant.

Increase your body’s “hair bulking” protein

Grow thicker, stronger hair – from the inside out

BULKINGUPYOURHAIR–FROMTHEINSIDE

By SaraH derBy

Staff Writer

April 2011 3

achieved from the inside out. Meaning it can’t “wash away.” It’s yours to keep, through rain, shine, and hotel shampoos. But it’s not magic. It’s real science at work. Here’s how BioSil works to thicken your hair:

Increaseyour“hair-bulking”protein

Have you heard of keratin? Keratin is the “hair bulking” protein. You see, your hair is made up of 97% keratin. That’s why keratin, like collagen, is considered one of Nature’s Beauty Proteins. And like collagen, keratin begins to diminish by the time we’re 21. Why? The answer is simple.

The gene responsible for producing keratin begins working slower and slower. Over time, there’s less and less keratin to “fill up” the hair shaft. Here’s a way to look at it. Think of your hair shaft as an un-inflated balloon, and air as the keratin. More air means a larger balloon. By the time we’re 45, some scientists believe we may have only half the keratin we used to. But that may not be a problem any longer.

You see, BioSil’s ch-OSA “turns on” the cells that produce keratin (called kera-tinoblasts). Day after day, your hair gets thicker and thicker. It looks healthier too. Plus, as ch-OSA generates more

let’s face it. Everybody wants thicker, shinier, more luxurious-looking hair. It’s no wonder. Hair is a symbol of your overall health and vitality. It also gives your face the ideal frame. Plus, it’s glamorous and sexy. Why else do you think Americans spend billions of dollars on hair care products every year? You’ve got spray on’s. Leave in’s. And rinse out’s. But the truth is, no exter-nally applied hair care product can genuinely change the basic quality of your hair. Not one. Real improvements in your hair happen from the inside out. And, as you’ll see, BioSil’s ch-OSA is clinically proven to do that.

You’ve got 100,000 hair follicles on your head. You can’t add more. But you can make each hair follicle thicker, and each hair strand stronger. And you can increase blood flow to your hair roots to ensure a healthy flow of nutrients. For the women participating in a clinical trial – that’s exactly what BioSil’s ch-OSA did. And can do for you too.

In fact, the individual diameter of each hair grew dramatically thicker after taking BioSil products. That adds up to much greater volume and far more body. And it’s bonafide thickness –

6 mg of ch-OSA daily. The result was an increase in their bone mineral density by a statistically significant 2.00% com-pared to placebo, measured at the critical thigh bone. That’s 200% over the mark of clinical relevance established by leading bone researchers.

It’s important to note that the 2.00% rise in BMD was the result of an actual increase in bone formation – not merely a lessening of bone loss. But there’s an even greater reason why ch-OSA is the focus of such intense research today.

or nothing. But when you increase the formation of collagen (calcium binding sites) you increase your bones’ calcium content.

This fact was demonstrated in a 12-month clinical trial conducted at the University of London, Research and Genetic Epidemiology Unit, St Thomas’ Hospital, Department of Pharmaceutical Sciences.

In the study, women who were already supplementing with 1000 mg of Calcium and 800 IU of vitamin D, added

Inside your bones, calcium binds to collagen. See Figure 6a. It

shows you how with fewer collagen strands, there’s less surface

area for calcium to attach itself. This causes diminished bone

mineral density. Now look at Figure 6b. BioSil’s ch-OSA increases

the collagen strands providing calcium more binding sites. This

results in greater bone mineral density.

Create the medically

ideal condition of bone Add bone flexibility to bone strengthIncrease your bones’ calcium “binding sites”

MOREBONECALCIUM“BINDINGSITES”MEANSHIGHERBONEMINERALDENSITY

Figure A: Before BioSil’s ch-OSA

Figure B:After BioSil’s ch-OSA

what you’re about to hear is bound to change the way you care for your bones from this day on. Until recently, the focus of bone health centered strictly on strength. That’s why you heard a lot about calcium and its ability to increase bone mineral density (BMD). And rightly so.

But today, the word in the medical community is “ideal condition of bone.” That means creating both bone strength (BMD) and bone flexibility (ability to withstand impact). And clinical trials now prove one compound, called ch-OSA, can do both.

