api-3200_br_final
DESCRIPTION
API 3200 ™ LC/MS/MS SYSTEM API 3200 ™ LC/MS/MS SYSTEM Reliability, reproducibility, and confidence in your data. With an unmatched heritage of technological innovation and dependability, the triple quadrupole API 3200 ™ System offers an attractive blend of performance, throughput, and value.TRANSCRIPT
Performance,productivity andvalue – combined
API 3200™ LC/MS/MS SYSTEM
API 3200™ LC/MS/MS SYSTEM
Reliability, reproducibility, and confidence in your data.
With an unmatched heritage of technological innovation
and dependability, the triple quadrupole API 3200™
System offers an attractive blend of performance,
throughput, and value.
High uptime, superior reproducibility, maximal productivityDesigned for high-throughput labs doing small molecule quantitation, the compact, affordable
API 3200™ System delivers best-in-class reliability and reproducibility over virtually all samples
encountered in environmental, food, clinical research, and pharmaceutical applications.
Like all of our industry-leading triple quadrupole and QTRAP® systems, the API 3200™ System platform features the Turbo V™ ion source
with plug-and-play probes that let you analyze an extended range of compounds over a wide range of flow rates. Patented Curtain Gas™
interface and LINAC® collision cell technologies provide superior ruggedness and selectivity for your most exacting quantitative analyses.
Powerful software, advanced automation features, and robust engineering increase your productivity, giving you the ability to routinely
analyze hundreds of samples – day after day, year after year.
• AbsoluteionizationInnovative Turbo V™ ion source efficiently
ionizes compounds and virtually eliminates cross-contamination,
even with large sample loads, for high-sensitivity quantitation
over a wide range of flow rates.
• SuperiorMS/MSperformancePatented, proven LINAC®
collision cell technology provides faster scan times. So you
can analyze more compounds per run, with no compromise in
sensitivity or mass spectral quality.
• MaximaluptimeProprietary Curtain Gas™ interface reduces
the need for routine maintenance and ensures maximal
productivity by protecting the interface region and quadrupole
analyzer from contamination.
• GreaterthroughputHigh-productivity software applications,
including automated methods development, enable unattended
operation and routine analysis of hundreds of samples per
day–every day.
• EaseofuseYou don’t have to be a mass spec expert to
achieve expert results. Advanced acquisition and processing
software completely automates setup and analysis.
• Results,systems,andsupportyoucancounton
The API 3200™ System is backed by one of the world’s most
extensive service and support organizations. Our promise is to
help keep your lab up and running at maximal productivity.
Ruggedness and reproducibility of the API 3200™ system. Running more than 1,200
injections of carbamate insecticides extracted from soil samples over the 3.5 days, the
API 3200™ system exhibits exceptional stability with relative standard deviations of
3.6% for the response of the two carbamates.
Injection Number
Aldicarb sulfone (rel std dev 3.6%)
Aldicarb (rel std dev 3.6%)
Re
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The API 3200™ LC/MS/MS System takes advantage of a number of proprietary mass spectrometry
innovations to deliver the performance required by demanding applications in regulated
environments–all at an excellent value.
An affordable benchtop platform built on premier technology
LINAC® Collision Cell
The patented LINAC® collision cell ensures maximal ion transfer
– free of crosstalk – from the interface to the detector in MS/MS
mode, allowing simultaneous multicomponent analyses. So you can
monitor more compounds and multiple reaction monitoring (MRM)
transitions without any appreciable loss in signal. LINAC® collision
cell technology also enables fast scanning, with uncompromised
performance in all modes of operation, including product ion,
precursor ion, and neutral loss scans.
3QI2QI
IQ1
Exit
STQ0 High Pressure Cell
Q1
LINAC ® Collision Cell
Q2 Q3DF
Detector
Q3
CurtainPlate
Curtain Gas™ Interface
Skimmer
Orifice
Source
Curtain Gas™ Interface
The proprietary Curtain Gas™ interface reduces the need for
routine maintenance and ensures maximal uptime and
productivity by protecting the interface region and quadrupole
analyzer from contamination.
CurtainPlate
Curtain Gas™ Interface
Skimmer
Orifice
Source
Convenient “Plug and Play” Ion Sources
Rugged, reliable, and easily interchangeable ion sources are available
for a wide range of applications and flow rates to suit your analysis
needs. Rapid source changeover minimizes downtime and simplifies
routine maintenance. All connections are fully integrated into the
source housing There are no extra lines to attach – and no lost time.