IncreaseyourBMDbycreatingmore

bonecalcium“bindingsites”

Have you ever seen a cross-section of your bones? Take a look at the bone figure. Notice how the calcium “binds to” collagen strands (core posts) inside your bone.

But as we age, our bone collagen production diminishes. There become fewer and fewer of these bone calcium “binding sites.” That’s when BMD declines. You can easily see why continuously pumping in more and more calcium may accomplish little

4 Women’s health & beauty news

DID you

KNOW…• Calcium along with other bone minerals, is the inorganic part of your bone, and accounts for 70% of total bone

• Collagen is the organic part of your bone, and makes up 30% of bone

BioSil: Unprecedented clinical results YourSkinThe clinical trial recruited fifty women between 40 and 65 years old with symptoms of aging facial skin. They were divided into two groups, one taking a placebo and the other taking 10 mg BioSil per day for the 20-week period (Barel et al., 2005). No other anti-aging treatment was followed. The results demonstrated that subjects taking BioSil experienced a 19% reduction in fine lines, wrinkles, and skin roughness. Similarly, the skin of the BioSil group exhibited improved elasticity compared with those taking the placebo.† YourHairThe ch-OSA in BioSil, was clinically shown in another clinical trial to significantly increase the diameter of each hair shaft – adding fullness and body to your hair. Plus, BioSil helps make your hair stronger, more elastic, and more break resistant (Wickett et al., 2007).†

YourNailsWomen participating in the clinical trial reported that BioSil strengthened their nails, making them more break resistant (Barel et al., 2005). The BioSil nail phenomenon has given birth to an new expression: “Unbreakable Beauty.”†

YourBoneMineralDensityThis may be the most important finding about BioSil. It concerns your bone mineral density in both full-length thigh bone and hip region of thigh bone. In a clinical trial (Spector et al., 2005), subjects were divided into two groups: BioSil and placebo. The BioSil groups took BioSil, calcium, and vitamin D. The placebo group took only calcium and vitamin D. Placebo subjects lost 1.22% in bone mineral density at the hip region whereas the BioSil subjects gained 0.78 %. That’s a significant difference of 2.00% – twice the clinically relevant threshold.†

YourJoints Collagen is essential for maintaining articular cartilage in your joints, as well as ensuring the integrity of your ligaments. BioSil provides you with patented choline-stabilized orthosilicic acid to stimulate collagen sybthesis in bone and joints.†

ch-OSA:Generatecollagenwithyour

ownDNAfingerprint

The women I speak with today are quite conscious about the ingredients they put into their body. I’m sure you are too. I often get questions like… “How do I know the collagen that ch-OSA gener- ates is natural?” That’s a very thoughtful question. The answer is a very com-forting one. ch-OSA works through your body’s natural pathways. So the collagen you generate has your own

DNA fingerprint on it. Today, you can find two products

that contain ch-OSA: BioSil Skin Hair Nails, and BioSil Beauty Bones Joints. On their label it shows you the actual results of the ch-OSA clinical trial. I still recommend you do some research for yourself. But studies on ch-OSA have been published in peer reviewed medical journals and I believe you can find the clinical results on Wikipedia.

Increaseyourresistancetoimpactby

adding“boneflexibility”

Preventing fractures requires bone flex-ibility. Or as bone researchers like to say, bone “toughness.” Here the brittle calcium in bone can do little. But this is where the collagen content of your bone takes over.

Bone collagen is extremely flexible. Something like rubber. When collagen receives a “blow” it simply bends slightly and returns to its form. That’s why collagen gives your bones their ability to withstand impact – reducing the risk of fracture.

So how do you increase your bones’ collagen content?

Unfortunately, you cannot eat colla-gen the way you do calcium. Your body uses the ingested collagen as just another protein source – such as chicken, fish, or eggs.

The good news is that you can increase bone collagen formation by stimulating your body’s own collagen producing cells. And that is exactly what ch-OSA was clinically proven to do. And keep in mind, increasing bone collagen has two separate and distinct benefits for you:1 increases BMD by creating more bone calcium “binding sites” 2 decreases risk of fracture by adding flexibility – or bone toughness

As you can see, it takes both bone collagen and bone calcium to create the ideal condition of bones. Think of it like this:

Calcium without collagen = Strong, but brittle bones

Collagen without calcium = Flexible, but jelly-like bones

Collagen plus calcium = Ideal condition of bone

April 2011 5

DID you

KNOW…• Calcium along with other bone minerals, is the inorganic part of your bone, and accounts for 70% of total bone

• Collagen is the organic part of your bone, and makes up 30% of bone

Re-build your skin’s “structural support”

Reduce wrinkles and add elasticity

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Multi-directional collagen

Smooth youthful skin

Re-build your skin’s “structural support”

at work. Elasticity gives your skin the ability to “bounce back” after a crease or fold. Like smiling.

Not surprisingly, the quality of your skin’s elasticity today is a predictor of the wrinkles that may form in the future. Stated in a positive way, when you increase your skin’s elasticity, you give it greater resistance to wrinkling. That’s why some researchers call elasticity the great wrinkle preventer. So how do you increase elasticity?

In a word, collagen. But it’s not just the quantity of collagen

you have, but also the “direction” the collagen fibers run. In wonderfully elastic skin, you find the collagen fibers running in all directions. The scientific name is isotropic (multi-directional). In wrinkled skin, however, the collagen fibers tend to go in one direction, known as anisotrophic (single directional). It’s sort of like the difference between linen and silk. Pinch linen, it stays creased. Pinch silk, it bounces back.

Now here’s the encouraging part.In a clinical trial conducted with

women, a compound called ch-OSA was shown to increase skin elasticity by creating a rich matrix of “multi-directional” collagen. It’s important to note that the women did not change their daily diet, exercise, or supplement routine. They simply added 10 mg of ch-OSA daily.

IMPORTANT note You can find clinically-proven ch-OSA in BioSil products. They offer you the same dosage used in the clinical trials

“Plumping”yourskinfromthe

insideout

Take a look at the skin diagram. Notice how the “younger skin” contains a youthful abundance of collagen fibers. Millions of fibers “pushing out” the skin at every point along the way. This is what gives skin its firm, smooth appearance. It also prevents wrinkling. Now look at the “ageing skin.” See how the collagen fibers are few and far between. These “gaps” between the fibers are exactly where wrinkles form. Skin literally “caves in.” What can you do about it? A lot, actually.

The key is to “turn on” your body’s own collagen-producing cells (called fibroblasts). In a clinical trial, a com-pound called ch-OSA (found in BioSil products) did just that. Week by week, for the women taking ch-OSA, more and more collagen fibers began to form. The wrinkle-causing gaps started filling in. The end result was a statisti-cally significant reduction in fine lines and wrinkles.

You might be asking… “But is there a way to prevent or slow down the forma-

tion of new wrinkles?” The answer seems to be yes.

“Bounceback”–thewrinklepreventer

Think about it. You laugh. You frown. You raise your eyebrows in surprise. Yet your face doesn’t crack. That’s elasticity

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Multi-directional collagen

Smooth youthful skin

Dominant-directional collagen

Aged skin

you never even considered it back then… but when you were a kid, you’d wake up in the morning with rosy moisture-drenched skin. Without the fine lines and wrinkles. It looked and felt smooth and flawless. No matter how the pillow scrunched your cheeks. It all happened without makeup. With- out creams. Without lotions. The reason is simple: Collagen. You had lots of this skin-plumping, wrinkle-eliminating, moisture-attracting collagen. That’s why collagen is called a “beauty protein.” But starting at age 21, collagen begins to break down. That’s when fine lines and wrinkles form. But don’t worry. Now, thanks to a clinically-proven com-pound, ch-OSA, you can regenerate the collagen.

The Beauty of

Authentic BioSil®

Advanced Collagen Generator

• Reduces fine lines and wrinkles†*

• Thickens and strengthens hair†

• Fortifies nails†

• Promotes healthy bones†

• Clinically proven and patented

T h e O n l y C h o l i n e - S t a b i l i z e d O r t h o s i l i c i c A c i d C o m p l e x©2011 Bio Minerals NV. Manufactured by Bio Minerals NV, Belgium. Packaged and distributed by : Natural Factors. ch-OSA and BioSil are registered trademarks of Bio Minerals NV and the ch-OSA logo is a trademark of Bio Minerals NV • www.BioSilUSA.com† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.*Based upon clinical testing on the forearm and forehead

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