The innovative Turbo V™ ion source efficiently ionizes compounds and
virtually eliminates cross-contamination, even with large sample
loads. Embedded ceramic heater technology and improved gas
dynamics contribute to the system’s low detection limits and enable
high-sensitivity quantitation over a wide flow range up to
3 mL/min. The quick-change ESI and APCI probes let you switch
between ionization modes in seconds.
The DuoSpray™Sourcecontains two separate inlets for ESI and
APCI probes, allowing the optimal ionization technique and
conditions for each compound during an LC run. It speeds up method
development while also increasing throughput and data quality.
The PhotoSpray®Source for atmospheric pressure photo-ionization
expands the range of compounds that can be analyzed, often at
higher sensitivities than ESI or APCI. The PhotoSpray® source can
ionize many compounds that are not easily ionized by ESI or APCI,
such as polyaromatic hydrocarbons (PAHs).
The NanoSpray®III Source is an ultra low flow source designed
for minimal sample consumption and highest sensitivity at flow
rates from 50 nL/min to 2 μL/min. It is ideal for analyzing biological
samples such as peptides and proteins – even with very small sample
amounts. The source features easy tip and column replacement with
finger-tight fittings and a quick release spray assembly for simplified
maintenance and troubleshooting.
DuoSpray™ PhotoSpray® NanoSpray® III
3QI2QI
IQ1
Exit
STQ0 High Pressure Cell
Q1
LINAC ® Collision Cell
Q2 Q3DF
Detector
Q3
CurtainPlate
Curtain Gas™ Interface
Skimmer
Orifice
Source
Turbo V™
A new generation of industry-trusted Analyst® software lets you configure, tune, acquire data,
explore, and quantitate with high confidence – even when working with complex matrices.
You can automatically create fully optimized methods for multiple compounds, quickly generate
new quantitation methods, and analyze and compare analytical results.
More reliable, more confident results from every experiment
Analyst® software also provides a comprehensive feature set for
GLP labs, including full support for 21 CFR Part 11 compliance.
It offers an easily administered, integrated security model that adapts
to the needs of your lab, and gives you added confidence in your
data. Powerful, automated add-on applications, such as Information
Dependent Acquisition (IDA) further extend the system’s data
acquisition and processing capabilities.
Impressive linearity over a wide dynamic range is demonstrated in this calibration
curve of five replicate injections at each concentration level of cyanazine, a triazine
herbicide. The excellent accuracy and percent coefficient of variation (%CV) illustrate
the consistent high-quality quantitative results achievable day after day with the
API 3200™ System.
Outstanding Inter- and Intra-day Quantitative Performance
In this way, a method can be developed on the API 3200™ System
and then transferred among other AB SCIEX platforms, such as
AB SCIEX 5500 Systems, providing extra flexibility for busy labs
looking to maximize output.
Simplified Cross-Platform Methods Transfer
Many labs employ multiple AB SCIEX triple quadrupole and
QTRAP® LC/MS/MS systems in their daily work. Because all of these
platforms use the same Analyst® software and Turbo V™ ion source,
method transfer is quick and easy–simply copy over the source
parameters, adjust compound-specific instrument parameters,
and start running.
To confirm the stability and reproducibility of the calibration and quantitative
performance of the API 3200™ System, three replicate injections of atrazine were run
at each concentration level to create the calibration curve above.
During the course of the four-day study, nine replicate injections were run at each
concentration level. The %CV and accuracy surpass the typical quantitative analysis
performance requirements and demonstrate the exceptional stability and reproducibility
of the API 3200™ System. Outstanding inter- and intra-day quantitative performance
makes rapid validation of your methods a certainty.
r=0.9999r=0.9998
ForResearchUseOnly.Notforuseindiagnosticprocedures.
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0280510-01 07/2010
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You invest in our technology.We invest in your success.As the world leader in mass spectrometry, AB SCIEX solutions are backed by the industry’s
most extensive service and support organization. With more than 1000 service professionals,
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dedicated to supporting your technical needs and helping you get the most out of your
AB SCIEX systems.
AB SCIEX service professionals are recognized as the most highly qualified in the industry.
They are certified on our instrument platforms through a rigorous 4-step certification program,
with re-certification occurring every two years. This award-winning program helps to ensure
that you receive the most efficient, highest-quality, and most up-to-date service available for
AB SCIEX products and technology. Choose from flexible service plans and a variety of services
for the right level of support for your laboratory’s needs and budget.
Our customer support network is available to provide expert assistance in the use and application
of AB SCIEX products through a comprehensive range of services, including application support,
technical service, and training.
Whether you access our service and support team by phone, email, on-site visits, or through
our innovative remote monitoring technology, you can be confident that the AB SCIEX
organization will be there for you 24x7.
For more information, visit www.absciex.com